Abstract:
:Blidingia sp. is a green alga that has spread rapidly in Subei Shoal, China. To explore the potential beneficial effects of Blidingia sp., we investigated the anti-inflammatory activity of its water-methanol extract of Blidingia sp. in a mouse model of lipopolysaccharide (LPS)-induced intestinal inflammation. The results revealed that the administration of Blidingia extract significantly alleviated the LPS-induced increase of the inflammatory cytokine content in the serum, as well as latter's gene expression in the ileum. Moreover, the extract inhibited the phosphorylation of NF-κB and IκBα in LPS-challenged mice. Apart from these changes, the extract also averted intestinal morphology damage(s) and cell apoptosis in mice. Interestingly, the extract also had beneficial effects on the diversity and composition of caecal microbiota in LPS-challenged mice. In conclusion, the results suggested that Blidingia extract had beneficial effects on the recovery of intestinal function by reducing the inflammatory response, improving the maintenance of intestinal morphology, and decreasing cell apoptosis in LPS-induced intestinal inflammation. In addition, the beneficial effects of the extract on caecal microbiota composition may play a role in its anti-inflammatory activity. These results suggested that Blidingia extract could be potentially used in preventing intestinal inflammation.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Song W,Li Y,Zhang X,Wang Zdoi
10.3389/fphys.2019.00763subject
Has Abstractpub_date
2019-06-25 00:00:00pages
763issn
1664-042Xjournal_volume
10pub_type
杂志文章abstract::Theoretical cardiac electrophysiology focuses on the dynamics of the membrane and sarcoplasmic reticulum ion currents; however, passive (e.g., membrane capacitance) and quasi-active (response to small signals) properties of the cardiac sarcolemma, which are quantified by impedance, are also important in determining th...
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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doi:10.3389/fphys.2017.00673
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pub_type: 杂志文章,评审
doi:10.3389/fphys.2018.01325
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doi:10.3389/fphys.2018.01808
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doi:10.3389/fphys.2020.578537
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