Experimental Pulmonary Hypertension Is Associated With Neuroinflammation in the Spinal Cord.

abstract：:Adaptation of arm reaching in a novel force field involves co-contraction of upper limb muscles, but it is not known how the co-ordination of multiple muscle activation is orchestrated. We have used intermuscular coherence (IMC) to test whether a coherent intermuscular coupling between muscle pairs is responsible for ...

journal_title：Frontiers in physiology

authors： Pizzamiglio S,De Lillo M,Naeem U,Abdalla H,Turner DL

更新日期：2017-01-09 00:00:00

abstract：:Octopuses (Octopus vulgaris) are generally considered to possess extraordinary cognitive abilities including the ability to successfully perform in a serial reversal learning task. During reversal learning, an animal is presented with a discrimination problem and after reaching a learning criterion, the signs of the s...

journal_title：Frontiers in physiology

authors： Bublitz A,Weinhold SR,Strobel S,Dehnhardt G,Hanke FD

更新日期：2017-02-07 00:00:00

abstract：:The emergence of -omics technologies has allowed the collection of vast amounts of data on biological systems. Although, the pace of such collection has been exponential, the impact of these data remains small on many critical biomedical applications such as drug development. Limited resources, high costs, and low hit...

journal_title：Frontiers in physiology

authors： Kandoi G,Acencio ML,Lemke N

更新日期：2015-12-08 00:00:00

abstract：:Secondary shifts develop in post-translational phosphorylation of sarcomeric proteins in multiple animal models of inherited cardiomyopathy. These signaling alterations together with the primary mutation are predicted to contribute to the overall cardiac phenotype. As a result, identification and integration of post-t...

journal_title：Frontiers in physiology

authors： Westfall MV

更新日期：2016-09-14 00:00:00

abstract：:Huntington's disease (HD) is an inherited neurodegenerative disorder typified by involuntary body movements, and psychiatric and cognitive abnormalities. Many HD patients also exhibit metabolic changes including progressive weight loss and appetite dysfunction. Here we have investigated metabolic function in pre-manif...

journal_title：Frontiers in physiology

authors： Wang R,Ross CA,Cai H,Cong WN,Daimon CM,Carlson OD,Egan JM,Siddiqui S,Maudsley S,Martin B

更新日期：2014-06-23 00:00:00

abstract：:Left ventricular hypertrophy (LVH) is a major contributor to the development of heart failure (HF). Alterations in cyclic adenosine monophosphate (cAMP)-dependent signaling pathways participate in cardiomyocyte hypertrophy and mitochondrial dysfunction occurring in LVH and HF. cAMP signals are received and integrated ...

journal_title：Frontiers in physiology

authors： Schiattarella GG,Boccella N,Paolillo R,Cattaneo F,Trimarco V,Franzone A,D'Apice S,Giugliano G,Rinaldi L,Borzacchiello D,Gentile A,Lombardi A,Feliciello A,Esposito G,Perrino C

更新日期：2018-05-28 00:00:00

abstract：:Skeletal muscle mass reflects a dynamic turnover between net protein synthesis and degradation. In addition, satellite cell inclusion may contribute to increase muscle mass while fiber loss results in a reduction of muscle mass. Since 2010, a few studies looked at the involvement of the newly discovered Hippo pathway ...

journal_title：Frontiers in physiology

authors： Gnimassou O,Francaux M,Deldicque L

更新日期：2017-03-29 00:00:00

abstract：:Long-duration spaceflight has been shown to negatively affect the lumbopelvic muscles of crewmembers. Through analysis of computed tomography scans of crewmembers on 4- to 6-month missions equipped with the interim resistive exercise device, the structural deterioration of the psoas, quadratus lumborum, and paraspinal...

journal_title：Frontiers in physiology

authors： McNamara KP,Greene KA,Moore AM,Lenchik L,Weaver AA

更新日期：2019-05-21 00:00:00

abstract：:We recorded via telemetry the arterial blood pressure (BP) and heart rate (HR) response to classical conditioning following the spontaneous onset of autoimmune diabetes in BBDP/Wor rats vs. age-matched, diabetes-resistant control (BBDR/Wor) rats. Our purpose was to evaluate the autonomic regulatory responses to an acu...

journal_title：Frontiers in physiology

authors： Randall DC,Speakman RO,Silcox DL,Brown LV,Brown DR,Gong MC,Patwardhan A,Reynolds LR,Karounos DG,Burgess DE,Anigbogu CN

更新日期：2011-08-27 00:00:00

abstract：:Voltage-gated potassium (Kv) channels shape the action potentials of excitable cells and regulate membrane potential and ion homeostasis in excitable and non-excitable cells. With 40 known members in the human genome and a variety of homomeric and heteromeric pore-forming α subunit interactions, post-translational mod...

journal_title：Frontiers in physiology

authors： Kanda VA,Abbott GW

更新日期：2012-06-28 00:00:00

abstract：:A Boolean model is a simple, discrete and dynamic model without the need to consider the effects at the intermediate levels. However, little effort has been made into constructing activation, inhibition, and protein decay networks, which could indicate the direct roles of a gene (or its synthesized protein) as an acti...

journal_title：Frontiers in physiology

authors： Chen L,Kulasiri D,Samarasinghe S

更新日期：2018-09-25 00:00:00

abstract：:Temporal computations are important in the acoustic communication of anurans. In many cases, calls between closely related species are nearly identical spectrally but differ markedly in temporal structure. Depending on the species, calls can differ in pulse duration, shape and/or rate (i.e., amplitude modulation), dir...

journal_title：Frontiers in physiology

authors： Rose GJ

更新日期：2014-05-30 00:00:00

abstract：:A coronary angiography-derived index of microvascular resistance (caIMR) is proposed for physiological assessment of microvasular diseases in coronary circulation. The aim of the study is to assess diagnostic performance of caIMR, using wire-derived index of microvascular resistance (IMR) as the reference standard. IM...

journal_title：Frontiers in physiology

authors： Ai H,Feng Y,Gong Y,Zheng B,Jin Q,Zhang HP,Sun F,Li J,Chen Y,Huo Y,Huo Y

更新日期：2020-12-16 00:00:00

abstract：:Regulation of cardiac physiology is well known to occur through the action of kinases that reversibly phosphorylate ion channels, calcium handling machinery, and signaling effectors. However, it is becoming increasingly apparent that palmitoylation or S-acylation, the post-translational modification of cysteines with ...

journal_title：Frontiers in physiology

authors： Essandoh K,Philippe JM,Jenkins PM,Brody MJ

更新日期：2020-02-19 00:00:00

abstract：:Atherosclerosis is considered as a chronic disease of arterial wall, with a strong contribution of inflammation. Dendritic cells (DCs) play a crucial role in the initiation of proatherogenic inflammatory response. Mature DCs present self-antigens thereby supporting differentiation of naïve T cells to effector cells th...

journal_title：Frontiers in physiology

authors： Chistiakov DA,Sobenin IA,Orekhov AN,Bobryshev YV

更新日期：2014-05-27 00:00:00

abstract：:Survivors of cerebral aneurysm rupture are at risk for significant morbidity and neurological deficits. Much of this is related to the effects of blood in the subarachnoid space which induces an inflammatory cascade with numerous downstream consequences. Recent clinical trials have not been able to reduce the toxic ef...

journal_title：Frontiers in physiology

authors： Blackburn SL,Kumar PT,McBride D,Zeineddine HA,Leclerc J,Choi HA,Dash PK,Grotta J,Aronowski J,Cardenas JC,Doré S

更新日期：2018-05-31 00:00:00

abstract：:Polarized (POL) training intensity distribution (TID) emphasizes high-volume low-intensity exercise in zone (Z)1 (< first lactate threshold) with a greater proportion of high-intensity Z3 (>second lactate threshold) compared to Z2 (between first and second lactate threshold). In highly trained rowers there is a lack o...

journal_title：Frontiers in physiology

authors： Treff G,Winkert K,Sareban M,Steinacker JM,Becker M,Sperlich B

更新日期：2017-08-02 00:00:00

abstract：:The non-linear stress-strain behavior of uniaxially-stretched lung parenchyma is thought to be an emergent phenomenon arising from the ensemble behavior of its microscopic constituents. Such behavior includes the alignment and elongation of randomly oriented alveolar walls with initially flaccid fibers in the directio...

journal_title：Frontiers in physiology

authors： Bou Jawde S,Takahashi A,Bates JHT,Suki B

更新日期：2020-02-25 00:00:00

abstract：:Telomeres are genomic complex at the end of chromosomes that protects the DNA and telomere length (TL) is related to several age-related diseases, lifespan, and cancer. On the other hand, cancer is a multifactorial disease that is responsible for reduce the quality of life and kills millions of people every year. Both...

journal_title：Frontiers in physiology

authors： Nomikos NN,Nikolaidis PT,Sousa CV,Papalois AE,Rosemann T,Knechtle B

更新日期：2018-12-18 00:00:00

abstract：INTRODUCTION:Exercise reduces arterial and central venous blood pressures during recovery, which contributes to its valuable anti-hypertensive effects and to facilitating hypervolemia. Repeated sprint exercise potently improves metabolic function, but its cardiovascular effects (esp. hematological) are less well-charac...

journal_title：Frontiers in physiology

authors： Graham MJ,Lucas SJ,Francois ME,Stavrianeas S,Parr EB,Thomas KN,Cotter JD

更新日期：2016-05-31 00:00:00

abstract：:Odontoblast cells generated from human dental pulp stem/progenitor cells (hDPSCs) secrete reparative dentin in responds to an injury. Endogenous Wnt signaling is also activated during this process, and these Wnt-activated cells are responsible for the following repair response. R-spondin 2 (Rspo2) is a potent stem cel...

journal_title：Frontiers in physiology

authors： Gong Y,Yuan S,Sun J,Wang Y,Liu S,Guo R,Dong W,Li R

更新日期：2020-08-07 00:00:00

abstract：:The luminal endoplasmic reticulum (ER) protein of 29 kDa (ERp29) is a ubiquitously expressed cellular agent with multiple critical roles. ERp29 regulates the biosynthesis and trafficking of several transmembrane and secretory proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR), the epith...

journal_title：Frontiers in physiology

authors： Brecker M,Khakhina S,Schubert TJ,Thompson Z,Rubenstein RC

更新日期：2020-09-08 00:00:00

abstract：:Social attachment formed by filial imprinting in newborn chicks undergoes a process of memory consolidation that involves rearrangement of its neural storage substrates. In the first 3 h after imprinting it depends on the integrity of the intermediate medial mesopallium (IMM) and beyond that time on unidentified memor...

journal_title：Frontiers in physiology

authors： Tiunova AA,Komissarova NV,Anokhin KV

更新日期：2019-03-29 00:00:00

abstract：:Aim: Tea is usually consumed at two temperatures (as hot tea or as iced tea). However, the importance of drink temperature on the cardiovascular system and on metabolism has not been thoroughly investigated. The purpose of this study was to compare the cardiovascular, metabolic and cutaneous responses to the ingestion...

journal_title：Frontiers in physiology

authors： Maufrais C,Sarafian D,Dulloo A,Montani JP

更新日期：2018-04-06 00:00:00

abstract：:The paired cranial sensory organs and peripheral nervous system of vertebrates arise from a thin strip of cells immediately adjacent to the developing neural plate. The neural plate border region comprises progenitors for four key populations of cells: neural plate cells, neural crest cells, the cranial placodes, and ...

journal_title：Frontiers in physiology

authors： Thawani A,Groves AK

更新日期：2020-12-07 00:00:00

abstract：:Circadian clocks consist of molecular negative feedback loops that coordinate physiological, neurological, and behavioral variables into "circa" 24-h rhythms. Rhythms in behavioral and other circadian outputs tend to weaken during aging, as evident in progressive disruptions of sleep-wake cycles in aging organisms. Ho...

journal_title：Frontiers in physiology

authors： Long DM,Giebultowicz JM

更新日期：2018-01-09 00:00:00

abstract：:Rapamycin, also known as sirolimus, is an antifungal agent and immunosuppressant drug used to prevent organ rejection in transplantation. However, little is known about the role of rapamycin in cardiac hypertrophy and the signaling pathways involved. Here, the effect of rapamycin was examined using phenylephrine (PE) ...

journal_title：Frontiers in physiology

authors： Gu J,Hu W,Song ZP,Chen YG,Zhang DD,Wang CQ

更新日期：2016-03-18 00:00:00

abstract：:Muscle and tendon stiffness are related to sports performance, tendinopathy, and tendon degeneration. However, the effects of habitual loading on muscle and tendon mechanical properties are unclear. Using amateur basketball players as examples, we investigated the effects of mechanical loading on the stiffness of the ...

journal_title：Frontiers in physiology

authors： Chang TT,Li Z,Wang XQ,Zhang ZJ

更新日期：2020-12-10 00:00:00

abstract：:A colony of social insects is not only an aggregation of individuals but also a functional unit. To achieve adaptive social behavior in fluctuating environmental conditions, in addition to coordination of physiological status in each individual, the whole colony is coordinated by interactions among colony members. The...

journal_title：Frontiers in physiology

authors： Watanabe D,Gotoh H,Miura T,Maekawa K

更新日期：2014-04-09 00:00:00

abstract：:Although insulin resistance (IR) is a key pathophysiologic condition underlying various metabolic disorders, impaired cellular glucose uptake is one of many manifestations of metabolic derangements in the human body. To study the systems-wide molecular changes associated with obesity-dependent IR, we integrated inform...

journal_title：Frontiers in physiology

authors： Choi H,Koh HWL,Zhou L,Cheng H,Loh TP,Parvaresh Rizi E,Toh SA,Ronnett GV,Huang BE,Khoo CM

更新日期：2019-04-05 00:00:00