Daily Intermittent Normobaric Hypoxia Over 2 Weeks Reduces BDNF Plasma Levels in Young Adults - A Randomized Controlled Feasibility Study.

abstract：:Cells expressing bitter taste receptors (T2Rs or Tas2rs) in extraoral tissues are considered to be chemosensory cells mediating protective responses to potentially harmful or even antiinflammatory or antimicrobial compounds. In a previous study the activity of the Tas2R143/Tas2R135/Tas2r126 cluster promoter in the sto...

journal_title：Frontiers in physiology

authors： Widmayer P,Partsch V,Pospiech J,Kusumakshi S,Boehm U,Breer H

更新日期：2020-02-07 00:00:00

abstract：:Tyrophagus putrescentiae (Schrank, 1781) is an emerging source of allergens in stored products and homes. Feces proteases are the major allergens of astigmatid mites (Acari: Acaridida). In addition, the mites are carriers of microorganisms and microbial adjuvant compounds that stimulate innate signaling pathways. We s...

journal_title：Frontiers in physiology

authors： Erban T,Rybanska D,Harant K,Hortova B,Hubert J

更新日期：2016-02-24 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphys.2016.00593.]. ...

journal_title：Frontiers in physiology

authors： Frontiers Production Office.

更新日期：2019-05-22 00:00:00

abstract：:Data indicate endothelium-dependent dilation (EDD) may be preserved in the skeletal muscle microcirculation of young, obese adults. Preserved EDD might be mediated by compensatory mechanisms, impeding insight into preclinical vascular dysfunction. We aimed to determine the functional roles of nitric oxide synthase (NO...

journal_title：Frontiers in physiology

authors： Harrell JW,Johansson RE,Evans TD,Sebranek JJ,Walker BJ,Eldridge MW,Serlin RC,Schrage WG

更新日期：2015-12-22 00:00:00

abstract：:Minimizing central nervous system (CNS) injury from preterm birth depends upon identification of the critical pathways that underlie essential neurodevelopmental and CNS pathophysiology. While chorioamnionitis (CHORIO), is a leading cause of preterm birth, the precise mechanism linking prenatal brain injury and long-t...

journal_title：Frontiers in physiology

authors： Yellowhair TR,Newville JC,Noor S,Maxwell JR,Milligan ED,Robinson S,Jantzie LL

更新日期：2019-04-02 00:00:00

abstract：:3-iodothyronamine (T1AM) is an endogenous amine, that has been detected in many rodent tissues, and in human blood. It has been hypothesized to derive from thyroid hormone metabolism, but this hypothesis still requires validation. T1AM is not a ligand for nuclear thyroid hormone receptors, but stimulates with nanomola...

journal_title：Frontiers in physiology

authors： Zucchi R,Accorroni A,Chiellini G

更新日期：2014-10-16 00:00:00

abstract：:Aims: Simultaneous measurement of right (RV) and left ventricle (LV) myocardial blood flow (MBF), oxygen extraction fraction (OEF), and oxygen consumption (MVO2) non-invasively in humans would provide new possibilities to understand cardiac physiology and different patho-physiological states. Methods: We developed and...

journal_title：Frontiers in physiology

authors： Kudomi N,Kalliokoski KK,Oikonen VJ,Han C,Kemppainen J,Sipilä HT,Knuuti J,Heinonen IHA

更新日期：2019-06-19 00:00:00

abstract：:To excrete body nitrogen waste and regulate electrolyte and fluid balance, the kidney has developed into an energy factory with only second to the heart in mitochondrial content in the body to meet the high-energy demand and regulate homeostasis. Energy supply from the renal mitochondria majorly depends on lipid metab...

journal_title：Frontiers in physiology

authors： Lin PH,Duann P

更新日期：2020-09-03 00:00:00

abstract：:The extracellular tooth enamel matrix is a unique, protein-rich environment that provides the structural basis for the growth of long and parallel oriented enamel crystals. Here we have conducted a series of in vivo and in vitro studies to characterize the changes in matrix shape and organization that take place durin...

journal_title：Frontiers in physiology

authors： Pandya M,Lin T,Li L,Allen MJ,Jin T,Luan X,Diekwisch TGH

更新日期：2017-10-17 00:00:00

abstract：:Circadian clocks consist of molecular negative feedback loops that coordinate physiological, neurological, and behavioral variables into "circa" 24-h rhythms. Rhythms in behavioral and other circadian outputs tend to weaken during aging, as evident in progressive disruptions of sleep-wake cycles in aging organisms. Ho...

journal_title：Frontiers in physiology

authors： Long DM,Giebultowicz JM

更新日期：2018-01-09 00:00:00

abstract：:In the last three decades, all efforts in bone tissue engineering were driven by the dogma that the ideal pore size in bone substitutes lies between 0.3 and 0.5 mm in diameter. Newly developed additive manufacturing methodologies for ceramics facilitate the total control over pore size, pore distribution, bottleneck s...

journal_title：Frontiers in physiology

authors： Ghayor C,Weber FE

更新日期：2018-07-19 00:00:00

abstract：:Denervation induces skeletal muscle atrophy, accompanied by complex biochemical and physiological changes, with potentially devastating outcomes even an increased mortality. Currently, however, there remains a paucity of effective strategies to treat skeletal muscle atrophy. Therefore, it is required to understand the...

journal_title：Frontiers in physiology

authors： Shen Y,Zhang R,Xu L,Wan Q,Zhu J,Gu J,Huang Z,Ma W,Shen M,Ding F,Sun H

更新日期：2019-10-11 00:00:00

abstract：:The central dogma of molecular biology has come under scrutiny in recent years. Here, we reviewed high-throughput mRNA and protein expression data of Escherichia coli, Saccharomyces cerevisiae, and several mammalian cells. At both single cell and population scales, the statistical comparisons between the entire transc...

journal_title：Frontiers in physiology

authors： Piras V,Tomita M,Selvarajoo K

更新日期：2012-11-23 00:00:00

abstract：:Early predispositions to preferentially orient toward cues associated with social partners have been documented in several vertebrate species including human neonates and domestic chicks. Human newborns at high familiar risk of Autism Spectrum Disorder (ASD) show differences in their attention toward these predisposed...

journal_title：Frontiers in physiology

authors： Lorenzi E,Pross A,Rosa-Salva O,Versace E,Sgadò P,Vallortigara G

更新日期：2019-04-30 00:00:00

abstract：:Calcium is an important second messenger required not only for the excitation-contraction coupling of the heart but also critical for the activation of cell signaling pathways involved in the adverse cardiac remodeling and consequently for the heart failure. Sustained neurohumoral activation, pressure-overload, or myo...

journal_title：Frontiers in physiology

authors： Falcón D,Galeano-Otero I,Calderón-Sánchez E,Del Toro R,Martín-Bórnez M,Rosado JA,Hmadcha A,Smani T

更新日期：2019-03-01 00:00:00

abstract：:Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes beating synchronously, thus assessing the contribution of several ion ...

journal_title：Frontiers in physiology

authors： Björk S,Ojala EA,Nordström T,Ahola A,Liljeström M,Hyttinen J,Kankuri E,Mervaala E

更新日期：2017-11-02 00:00:00

abstract：:Survivors of cerebral aneurysm rupture are at risk for significant morbidity and neurological deficits. Much of this is related to the effects of blood in the subarachnoid space which induces an inflammatory cascade with numerous downstream consequences. Recent clinical trials have not been able to reduce the toxic ef...

journal_title：Frontiers in physiology

authors： Blackburn SL,Kumar PT,McBride D,Zeineddine HA,Leclerc J,Choi HA,Dash PK,Grotta J,Aronowski J,Cardenas JC,Doré S

更新日期：2018-05-31 00:00:00

abstract：:Patients undergoing hyperbaric oxygen therapy and divers engaged in underwater activity are at risk of central nervous system oxygen toxicity. An algorithm for predicting CNS oxygen toxicity in active underwater diving has been published previously, but not for humans at rest. Using a procedure similar to that employe...

journal_title：Frontiers in physiology

authors： Aviner B,Arieli R,Yalov A

更新日期：2020-08-17 00:00:00

abstract：:This study aimed to evaluate the effect of the stretch-shortening cycle (SSC) on different portions of the force-velocity (F-V) relationship in older adults with and without chronic obstructive pulmonary disease (COPD), and to assess its association with physical function. The participants were 26 older adults with CO...

journal_title：Frontiers in physiology

authors： Navarro-Cruz R,Alcazar J,Rodriguez-Lopez C,Losa-Reyna J,Alfaro-Acha A,Ara I,García-García FJ,Alegre LM

更新日期：2019-03-26 00:00:00

abstract：:Deep learning (DL) has attracted the attention of computational toxicologists as it offers a potentially greater power for in silico predictive toxicology than existing shallow learning algorithms. However, contradicting reports have been documented. To further explore the advantages of DL over shallow learning, we co...

journal_title：Frontiers in physiology

authors： Idakwo G,Thangapandian S,Luttrell J 4th,Zhou Z,Zhang C,Gong P

更新日期：2019-08-13 00:00:00

abstract：Background:Several mechanisms allow humans to resist the extreme conditions encountered during breath-hold diving. Available nitric oxide (NO) is one of the major contributors to such complex adaptations at depth and oxidative stress is one of the major collateral effects of diving. Due to technical difficulties, these...

journal_title：Frontiers in physiology

authors： Cialoni D,Brizzolari A,Samaja M,Bosco G,Paganini M,Pieri M,Lancellotti V,Marroni A

更新日期：2021-01-07 00:00:00

abstract：:The vascular endothelium supplying the brain exhibits very low paracellular and transcellular permeability and is a major constituent of the blood-brain barrier. High-density lipoprotein (HDL) crosses the blood-brain barrier by transcytosis, but technical limitations have made it difficult to elucidate its regulation....

journal_title：Frontiers in physiology

authors： Fung KY,Wang C,Nyegaard S,Heit B,Fairn GD,Lee WL

更新日期：2017-10-30 00:00:00

abstract：:The bacterium Rickettsia rickettsii is the etiological agent of Brazilian spotted fever (BSF), which is transmitted in Brazil mainly by the tick Amblyomma sculptum. Herein, larvae and nymphs of six populations of A. sculptum were exposed to R. rickettsii by feeding on needle-inoculated guinea pigs, and thereafter rear...

journal_title：Frontiers in physiology

authors： Gerardi M,Ramírez-Hernández A,Binder LC,Krawczak FS,Gregori F,Labruna MB

更新日期：2019-05-28 00:00:00

abstract：:Studies have revealed a robust and independent correlation between chronic kidney disease (CKD) and cardiovascular (CV) events, including death, heart failure, and myocardial infarction. Recent clinical trials extend this range of adverse CV events, including malignant ventricular arrhythmias and sudden cardiac death ...

journal_title：Frontiers in physiology

authors： Kiuchi MG,Ho JK,Nolde JM,Gavidia LML,Carnagarin R,Matthews VB,Schlaich MP

更新日期：2020-01-14 00:00:00

abstract：:Cardiac arrest is a prevalent condition with a poor prognosis, attributable in part to persistent myocardial dysfunction following resuscitation. The molecular basis of this dysfunction remains unclear. We induced cardiac arrest in a porcine model of acute sudden death and assessed the impact of ischemia and reperfusi...

journal_title：Frontiers in physiology

authors： Woodward M,Previs MJ,Mader TJ,Debold EP

更新日期：2015-07-16 00:00:00

abstract：:Environmental hypoxia represents a major physiological challenge for Eriocheir sinensis and Palaemonetes sinensis and is a severe problem in aquaculture. Therefore, understanding the metabolic response mechanisms of E. sinensis and P. sinensis, which are economically important species, to environmental hypoxia and reo...

journal_title：Frontiers in physiology

authors： Bao J,Li X,Yu H,Jiang H

更新日期：2018-11-06 00:00:00

abstract：:Defects in mid-facial development, including cleft lip/palate, account for a large number of human birth defects annually. In many cases, aberrant gene expression results in either a reduction in the number of neural crest cells (NCCs) that reach the frontonasal region and form much of the facial skeleton or subsequen...

journal_title：Frontiers in physiology

authors： Ding HL,Hooper JE,Batzel P,Eames BF,Postlethwait JH,Artinger KB,Clouthier DE

更新日期：2016-07-14 00:00:00

abstract：:Alzheimer's disease (AD) is a major neurodegenerative disease and is one of the most common cause of dementia in older adults. Among several factors, neuroinflammation is known to play a critical role in the pathogenesis of chronic neurodegenerative diseases. In particular, studies of brains affected by AD show a clea...

journal_title：Frontiers in physiology

authors： Ravichandran S,Michelucci A,Del Sol A

更新日期：2018-03-02 00:00:00

abstract：:The epidemics of obesity and diabetes mellitus are associated with an increased incidence of both atrial fibrillation (AF), the most common sustained arrhythmia in adults, and sudden cardiac death (SCD). Obesity and DM are known to have adverse effects on cardiac structure and function. The pathologic mechanisms are t...

journal_title：Frontiers in physiology

authors： Homan EA,Reyes MV,Hickey KT,Morrow JP

更新日期：2019-01-07 00:00:00

abstract：Rationale:Pulmonary hypertension (PH) is a rare but fatal disease characterized by elevated pulmonary pressures and vascular remodeling, leading to right ventricular failure and death. Recently, neuroinflammation has been suggested to be involved in the sympathetic activation in experimental PH. Whether PH is associate...

journal_title：Frontiers in physiology

authors： Vaillancourt M,Chia P,Medzikovic L,Cao N,Ruffenach G,Younessi D,Umar S

更新日期：2019-09-20 00:00:00