A Signature of Circulating microRNAs Predicts the Susceptibility of Acute Mountain Sickness.

Abstract:

:Background: Acute mountain sickness (AMS) is a common disabling condition in individuals experiencing high altitudes, which may progress to life-threatening high altitude cerebral edema. Today, no established biomarkers are available for prediction the susceptibility of AMS. MicroRNAs emerge as promising sensitive and specific biomarkers for a variety of diseases. Thus, we sought to identify circulating microRNAs suitable for prediction the susceptible of AMS before exposure to high altitude. Methods: We enrolled 109 healthy man adults and collected blood samples before their exposure to high altitude. Then we took them to an elevation of 3648 m for 5 days. Circulating microRNAs expression was measured by microarray and quantitative reverse-transcription polymerase chain reaction (qRT-PCR). AMS was defined as Lake Louise score ≥3 and headache using Lake Louise Acute Mountain Sickness Scoring System. Results: A total of 31 microRNAs were differentially expressed between AMS and Non-AMS groups, 15 up-regulated and 16 down-regulated. Up-regulation of miR-369-3p, miR-449b-3p, miR-136-3p, and miR-4791 in patients with AMS compared with Non-AMS individuals were quantitatively confirmed using qRT-PCR (all, P < 0.001). With multiple logistic regression analysis, a unique signature encompassing miR-369-3p, miR-449b-3p, and miR-136-3p discriminate AMS from Non-AMS (area under the curve 0.986, 95%CI 0.970-1.000, P < 0.001, LR+: 14.21, LR-: 0.08). This signature yielded a 92.68% sensitivity and a 93.48% specificity for AMS vs. Non-AMS. Conclusion: The study here, for the first time, describes a signature of three circulating microRNAs as a robust biomarker to predict the susceptibility of AMS before exposure to high altitude.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Liu B,Huang H,Wu G,Xu G,Sun BD,Zhang EL,Chen J,Gao YQ

doi

10.3389/fphys.2017.00055

subject

Has Abstract

pub_date

2017-02-08 00:00:00

pages

55

issn

1664-042X

journal_volume

8

pub_type

杂志文章
  • Heart rate variability in patients being treated for dengue viral infection: new insights from mathematical correction of heart rate.

    abstract:INTRODUCTION:Severe dengue hemorrhagic fever (DHF) is a viral infection that acts to increase permeability of capillaries, resulting in internal hemorrhage. Linear frequency domain Fourier spectral analysis represents the most published noninvasive tool for diagnosing and assessing health status via calculated heart ra...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2014.00046

    authors: Carter R 3rd,Hinojosa-Laborde C,Convertino VA

    更新日期:2014-02-25 00:00:00

  • Interpreting Signal Amplitudes in Surface Electromyography Studies in Sport and Rehabilitation Sciences.

    abstract::Surface electromyography (sEMG) is a popular research tool in sport and rehabilitation sciences. Common study designs include the comparison of sEMG amplitudes collected from different muscles as participants perform various exercises and techniques under different loads. Based on such comparisons, researchers attempt...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2017.00985

    authors: Vigotsky AD,Halperin I,Lehman GJ,Trajano GS,Vieira TM

    更新日期:2018-01-04 00:00:00

  • Limb-Specific Features and Asymmetry of Nerve Conduction Velocity and Nerve Trunk Size in Human.

    abstract::This study aimed to simultaneously examine the differences of human nerve conduction velocity (NCV) and nerve cross-sectional area (nCSA) between the upper and lower limbs and between different regions of the upper and lower limbs. Thirty healthy subjects volunteered for the study. NCV and nCSA of the ulnar and tibial...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.609006

    authors: Nobue A,Kunimasa Y,Tsuneishi H,Sano K,Oda H,Ishikawa M

    更新日期:2020-12-03 00:00:00

  • Endocrine pancreatic development: impact of obesity and diet.

    abstract::During embryonic development, multipotent endodermal cells differentiate to form the pancreas. Islet cell clusters arising from the pancreatic bud form the acini tissue and exocrine ducts whilst pancreatic islets form around the edges of the clusters. The successive steps of islet differentiation are controlled by a c...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2013.00170

    authors: O'Dowd JF,Stocker CJ

    更新日期:2013-07-18 00:00:00

  • Following a Long-Distance Classical Race the Whole-Body Kinematics of Double Poling by Elite Cross-Country Skiers Are Altered.

    abstract::Introduction: Although short-term (approximately 10-min) fatiguing DP has been reported not to alter the joint kinematics or displacement of the centre of mass (COM) of high-level skiers, we hypothesize that prolonged DP does change these kinematics, since muscular strength is impaired following endurance events lasti...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00978

    authors: Zoppirolli C,Bortolan L,Stella F,Boccia G,Holmberg HC,Schena F,Pellegrini B

    更新日期:2018-07-25 00:00:00

  • Sport-Specific Assessment of the Effectiveness of Neuromuscular Training in Young Athletes.

    abstract::Neuromuscular training in young athletes improves performance and decreases the risk of injuries during sports activities. These effects are primarily ascribed to the enhancement of muscle strength and power but also balance, speed and agility. However, most studies have failed to demonstrate significant improvement i...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2018.00264

    authors: Zemková E,Hamar D

    更新日期:2018-04-11 00:00:00

  • The multiple roles of fatty acid handling proteins in brain.

    abstract::Lipids are essential components of a living organism as energy source but also as constituent of the membrane lipid bilayer. In addition fatty acid (FA) derivatives interact with many signaling pathways. FAs have amphipathic properties and therefore require being associated to protein for both transport and intracellu...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00385

    authors: Moullé VS,Cansell C,Luquet S,Cruciani-Guglielmacci C

    更新日期:2012-09-28 00:00:00

  • The Transcription Factor MafB Regulates the Susceptibility of Bactrocera dorsalis to Abamectin via GSTz2.

    abstract::Pesticide resistance is a serious problem that poses a major challenge to pest control. One of the most potent resistance mechanisms is the overexpression of genes coding for detoxification enzymes. The expression of detoxification genes is regulated by a series of transcription factors. Previous studies have revealed...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01068

    authors: Tang GH,Xiong Y,Liu Y,Song ZH,Yang Y,Shen GM,Wang JJ,Jiang HB

    更新日期:2019-08-20 00:00:00

  • Controlling Parasympathetic Regulation of Heart Rate: A Gatekeeper Role for RGS Proteins in the Sinoatrial Node.

    abstract::Neurotransmitters released from sympathetic and parasympathetic nerve terminals in the sinoatrial node (SAN) exert their effects via G-protein-coupled receptors. Integration of these different G-protein signals within pacemaker cells of the SAN is critical for proper regulation of heart rate and function. For example,...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00204

    authors: Mighiu AS,Heximer SP

    更新日期:2012-06-13 00:00:00

  • Comparison of two mouse ameloblast-like cell lines for enamel-specific gene expression.

    abstract::Ameloblasts are ectoderm-derived cells that produce an extracellular enamel matrix that mineralizes to form enamel. The development and use of immortalized cell lines, with a stable phenotype, is an important contribution to biological studies as it allows for the investigation of molecular activities without the cont...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2014.00277

    authors: Sarkar J,Simanian EJ,Tuggy SY,Bartlett JD,Snead ML,Sugiyama T,Paine ML

    更新日期:2014-07-25 00:00:00

  • Change in Ubiquitin Proteasome System of Grass Carp Ctenopharyngodon idellus Reared in the Different Stocking Densities.

    abstract::The ubiquitin proteasome system (UPS) is a highly regulated mechanism of intracellular protein degradation and turnover. To evaluate the effect of crowding stress on the UPS in fish, grass carp (Ctenopharyngodon idellus) were randomly reared at low stocking density (LSD, 0.9 kg m-2) or high stocking density (HSD, 5.9 ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00837

    authors: Sun Y,Liang X,Chen J,Tang R,Li L,Li D

    更新日期:2018-07-05 00:00:00

  • Investigating the Combinatory Effects of Biological Networks on Gene Co-expression.

    abstract::Co-expressed genes often share similar functions, and gene co-expression networks have been widely used in studying the functionality of gene modules. Previous analysis indicated that genes are more likely to be co-expressed if they are either regulated by the same transcription factors, forming protein complexes or s...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00160

    authors: Zhang C,Lee S,Mardinoglu A,Hua Q

    更新日期:2016-05-02 00:00:00

  • Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes.

    abstract::Background and Purpose: Store-operated calcium entry (SOCE) is an important physiological phenomenon that extensively mediates intracellular calcium ion (Ca2+) load. It has been previously found in myocytes isolated from neonatal or diseased hearts. We aimed to determine its existence, molecular nature in undiseased h...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01785

    authors: Wen H,Zhao Z,Fefelova N,Xie LH

    更新日期:2018-12-13 00:00:00

  • Intertwined arbovirus transmission activity: reassessing the transmission cycle paradigm.

    abstract::Arboviruses are emerging/reemerging infectious agents worldwide. The factors within this scenario include vector and host population fluctuations, climatic changes, anthropogenic activities that disturb ecosystems, an increase in international flights, human mobility, and genetic mutations that allow spill-over phenom...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00493

    authors: Diaz LA,Flores FS,Quaglia A,Contigiani MS

    更新日期:2013-01-11 00:00:00

  • Integrative Computational Network Analysis Reveals Site-Specific Mediators of Inflammation in Alzheimer's Disease.

    abstract::Alzheimer's disease (AD) is a major neurodegenerative disease and is one of the most common cause of dementia in older adults. Among several factors, neuroinflammation is known to play a critical role in the pathogenesis of chronic neurodegenerative diseases. In particular, studies of brains affected by AD show a clea...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00154

    authors: Ravichandran S,Michelucci A,Del Sol A

    更新日期:2018-03-02 00:00:00

  • Myocardial Blood Flow and Metabolic Rate of Oxygen Measurement in the Right and Left Ventricles at Rest and During Exercise Using 15O-Labeled Compounds and PET.

    abstract::Aims: Simultaneous measurement of right (RV) and left ventricle (LV) myocardial blood flow (MBF), oxygen extraction fraction (OEF), and oxygen consumption (MVO2) non-invasively in humans would provide new possibilities to understand cardiac physiology and different patho-physiological states. Methods: We developed and...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00741

    authors: Kudomi N,Kalliokoski KK,Oikonen VJ,Han C,Kemppainen J,Sipilä HT,Knuuti J,Heinonen IHA

    更新日期:2019-06-19 00:00:00

  • Goggatomy: A Method for Opening Small Cuticular Compartments in Arthropods for Physiological Experiments.

    abstract::Most sense organs of arthropods are ensconced in small exoskeletal compartments that hinder direct access to plasma membranes. We have developed a method for exposing live sensory and supporting cells in such structures. The technique uses a viscous light cured resin to embed and support the structure, which is then s...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00398

    authors: Kay AR,Raccuglia D,Scholte J,Sivan-Loukianova E,Barwacz CA,Armstrong SR,Guymon CA,Nitabach MN,Eberl DF

    更新日期:2016-09-12 00:00:00

  • Patients with Chronic Obstructive Pulmonary Disease Suffer from Worse Periodontal Health-Evidence from a Meta-Analysis.

    abstract::Background and Objective: It is widely accepted that there is an association between chronic obstructive pulmonary disease (COPD) and periodontitis. However, whether the periodontal status of the COPD patients is worse than that of the non-COPD subjects is seldom assessed. The findings currently available are inconsis...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00033

    authors: Shi Q,Zhang B,Xing H,Yang S,Xu J,Liu H

    更新日期:2018-01-25 00:00:00

  • The Effects of Different Signaling Pathways in Adenylyl Cyclase Stimulation on Red Blood Cells Deformability.

    abstract::Signaling pathways of red blood cells' (RBCs) micromechanics regulation, which are responsible for maintaining microcirculation, constitute an important property of RBC physiology. Selective control over these processes may serve as an indispensable tool for correction of hemorheological disorders, which accompany a n...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00923

    authors: Semenov AN,Shirshin EA,Muravyov AV,Priezzhev AV

    更新日期:2019-08-14 00:00:00

  • A Potential Role of Bone Morphogenetic Protein 7 in Shell Formation and Growth in the Razor Clam Sinonovacula constricta.

    abstract::Bone morphogenetic proteins (BMPs) not only play essential roles in bone development but also are involved in embryonic growth, organogenesis cell proliferation and differentiation. However, the previous studies on the functions of shellfish BMPs genes are still very limited. To better understand its molecular structu...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.01059

    authors: Zhao J,Cui B,Yao H,Lin Z,Dong Y

    更新日期:2020-08-28 00:00:00

  • Recent advances in the involvement of long non-coding RNAs in neural stem cell biology and brain pathophysiology.

    abstract::Exploration of non-coding genome has recently uncovered a growing list of formerly unknown regulatory long non-coding RNAs (lncRNAs) with important functions in stem cell pluripotency, development and homeostasis of several tissues. Although thousands of lncRNAs are expressed in mammalian brain in a highly patterned m...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2014.00155

    authors: Antoniou D,Stergiopoulos A,Politis PK

    更新日期:2014-04-22 00:00:00

  • Effects of Mindfulness-Based Interventions on Salivary Cortisol in Healthy Adults: A Meta-Analytical Review.

    abstract::Objective: The aim of the present study was to elucidate the effects of Mindfulness-based interventions (MBIs) on salivary cortisol levels in healthy adult populations. Method: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs), published between January 1980 and June 2015 in Pub...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00471

    authors: Sanada K,Montero-Marin J,Alda Díez M,Salas-Valero M,Pérez-Yus MC,Morillo H,Demarzo MM,García-Toro M,García-Campayo J

    更新日期:2016-10-19 00:00:00

  • Placental Vascular Calcification and Cardiovascular Health: It Is Time to Determine How Much of Maternal and Offspring Health Is Written in Stone.

    abstract::Vascular calcification is the deposition of calcium phosphate minerals in vascular tissue. Vascular calcification occurs by both active and passive processes. Extent and tissue-specific patterns of vascular calcification are predictors of cardiovascular morbidity and mortality. The placenta is a highly vascularized or...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01044

    authors: Wallingford MC,Benson C,Chavkin NW,Chin MT,Frasch MG

    更新日期:2018-08-07 00:00:00

  • Resistance Training with Co-ingestion of Anti-inflammatory Drugs Attenuates Mitochondrial Function.

    abstract::Aim: The current study aimed to examine the effects of resistance exercise with concomitant consumption of high vs. low daily doses of non-steroidal anti-inflammatory drugs (NSAIDs) on mitochondrial oxidative phosphorylation in skeletal muscle. As a secondary aim, we compared the effects of eccentric overload with con...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.01074

    authors: Cardinale DA,Lilja M,Mandić M,Gustafsson T,Larsen FJ,Lundberg TR

    更新日期:2017-12-19 00:00:00

  • Toward Accurate Extraction of Respiratory Frequency From the Photoplethysmogram: Effect of Measurement Site.

    abstract::Background: It is known that the respiration-modulated photoplethysmographic (PPG) signals could be used to derive respiratory frequency (RF) and that PPG signals could be measured from different body sites. However, the accuracy of RF derived from PPG signals of different body sites has not been comprehensively inves...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00732

    authors: Hartmann V,Liu H,Chen F,Hong W,Hughes S,Zheng D

    更新日期:2019-06-18 00:00:00

  • The acute effects of a single session of expiratory muscle strength training on blood pressure, heart rate, and oxygen saturation in healthy adults.

    abstract::Expiratory muscle strength training (EMST) is a rehabilitative program that has been tested for outcomes related to respiratory muscle strength, cough, swallow, and voice function in healthy young adult, elderly individuals, and in patients with progressive neurodegenerative disease. Because EMST has been used in pati...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00048

    authors: Laciuga H,Davenport P,Sapienza C

    更新日期:2012-03-13 00:00:00

  • Disease and Disorders of Freshwater Unionid Mussels: A Brief Overview of Recent Studies.

    abstract::The use of aquatic invertebrates in biomedical research and as environmental sentinels has dramatically grown in recent decades, with an increased need in understanding of comparative pathology. The Unionids freshwater mussels are a group of worldwide distributed bivalves residing small ditches and ponds, lakes, canal...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2016.00489

    authors: Carella F,Villari G,Maio N,De Vico G

    更新日期:2016-11-01 00:00:00

  • Role of NADPH Oxidase-4 in Human Endothelial Progenitor Cells.

    abstract::Introduction: Endothelial progenitor cells (EPCs) display a unique ability to promote angiogenesis and restore endothelial function in injured blood vessels. NADPH oxidase 4 (NOX4)-derived hydrogen peroxide (H2O2) serves as a signaling molecule and promotes endothelial cell proliferation and migration as well as prote...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00150

    authors: Hakami NY,Ranjan AK,Hardikar AA,Dusting GJ,Peshavariya HM

    更新日期:2017-03-23 00:00:00

  • Deep Learning-Based Structure-Activity Relationship Modeling for Multi-Category Toxicity Classification: A Case Study of 10K Tox21 Chemicals With High-Throughput Cell-Based Androgen Receptor Bioassay Data.

    abstract::Deep learning (DL) has attracted the attention of computational toxicologists as it offers a potentially greater power for in silico predictive toxicology than existing shallow learning algorithms. However, contradicting reports have been documented. To further explore the advantages of DL over shallow learning, we co...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01044

    authors: Idakwo G,Thangapandian S,Luttrell J 4th,Zhou Z,Zhang C,Gong P

    更新日期:2019-08-13 00:00:00

  • Liver Cirrhosis Patients Who Had Normal Liver Function Before Liver Cirrhosis Development Have the Altered Metabolic Profiles Before the Disease Occurrence Compared to Healthy Controls.

    abstract::Liver cirrhosis (LC) is the final usual outcome of liver damage induced by various chronic liver diseases. Because of asymptomatic nature of LC, it is usually diagnosed at late and advanced stages, and patients are easy to miss the best timing for treatment. Thus, the early detection of LC is needed. In the prospectiv...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01421

    authors: Yoo HJ,Jung KJ,Kim M,Kim M,Kang M,Jee SH,Choi Y,Lee JH

    更新日期:2019-11-19 00:00:00