Non-invasive Assessment of Systolic and Diastolic Cardiac Function During Rest and Stress Conditions Using an Integrated Image-Modeling Approach.

Abstract:

:Background: The possibility of non-invasively assessing load-independent parameters characterizing cardiac function is of high clinical value. Typically, these parameters are assessed during resting conditions. However, for diagnostic purposes, the parameter behavior across a physiologically relevant range of heart rate and loads is more relevant than the isolated measurements performed at rest. This study sought to evaluate changes in non-invasive estimations of load-independent parameters of left-ventricular contraction and relaxation patterns at rest and during dobutamine stress. Methods: We applied a previously developed approach that combines non-invasive measurements with a physiologically-based, reduced-order model of the cardiovascular system to provide subject-specific estimates of parameters characterizing left ventricular function. In this model, the contractile state of the heart at each time point along the cardiac cycle is modeled using a time-varying elastance curve. Non-invasive data, including four-dimensional magnetic resonance imaging (4D Flow MRI) measurements, were acquired in nine subjects without a known heart disease at rest and during dobutamine stress. For each of the study subjects, we constructed two personalized models corresponding to the resting and the stress state. Results: Applying the modeling framework, we identified significant increases in the left ventricular contraction rate constant [from 1.5 ± 0.3 to 2 ± 0.5 (p = 0.038)] and relaxation constant [from 37.2 ± 6.9 to 46.1 ± 12 (p = 0.028)]. In addition, we found a significant decrease in the elastance diastolic time constant from 0.4 ± 0.04 s to 0.3 ± 0.03 s (p = 0.008). Conclusions: The integrated image-modeling approach allows the assessment of cardiovascular function given as model-based parameters. The agreement between the estimated parameter values and previously reported effects of dobutamine demonstrates the potential of the approach to assess advanced metrics of pathophysiology that are otherwise difficult to obtain non-invasively in clinical practice.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Casas B,Viola F,Cedersund G,Bolger AF,Karlsson M,Carlhäll CJ,Ebbers T

doi

10.3389/fphys.2018.01515

subject

Has Abstract

pub_date

2018-10-30 00:00:00

pages

1515

issn

1664-042X

journal_volume

9

pub_type

杂志文章
  • Detrusor Smooth Muscle KV7 Channels: Emerging New Regulators of Urinary Bladder Function.

    abstract::Relaxation and contraction of the urinary bladder smooth muscle, also known as the detrusor smooth muscle (DSM), facilitate the micturition cycle. DSM contractility depends on cell excitability, which is established by the synchronized activity of multiple diverse ion channels. K+ channels, the largest family of chann...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2020.01004

    authors: Malysz J,Petkov GV

    更新日期:2020-09-16 00:00:00

  • Trawling bats exploit an echo-acoustic ground effect.

    abstract::A water surface acts not only as an optic mirror but also as an acoustic mirror. Echolocation calls emitted by bats at low heights above water are reflected away from the bat, and hence the background clutter is reduced. Moreover, targets on the surface create an enhanced echo. Here, we formally quantified the effect ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2013.00065

    authors: Zsebok S,Kroll F,Heinrich M,Genzel D,Siemers BM,Wiegrebe L

    更新日期:2013-04-05 00:00:00

  • Validity and Reliability of the 30-s Continuous Jump for Anaerobic Power and Capacity Assessment in Combat Sport.

    abstract::Cycling test such Wingate anaerobic test (WAnT) is used to measure anaerobic power (AP), but not anaerobic capacity (AC, i.e., the metabolic energy demand). However, in sports that do not involve cycling movements (Karate), the continuous jump for 30 s (vertical jumps for 30 s) has been extensively used to measure ana...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00543

    authors: Čular D,Ivančev V,Zagatto AM,Milić M,Beslija T,Sellami M,Padulo J

    更新日期:2018-05-15 00:00:00

  • Connexin and pannexin (hemi)channels in the liver.

    abstract::The liver was among the first organs in which connexin proteins have been identified. Hepatocytes harbor connexin32 and connexin26, while non-parenchymal liver cells typically express connexin43. Connexins give rise to hemichannels, which dock with counterparts on adjacent cells to form gap junctions. Both hemichannel...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2013.00405

    authors: Maes M,Decrock E,Cogliati B,Oliveira AG,Marques PE,Dagli ML,Menezes GB,Mennecier G,Leybaert L,Vanhaecke T,Rogiers V,Vinken M

    更新日期:2014-01-10 00:00:00

  • Validation of a Method for the Assessment of Urinary Neopterin Levels to Monitor Health Status in Non-human-primate Species.

    abstract::Determining individual health status is of great importance for a better understanding of life history trade-offs between growth, reproduction, and maintenance. However, existing immunological methods are invasive and therefore not suitable for investigating health status in wild populations. Thus, there is an urgent ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00051

    authors: Behringer V,Stevens JM,Leendertz FH,Hohmann G,Deschner T

    更新日期:2017-02-06 00:00:00

  • Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice.

    abstract:Aim:Guanidinoacetate N-methyltransferase (GAMT) is the second essential enzyme in creatine (Cr) biosynthesis. Short-term Cr deficiency is metabolically well tolerated as GAMT-/- mice exhibit normal exercise capacity and response to ischemic heart failure. However, we hypothesized long-term consequences of Cr deficiency...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01535

    authors: Aksentijević D,Zervou S,Eykyn TR,McAndrew DJ,Wallis J,Schneider JE,Neubauer S,Lygate CA

    更新日期:2020-01-21 00:00:00

  • Composite Measures of Physical Fitness to Discriminate Between Healthy Aging and Heart Failure: The COmPLETE Study.

    abstract:Background:Aging and changing age demographics represent critical problems of our time. Physiological functions decline with age, often ending in a systemic process that contributes to numerous impairments and age-related diseases including heart failure (HF). We aimed to analyze whether differences in composite measur...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.596240

    authors: Wagner J,Knaier R,Königstein K,Klenk C,Carrard J,Lichtenstein E,Scharnagl H,März W,Hanssen H,Hinrichs T,Schmidt-Trucksäss A,Arbeev K

    更新日期:2020-12-15 00:00:00

  • A 5-year comparison of marginal bone level following immediate loading of single-tooth implants placed in healed alveolar ridges and extraction sockets in the maxilla.

    abstract:PURPOSE:The aim of present investigation was to evaluate marginal bone level after 5-year follow-up of implants placed in healed ridges and fresh extraction sockets in maxilla with immediate loading protocol. MATERIALS AND METHODS:Thirty-six patients in need of a single-tooth replacement in the anterior maxilla receiv...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2014.00029

    authors: Berberi AN,Sabbagh JM,Aboushelib MN,Noujeim ZF,Salameh ZA

    更新日期:2014-01-31 00:00:00

  • Corrigendum: The Application of the Extended Poincaré Plot in the Analysis of Physiological Variabilities.

    abstract::[This corrects the article DOI: 10.3389/fphys.2019.00116.]. ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fphys.2019.00669

    authors: Satti R,Abid NU,Bottaro M,De Rui M,Garrido M,Raoufy MR,Montagnese S,Mani AR

    更新日期:2019-05-28 00:00:00

  • MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease.

    abstract::Skeletal muscle makes up approximately 40% of the total body mass, providing structural support and enabling the body to maintain posture, to control motor movements and to store energy. It therefore plays a vital role in whole body metabolism. Skeletal muscle displays remarkable plasticity and is able to alter its si...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2013.00266

    authors: Zacharewicz E,Lamon S,Russell AP

    更新日期:2013-09-30 00:00:00

  • Essential Amino Acids (EAA) Mixture Supplementation: Effects of an Acute Administration Protocol on Myoelectric Manifestations of Fatigue in the Biceps Brachii After Resistance Exercise.

    abstract::Background: The purpose of this study was to investigate the acute effects of a single oral administration of an essential amino acids enriched mixture (EAA) on myoelectric descriptors of fatigue and maximal force production after a resistance exercise protocol (REP). Methods: Twenty adult males (age: 27 ± 6 years; bo...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01140

    authors: Negro M,Segreto V,Barbero M,Cescon C,Castelli L,Calanni L,D'Antona G

    更新日期:2018-08-17 00:00:00

  • Thiamethoxam Resistance in Aphis gossypii Glover Relies on Multiple UDP-Glucuronosyltransferases.

    abstract::Uridine diphosphate (UDP)-glycosyltransferases (UGTs) are major phase II enzymes that conjugate a variety of small lipophilic molecules with UDP sugars and alter them into more water-soluble metabolites. Therefore, glucosidation plays a major role in the inactivation and excretion of a great variety of both endogenous...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00322

    authors: Pan Y,Tian F,Wei X,Wu Y,Gao X,Xi J,Shang Q

    更新日期:2018-04-03 00:00:00

  • The Total Artificial Heart in End-Stage Congenital Heart Disease.

    abstract::The development of durable ventricular assist devices (VADs) has improved mortality rates and quality of life in patients with end stage heart failure. While the use of VADs has increased dramatically in recent years, there is limited experience with VAD implantation in patients with complex congenital heart disease (...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2017.00131

    authors: Villa CR,Morales DLS

    更新日期:2017-05-09 00:00:00

  • The Evolutionary History and Functional Divergence of Trehalase (treh) Genes in Insects.

    abstract::Trehalases (treh) have been found in different organisms, such as bacteria, fungi, yeast, nematodes, insects, vertebrates, and plants. Their biochemical properties are extremely variable and not yet fully understood. Gene expression patterns have shown differences among insect species suggesting a potential functional...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00062

    authors: Nardelli A,Vecchi M,Mandrioli M,Manicardi GC

    更新日期:2019-02-15 00:00:00

  • Heat Shock Factor Is Involved in Regulating the Transcriptional Expression of Two Potential Hsps (AhHsp70 and AhsHsp21) and Its Role in Heat Shock Response of Agasicles hygrophila.

    abstract::Heat shock proteins are molecular chaperones that are involved in numerous normal cellular processes and stress responses, and heat shock factors are transcriptional activators of heat shock proteins. Heat shock factors and heat shock proteins are coordinated in various biological processes. The regulatory function of...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.562204

    authors: Jin J,Li Y,Zhou Z,Zhang H,Guo J,Wan F

    更新日期:2020-09-15 00:00:00

  • Cancer Metabolism: A Modeling Perspective.

    abstract::Tumor cells alter their metabolism to maintain unregulated cellular proliferation and survival, but this transformation leaves them reliant on constant supply of nutrients and energy. In addition to the widely studied dysregulated glucose metabolism to fuel tumor cell growth, accumulating evidences suggest that utiliz...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2015.00382

    authors: Ghaffari P,Mardinoglu A,Nielsen J

    更新日期:2015-12-16 00:00:00

  • Fibrogenic Secretome of Sirtuin 1-Deficient Endothelial Cells: Wnt, Notch and Glycocalyx Rheostat.

    abstract::Sirtuins (SIRT) are ubiquitous histone and protein deacetylases and a member of this family, SIRT1, is the best-studied one. Its functions in endothelial cells encompass branching angiogenesis, activation of endothelial nitric oxide synthase, regulation of proapoptotic and proinflammatory pathways, among others. Defec...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2018.01325

    authors: Lipphardt M,Dihazi H,Müller GA,Goligorsky MS

    更新日期:2018-09-21 00:00:00

  • Personalized Cardiovascular Disease Prediction and Treatment-A Review of Existing Strategies and Novel Systems Medicine Tools.

    abstract::Cardiovascular disease (CVD) continues to constitute the leading cause of death globally. CVD risk stratification is an essential tool to sort through heterogeneous populations and identify individuals at risk of developing CVD. However, applications of current risk scores have recently been shown to result in conside...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2016.00002

    authors: Björnson E,Borén J,Mardinoglu A

    更新日期:2016-01-26 00:00:00

  • Ultrasound Imaging of Mouse Fetal Intracranial Hemorrhage Due to Ischemia/Reperfusion.

    abstract::Despite vast improvement in perinatal care during the 30 years, the incidence rate of neonatal encephalopathy remains unchanged without any further Progress towards preventive strategies for the clinical impasse. Antenatal brain injury including fetal intracranial hemorrhage caused by ischemia/reperfusion is known as ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00340

    authors: Funamoto K,Ito T,Funamoto K,Velayo CL,Kimura Y

    更新日期:2017-05-24 00:00:00

  • Phenotyping for drought tolerance of crops in the genomics era.

    abstract::Improving crops yield under water-limited conditions is the most daunting challenge faced by breeders. To this end, accurate, relevant phenotyping plays an increasingly pivotal role for the selection of drought-resilient genotypes and, more in general, for a meaningful dissection of the quantitative genetic landscape ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00347

    authors: Tuberosa R

    更新日期:2012-09-19 00:00:00

  • Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-Associated Protein 9 Mediated Knockout Reveals Functions of the yellow-y Gene in Spodoptera litura.

    abstract::Yellow genes are thought to be involved in the melanin biosynthetic pathway and play a crucial role in pigmentation reactions in insects. However, little research has been done on yellow genes in lepidopteran pests. To clarify the function of one of the yellow genes (yellow-y) in Spodoptera litura, we cloned the full-...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.615391

    authors: Liu XL,Han WK,Ze LJ,Peng YC,Yang YL,Zhang J,Yan Q,Dong SL

    更新日期:2020-12-17 00:00:00

  • Metabolic Reprogramming Promotes Myogenesis During Aging.

    abstract::Sarcopenia is the age-related progressive loss of skeletal muscle mass and strength finally leading to poor physical performance. Impaired myogenesis contributes to the pathogenesis of sarcopenia, while mitochondrial dysfunctions are thought to play a primary role in skeletal muscle loss during aging. Here we studied ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00897

    authors: Belli R,Bonato A,De Angelis L,Mirabilii S,Ricciardi MR,Tafuri A,Molfino A,Leigheb M,Costelli P,Caruso M,Muscaritoli M,Ferraro E

    更新日期:2019-07-10 00:00:00

  • Optogenetic Termination of Cardiac Arrhythmia: Mechanistic Enlightenment and Therapeutic Application?

    abstract::Optogenetic methods enable selective de- and hyperpolarization of cardiomyocytes expressing light-sensitive proteins within the myocardium. By using light, this technology provides very high spatial and temporal precision, which is in clear contrast to electrical stimulation. In addition, cardiomyocyte-specific expres...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2019.00675

    authors: Sasse P,Funken M,Beiert T,Bruegmann T

    更新日期:2019-06-06 00:00:00

  • The Gβ1 and Gβ3 Subunits Differentially Regulate Rat Vascular Kv7 Channels.

    abstract::Within the vasculature Kv7 channels are key regulators of basal tone and contribute to a variety of receptor mediated vasorelaxants. The Kv7.4 isoform, abundant within the vasculature, is key to these processes and was recently shown to have an obligatory requirement of G-protein βγ subunits for its voltage dependent ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01573

    authors: Greenwood IA,Stott JB

    更新日期:2020-01-14 00:00:00

  • A trade-off study revealing nested timescales of constraint.

    abstract::This study investigates human performance in a cyclic Fitts task at three different scales of observation, either in the presence (difficult condition) or in the absence (easy condition) of a speed-accuracy trade-off. At the fastest scale, the harmonicity of the back and forth movements, which reflects the dissipation...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00116

    authors: Wijnants ML,Cox RF,Hasselman F,Bosman AM,Van Orden G

    更新日期:2012-05-23 00:00:00

  • Intestinal Metagenomes and Metabolomes in Healthy Young Males: Inactivity and Hypoxia Generated Negative Physiological Symptoms Precede Microbial Dysbiosis.

    abstract::We explored the metagenomic, metabolomic and trace metal makeup of intestinal microbiota and environment in healthy male participants during the run-in (5 day) and the following three 21-day interventions: normoxic bedrest (NBR), hypoxic bedrest (HBR) and hypoxic ambulation (HAmb) which were carried out within a contr...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00198

    authors: Šket R,Debevec T,Kublik S,Schloter M,Schoeller A,Murovec B,Vogel Mikuš K,Makuc D,Pečnik K,Plavec J,Mekjavić IB,Eiken O,Prevoršek Z,Stres B

    更新日期:2018-03-13 00:00:00

  • Determination of the Maximum Velocity of Filaments in the in vitro Motility Assay.

    abstract::The in vitro motility assay (IVMA) is a powerful tool commonly used in basic muscle research and for drug screenings with the aim to find treatment options for neuromuscular disorders. In brief, the sliding movement of fluorescence-labeled actin filaments on myosin motor proteins is recorded, and the sliding velocity ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00289

    authors: Bopp N,Scheid LM,Fink RHA,Rohr K

    更新日期:2019-03-27 00:00:00

  • Targeting the Substrate in Ablation of Persistent Atrial Fibrillation: Recent Lessons and Future Directions.

    abstract::While isolation of the pulmonary veins is firmly established as effective treatment for the majority of paroxysmal atrial fibrillation (AF) patients, there is recognition that patients with persistent AF have substrate for perpetuation of arrhythmia existing outside of the pulmonary veins. Various computational approa...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2018.01158

    authors: Stiles MK,Sanders P,Lau DH

    更新日期:2018-09-18 00:00:00

  • SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress.

    abstract::Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19 inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation and disease processes like thrombosis, atherosclerosis, and lung injury. In endothelial cells, mitochondria regulate these inflammatory pathways ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2020.605908

    authors: Chang R,Mamun A,Dominic A,Le NT

    更新日期:2021-01-15 00:00:00

  • Intense Physical Exercise Induces an Anti-inflammatory Change in IgG N-Glycosylation Profile.

    abstract::Exercise is known to improve many aspects of human health, including modulation of the immune system and inflammatory status. It is generally understood that exercise reduces inflammation, but there are missing links in terms of understanding the mechanisms as well as the differences between exercise modalities. N-gly...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01522

    authors: Tijardović M,Marijančević D,Bok D,Kifer D,Lauc G,Gornik O,Keser T

    更新日期:2019-12-20 00:00:00