The multiple roles of fatty acid handling proteins in brain.

Abstract:

:Lipids are essential components of a living organism as energy source but also as constituent of the membrane lipid bilayer. In addition fatty acid (FA) derivatives interact with many signaling pathways. FAs have amphipathic properties and therefore require being associated to protein for both transport and intracellular trafficking. Here we will focus on several FA handling proteins, among which the fatty acid translocase/CD36 (FAT/CD36), members of fatty acid transport proteins (FATPs), and lipid chaperones fatty acid-binding proteins (FABPs). A decade of extensive studies has helped decipher the mechanism of action of these proteins in peripheral tissue with high lipid metabolism. However, considerably less information is available regarding their role in the brain, despite the high lipid content of this tissue. This review will primarily focus on the recent studies that have highlighted the crucial role of lipid handling proteins in brain FA transport, neuronal differentiation and development, cognitive processes and brain diseases. Finally a special focus will be made on the recent studies that have revealed the role of FAT/CD36 in brain lipid sensing and nervous control of energy balance.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Moullé VS,Cansell C,Luquet S,Cruciani-Guglielmacci C

doi

10.3389/fphys.2012.00385

subject

Has Abstract

pub_date

2012-09-28 00:00:00

pages

385

issn

1664-042X

journal_volume

3

pub_type

杂志文章
  • Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile.

    abstract::Exercise is known to improve many aspects of human health, including modulation of the immune system and inflammatory status. It is generally understood that exercise reduces inflammation, but there are missing links in terms of understanding the mechanisms as well as the differences between exercise modalities. N-gly...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01522

    authors: Tijardović M,Marijančević D,Bok D,Kifer D,Lauc G,Gornik O,Keser T

    更新日期:2019-12-20 00:00:00

  • Arsenic toxicity: the effects on plant metabolism.

    abstract::The two forms of inorganic arsenic, arsenate (AsV) and arsenite (AsIII), are easily taken up by the cells of the plant root. Once in the cell, AsV can be readily converted to AsIII, the more toxic of the two forms. AsV and AsIII both disrupt plant metabolism, but through distinct mechanisms. AsV is a chemical analog o...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00182

    authors: Finnegan PM,Chen W

    更新日期:2012-06-06 00:00:00

  • Effects of Resistance Exercise and Nutritional Supplementation on Dynamic Cerebral Autoregulation in Head-Down Bed Rest.

    abstract::Head-down bed rest (HDBR) is commonly considered as ground-based analog to spaceflight and simulates the headward fluid shift and cardiovascular deconditioning associated with spaceflight. We investigated in healthy volunteers whether HDBR, with or without countermeasures, affect cerebral autoregulation (CA). Twelve m...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01114

    authors: Kermorgant M,Nasr N,Custaud MA,Navasiolava N,Arbeille P,Guinet P,Labrunée M,Besnier F,Arvanitis DN,Czosnyka M,Senard JM,Pavy-Le Traon A

    更新日期:2019-08-27 00:00:00

  • Acute Effects of Continuous and Intermittent Blood Flow Restriction on Movement Velocity During Bench Press Exercise Against Different Loads.

    abstract::This study evaluated the effects of continuous and intermittent blood flow restriction (BFR) with 70% of full arterial occlusion pressure on bar velocity during the bench press exercise against a wide range of resistive loads. Eleven strength-trained males (age: 23.5 ± 1.4 years; resistance training experience: 2.8 ± ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.569915

    authors: Wilk M,Gepfert M,Krzysztofik M,Stastny P,Zajac A,Bogdanis GC

    更新日期:2020-11-27 00:00:00

  • Strength Training Improves Metabolic Health Markers in Older Individual Regardless of Training Frequency.

    abstract::The main purpose of the present study was to investigate the effect of frequency, thereby increasing training volume, of resistance training on body composition, inflammation markers, lipid and glycemic profile in healthy older individuals (age range 65-75 year). Ninety-two healthy participants were randomly assigned ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00032

    authors: Ihalainen JK,Inglis A,Mäkinen T,Newton RU,Kainulainen H,Kyröläinen H,Walker S

    更新日期:2019-02-01 00:00:00

  • Effects of Blidingia sp. Extract on Intestinal Inflammation and Microbiota Composition in LPS-Challenged Mice.

    abstract::Blidingia sp. is a green alga that has spread rapidly in Subei Shoal, China. To explore the potential beneficial effects of Blidingia sp., we investigated the anti-inflammatory activity of its water-methanol extract of Blidingia sp. in a mouse model of lipopolysaccharide (LPS)-induced intestinal inflammation. The resu...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00763

    authors: Song W,Li Y,Zhang X,Wang Z

    更新日期:2019-06-25 00:00:00

  • Expression of South East Asian Ovalocytic Band 3 Disrupts Erythroblast Cytokinesis and Reticulocyte Maturation.

    abstract::Southeast Asian Ovalocytosis results from a heterozygous deletion of 9 amino acids in the erythrocyte anion exchange protein AE1 (band 3). The report of the first successful birth of an individual homozygous for this mutation showed an association with severe dyserythropoietic anemia. Imaging of the proband's erythroc...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00357

    authors: Flatt JF,Stevens-Hernandez CJ,Cogan NM,Eggleston DJ,Haines NM,Heesom KJ,Picard V,Thomas C,Bruce LJ

    更新日期:2020-04-28 00:00:00

  • Relationships between predicted moonlighting proteins, human diseases, and comorbidities from a network perspective.

    abstract::Moonlighting proteins are a subset of multifunctional proteins characterized by their multiple, independent, and unrelated biological functions. We recently set up a large-scale identification of moonlighting proteins using a protein-protein interaction (PPI) network approach. We established that 3% of the current hum...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2015.00171

    authors: Zanzoni A,Chapple CE,Brun C

    更新日期:2015-06-23 00:00:00

  • Pathophysiological Mechanisms of Sino-Atrial Dysfunction and Ventricular Conduction Disease Associated with SCN5A Deficiency: Insights from Mouse Models.

    abstract::Genetically modified mice provide a number of models for studying cardiac channelopathies related to cardiac Na(+) channel (SCN5A) abnormalities. We review key pathophysiological features in these murine models that may underlie clinical features observed in sinus node dysfunction and progressive cardiac conduction di...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00234

    authors: Huang CL,Lei L,Matthews GD,Zhang Y,Lei M

    更新日期:2012-07-06 00:00:00

  • Insects With Survival Kits for Desiccation Tolerance Under Extreme Water Deficits.

    abstract::The year 2002 marked the tercentenary of Antonie van Leeuwenhoek's discovery of desiccation tolerance in animals. This remarkable phenomenon to sustain 'life' in the absence of water can be revived upon return of hydrating conditions. Today, coping with climate change-related factors, especially temperature-humidity i...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2018.01843

    authors: Thorat L,Nath BB

    更新日期:2018-12-21 00:00:00

  • Daily Intermittent Normobaric Hypoxia Over 2 Weeks Reduces BDNF Plasma Levels in Young Adults - A Randomized Controlled Feasibility Study.

    abstract::Background: The results from animal and human research indicate that acute intermittent hypoxia can enhance brain-derived neurotrophic factor (BDNF) plasma levels and gene expression. As BDNF is known to promote the differentiation of new neurons and the formation of synapses, it has been proposed to mediate adult neu...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01337

    authors: Becke A,Müller P,Dordevic M,Lessmann V,Brigadski T,Müller NG

    更新日期:2018-10-01 00:00:00

  • Inhibition does not affect the timing code for vocalizations in the mouse auditory midbrain.

    abstract::Many animals use a diverse repertoire of complex acoustic signals to convey different types of information to other animals. The information in each vocalization therefore must be coded by neurons in the auditory system. One way in which the auditory system may discriminate among different vocalizations is by having h...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2014.00140

    authors: Dimitrov AG,Cummins GI,Mayko ZM,Portfors CV

    更新日期:2014-04-16 00:00:00

  • Osmoregulation in the Plotosidae Catfish: Role of the Salt Secreting Dendritic Organ.

    abstract::Unlike other marine teleosts, the Plotosidae catfishes reportedly have an extra-branchial salt secreting dendritic organ (DO). Salinity acclimation [brackishwater (BW) 3aaa, seawater (SWcontrol) 34aaa, and hypersaline water (HSW) 60aaa] for 14 days was used to investigate the osmoregulatory abilities of Plotosus linea...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00761

    authors: Malakpour Kolbadinezhad S,Coimbra J,Wilson JM

    更新日期:2018-07-03 00:00:00

  • Eleven-Week Preparation Involving Polarized Intensity Distribution Is Not Superior to Pyramidal Distribution in National Elite Rowers.

    abstract::Polarized (POL) training intensity distribution (TID) emphasizes high-volume low-intensity exercise in zone (Z)1 (< first lactate threshold) with a greater proportion of high-intensity Z3 (>second lactate threshold) compared to Z2 (between first and second lactate threshold). In highly trained rowers there is a lack o...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00515

    authors: Treff G,Winkert K,Sareban M,Steinacker JM,Becker M,Sperlich B

    更新日期:2017-08-02 00:00:00

  • Plasticity of collective behavior in a nomadic early spring folivore.

    abstract::Collective behavior in the forest tent caterpillar (Malacosoma disstria) meets the thermal constraints of being an early spring folivore, but introduces other constraints in food choice. These are minimized by state-dependent, inter-individual, and ontogenetic variations in responses to social cues. Forest tent caterp...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2013.00054

    authors: Despland E

    更新日期:2013-03-22 00:00:00

  • Benchmarking Procedures for High-Throughput Context Specific Reconstruction Algorithms.

    abstract::Recent progress in high-throughput data acquisition has shifted the focus from data generation to processing and understanding of how to integrate collected information. Context specific reconstruction based on generic genome scale models like ReconX or HMR has the potential to become a diagnostic and treatment tool t...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2015.00410

    authors: Pacheco MP,Pfau T,Sauter T

    更新日期:2016-01-22 00:00:00

  • Self-Organization of Blood Pressure Regulation: Experimental Evidence.

    abstract::Blood pressure regulation is a prime example of homeostatic regulation. However, some characteristics of the cardiovascular system better match a non-linear self-organized system than a homeostatic one. To determine whether blood pressure regulation is self-organized, we repeated the seminal demonstration of self-orga...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00112

    authors: Fortrat JO,Levrard T,Courcinous S,Victor J

    更新日期:2016-03-31 00:00:00

  • The Effects of Different Signaling Pathways in Adenylyl Cyclase Stimulation on Red Blood Cells Deformability.

    abstract::Signaling pathways of red blood cells' (RBCs) micromechanics regulation, which are responsible for maintaining microcirculation, constitute an important property of RBC physiology. Selective control over these processes may serve as an indispensable tool for correction of hemorheological disorders, which accompany a n...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00923

    authors: Semenov AN,Shirshin EA,Muravyov AV,Priezzhev AV

    更新日期:2019-08-14 00:00:00

  • Designing Brains for Pain: Human to Mollusc.

    abstract::There is compelling evidence that the "what it feels like" subjective experience of sensory stimuli arises in the cerebral cortex in both humans as well as mammalian experimental animal models. Humans are alone in their ability to verbally communicate their experience of the external environment. In other species, sen...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01027

    authors: Key B,Brown D

    更新日期:2018-08-02 00:00:00

  • β-catenin and Its Relation to Alveolar Bone Mechanical Deformation - A Study Conducted in Rats With Tooth Extraction.

    abstract::The aim of this study was to analyze the relationship between alveolar bone deformation and β-catenin expression levels in response to the mechanical load changed by dental extraction in adult rats. Twenty-four male rats (Rattus norvegicus albinus), Wistar linage, at 2 months of age, were used. The right upper incisor...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00549

    authors: Ferreira BC,Freire AR,Araujo R,do Amaral-Silva GK,Okamoto R,Prado FB,Rossi AC

    更新日期:2020-06-05 00:00:00

  • An Analytical Model for Estimating Alveolar Wall Elastic Moduli From Lung Tissue Uniaxial Stress-Strain Curves.

    abstract::The non-linear stress-strain behavior of uniaxially-stretched lung parenchyma is thought to be an emergent phenomenon arising from the ensemble behavior of its microscopic constituents. Such behavior includes the alignment and elongation of randomly oriented alveolar walls with initially flaccid fibers in the directio...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00121

    authors: Bou Jawde S,Takahashi A,Bates JHT,Suki B

    更新日期:2020-02-25 00:00:00

  • Effect of phenylephrine vs. ephedrine on frontal lobe oxygenation during caesarean section with spinal anesthesia: an open label randomized controlled trial.

    abstract:BACKGROUND:During caesarean section spinal anesthesia may provoke maternal hypotension that we prevent by administration of phenylephrine and/or ephedrine. Phenylephrine is however reported to reduce the near infrared spectroscopy-determined frontal lobe oxygenation (ScO2) but whether that is the case for patients expo...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2014.00081

    authors: Foss VT,Christensen R,Rokamp KZ,Nissen P,Secher NH,Nielsen HB

    更新日期:2014-03-03 00:00:00

  • The efficacy of antihypertensive drugs in chronic intermittent hypoxia conditions.

    abstract::Sleep apnea/hypopnea disorders include centrally originated diseases and obstructive sleep apnea (OSA). This last condition is renowned as a frequent secondary cause of hypertension (HT). The mechanisms involved in the pathogenesis of HT can be summarized in relation to two main pathways: sympathetic nervous system st...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2014.00361

    authors: Diogo LN,Monteiro EC

    更新日期:2014-09-22 00:00:00

  • Apelin and energy metabolism.

    abstract::A wide range of adipokines identified over the past years has allowed considering the white adipose tissue as a secretory organ closely integrated into overall physiological and metabolic control. Apelin, a ubiquitously expressed peptide was known to exert different physiological effects mainly on the cardiovascular s...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2015.00115

    authors: Bertrand C,Valet P,Castan-Laurell I

    更新日期:2015-04-10 00:00:00

  • Activation and Biological Properties of Human β Defensin 4 in Stem Cells Derived From Human Exfoliated Deciduous Teeth.

    abstract::Pulpitis in primary teeth, a condition caused by presence of bacteria, is highly prevalent worldwide. The use of biocompatibility materials with anti-inflammatory, anti-bacterial, and regenerative properties is critical for prognosis of this endodontic disease. This study aimed to identify expression of human β defens...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01304

    authors: Zhai Y,Wang Y,Rao N,Li J,Li X,Fang T,Zhao Y,Ge L

    更新日期:2019-10-22 00:00:00

  • Entropy Analysis of RR-Time Series From Stress Tests.

    abstract::The RR-interval time series or tachograms obtained from electrocardiograms have been widely studied since they reflect the cardiac variability, and this is an indicative of the health status of a person. The tachogram can be seen as a highly non-linear and complex time series, and therefore, should be analyzed with no...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00981

    authors: Solís-Montufar EE,Gálvez-Coyt G,Muñoz-Diosdado A

    更新日期:2020-08-12 00:00:00

  • Coexisting Frailty With Heart Failure.

    abstract::People over 65 years of age constitute over 80% of patients with heart failure (HF) and the incidence of HF is 10 per 1,000 in people aged above 65 years. Approximately 25% of older patients with HF exhibit evidence of frailty. Frail patients with cardiovascular disease (CVD) have a worse prognosis than non-frail pati...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2019.00791

    authors: Uchmanowicz I,Nessler J,Gobbens R,Gackowski A,Kurpas D,Straburzynska-Migaj E,Kałuzna-Oleksy M,Jankowska EA

    更新日期:2019-07-03 00:00:00

  • α1-Microglobulin Protects Against Bleeding-Induced Oxidative Damage in Knee Arthropathies.

    abstract::Knee injury increases the risk of developing knee osteoarthritis (OA). Recent evidence suggests involvement of oxidative stress induced by inflammation and bleeding in the joint. This study investigates the role in this process of α1-microglobulin (A1M), a plasma and tissue antioxidant protein with reducing function, ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01596

    authors: Larsson S,Åkerström B,Gram M,Lohmander LS,Struglics A

    更新日期:2018-11-16 00:00:00

  • Aged Nicotinamide Riboside Kinase 2 Deficient Mice Present an Altered Response to Endurance Exercise Training.

    abstract::Background: Skeletal muscle aging is marked by the development of a sarcopenic phenotype, a global decline of muscle energetic capacities, and an intolerance to exercise. Among the metabolic disorders involved in this syndrome, NAD metabolism was shown to be altered in skeletalmuscle, with an important role for the NA...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01290

    authors: Deloux R,Tannous C,Ferry A,Li Z,Mericskay M

    更新日期:2018-09-19 00:00:00

  • Conjugating Existing Clinical Drugs With Gold Nanoparticles for Better Treatment of Heart Diseases.

    abstract::Developing new methods to treat heart diseases is always a focus for basic research and clinical applications. Existing drugs have strong side-effects and also require lifetime administration for patients. Recent attempts of using nanoparticles (NPs) in treating atherosclerosis in animals and some heart diseases such ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00642

    authors: Zhang J,Ma A,Shang L

    更新日期:2018-05-29 00:00:00