Modeling the Interactions Between Sodium Channels Provides Insight Into the Negative Dominance of Certain Channel Mutations.

abstract：Aim:Guanidinoacetate N-methyltransferase (GAMT) is the second essential enzyme in creatine (Cr) biosynthesis. Short-term Cr deficiency is metabolically well tolerated as GAMT-/- mice exhibit normal exercise capacity and response to ischemic heart failure. However, we hypothesized long-term consequences of Cr deficiency...

journal_title：Frontiers in physiology

authors： Aksentijević D,Zervou S,Eykyn TR,McAndrew DJ,Wallis J,Schneider JE,Neubauer S,Lygate CA

更新日期：2020-01-21 00:00:00

abstract：:Regular exercise prevents lipid abnormalities and conditions such as diabetes mellitus, hypertension, and obesity; it considerably benefits sedentary individuals. However, individuals exhibit highly variable responses to exercise, probably due to genetic variations. Animal models are typically used to investigate the ...

journal_title：Frontiers in physiology

authors： Tung YT,Hsu YJ,Liao CC,Ho ST,Huang CC,Huang WC

更新日期：2019-09-18 00:00:00

abstract：:Molecular chaperones are stress proteins that allow the correct folding or unfolding as well as the assembly or disassembly of macromolecular cellular components. Changes in expression and post-translational modifications of chaperones have been linked to a number of age- and stress-related diseases including cancer, ...

journal_title：Frontiers in physiology

authors： Penna C,Sorge M,Femminò S,Pagliaro P,Brancaccio M

更新日期：2018-03-16 00:00:00

abstract：:Myocardial electrical impedance is a biophysical property of the heart that is influenced by the intrinsic structural characteristics of the tissue. Therefore, the structural derangements elicited in a chronic myocardial infarction should cause specific changes in the local systolic-diastolic myocardial impedance, but...

journal_title：Frontiers in physiology

authors： Amorós-Figueras G,Jorge E,García-Sánchez T,Bragós R,Rosell-Ferrer J,Cinca J

更新日期：2016-08-31 00:00:00

abstract：:Prone position can reduce mortality in acute respiratory distress syndrome (ARDS), but several studies found variable effects on oxygenation and lung mechanics. It is unclear whether different positive end-expiratory pressure (PEEP) titration techniques modify the effect of prone position. We tested, in an animal mode...

journal_title：Frontiers in physiology

authors： Scaramuzzo G,Ball L,Pino F,Ricci L,Larsson A,Guérin C,Pelosi P,Perchiazzi G

更新日期：2020-03-12 00:00:00

abstract：:F1F0-ATP synthase inhibitory factor 1 (IF1) inhibits the reverse mode of F1F0-ATP synthase, and therefore protects cellular ATP content at the expense of accelerated loss of mitochondrial membrane potential (ΔΨm). There is considerable variability in IF1 expression and its influence on bioenergetics between different ...

journal_title：Frontiers in physiology

authors： Tanton H,Voronina S,Evans A,Armstrong J,Sutton R,Criddle DN,Haynes L,Schmid MC,Campbell F,Costello E,Tepikin AV

更新日期：2018-07-11 00:00:00

abstract：:Skeletal muscles are large cells with multiple nuclei that are precisely positioned. The importance of the correct nuclear position is highlighted by the correlation between mispositioned nuclei and muscle disease (Spiro et al., 1966; Gueneau et al., 2009). Myonuclei are generally considered to be equivalent and there...

journal_title：Frontiers in physiology

authors： Perillo M,Folker ES

更新日期：2018-11-01 00:00:00

abstract：:Spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), and spinal-bulbar muscular atrophy (SBMA) are devastating diseases characterized by the degeneration of motor neurons. Although the molecular causes underlying these diseases differ, recent findings have highlighted the contribution of intrinsic skele...

journal_title：Frontiers in physiology

authors： Boyer JG,Ferrier A,Kothary R

更新日期：2013-12-18 00:00:00

abstract：:Perfluorooctanoic acid (PFOA) has been detected in various water bodies and caused harm to aquatic organisms. The aim of this study was to investigate the cytotoxicity and mechanism associated with autophagy and oxidative stress after exposure to PFOA (0, 1, 10, 100 μg/L) for 12 h on lymphocytes, which was isolated fr...

journal_title：Frontiers in physiology

authors： Tang J,Lu X,Chen F,Ye X,Zhou D,Yuan J,He J,Chen B,Shan X,Jiang J,Liu W,Zhang H

更新日期：2018-12-05 00:00:00

abstract：:Reticuloendothelial macrophages engulf ∼0.2 trillion senescent erythrocytes daily in a process called erythrophagocytosis (EP). This critical mechanism preserves systemic heme-iron homeostasis by regulating red blood cell (RBC) catabolism and iron recycling. Although extensive work has demonstrated the various effects...

journal_title：Frontiers in physiology

authors： Catala A,Youssef LA,Reisz JA,Dzieciatkowska M,Powers NE,Marchetti C,Karafin M,Zimring JC,Hudson KE,Hansen KC,Spitalnik SL,D'Alessandro A

更新日期：2020-04-30 00:00:00

abstract：:Toll receptors are involved in innate immunity of invertebrates. In this study, we identify and characterize two Toll genes (named HcToll4 and HcToll5) from triangle sail mussel Hyriopsis cumingii. HcToll4 has complete cDNA sequence of 3,162 bp and encodes a protein of 909 amino acids. HcToll5 cDNA is 4,501 bp in leng...

journal_title：Frontiers in physiology

authors： Huang Y,Han K,Ren Q

更新日期：2018-03-05 00:00:00

abstract：:Human diseases have been investigated in the context of single genes as well as complex networks of genes. Though single gene approaches have been extremely successful in the past, most human diseases are complex and better characterized by multiple interacting genes commonly known as networks or pathways. With the ad...

journal_title：Frontiers in physiology

authors： Sahoo D

更新日期：2012-07-23 00:00:00

abstract：:New therapeutic agents are needed in digestive tract tumors. Co-029/tspan8 is a tetraspanin frequently expressed on human colorectal tumors, In this work, we report the effects of the monoclonal antibody Ts29.2, targeting Co-029/tspan8, on colorectal tumor cells in vitro and after implantation in nude mice. HT29, Isre...

journal_title：Frontiers in physiology

authors： Ailane N,Greco C,Zhu Y,Sala-Valdés M,Billard M,Casal I,Bawa O,Opolon P,Rubinstein E,Boucheix C

更新日期：2014-09-19 00:00:00

abstract：:Ecdysteroids play an essential role in controlling insect development and reproduction. Their pathway is regulated by a group of enzymes called Halloween gene proteins. The relationship between the Halloween genes and ecdysteroid synthesis has yet to be clearly understood in diamondback moth, Plutella xylostella (L.),...

journal_title：Frontiers in physiology

authors： Peng L,Wang L,Zou MM,Vasseur L,Chu LN,Qin YD,Zhai YL,You MS

更新日期：2019-08-28 00:00:00

abstract：:A sedentary lifestyle is associated with increased cardiovascular risk factors and reduced cardiac compliance when compared to a lifestyle that includes exercise training. Exercise training increases cardiac compliance in humans, but the mechanisms underlying this improvement are unknown. A major determinant of cardia...

journal_title：Frontiers in physiology

authors： Chung CS,Hiske MA,Chadha A,Mueller PJ

更新日期：2020-02-05 00:00:00

abstract：:The sympathetic nervous system (SNS) contribution to long-term setting of blood pressure (BP) and hence hypertension has been a continuing controversy over many decades. However, the contribution of increased sympathetic vasomotor tone to the heart, kidney, and blood vessels has been suggested as a major influence on ...

journal_title：Frontiers in physiology

authors： Head GA,Jackson KL,Gueguen C

更新日期：2019-12-12 00:00:00

abstract：:Circadian rhythms are essential for health and regulate various physiological functions. These rhythms are regulated by a negative-feedback loop involving clock genes in the suprachiasmatic nucleus (SCN) and peripheral tissues. The rate of secretion of salivary substances, ions, and water follows a circadian rhythm, h...

journal_title：Frontiers in physiology

authors： Satou R,Sato M,Kimura M,Ishizuka Y,Tazaki M,Sugihara N,Shibukawa Y

更新日期：2017-05-23 00:00:00

abstract：:It has been proposed that group III and IV muscle afferents provide inhibitory feedback from locomotor muscles to the central nervous system, setting an absolute threshold for the development of peripheral fatigue during exercise. The aim of this study was to test the validity of this theory. Thus, we asked whether th...

journal_title：Frontiers in physiology

authors： Froyd C,Beltrami FG,Millet GY,Noakes TD

更新日期：2016-12-19 00:00:00

abstract：:Defining variations in skeletal muscle passive mechanical properties at different size scales ranging from single muscle fibers to whole muscles is required in order to understand passive muscle function. It is also of interest from a muscle structural point-of-view to identify the source(s) of passive tension that fu...

journal_title：Frontiers in physiology

authors： Ward SR,Winters TM,O'Connor SM,Lieber RL

更新日期：2020-03-20 00:00:00

abstract：:The capacity of the human brain to interpret and respond to multiple temporal scales in its surroundings suggests that its internal interactions must also be able to operate over a broad temporal range. In this paper, we utilize a recently introduced method for characterizing the rate of change of the phase difference...

journal_title：Frontiers in physiology

authors： Botcharova M,Berthouze L,Brookes MJ,Barnes GR,Farmer SF

更新日期：2015-06-17 00:00:00

abstract：:Pancreatic cancer is one of the deadliest human malignancies and little progress has been achieved in its treatment over the past decades. Advances in our understanding of the biology of this disease provide new potential opportunities for treatment. Pancreatic cancer is preceded by precursor lesions, the most common ...

journal_title：Frontiers in physiology

authors： Collins MA,Pasca di Magliano M

更新日期：2014-01-21 00:00:00

abstract：:Rising atmospheric carbon dioxide (CO2) concentration is likely to influence insect-plant interactions. Aphid, as a typical phloem-feeding herbivorous insect, has shown consistently more positive responses in fitness to elevated CO2 concentrations than those seen in leaf-chewing insects. But, little is known about the...

journal_title：Frontiers in physiology

authors： Jiang S,Dai Y,Lu Y,Fan S,Liu Y,Bodlah MA,Parajulee MN,Chen F

更新日期：2018-11-12 00:00:00

abstract：:In addition to its roles in the maintenance of interstitial fluid homeostasis and immunosurveillance, the lymphatic system has a critical role in regulating transport of dietary lipids to the blood circulation. Recent work within the past two decades has identified an important relationship between lymphatic dysfuncti...

journal_title：Frontiers in physiology

authors： Norden PR,Kume T

更新日期：2020-05-05 00:00:00

abstract：:Milk and dairy products are relevant components of daily diet and are part of dietary recommendation in many countries due to their content of key nutrients. However, the relatively high content of saturated fat of the milk and its extensive usage for every age group raises concerns about its potential negative health...

journal_title：Frontiers in physiology

authors： Trinchese G,Cavaliere G,Penna E,De Filippo C,Cimmino F,Catapano A,Musco N,Tudisco R,Lombardi P,Infascelli F,Messina G,Muredda L,Banni S,Monda M,Crispino M,Mollica MP

更新日期：2019-01-17 00:00:00

abstract：PURPOSE:Breathlessness is a complex set of symptoms that are comprised of both sensory and affective (emotional) dimensions. While ventilation is now understood to be a potential limiter to performance in highly-trained individuals, the contribution of breathlessness-anxiety in those nearing maximal ventilation during ...

journal_title：Frontiers in physiology

authors： Faull OK,Cox PJ,Pattinson KT

更新日期：2016-06-16 00:00:00

abstract：:During embryonic development, multipotent endodermal cells differentiate to form the pancreas. Islet cell clusters arising from the pancreatic bud form the acini tissue and exocrine ducts whilst pancreatic islets form around the edges of the clusters. The successive steps of islet differentiation are controlled by a c...

journal_title：Frontiers in physiology

authors： O'Dowd JF,Stocker CJ

更新日期：2013-07-18 00:00:00

abstract：:This study was designed to investigate the effects of a newly synthesized carboxymethyl-glucan (CM-G) on blood pressure (BP), baroreflex sensitivity (BRS) and sympathetic vascular modulation in renovascular hypertensive rats. Male Wistar rats were divided into four groups: Sham (n = 10); 2K1C (subjected to renal arter...

journal_title：Frontiers in physiology

authors： Carvalho-Galvão A,Gadelha DDA,de Brito Alves JL,Khan BA,Castro-Gomez RJH,Cruz JC,Magnani M,Braga VA

更新日期：2018-05-23 00:00:00

abstract：:Background: The superior cervical ganglion (SCG) of the autonomic nervous system plays an important role in different cardiovascular diseases. In this study, we investigated the effects of ischemia and fluvastatin treatment on the ion channel characteristics of SCG neurons in a rabbit myocardial ischemia (MI) model. M...

journal_title：Frontiers in physiology

authors： Cheng L,Wang X,Liu T,Tse G,Fu H,Li G

更新日期：2018-09-10 00:00:00

abstract：:Several clinical studies have investigated the potential benefits of endothelin receptor antagonism in chronic pathologies such as diabetic kidney disease. However, fluid retention and edema have been identified as major side effects of endothelin receptor antagonists. In the present study we hypothesized that avosent...

journal_title：Frontiers in physiology

authors： Baltatu OC,Iliescu R,Zaugg CE,Reckelhoff JF,Louie P,Schumacher C,Campos LA

更新日期：2012-04-18 00:00:00

abstract：:The striped stem borer, Chilo suppressalis (Walker), is a notorious pest of rice that causes large losses in China. Breeding and screening of resistance rice cultivars are effective strategies for C. suppressalis management. In this study, insect-resistant traits of 47 rice cultivars were investigated by C. suppressal...

journal_title：Frontiers in physiology

authors： Wang Y,Ju D,Yang X,Ma D,Wang X

更新日期：2018-11-30 00:00:00