Dyslipidemia in Kidney Disorders: Perspectives on Mitochondria Homeostasis and Therapeutic Opportunities.

abstract：:Previous studies report greater activation in the cortical motor network in controlling eccentric contraction (EC) than concentric contraction (CC) of human skeletal muscles despite lower activation level of the muscle associated with EC. It is unknown, however, whether the strength of functional coupling between the ...

journal_title：Frontiers in physiology

authors： Yao WX,Jiang Z,Li J,Jiang C,Franlin CG,Lancaster JL,Huang Y,Yue GH

更新日期：2016-11-15 00:00:00

abstract：:The senescence of vascular smooth muscle cells (VSMCs) has been implicated as a causal pro-inflammatory mechanism for cardiovascular disease development and progression of atherosclerosis, the instigator of ischemic heart disease. Contemporary limitations related to studying this cellular population and senescence-rel...

journal_title：Frontiers in physiology

authors： Stojanović SD,Fuchs M,Kunz M,Xiao K,Just A,Pich A,Bauersachs J,Fiedler J,Sedding D,Thum T

更新日期：2020-05-25 00:00:00

abstract：Objectives:Carotid artery geometry influences blood flow disturbances and is thus an important risk factor for carotid atherosclerosis. Extracellular matrix (ECM) and yes-associated protein (YAP) expression may play essential roles in the pathophysiology of carotid artery stenosis, but the effect of blood flow disturba...

journal_title：Frontiers in physiology

authors： Cui Y,Lv X,Wang F,Kong J,Zhao H,Ye Z,Si C,Pan L,Liu P,Wen J

更新日期：2020-01-21 00:00:00

abstract：:It has been proposed that group III and IV muscle afferents provide inhibitory feedback from locomotor muscles to the central nervous system, setting an absolute threshold for the development of peripheral fatigue during exercise. The aim of this study was to test the validity of this theory. Thus, we asked whether th...

journal_title：Frontiers in physiology

authors： Froyd C,Beltrami FG,Millet GY,Noakes TD

更新日期：2016-12-19 00:00:00

abstract：:Background: RNase A (the bovine equivalent to human RNase 1) and RNase 5 (angiogenin) are two closely related ribonucleases. RNase 5 is described as a powerful angiogenic factor. Whether RNase A shares the same angiogenic characteristic, or interferes with vessel growth as demonstrated for arteriogenesis, has never be...

journal_title：Frontiers in physiology

authors： Lasch M,Kumaraswami K,Nasiscionyte S,Kircher S,van den Heuvel D,Meister S,Ishikawa-Ankerhold H,Deindl E

更新日期：2020-11-06 00:00:00

abstract：:Aim: To investigate whether housing temperature influences rat adiposity, and the extent it is modified by diet and/or pregnancy. Housing temperature impacts on brown adipose tissue, that possess a unique uncoupling protein (UCP) 1, which, when activated by reduced ambient temperature, enables rapid heat generation. M...

journal_title：Frontiers in physiology

authors： Albustanji L,Perez GS,AlHarethi E,Aldiss P,Bloor I,Barreto-Medeiros JM,Budge H,Symonds ME,Dellschaft N

更新日期：2019-03-06 00:00:00

abstract：:Background: The results from animal and human research indicate that acute intermittent hypoxia can enhance brain-derived neurotrophic factor (BDNF) plasma levels and gene expression. As BDNF is known to promote the differentiation of new neurons and the formation of synapses, it has been proposed to mediate adult neu...

journal_title：Frontiers in physiology

authors： Becke A,Müller P,Dordevic M,Lessmann V,Brigadski T,Müller NG

更新日期：2018-10-01 00:00:00

abstract：:Patients undergoing hyperbaric oxygen therapy and divers engaged in underwater activity are at risk of central nervous system oxygen toxicity. An algorithm for predicting CNS oxygen toxicity in active underwater diving has been published previously, but not for humans at rest. Using a procedure similar to that employe...

journal_title：Frontiers in physiology

authors： Aviner B,Arieli R,Yalov A

更新日期：2020-08-17 00:00:00

abstract：:Secretory glands including salivary glands by many hormonal inputs produce and secrete biological fluids determined by variety of ion transporters. Spinophilin is a multifunctional scaffolding protein, which involved in receptor signaling and regulation of anion exchangers AE2 activity. We found that spinophilin expre...

journal_title：Frontiers in physiology

authors： Lee D,Lee SA,Shin DM,Hong JH

更新日期：2018-07-19 00:00:00

abstract：:Clinical investigations prove that blue light irradiation reduces the severity of psoriasis vulgaris. Nevertheless, the mechanisms involved in the management of this condition remain poorly defined. Despite the encouraging results of the clinical studies, no clear guidelines are specified in the literature for the irr...

journal_title：Frontiers in physiology

authors： Félix Garza ZC,Liebmann J,Born M,Hilbers PA,van Riel NA

更新日期：2017-01-26 00:00:00

abstract：:To understand dynamic changes in polyamines (PAs) forms and components of polyamine metabolism in zoysiagrass (Zoysia japonica Steud.) response to salt stress with exogenous spermidine (Spd) application, two Chinese zoysia cultivars, z081 and z057, were exposed to sodium chloride stress for 2, 4, 6, and 8 days. The z0...

journal_title：Frontiers in physiology

authors： Li S,Cui L,Zhang Y,Wang Y,Mao P

更新日期：2017-04-06 00:00:00

abstract：:In this paper we develop a novel mathematical model of the insulin-TOR-MAPK signaling network that controls growth. Most data on the properties of the insulin and MAPK signaling networks are static and the responses to experimental interventions, such as knockouts, overexpression, and hormonal input are typically repo...

journal_title：Frontiers in physiology

authors： Nijhout HF,Callier V

更新日期：2013-09-12 00:00:00

abstract：:Forced sustained swimming exercise at optimal speed enhances growth in many fish species, particularly through hypertrophy of the white skeletal muscle. The exact mechanism of this effect has not been resolved yet. To explore the role of cortisol, we first subjected wild-type zebrafish to an exercise protocol validate...

journal_title：Frontiers in physiology

authors： Palstra AP,Mendez S,Dirks RP,Schaaf MJM

更新日期：2019-01-14 00:00:00

abstract：:Triceps surae (TS) muscle volume can be estimated in young adults by only considering the maximal anatomical cross-sectional area (ACSAmax) and the length of the muscle due to the presence of a constant muscle-specific shape factor. This study aimed to investigate if this simplified muscle volume assessment is also ap...

journal_title：Frontiers in physiology

authors： Karamanidis K,Epro G,König M,Mersmann F,Arampatzis A

更新日期：2019-10-10 00:00:00

abstract：:Background: Dental aberrations have been mentioned in relation to non-surgical hypoparathyroidism (Ns-HypoPT) and pseudohypoparathyroidism (PHP). However, a systematic review of dental characteristics have not been performed. The present systematic review describes the dental findings in patients with Ns-HypoPT and PH...

journal_title：Frontiers in physiology

authors： Hejlesen J,Underbjerg L,Gjørup H,Bloch-Zupan A,Sikjaer T,Rejnmark L,Haubek D

更新日期：2018-06-19 00:00:00

abstract：:The two forms of inorganic arsenic, arsenate (AsV) and arsenite (AsIII), are easily taken up by the cells of the plant root. Once in the cell, AsV can be readily converted to AsIII, the more toxic of the two forms. AsV and AsIII both disrupt plant metabolism, but through distinct mechanisms. AsV is a chemical analog o...

journal_title：Frontiers in physiology

authors： Finnegan PM,Chen W

更新日期：2012-06-06 00:00:00

abstract：:Background: Molting is a crucial physiological behavior during arthropod growth. In the past few years, molting as well as chitin biosynthesis triggered by molting, is subject to regulation by miRNAs. However, how many miRNAs are involved in insect molting at the genome-wide level remains unknown. Results: We deeply s...

journal_title：Frontiers in physiology

authors： Chen J,Li TC,Pang R,Yue XZ,Hu J,Zhang WQ

更新日期：2018-12-20 00:00:00

abstract：:Increased central sympathetic drive is a hallmark of several important clinical conditions including essential hypertension, heart failure, chronic kidney disease, and insulin resistance. Afferent signaling from the kidneys has been identified as an important contributor to elevated central sympathetic drive and incre...

journal_title：Frontiers in physiology

authors： Schlaich MP,Hering D,Sobotka P,Krum H,Lambert GW,Lambert E,Esler MD

更新日期：2012-02-02 00:00:00

abstract：:The complex interactions that give rise to heart rate variability (HRV) involve coupled physiological oscillators operating over a wide range of different frequencies and length-scales. Based on the premise that interactions are key to the functioning of complex systems, the time-dependent deterministic coupling param...

journal_title：Frontiers in physiology

authors： Ticcinelli V,Stankovski T,Iatsenko D,Bernjak A,Bradbury AE,Gallagher AR,Clarkson PBM,McClintock PVE,Stefanovska A

更新日期：2017-10-13 00:00:00

abstract：:Cardiovascular disease (CVD) continues to constitute the leading cause of death globally. CVD risk stratification is an essential tool to sort through heterogeneous populations and identify individuals at risk of developing CVD. However, applications of current risk scores have recently been shown to result in conside...

journal_title：Frontiers in physiology

authors： Björnson E,Borén J,Mardinoglu A

更新日期：2016-01-26 00:00:00

abstract：:In this study, we analyzed the role of mammalian STE20-like protein kinase 2 (Mst2), a serine-threonine protein kinase, in Lipopolysaccharides (LPS)-mediated inflammation and apoptosis in the H9C2 cardiomyocytes. Mst2 mRNA and protein levels were significantly upregulated in the LPS-treated H9C2 cardiomyocytes. LPS tr...

journal_title：Frontiers in physiology

authors： Tian Y,Song H,Qin W,Ding Z,Zhang Y,Shan W,Jin D

更新日期：2020-08-06 00:00:00

abstract：:Xinnao shutong (XNST) capsules have been clinically used in China to treat cerebrovascular diseases. Previous studies have demonstrated that XNST has significant neuroprotective effects against acute cerebral ischemic stroke. The present study investigated the effects and mechanisms of XNST treatment following chronic...

journal_title：Frontiers in physiology

authors： Wang L,Wang R,Chen Z,Zhao H,Luo Y

更新日期：2018-05-15 00:00:00

abstract：:Voltage gated potassium channels (KV) are membrane proteins that allow selective flow of K+ ions in a voltage-dependent manner. These channels play an important role in several excitable cells as neurons, cardiomyocytes, and vascular smooth muscle. Over the last 20 years, it has been shown that omega-3 polyunsaturated...

journal_title：Frontiers in physiology

authors： Moreno C,de la Cruz A,Valenzuela C

更新日期：2016-11-24 00:00:00

abstract：UNLABELLED:Oxycodone (OXY) is one of the most commonly abused opiates during pregnancy. Perinatal opiate exposure (POE) is associated with neurobehavioral and hormone changes. Little is known about the effects of perinatal OXY on the cardiovascular (CV) responses to stress. OBJECTIVES:to determine the effects of POE o...

journal_title：Frontiers in physiology

authors： Sithisarn T,Bada HS,Charnigo RJ,Legan SJ,Randall DC

更新日期：2013-04-24 00:00:00

abstract：:Global environmental change is leading to an increase in the frequency, intensity, and duration of extreme weather events, so effective environmental management requires an understanding not only of the physiological response of organisms to increased mean temperatures, but also to extreme environmental conditions. To...

journal_title：Frontiers in physiology

authors： Cooper CE,Withers PC,Hurley LL,Griffith SC

更新日期：2019-11-20 00:00:00

abstract：:Genome-wide association studies and physiological investigations have linked alterations in acid-base transporters to hypertension. Accordingly, Na(+)-coupled HCO(-) 3-transporters, Na(+)/H(+)-exchangers, and anion-exchangers have emerged as putative mechanistic components in blood pressure disturbances. Even though h...

journal_title：Frontiers in physiology

authors： Boedtkjer E,Aalkjaer C

更新日期：2013-12-24 00:00:00

abstract：:Activation of autonomic neural pathways by chronic hypertensive stimuli plays a significant role in pathogenesis of hypertension. Here, we proposed that even a single acute hypertensive stimulus will activate neural and immune pathways that may be important in initiation of memory imprinting seen in chronic hypertensi...

journal_title：Frontiers in physiology

authors： Zubcevic J,Santisteban MM,Perez PD,Arocha R,Hiller H,Malphurs WL,Colon-Perez LM,Sharma RK,de Kloet A,Krause EG,Febo M,Raizada MK

更新日期：2017-08-31 00:00:00

abstract：BACKGROUND:During caesarean section spinal anesthesia may provoke maternal hypotension that we prevent by administration of phenylephrine and/or ephedrine. Phenylephrine is however reported to reduce the near infrared spectroscopy-determined frontal lobe oxygenation (ScO2) but whether that is the case for patients expo...

journal_title：Frontiers in physiology

authors： Foss VT,Christensen R,Rokamp KZ,Nissen P,Secher NH,Nielsen HB

更新日期：2014-03-03 00:00:00

abstract：:Introduction: Heart Rate Variability (HRV) and Pulse Rate Variability (PRV), are non-invasive techniques for monitoring changes in the cardiac cycle. Both techniques have been used for assessing the autonomic activity. Although highly correlated in healthy subjects, differences in HRV and PRV have been observed under ...

journal_title：Frontiers in physiology

authors： Mejía-Mejía E,Budidha K,Abay TY,May JM,Kyriacou PA

更新日期：2020-07-23 00:00:00

abstract：:There are animal species that have adapted to life at high altitude and hypobaric hypoxia conditions in the Andean highlands. One such species is the llama (Lama glama), which seem to have developed efficient protective mechanisms to avoid maladaptation resulting from chronic hypoxia, such as a resistance to the devel...

journal_title：Frontiers in physiology

authors： López V,Moraga FA,Llanos AJ,Ebensperger G,Taborda MI,Uribe E

更新日期：2018-05-29 00:00:00