Clinical Overview of Obesity and Diabetes Mellitus as Risk Factors for Atrial Fibrillation and Sudden Cardiac Death.


:The epidemics of obesity and diabetes mellitus are associated with an increased incidence of both atrial fibrillation (AF), the most common sustained arrhythmia in adults, and sudden cardiac death (SCD). Obesity and DM are known to have adverse effects on cardiac structure and function. The pathologic mechanisms are thought to involve cardiac tissue remodeling, metabolic dysregulation, inflammation, and oxidative stress. Clinical data suggest that left atrial size, epicardial fat pad thickness, and other modifiable risk factors such as hypertension, glycemic control, and obstructive sleep apnea may mediate the association with AF. Data from human atrial tissue biopsies demonstrate alterations in atrial lipid content and evidence of mitochondrial dysfunction. With respect to ventricular arrhythmias, abnormalities such as long QT syndrome, frequent premature ventricular contractions, and left ventricular hypertrophy with diastolic dysfunction are commonly observed in obese and diabetic humans. The increased risk of SCD in this population may also be related to excessive cardiac lipid deposition and insulin resistance. While nutritional interventions have had limited success, perhaps due to poor long-term compliance, weight loss and improved cardiorespiratory fitness may reduce the frequency and severity of AF.


Front Physiol


Frontiers in physiology


Homan EA,Reyes MV,Hickey KT,Morrow JP




Has Abstract


2019-01-07 00:00:00








  • Cirrhotic Endothelial Progenitor Cells Enhance Liver Angiogenesis and Fibrosis and Aggravate Portal Hypertension in Bile Duct-Ligated Cirrhotic Rats.

    abstract:Background:Circulating cirrhotic endothelial progenitor cells (EPC) interact with both liver sinusoidal endothelial cells (LSEC) and hepatic stellate cells (HSC) and promote angiogenesis in vitro. This study evaluated the effect of cirrhotic and control EPCs on hepatic angiogenesis, microcirculation, and fibrosis in vi...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Tripathi DM,Hassan M,Siddiqui H,Kaur I,Rawal P,Bihari C,Kaur S,Sarin SK

    更新日期:2020-06-11 00:00:00

  • Neuronal and Glial Clocks Underlying Structural Remodeling of Pacemaker Neurons in Drosophila.

    abstract::A number of years ago we reported that ventral Lateral Neurons (LNvs), which are essential in the control of rest-activity cycles in Drosophila, undergo circadian remodeling of their axonal projections. This structural plasticity gives rise to changes in the degree of connectivity, which could provide a means of trans...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Herrero A,Duhart JM,Ceriani MF

    更新日期:2017-11-14 00:00:00

  • Ratings of Perceived Exertion Misclassify Intensities for Sedentary Older Adults During Graded Cycling Test: Effect of Supramaximal High-Intensity Interval Training.

    abstract::The present study aims (1) to evaluate ratings of perceived exertion (RPE) and corresponding intensities during a maximal graded cycling test and (2) to determine the effects of 6 weeks of supramaximal cycling exercise (SCE) intervention on RPE and associated physiological factors in young and older sedentary groups. ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Jabbour G,Majed L

    更新日期:2018-10-25 00:00:00

  • F1F0-ATP Synthase Inhibitory Factor 1 in the Normal Pancreas and in Pancreatic Ductal Adenocarcinoma: Effects on Bioenergetics, Invasion and Proliferation.

    abstract::F1F0-ATP synthase inhibitory factor 1 (IF1) inhibits the reverse mode of F1F0-ATP synthase, and therefore protects cellular ATP content at the expense of accelerated loss of mitochondrial membrane potential (ΔΨm). There is considerable variability in IF1 expression and its influence on bioenergetics between different ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Tanton H,Voronina S,Evans A,Armstrong J,Sutton R,Criddle DN,Haynes L,Schmid MC,Campbell F,Costello E,Tepikin AV

    更新日期:2018-07-11 00:00:00

  • Antidiuretic effects of the endothelin receptor antagonist avosentan.

    abstract::Several clinical studies have investigated the potential benefits of endothelin receptor antagonism in chronic pathologies such as diabetic kidney disease. However, fluid retention and edema have been identified as major side effects of endothelin receptor antagonists. In the present study we hypothesized that avosent...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Baltatu OC,Iliescu R,Zaugg CE,Reckelhoff JF,Louie P,Schumacher C,Campos LA

    更新日期:2012-04-18 00:00:00

  • Corrigendum: Neuromuscular and Perceptual Responses to Sub-Maximal Eccentric Cycling.

    abstract::[This corrects the article on p. 354 in vol. 10, PMID: 30984032.]. ...

    journal_title:Frontiers in physiology

    pub_type: 已发布勘误


    authors: Clos P,Laroche D,Stapley PJ,Lepers R

    更新日期:2020-08-12 00:00:00

  • Adjustments in Torque Steadiness During Fatiguing Contractions Are Inversely Correlated With IQ in Persons With Multiple Sclerosis.

    abstract::Fatigue is one of the most debilitating symptoms of multiple sclerosis (MS), and the underlying mechanisms are poorly understood. When exposed to a physical or cognitive challenge, individuals with MS tend to exhibit greater declines in task performance (performance fatigability) and increased levels of self-reported ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Gould JR,Reineberg AE,Cleland BT,Knoblauch KE,Clinton GK,Banich MT,Corboy JR,Enoka RM

    更新日期:2018-10-17 00:00:00

  • Effects of exercise on cardiovascular performance in the elderly.

    abstract::Progressive aging induces several structural and functional alterations in the cardiovascular system, among whom particularly important are a reduced number of myocardial cells and increased interstitial collagen fibers, which result in impaired left ventricular diastolic function. Even in the absence of cardiovascula...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Vigorito C,Giallauria F

    更新日期:2014-02-20 00:00:00

  • Activation and Biological Properties of Human β Defensin 4 in Stem Cells Derived From Human Exfoliated Deciduous Teeth.

    abstract::Pulpitis in primary teeth, a condition caused by presence of bacteria, is highly prevalent worldwide. The use of biocompatibility materials with anti-inflammatory, anti-bacterial, and regenerative properties is critical for prognosis of this endodontic disease. This study aimed to identify expression of human β defens...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Zhai Y,Wang Y,Rao N,Li J,Li X,Fang T,Zhao Y,Ge L

    更新日期:2019-10-22 00:00:00

  • Vesicle-Mediated Control of Cell Function: The Role of Extracellular Matrix and Microenvironment.

    abstract::Extracellular vesicles (EVs) - including exosomes, microvesicles and apoptotic bodies - have received much scientific attention last decade as mediators of a newly discovered cell-to-cell communication system, acting at short and long distances. EVs carry biologically active molecules, thus providing signals that infl...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Rackov G,Garcia-Romero N,Esteban-Rubio S,Carrión-Navarro J,Belda-Iniesta C,Ayuso-Sacido A

    更新日期:2018-06-05 00:00:00

  • Identification and Expression Profiling of Chemosensory Genes in Dendrolimus punctatus Walker.

    abstract::Dendrolimus punctatus Walker is a serious pest affecting conifers in southern China. As extensive pesticide spraying is currently required to control D. punctatus, new control strategies are urgently needed. Chemosensory genes represent potential molecular targets for development of alternative pest control strategies...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Zhang SF,Liu HH,Kong XB,Wang HB,Liu F,Zhang Z

    更新日期:2017-07-07 00:00:00

  • Transport and Mixing Induced by Beating Cilia in Human Airways.

    abstract::The fluid transport and mixing induced by beating cilia, present in the bronchial airways, are studied using a coupled lattice Boltzmann-Immersed Boundary solver. This solver allows the simulation of both single and multi-component fluid flows around moving solid boundaries. The cilia are modeled by a set of Lagrangia...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Chateau S,D'Ortona U,Poncet S,Favier J

    更新日期:2018-03-06 00:00:00

  • Mechanisms regulating nutrition-dependent developmental plasticity through organ-specific effects in insects.

    abstract::Nutrition, via the insulin/insulin-like growth factor (IIS)/Target of Rapamycin (TOR) signaling pathway, can provide a strong molding force for determining animal size and shape. For instance, nutrition induces a disproportionate increase in the size of male horns in dung and rhinoceros beetles, or mandibles in stagho...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Koyama T,Mendes CC,Mirth CK

    更新日期:2013-09-26 00:00:00

  • Mesenchymal Remodeling during Palatal Shelf Elevation Revealed by Extracellular Matrix and F-Actin Expression Patterns.

    abstract::During formation of the secondary palate in mammalian embryos, two vertically oriented palatal shelves rapidly elevate into a horizontal position above the tongue, meet at the midline, and fuse to form a single entity. Previous observations suggested that elevation occurs by a simple 90° rotation of the palatal shelve...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Chiquet M,Blumer S,Angelini M,Mitsiadis TA,Katsaros C

    更新日期:2016-09-07 00:00:00

  • Transport and Recovery of Gilthead Seabream (Sparus aurata L.) Sedated With Clove Oil and MS-222: Effects on Stress Axis Regulation and Intermediary Metabolism.

    abstract::Transport processes between aquaculture facilities activate the stress response in fish. To deal with these situations, the hypothalamic-pituitary-interrenal (HPI) axis releases cortisol, leading to an increase in circulating energy resources to restore homeostasis. However, if the allostatic load generated exceeds fi...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Jerez-Cepa I,Fernández-Castro M,Del Santo O'Neill TJ,Martos-Sitcha JA,Martínez-Rodríguez G,Mancera JM,Ruiz-Jarabo I

    更新日期:2019-05-31 00:00:00

  • Identification of Halloween Genes and RNA Interference-Mediated Functional Characterization of a Halloween Gene shadow in Plutella xylostella.

    abstract::Ecdysteroids play an essential role in controlling insect development and reproduction. Their pathway is regulated by a group of enzymes called Halloween gene proteins. The relationship between the Halloween genes and ecdysteroid synthesis has yet to be clearly understood in diamondback moth, Plutella xylostella (L.),...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Peng L,Wang L,Zou MM,Vasseur L,Chu LN,Qin YD,Zhai YL,You MS

    更新日期:2019-08-28 00:00:00

  • Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes.

    abstract::Background and Purpose: Store-operated calcium entry (SOCE) is an important physiological phenomenon that extensively mediates intracellular calcium ion (Ca2+) load. It has been previously found in myocytes isolated from neonatal or diseased hearts. We aimed to determine its existence, molecular nature in undiseased h...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Wen H,Zhao Z,Fefelova N,Xie LH

    更新日期:2018-12-13 00:00:00

  • Topical Application of Wogonin Provides a Novel Treatment of Knee Osteoarthritis.

    abstract::Osteoarthritis (OA) is a degenerative joint disease characterized by inflammatory degradation of articular cartilage and subchondral bone. Wogonin, a compound extracted from the plant Scutellaria baicalensis (colloquially known as skullcap), has previously been shown to have direct anti-inflammatory and antioxidative ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Smith JF,Starr EG,Goodman MA,Hanson RB,Palmer TA,Woolstenhulme JB,Weyand JA,Marchant AD,Bueckers SL,Nelson TK,Sterling MT,Rose BJ,Porter JP,Eggett DL,Kooyman DL

    更新日期:2020-02-18 00:00:00

  • A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.

    abstract::Today, in silico studies and trial simulations already complement experimental approaches in pharmaceutical R&D and have become indispensable tools for decision making and communication with regulatory agencies. While biology is multiscale by nature, project work, and software tools usually focus on isolated aspects o...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Eissing T,Kuepfer L,Becker C,Block M,Coboeken K,Gaub T,Goerlitz L,Jaeger J,Loosen R,Ludewig B,Meyer M,Niederalt C,Sevestre M,Siegmund HU,Solodenko J,Thelen K,Telle U,Weiss W,Wendl T,Willmann S,Lippert J

    更新日期:2011-02-24 00:00:00

  • Zinc-α2-Glycoprotein Is Associated with Obesity in Chinese People and HFD-Induced Obese Mice.

    abstract::Zinc-α2-glycoprotein (ZAG) plays an important role in the regulation of body weight, body fat, and glucose metabolism. In this study, we first measured ZAG levels in serum and ZAG mRNA levels in subcutaneous white adipose tissue (sWAT) among overweight/obese patients and lean control subjects. Second, we investigated ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Liu M,Zhu H,Dai Y,Pan H,Li N,Wang L,Yang H,Yan K,Gong F

    更新日期:2018-02-07 00:00:00

  • The blue-collar brain.

    abstract::Much effort has gone into elucidating control of the body by the brain, less so the role of the body in controlling the brain. This essay develops the idea that the brain does a great deal of work in the service of behavior that is controlled by the body, a blue-collar role compared to the white-collar control exercis...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Van Orden G,Hollis G,Wallot S

    更新日期:2012-06-18 00:00:00

  • QT Interval Derived Measurements in Patients with Cardiac Syndrome X Compared to Coronary Artery Disease.

    abstract::Previous studies assessing effect of ischemia on ventricular repolarization are mostly directed toward patients with coronary artery disease (CAD); however, similar reports on cardiac syndrome X (CSX) are scarce. Whether microvascular dysfunction of CSX and ischemia induced by CAD produce comparable effect on ventricu...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Lutfi MF

    更新日期:2016-09-21 00:00:00

  • Insecticidal Effects of Hemocoelic Delivery of Bacillus thuringiensis Cry Toxins in Achaea janata Larvae.

    abstract::Insecticidal effects of Bacillus thuringiensis Cry toxins in hemocoel of larvae have not been properly evaluated. In the present study, hemocoelic injection of four representative Cry toxins i.e., Cry1Aa, Cry1Ab, Cry1Ac, and DOR5 to an economically important lepidopteran insect pest Achaea janata, induced larval morta...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Ningshen TJ,Chauhan VK,Dhania NK,Dutta-Gupta A

    更新日期:2017-05-10 00:00:00

  • Pulsatility of Lenticulostriate Arteries Assessed by 7 Tesla Flow MRI-Measurement, Reproducibility, and Applicability to Aging Effect.

    abstract::Characterization of flow properties in cerebral arteries with 1.5 and 3 Tesla MRI is usually limited to large cerebral arteries and difficult to evaluate in the small perforating arteries due to insufficient spatial resolution. In this study, we assessed the feasibility to measure blood flow waveforms in the small len...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Schnerr RS,Jansen JFA,Uludag K,Hofman PAM,Wildberger JE,van Oostenbrugge RJ,Backes WH

    更新日期:2017-11-24 00:00:00

  • Annexin II Light Chain p11 Interacts With ENaC to Increase Functional Activity at the Membrane.

    abstract::The epithelial Na+ channel (ENaC) provides for Na+ absorption in various types of epithelia including the kidney, lung, and colon where ENaC is localized to the apical membrane to enable Na+ entry into the cell. The degree of Na+ entry via ENaC largely depends on the number of active channels localized to the cell mem...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Cheung TT,Ismail NAS,Moir R,Arora N,McDonald FJ,Condliffe SB

    更新日期:2019-02-08 00:00:00

  • β-adrenergic receptor responsiveness in aging heart and clinical implications.

    abstract::Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle inotropic reserve related to increased vascular afterload, arterial-ventricular load mismatching, physical deconditioning and impaired autonomic regulation (the so called "β-adrenergic desensitization"). Adrenergic responsiven...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Ferrara N,Komici K,Corbi G,Pagano G,Furgi G,Rengo C,Femminella GD,Leosco D,Bonaduce D

    更新日期:2014-01-09 00:00:00

  • SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1.

    abstract::The vascular endothelium supplying the brain exhibits very low paracellular and transcellular permeability and is a major constituent of the blood-brain barrier. High-density lipoprotein (HDL) crosses the blood-brain barrier by transcytosis, but technical limitations have made it difficult to elucidate its regulation....

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Fung KY,Wang C,Nyegaard S,Heit B,Fairn GD,Lee WL

    更新日期:2017-10-30 00:00:00

  • Abnormal Haemodynamic Flow Patterns in Bicuspid Pulmonary Valve Disease.

    abstract::Abnormal flow patterns in the aortas of those with bicuspid aortic valves (BAVs) are increasingly recognized as important in the pathogenesis of aortic dilatation but pulmonary flow patterns in bicuspid pulmonary valves have not been studied. Bicuspid pulmonary valve disease is rare and a small numbers of case reports...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Bissell MM,Loudon M,Neubauer S,Myerson SG

    更新日期:2017-05-31 00:00:00

  • Coexisting Frailty With Heart Failure.

    abstract::People over 65 years of age constitute over 80% of patients with heart failure (HF) and the incidence of HF is 10 per 1,000 in people aged above 65 years. Approximately 25% of older patients with HF exhibit evidence of frailty. Frail patients with cardiovascular disease (CVD) have a worse prognosis than non-frail pati...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Uchmanowicz I,Nessler J,Gobbens R,Gackowski A,Kurpas D,Straburzynska-Migaj E,Kałuzna-Oleksy M,Jankowska EA

    更新日期:2019-07-03 00:00:00

  • Abdominal Binding Improves Neuromuscular Efficiency of the Human Diaphragm during Exercise.

    abstract::We tested the hypothesis that elastic binding of the abdomen (AB) would enhance neuromuscular efficiency of the human diaphragm during exercise. Twelve healthy non-obese men aged 24.8 ± 1.7 years (mean ± SE) completed a symptom-limited constant-load cycle endurance exercise test at 85% of their peak incremental power ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Abdallah SJ,Chan DS,Glicksman R,Mendonca CT,Luo Y,Bourbeau J,Smith BM,Jensen D

    更新日期:2017-05-31 00:00:00