Is central dogma a global property of cellular information flow?

abstract：:Molar hypomineralisation (MH) is becoming globally recognised as a significant public health problem linked to childhood tooth decay. However, with causation and pathogenesis unclear after 100 years of investigation, better pathological understanding is needed if MH is to become preventable. Our studies have implicate...

journal_title：Frontiers in physiology

authors： Perez VA,Mangum JE,Hubbard MJ

更新日期：2020-09-30 00:00:00

abstract：:The mitochondrial oxidative stress theory of aging posits that membrane susceptibility to peroxidation and the organization of the electron transport system (ETS) linked with reactive oxygen species (ROS) generation are two main drivers of lifespan. While a clear correlation has been established from species comparati...

journal_title：Frontiers in physiology

authors： Rodríguez E,Dégletagne C,Hagen TM,Abele D,Blier PU

更新日期：2019-07-26 00:00:00

abstract：:Consumption of acidic foods and drinks and other factors that cause enamel wear are responsible for the daily enamel loss and degradation. Use of some toothpastes that have been showed to possess different properties of remineralisation and/or repair of the enamel surface may help to protect tooth enamel. The aim of t...

journal_title：Frontiers in physiology

authors： Lelli M,Putignano A,Marchetti M,Foltran I,Mangani F,Procaccini M,Roveri N,Orsini G

更新日期：2014-09-05 00:00:00

abstract：:Circulating mitochondrial DNA (mtDNA) is receiving increasing attention as a danger-associated molecular pattern in conditions such as autoimmunity or trauma. In the context of decompression sickness (DCS), the course of which is sometimes erratic, we hypothesize that mtDNA plays a not insignificant role particularly ...

journal_title：Frontiers in physiology

authors： Blatteau JE,Gaillard S,De Maistre S,Richard S,Louges P,Gempp E,Druelles A,Lehot H,Morin J,Castagna O,Abraini JH,Risso JJ,Vallée N

更新日期：2018-11-29 00:00:00

abstract：:In the chronic stage of myocardial infarction, a significant number of patients develop life-threatening ventricular tachycardias (VT) due to the arrhythmogenic nature of the remodeled myocardium. Radiofrequency ablation (RFA) is a common procedure to isolate reentry pathways across the infarct scar that are responsib...

journal_title：Frontiers in physiology

authors： Lopez-Perez A,Sebastian R,Izquierdo M,Ruiz R,Bishop M,Ferrero JM

更新日期：2019-05-15 00:00:00

abstract：:We present here a longitudinal study determining the effects of two 3 week-periods of high intensity high volume interval training (HIHVT) (90 intervals of 6 s cycling at 250% maximum power, Pmax/24 s) on a cycle ergometer. HIHVT was evaluated by comparing performance tests before and after the entire training (baseli...

journal_title：Frontiers in physiology

authors： Eigendorf J,May M,Friedrich J,Engeli S,Maassen N,Gros G,Meissner JD

更新日期：2018-05-29 00:00:00

abstract：:Research on the effects of climate change in the marine environment continues to accelerate, yet we know little about the effects of multiple climate drivers in more complex, ecologically relevant settings - especially in sub-tropical and tropical systems. In marine ecosystems, climate change (warming and freshening f...

journal_title：Frontiers in physiology

authors： Turner LM,Havenhand JN,Alsterberg C,Turner AD,K GS,Rai A,Venugopal MN,Karunasagar I,Godhe A

更新日期：2019-04-04 00:00:00

abstract：:Many disease fighting strategies have focused on the generation of NK cells, since they constitute the main immune barrier against cancer and intracellular pathogens such as viruses. Therefore, a predictive model for the development of NK cells would constitute a useful tool to test several hypotheses regarding the pr...

journal_title：Frontiers in physiology

authors： Liquitaya-Montiel AJ,Mendoza L

更新日期：2018-08-02 00:00:00

abstract：:The need for radiotherapy personalization is now widely recognized, however, it would require considerations not only on the probability of control and survival of the tumor, but also on the possible toxic effects, on the quality of the expected life and the economic efficiency of the treatment. In this paper, we prop...

journal_title：Frontiers in physiology

authors： Belfatto A,Jereczek-Fossa BA,Baroni G,Cerveri P

更新日期：2018-10-15 00:00:00

abstract：:Defects in mid-facial development, including cleft lip/palate, account for a large number of human birth defects annually. In many cases, aberrant gene expression results in either a reduction in the number of neural crest cells (NCCs) that reach the frontonasal region and form much of the facial skeleton or subsequen...

journal_title：Frontiers in physiology

authors： Ding HL,Hooper JE,Batzel P,Eames BF,Postlethwait JH,Artinger KB,Clouthier DE

更新日期：2016-07-14 00:00:00

abstract：:Background: Understanding the microscopic dynamics of the beating heart has been challenging due to the technical nature of imaging with micrometer resolution while the heart moves. The development of multiphoton microscopy has made in vivo, cell-resolved measurements of calcium dynamics and vascular function possible...

journal_title：Frontiers in physiology

authors： Jones JS,Small DM,Nishimura N

更新日期：2018-07-31 00:00:00

abstract：:We describe a new nonlinear dynamic model of insect phototransduction using a NLN (nonlinear, linear, nonlinear) block structure. The first nonlinear stage provides a single exponential decline in gain and mean following the start of light stimulation. The linear stage uses a two-parameter log-normal convolution model...

journal_title：Frontiers in physiology

authors： French AS,Immonen EV,Frolov RV

更新日期：2016-10-25 00:00:00

abstract：:Molecular chaperones are stress proteins that allow the correct folding or unfolding as well as the assembly or disassembly of macromolecular cellular components. Changes in expression and post-translational modifications of chaperones have been linked to a number of age- and stress-related diseases including cancer, ...

journal_title：Frontiers in physiology

authors： Penna C,Sorge M,Femminò S,Pagliaro P,Brancaccio M

更新日期：2018-03-16 00:00:00

abstract：:Background: The purpose of this study was to investigate the acute effects of a single oral administration of an essential amino acids enriched mixture (EAA) on myoelectric descriptors of fatigue and maximal force production after a resistance exercise protocol (REP). Methods: Twenty adult males (age: 27 ± 6 years; bo...

journal_title：Frontiers in physiology

authors： Negro M,Segreto V,Barbero M,Cescon C,Castelli L,Calanni L,D'Antona G

更新日期：2018-08-17 00:00:00

abstract：:Coronary microembolization (CME) is an important clinical problem, and it is related to poor outcome. The specific molecular mechanisms of CME are not fully understood. In the present study, we established a mice model of CME. Isobaric tags for relative and absolute quantitation (iTRAQ) and liquid chromatography coupl...

journal_title：Frontiers in physiology

authors： Chen A,Chen Z,Xia Y,Lu D,Jia J,Hu K,Sun A,Zou Y,Qian J,Ge J

更新日期：2018-09-19 00:00:00

abstract：:Sepsis is a systemic inflammatory disease with infection, and autophagy has been shown to play an important role in sepsis. This review summarizes the main regulatory mechanisms of autophagy in sepsis and its latest research. Recent studies have shown that autophagy can regulate innate immune processes and acquired im...

journal_title：Frontiers in physiology

authors： Yin X,Xin H,Mao S,Wu G,Guo L

更新日期：2019-08-23 00:00:00

abstract：:Aims: Simultaneous measurement of right (RV) and left ventricle (LV) myocardial blood flow (MBF), oxygen extraction fraction (OEF), and oxygen consumption (MVO2) non-invasively in humans would provide new possibilities to understand cardiac physiology and different patho-physiological states. Methods: We developed and...

journal_title：Frontiers in physiology

authors： Kudomi N,Kalliokoski KK,Oikonen VJ,Han C,Kemppainen J,Sipilä HT,Knuuti J,Heinonen IHA

更新日期：2019-06-19 00:00:00

abstract：:The mouse is one of the most important model organisms for understanding human genetic function and disease. This includes characterization of the factors that influence energy expenditure and dysregulation of energy balance leading to obesity and its sequelae. Measuring energy metabolism in the mouse presents a chall...

journal_title：Frontiers in physiology

authors： Speakman JR

更新日期：2013-03-14 00:00:00

abstract：:Earlier research work on the dynamics of the brain, disclosing the existence of crucial events, is revisited for the purpose of making the action of crucial events, responsible for the 1/f -noise in the brain, compatible with the wave-like nature of the brain processes. We review the relevant neurophysiological litera...

journal_title：Frontiers in physiology

authors： Bohara G,West BJ,Grigolini P

更新日期：2018-08-29 00:00:00

abstract：:Domestic pig molars provide an interesting system to study the biomineralization process. The large size, thick enamel and complex crown morphology make pig molars relatively similar to human molars. However, compared to human molars, pig molars develop considerably faster. Here we use microCT to image the developing ...

journal_title：Frontiers in physiology

authors： Sova SS,Tjäderhane L,Heikkilä PA,Jernvall J

更新日期：2018-02-09 00:00:00

abstract：:Basketball is a team sport, where fundamental skills - fundamentals - are key determinants for success. Jump-shot (JS) is a basketball fundamental used frequently during game. It is interesting to spread light on the relationship between effort intensity and JS ability. Study aim was to investigate different heart rat...

journal_title：Frontiers in physiology

authors： Padulo J,Nikolaidis PT,Cular D,Dello Iacono A,Vando S,Galasso M,Lo Storto D,Ardigò LP

更新日期：2018-08-03 00:00:00

abstract：:Immunity and cellular metabolism are tightly interconnected but it is not clear whether different pathogens elicit specific metabolic responses. To address this issue, we studied differential metabolic regulation in peripheral blood mononuclear cells (PBMCs) of healthy volunteers challenged by Candida albicans, Borrel...

journal_title：Frontiers in physiology

authors： Zhang X,Mardinoglu A,Joosten LAB,Kuivenhoven JA,Li Y,Netea MG,Groen AK

更新日期：2018-02-27 00:00:00

abstract：:Background: Molting is a crucial physiological behavior during arthropod growth. In the past few years, molting as well as chitin biosynthesis triggered by molting, is subject to regulation by miRNAs. However, how many miRNAs are involved in insect molting at the genome-wide level remains unknown. Results: We deeply s...

journal_title：Frontiers in physiology

authors： Chen J,Li TC,Pang R,Yue XZ,Hu J,Zhang WQ

更新日期：2018-12-20 00:00:00

abstract：:Aim: mircoRNAs (miRNAs), small non-coding RNAs regulating gene expression, are stably secreted into the blood and circulating miRNAs (c-miRNAs) may play an important role in cell-cell communication. Furthermore, c-miRNAs might serve as novel biomarkers of the current vascular cell status. Here, we examined how the lev...

journal_title：Frontiers in physiology

authors： Wahl P,Wehmeier UF,Jansen FJ,Kilian Y,Bloch W,Werner N,Mester J,Hilberg T

更新日期：2016-12-26 00:00:00

abstract：Background:Perturbation of endothelial function in people with cystic fibrosis (CF) has been reported, which may be associated with endothelial cell expression of the cystic fibrosis transmembrane conductance regulator (CFTR). Previous reports indicate that CFTR activity upregulates endothelial barrier function, endoth...

journal_title：Frontiers in physiology

authors： Khalaf M,Scott-Ward T,Causer A,Saynor Z,Shepherd A,Górecki D,Lewis A,Laight D,Shute J

更新日期：2020-07-29 00:00:00

abstract：:One of the key defining features of an endogenous circadian clock is that it can be entrained or set to local time. Though a number of cues can perform this role, light is the predominant environmental signal that acts to entrain circadian pacemakers in most species. For the past 20 years, a great deal of work has bee...

journal_title：Frontiers in physiology

authors： Steindal IAF,Whitmore D

更新日期：2020-08-14 00:00:00

abstract：:Objective: Despite the improvement in ventricular assist device (VAD) therapy in adults and in adolescents, in infant population only Berlin Heart EXCOR (BHE) is licensed as long term VAD to bridge children to Heart Transplantation (HTx). Particularly demanding in terms of morbidity and mortality are smallest patients...

journal_title：Frontiers in physiology

authors： Di Molfetta A,Gandolfo F,Filippelli S,Perri G,Di Chiara L,Iacobelli R,Adorisio R,Favia I,Rizza A,Testa G,Di Nardo M,Amodeo A

更新日期：2016-12-06 00:00:00

abstract：:The spawning migration of the European eel is an extensive journey over 5000 to 7000 km from the European coast to the Sargasso Sea. Eels do not feed during this journey and on-board fuels must be sufficient to support the journey of 3.5 to 6 month, as well as sexual maturation and the spawning activity. Swimming of e...

journal_title：Frontiers in physiology

authors： Pelster B

更新日期：2015-01-05 00:00:00

abstract：:The multifunctional CD36 scavenger receptor facilitates fatty acid (FA) uptake and oxidation and it has been involved in the pathophysiology related to dysfunctional FA metabolism. The common variant in the CD36 gene, rs1761667 (A/G), whose allele A is characterized by a reduced protein expression, has been associated...

journal_title：Frontiers in physiology

authors： Melis M,Carta G,Pintus S,Pintus P,Piras CA,Murru E,Manca C,Di Marzo V,Banni S,Tomassini Barbarossa I

更新日期：2017-12-06 00:00:00

abstract：:Spermatogenesis is a complicated process including spermatogonial stem cells self-renewal and differentiates into mature spermatozoa. MicroRNAs (miRNAs) as a class of small non-coding RNAs play a crucial role during the process of spermatogenesis. However, the function of a plenty of miRNAs on spermatogenesis and the ...

journal_title：Frontiers in physiology

authors： Gao H,Wen H,Cao C,Dong D,Yang C,Xie S,Zhang J,Huang X,Huang X,Yuan S,Dong W

更新日期：2019-06-18 00:00:00