Abstract：
:Early predispositions to preferentially orient toward cues associated with social partners have been documented in several vertebrate species including human neonates and domestic chicks. Human newborns at high familiar risk of Autism Spectrum Disorder (ASD) show differences in their attention toward these predisposed stimuli, suggesting potential impairments in the social-orienting mechanisms in ASD. Using embryonic exposure to valproic acid (VPA) we modeled ASD behavioral deficits in domestic chicks. To investigate social predispositions toward animate motion in domestic chicks, we focused on self-propulsion, using two video-animations representing a simple red circle moving at constant speed (speed-constant) or one that was changing its speed (accelerating and decelerating; speed-change). Using a spontaneous choice test for the two stimuli, we compared spontaneous preferences for stimuli that autonomously change speed between VPA- and vehicle-injected chicks. We found that the preference for speed changes was abolished in VPA-injected chicks compared to vehicle-injected controls. These results add to previous findings indicating similar impairments for static social stimuli and suggest a specific effect of VPA on the development of mechanisms that enhance orienting toward animate stimuli. These findings strengthen the hypothesis of an early impairment of predispositions in the early development of ASD. Hence, early predispositions are a potentially useful tool to detect early ASD symptoms in human neonates and to investigate the molecular and neurobiological mechanisms underlying the onset of this neurodevelopmental disorder.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Lorenzi E,Pross A,Rosa-Salva O,Versace E,Sgadò P,Vallortigara Gdoi
10.3389/fphys.2019.00501subject
Has Abstractpub_date
2019-04-30 00:00:00pages
501issn
1664-042Xjournal_volume
10pub_type
杂志文章abstract：:Hypoxic environments at high altitude have significant effects on kidney injury. Following injury, renal primary cilia display length alterations. Primary cilia are mechanosensory organelles that regulate tubular architecture. The effect of hypoxia on cilia length is still controversial in cultured cells, and no corre...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00677
更新日期：2017-09-20 00:00:00
abstract：:Skeletal myofibers are injured due to mechanical stresses experienced during physical activity, or due to myofiber fragility caused by genetic diseases. The injured myofiber needs to be repaired or regenerated to restore the loss in muscle tissue function. Myofiber repair and regeneration requires coordinated action o...
journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2019.00828
更新日期：2019-07-18 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2020.00494
更新日期：2020-05-29 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2014.00075
更新日期：2014-03-05 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.00543
更新日期：2018-05-15 00:00:00
abstract：:A number of years ago we reported that ventral Lateral Neurons (LNvs), which are essential in the control of rest-activity cycles in Drosophila, undergo circadian remodeling of their axonal projections. This structural plasticity gives rise to changes in the degree of connectivity, which could provide a means of trans...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00918
更新日期：2017-11-14 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2020.569221
更新日期：2020-10-15 00:00:00
abstract：:[This corrects the article DOI: 10.3389/fphys.2016.00260.]. ...
journal_title：Frontiers in physiology
pub_type： 杂志文章,已发布勘误
doi：10.3389/fphys.2018.00771
更新日期：2018-07-16 00:00:00
abstract：:Renal fibrosis is a common pathway of virtually all progressive kidney diseases. Osthole (OST, 7-Methoxy-8-(3-methylbut-2-enyl)-2-chromenone), a derivative of coumarin mainly found in plants of the Apiaceae family, has shown inhibitory effects on inflammation, oxidative stress, fibrosis and tumor progression. The pres...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.01650
更新日期：2018-11-21 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2014.00433
更新日期：2014-11-10 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2020.619230
更新日期：2021-01-11 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.00316
更新日期：2019-03-26 00:00:00
abstract：:Renal fibrosis is characterized by progressive accumulation of extracellular matrix (ECM) proteins, resulting in loss of organ function and eventually requiring renal replacement therapy. Unfortunately, no efficacious treatment options are available to halt renal fibrosis and translational models to test pharmacologic...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.01026
更新日期：2017-12-12 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.00202
更新日期：2019-03-05 00:00:00
abstract：:Acute liver failure (ALF) is characterized by a sudden and severe deterioration of liver function, typically mirrored by a marked increase of the international normalized ratio (INR) and hepatic encephalopathy (HE). Due to various possible causes hepatocytes get damaged via either apoptotic or necrotic pathways. Antic...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2012.00340
更新日期：2012-08-28 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.01573
更新日期：2020-01-14 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.00448
更新日期：2018-04-27 00:00:00
abstract：:Maternal over- and restricted-feeding during gestation have similar negative consequences for the offspring, including decreased muscularity, increased adiposity, and altered metabolism. Our objective was to determine the effects of poor maternal nutrition during gestation (over- and restricted-feeding) on the offspri...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.00515
更新日期：2019-05-01 00:00:00
abstract：:The sterile insect technique (SIT) may reduce pest populations by allowing sufficient amount of irradiation-induced sterile males to mate with wild females whilst maintaining mating ability comparable to wild males. Although the SIT methods are well understood, the optimal sterilizing dose and processing development s...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.00118
更新日期：2018-02-20 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.00386
更新日期：2019-04-16 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2014.00052
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journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.00860
更新日期：2019-07-05 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2020.562204
更新日期：2020-09-15 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.00883
更新日期：2019-07-09 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
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更新日期：2015-01-05 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2017.00241
更新日期：2017-04-27 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2012.00347
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00226
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abstract：:Alcoholic liver disease (ALD) encompasses hepatic steatosis, which may progress to alcoholic hepatitis, fibrosis, and cirrhosis. It remains a leading cause of morbidity and mortality in the US and worldwide. The severity of liver disease correlates with plasma levels of bacterial products in patients, and experimental...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2012.00402
更新日期：2012-10-11 00:00:00
