Effects of Resistance Exercise and Nutritional Supplementation on Dynamic Cerebral Autoregulation in Head-Down Bed Rest.

Abstract:

:Head-down bed rest (HDBR) is commonly considered as ground-based analog to spaceflight and simulates the headward fluid shift and cardiovascular deconditioning associated with spaceflight. We investigated in healthy volunteers whether HDBR, with or without countermeasures, affect cerebral autoregulation (CA). Twelve men (at selection: 34 ± 7 years; 176 ± 7 cm; 70 ± 7 kg) underwent three interventions of a 21-day HDBR: a control condition without countermeasure (CON), a condition with resistance vibration exercise (RVE) comprising of squats, single leg heel, and bilateral heel raises and a condition using also RVE associated with nutritional supplementation (NeX). Cerebral blood flow velocity was assessed using transcranial Doppler ultrasonography. CA was evaluated by transfer function analysis and by the autoregulatory index (Mxa) in order to determine the relationship between mean cerebral blood flow velocity and mean arterial blood pressure. In RVE condition, coherence was increased after HDBR. In CON condition, Mxa index was significantly reduced after HDBR. In contrast, in RVE and NeX conditions, Mxa were increased after HBDR. Our results indicate that HDBR without countermeasures may improve dynamic CA, but this adaptation may be dampened with RVE. Furthermore, nutritional supplementation did not enhance or worsen the negative effects of RVE. These findings should be carefully considered and could not be applied in spaceflight. Indeed, the subjects spent their time in supine position during bed rest, unlike the astronauts who perform normal daily activities.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Kermorgant M,Nasr N,Custaud MA,Navasiolava N,Arbeille P,Guinet P,Labrunée M,Besnier F,Arvanitis DN,Czosnyka M,Senard JM,Pavy-Le Traon A

doi

10.3389/fphys.2019.01114

subject

Has Abstract

pub_date

2019-08-27 00:00:00

pages

1114

issn

1664-042X

journal_volume

10

pub_type

杂志文章
  • Brain Functional Connectivity Is Different during Voluntary Concentric and Eccentric Muscle Contraction.

    abstract::Previous studies report greater activation in the cortical motor network in controlling eccentric contraction (EC) than concentric contraction (CC) of human skeletal muscles despite lower activation level of the muscle associated with EC. It is unknown, however, whether the strength of functional coupling between the ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00521

    authors: Yao WX,Jiang Z,Li J,Jiang C,Franlin CG,Lancaster JL,Huang Y,Yue GH

    更新日期:2016-11-15 00:00:00

  • Altered Ca2+ and Na+ Homeostasis in Human Hypertrophic Cardiomyopathy: Implications for Arrhythmogenesis.

    abstract::Hypertrophic cardiomyopathy (HCM) is the most common mendelian heart disease, with a prevalence of 1/500. HCM is a primary cause of sudden death, due to an heightened risk of ventricular tachyarrhythmias that often occur in young asymptomatic patients. HCM can slowly progress toward heart failure, either with preserve...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01391

    authors: Coppini R,Ferrantini C,Mugelli A,Poggesi C,Cerbai E

    更新日期:2018-10-16 00:00:00

  • Application of Feedback System Control Optimization Technique in Combined Use of Dual Antiplatelet Therapy and Herbal Medicines.

    abstract::Aim: Combined use of herbal medicines in patients underwent dual antiplatelet therapy (DAPT) might cause bleeding or thrombosis because herbal medicines with anti-platelet activities may exhibit interactions with DAPT. In this study, we tried to use a feedback system control (FSC) optimization technique to optimize do...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00491

    authors: Liu W,Li YL,Feng MT,Zhao YW,Ding X,He B,Liu X

    更新日期:2018-05-04 00:00:00

  • The pathophysiology of extracellular hemoglobin associated with enhanced oxidative reactions.

    abstract::Hemoglobin (Hb) continuously undergoes autoxidation producing superoxide which dismutates into hydrogen peroxide (H2O2) and is a potential source for subsequent oxidative reactions. Autoxidation is most pronounced under hypoxic conditions in the microcirculation and for unstable dimers formed at reduced Hb concentrati...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2014.00500

    authors: Rifkind JM,Mohanty JG,Nagababu E

    更新日期:2015-01-14 00:00:00

  • Stars and stripes in pancreatic cancer: role of stellate cells and stroma in cancer progression.

    abstract::Pancreatic cancer is a devastating disease with an unacceptably high mortality to incidence ratio. Traditional therapeutic approaches such as surgery in combination with chemo- or radiotherapy have had limited efficacy in improving the outcome of this disease. Up until just under a decade ago, the prominent desmoplast...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2014.00052

    authors: Wilson JS,Pirola RC,Apte MV

    更新日期:2014-02-14 00:00:00

  • Sedentary Behavior Is Only Marginally Associated with Physical Function in Adults Aged 40-75 Years-the Maastricht Study.

    abstract::Background: In an aging population, regular physical activity (PA) and exercise have been recognized as important factors in maintaining physical function and thereby preventing loss of independence and disability. However, (older) adults spent the majority of their day sedentary and therefore insight into the consequ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00242

    authors: van der Velde JHPM,Savelberg HHCM,van der Berg JD,Sep SJS,van der Kallen CJH,Dagnelie PC,Schram MT,Henry RMA,Reijven PLM,van Geel TACM,Stehouwer CDA,Koster A,Schaper NC

    更新日期:2017-04-25 00:00:00

  • Crayfish Self-Administer Amphetamine in a Spatially Contingent Task.

    abstract::Natural reward is an essential element of any organism's ability to adapt to environmental variation. Its underlying circuits and mechanisms guide the learning process as they help associate an event, or cue, with the perception of an outcome's value. More generally, natural reward serves as the fundamental generator ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00433

    authors: Datta U,van Staaden M,Huber R

    更新日期:2018-05-14 00:00:00

  • A Newly Isolated Carboxymethyl-Glucan (CM-G) Restores Depressed Baroreflex Sensitivity in Renovascular Hypertensive Rats.

    abstract::This study was designed to investigate the effects of a newly synthesized carboxymethyl-glucan (CM-G) on blood pressure (BP), baroreflex sensitivity (BRS) and sympathetic vascular modulation in renovascular hypertensive rats. Male Wistar rats were divided into four groups: Sham (n = 10); 2K1C (subjected to renal arter...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00607

    authors: Carvalho-Galvão A,Gadelha DDA,de Brito Alves JL,Khan BA,Castro-Gomez RJH,Cruz JC,Magnani M,Braga VA

    更新日期:2018-05-23 00:00:00

  • Effects of Kefir on the Cardiac Autonomic Tones and Baroreflex Sensitivity in Spontaneously Hypertensive Rats.

    abstract:AIMS:It has been previously shown that the probiotic kefir (a symbiotic matrix containing acid bacteria and yeasts) attenuated the hypertension and the endothelial dysfunction in spontaneously hypertensive rats (SHR). In the present study, the effect of chronic administration of kefir on the cardiac autonomic control o...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00211

    authors: Klippel BF,Duemke LB,Leal MA,Friques AG,Dantas EM,Dalvi RF,Gava AL,Pereira TM,Andrade TU,Meyrelles SS,Campagnaro BP,Vasquez EC

    更新日期:2016-06-07 00:00:00

  • Dose of Alcohol From Beer Required for Acute Reduction in Arterial Stiffness.

    abstract::Acute beer or alcohol ingestion reduces arterial stiffness, but the dose required to reduce arterial stiffness is unclear. Therefore, this study aimed to determine the acute effects of ingesting various amounts of beer on arterial stiffness in healthy men. Nine men (20-22 years) participated, in eight trials in random...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.01033

    authors: Nishiwaki M,Yamaguchi T,Nishida R,Matsumoto N

    更新日期:2020-08-28 00:00:00

  • Slow-Paced Breathing and Autonomic Function in People Post-stroke.

    abstract::Purpose: To determine if acute slow breathing at 6 breaths/min would improve baroreflex sensitivity (BRS) and heart rate variability (HRV), and lower blood pressure (BP) in adults after stroke. Methods: Twelve individuals completed two randomized study visits where they performed a 15-min bout of breathing exercises a...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.573325

    authors: Larson M,Chantigian DP,Asirvatham-Jeyaraj N,Van de Winckel A,Keller-Ross ML

    更新日期:2020-10-30 00:00:00

  • Dynamic Metabolic Zonation of the Hepatic Glucose Metabolism Is Accomplished by Sinusoidal Plasma Gradients of Nutrients and Hormones.

    abstract::Being the central metabolic organ of vertebrates, the liver possesses the largest repertoire of metabolic enzymes among all tissues and organs. Almost all metabolic pathways are resident in the parenchymal cell, hepatocyte, but the pathway capacities may largely differ depending on the localization of hepatocytes with...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01786

    authors: Berndt N,Holzhütter HG

    更新日期:2018-12-12 00:00:00

  • Antineoplastic Drug-Induced Cardiotoxicity: A Redox Perspective.

    abstract::Antineoplastic drugs can be associated with several side effects, including cardiovascular toxicity (CTX). Biochemical studies have identified multiple mechanisms of CTX. Chemoterapeutic agents can alter redox homeostasis by increasing the production of reactive oxygen species (ROS) and reactive nitrogen species RNS. ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2018.00167

    authors: Varricchi G,Ameri P,Cadeddu C,Ghigo A,Madonna R,Marone G,Mercurio V,Monte I,Novo G,Parrella P,Pirozzi F,Pecoraro A,Spallarossa P,Zito C,Mercuro G,Pagliaro P,Tocchetti CG

    更新日期:2018-03-07 00:00:00

  • Unique Contribution of Haptoglobin and Haptoglobin Genotype in Aneurysmal Subarachnoid Hemorrhage.

    abstract::Survivors of cerebral aneurysm rupture are at risk for significant morbidity and neurological deficits. Much of this is related to the effects of blood in the subarachnoid space which induces an inflammatory cascade with numerous downstream consequences. Recent clinical trials have not been able to reduce the toxic ef...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2018.00592

    authors: Blackburn SL,Kumar PT,McBride D,Zeineddine HA,Leclerc J,Choi HA,Dash PK,Grotta J,Aronowski J,Cardenas JC,Doré S

    更新日期:2018-05-31 00:00:00

  • Distinct Cell Types With the Bitter Receptor Tas2r126 in Different Compartments of the Stomach.

    abstract::Cells expressing bitter taste receptors (T2Rs or Tas2rs) in extraoral tissues are considered to be chemosensory cells mediating protective responses to potentially harmful or even antiinflammatory or antimicrobial compounds. In a previous study the activity of the Tas2R143/Tas2R135/Tas2r126 cluster promoter in the sto...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00032

    authors: Widmayer P,Partsch V,Pospiech J,Kusumakshi S,Boehm U,Breer H

    更新日期:2020-02-07 00:00:00

  • Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile.

    abstract::Exercise is known to improve many aspects of human health, including modulation of the immune system and inflammatory status. It is generally understood that exercise reduces inflammation, but there are missing links in terms of understanding the mechanisms as well as the differences between exercise modalities. N-gly...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01522

    authors: Tijardović M,Marijančević D,Bok D,Kifer D,Lauc G,Gornik O,Keser T

    更新日期:2019-12-20 00:00:00

  • Masticatory Dysfunction by Extensive Tooth Loss as a Risk Factor for Cognitive Deficit: A Systematic Review and Meta-Analysis.

    abstract::Background: An amount of cognition decline is normal with aging; however, intrinsic and extrinsic risk factors may exacerbate it, affecting social and occupational tasks. Masticatory dysfunction (MD), as a general term, refers to an impairment in the masticatory function triggered by a structural factor, such as tooth...

    journal_title:Frontiers in physiology

    pub_type:

    doi:10.3389/fphys.2019.00832

    authors: Alvarenga MOP,Ferreira RO,Magno MB,Fagundes NCF,Maia LC,Lima RR

    更新日期:2019-07-03 00:00:00

  • The Transcription Factor MafB Regulates the Susceptibility of Bactrocera dorsalis to Abamectin via GSTz2.

    abstract::Pesticide resistance is a serious problem that poses a major challenge to pest control. One of the most potent resistance mechanisms is the overexpression of genes coding for detoxification enzymes. The expression of detoxification genes is regulated by a series of transcription factors. Previous studies have revealed...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01068

    authors: Tang GH,Xiong Y,Liu Y,Song ZH,Yang Y,Shen GM,Wang JJ,Jiang HB

    更新日期:2019-08-20 00:00:00

  • The Comparison of Different Stretching Intensities on the Range of Motion and Muscle Stiffness of the Quadriceps Muscles.

    abstract::Muscle strain is one of the most frequent sports injuries, having the rectus femoris (RF) muscle as the reported preferred site of quadriceps muscle strain. The decrease muscle stiffness could be an effective RF muscle strain prevention. In recent studies, a high-intensity static stretching intervention decreased pass...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.628870

    authors: Nakamura M,Sato S,Murakami Y,Kiyono R,Yahata K,Sanuki F,Yoshida R,Fukaya T,Takeuchi K

    更新日期:2021-01-13 00:00:00

  • A Chemosensory Protein BtabCSP11 Mediates Reproduction in Bemisia tabaci.

    abstract::The olfactory system serves a vital role in the evolution and survival of insects, being involved in behaviors such as host seeking, foraging, mating, and oviposition. Odorant-binding proteins (OBPs) and chemosensory proteins (CSPs) are involved in the olfactory recognition process. In this study, BtabCSP11, a CSP11 g...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00709

    authors: Zeng Y,Merchant A,Wu Q,Wang S,Kong L,Zhou X,Xie W,Zhang Y

    更新日期:2020-06-30 00:00:00

  • Trace conditioning in insects-keep the trace!

    abstract::Trace conditioning is a form of associative learning that can be induced by presenting a conditioned stimulus (CS) and an unconditioned stimulus (US) following each other, but separated by a temporal gap. This gap distinguishes trace conditioning from classical delay conditioning, where the CS and US overlap. To bridg...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2013.00067

    authors: Dylla KV,Galili DS,Szyszka P,Lüdke A

    更新日期:2013-08-23 00:00:00

  • Being Anxious, Thinking Positively: The Effect of Emotional Context on Respiratory Sensory Gating.

    abstract::Respiratory sensory gating function has been found decreased by induced negative emotion in healthy adults. The increased ratio of the respiratory-related evoked potential (RREP) N1 peak amplitude for the second occlusion (S2) vs. the first occlusion (S1), S2/S1, is indicative of such decreased respiratory sensory gat...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00019

    authors: Chan PY,Cheng CH,Jhu YJ,Chen CL,von Leupoldt A

    更新日期:2016-02-16 00:00:00

  • Toward Accurate Extraction of Respiratory Frequency From the Photoplethysmogram: Effect of Measurement Site.

    abstract::Background: It is known that the respiration-modulated photoplethysmographic (PPG) signals could be used to derive respiratory frequency (RF) and that PPG signals could be measured from different body sites. However, the accuracy of RF derived from PPG signals of different body sites has not been comprehensively inves...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00732

    authors: Hartmann V,Liu H,Chen F,Hong W,Hughes S,Zheng D

    更新日期:2019-06-18 00:00:00

  • Muscle Responses to Passive Joint Movements in Infants During the First Year of Life.

    abstract::Muscle tone represents one of the important concepts for characterizing changes in the state of the developing nervous system. It can be manifested in the level of activity of flexors and extensors and in muscle reactions to its passive stretching (StR) or shortening (ShR). Here we investigated such reactions in a coh...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01158

    authors: Solopova IA,Zhvansky DS,Dolinskaya IY,Keshishian ES,Selionov VA,Sylos-Labini F,Lacquaniti F,Ivanenko Y

    更新日期:2019-09-13 00:00:00

  • Robustness of Nutrient Signaling Is Maintained by Interconnectivity Between Signal Transduction Pathways.

    abstract::Systems biology approaches provide means to study the interplay between biological processes leading to the mechanistic understanding of the properties of complex biological systems. Here, we developed a vector format rule-based Boolean logic model of the yeast S. cerevisiae cAMP-PKA, Snf1, and the Snf3-Rgt2 pathway t...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01964

    authors: Welkenhuysen N,Schnitzer B,Österberg L,Cvijovic M

    更新日期:2019-01-21 00:00:00

  • Criticality Maximizes Complexity in Neural Tissue.

    abstract::The analysis of neural systems leverages tools from many different fields. Drawing on techniques from the study of critical phenomena in statistical mechanics, several studies have reported signatures of criticality in neural systems, including power-law distributions, shape collapses, and optimized quantities under t...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00425

    authors: Timme NM,Marshall NJ,Bennett N,Ripp M,Lautzenhiser E,Beggs JM

    更新日期:2016-09-27 00:00:00

  • Calcium-permeable ion channels in control of autophagy and cancer.

    abstract::Autophagy, or cellular self-eating, is a tightly regulated cellular pathway the main purpose of which is lysosomal degradation and subsequent recycling of cytoplasmic material to maintain normal cellular homeostasis. Defects in autophagy are linked to a variety of pathological states, including cancer. Cancer is the d...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2013.00272

    authors: Kondratskyi A,Yassine M,Kondratska K,Skryma R,Slomianny C,Prevarskaya N

    更新日期:2013-10-02 00:00:00

  • Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction.

    abstract::Heart failure with preserved ejection fraction (HFpEF) is an increasingly studied entity accounting for 50% of all diagnosed heart failure and that has claimed its own dignity being markedly different from heart failure with reduced EF in terms of etiology and natural history (Graziani et al., 2018). Recently, a growi...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2019.01347

    authors: D'Amario D,Migliaro S,Borovac JA,Restivo A,Vergallo R,Galli M,Leone AM,Montone RA,Niccoli G,Aspromonte N,Crea F

    更新日期:2019-11-05 00:00:00

  • Analysis of enamel development using murine model systems: approaches and limitations.

    abstract::A primary goal of enamel research is to understand and potentially treat or prevent enamel defects related to amelogenesis imperfecta (AI). Rodents are ideal models to assist our understanding of how enamel is formed because they are easily genetically modified, and their continuously erupting incisors display all sta...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2014.00313

    authors: Pugach MK,Gibson CW

    更新日期:2014-09-17 00:00:00

  • Modeling Pulmonary Gas Exchange and Single-Exhalation Profiles of Carbon Monoxide.

    abstract::Exhaled breath carbon monoxide (eCO) is a candidate biomarker for non-invasive assessment of oxidative stress and respiratory diseases. Standard end-tidal CO analysis, however, cannot distinguish, whether eCO reflects endogenous CO production, lung diffusion properties or exogenous sources, and is unable to resolve a ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00927

    authors: Ghorbani R,Blomberg A,Schmidt FM

    更新日期:2018-07-30 00:00:00