Cortisol Acting Through the Glucocorticoid Receptor Is Not Involved in Exercise-Enhanced Growth, But Does Affect the White Skeletal Muscle Transcriptome in Zebrafish (Danio rerio).


:Forced sustained swimming exercise at optimal speed enhances growth in many fish species, particularly through hypertrophy of the white skeletal muscle. The exact mechanism of this effect has not been resolved yet. To explore the role of cortisol, we first subjected wild-type zebrafish to an exercise protocol validated for exercise-enhanced growth, and showed that exercised zebrafish, which indeed showed enhanced growth, had higher cortisol levels than the non-exercised controls. A central role was therefore hypothesized for the steroid hormone cortisol acting through the Glucocorticoid receptor (Gr). Second, we subjected wild-type zebrafish and zebrafish with a mutant Gr to exercise at optimal, suboptimal, and super-optimal speeds and compared them with non-exercised controls. Exercised zebrafish showed growth enhancement at all speeds, with highest growth at optimal speeds. In the Gr mutant fish, exercise resulted in growth enhancement similar to wild-type zebrafish, indicating that cortisol signaling through Gr cannot be considered as a main determinant of exercise-enhanced growth. Finally, the transcriptome of white skeletal muscle tissue was analyzed by RNA sequencing. The results of this analysis showed that in the muscle tissue of Gr mutant fish a lower number of genes is regulated by exercise than in wild-type fish (183 vs. 351). A cluster of 36 genes was regulated by exercise in both wild-type and mutant fish, and in this cluster genes involved in transcriptional regulation and protein ubiquitination were overrepresented. Because these two processes appear to be regulated in both wild type and mutant fish, which both display exercise-enhanced growth, we suggest that they play an important role in the growth of muscles upon exercise.


Front Physiol


Frontiers in physiology


Palstra AP,Mendez S,Dirks RP,Schaaf MJM




Has Abstract


2019-01-14 00:00:00








  • Viral Delivery of dsRNA for Control of Insect Agricultural Pests and Vectors of Human Disease: Prospects and Challenges.

    abstract::RNAi is applied as a new and safe method for pest control in agriculture but efficiency and specificity of delivery of dsRNA trigger remains a critical issue. Various agents have been proposed to augment dsRNA delivery, such as engineered micro-organisms and synthetic nanoparticles, but the use of viruses has received...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Kolliopoulou A,Taning CNT,Smagghe G,Swevers L

    更新日期:2017-06-14 00:00:00

  • Computational tools to investigate genetic cardiac channelopathies.

    abstract::The aim of this perspective article is to share with the community of ion channel scientists our thoughts and expectations regarding the increasing role that computational tools will play in the future of our field. The opinions and comments detailed here are the result of a 3-day long international exploratory worksh...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Abriel H,de Lange E,Kucera JP,Loussouarn G,Tarek M

    更新日期:2013-12-26 00:00:00

  • HuangqiGuizhiWuwu Decoction Prevents Vascular Dysfunction in Diabetes via Inhibition of Endothelial Arginase 1.

    abstract::Hyperglycemia induces vascular endothelial dysfunction, which contributes to the development of vascular complication of diabetes. A classic prescription of traditional medicine, HuangqiGuizhiWuwu Decoction (HGWWD) has been used for the treatment of various cardiovascular and cerebrovascular diseases, which all are re...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Cheng H,Lu T,Wang J,Xia Y,Chai X,Zhang M,Yao Y,Zhou N,Zhou S,Chen X,Su W,Liu C,Yi W,Chen Y,Yao L

    更新日期:2020-03-25 00:00:00

  • Neuromuscular Electrical Stimulation: A New Therapeutic Option for Chronic Diseases Based on Contraction-Induced Myokine Secretion.

    abstract::Myokines are peptides known to modulate brain neuroplasticity, adipocyte metabolism, bone mineralization, endothelium repair and cell growth arrest in colon and breast cancer, among other processes. Repeated skeletal muscle contraction induces the production and secretion of myokines, which have a wide range of functi...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Sanchis-Gomar F,Lopez-Lopez S,Romero-Morales C,Maffulli N,Lippi G,Pareja-Galeano H

    更新日期:2019-11-28 00:00:00

  • Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations.

    abstract::Carbon monoxide (CO) that is produced in a number of different mammalian tissues is now known to have significant effects on the cardiovascular system. These include: (i) vasodilation, (ii) changes in heart rate and strength of contractions, and (iii) modulation of autonomic nervous system input to both the primary pa...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Trenor B,Cardona K,Saiz J,Rajamani S,Belardinelli L,Giles WR

    更新日期:2013-10-17 00:00:00

  • Mitochondrial Bioenergetics and Fiber Type Assessments in Microbiopsy vs. Bergstrom Percutaneous Sampling of Human Skeletal Muscle.

    abstract::Microbiopsies of human skeletal muscle are increasingly adopted by physiologists for a variety of experimental assays given the reduced invasiveness of this procedure compared to the classic Bergstrom percutaneous biopsy technique. However, a recent report demonstrated lower mitochondrial respiration in saponin-permea...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Hughes MC,Ramos SV,Turnbull PC,Nejatbakhsh A,Baechler BL,Tahmasebi H,Laham R,Gurd BJ,Quadrilatero J,Kane DA,Perry CG

    更新日期:2015-12-18 00:00:00

  • Stiffness of the Gastrocnemius-Achilles Tendon Complex Between Amateur Basketball Players and the Non-athletic General Population.

    abstract::Muscle and tendon stiffness are related to sports performance, tendinopathy, and tendon degeneration. However, the effects of habitual loading on muscle and tendon mechanical properties are unclear. Using amateur basketball players as examples, we investigated the effects of mechanical loading on the stiffness of the ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Chang TT,Li Z,Wang XQ,Zhang ZJ

    更新日期:2020-12-10 00:00:00

  • Mechanisms regulating nutrition-dependent developmental plasticity through organ-specific effects in insects.

    abstract::Nutrition, via the insulin/insulin-like growth factor (IIS)/Target of Rapamycin (TOR) signaling pathway, can provide a strong molding force for determining animal size and shape. For instance, nutrition induces a disproportionate increase in the size of male horns in dung and rhinoceros beetles, or mandibles in stagho...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Koyama T,Mendes CC,Mirth CK

    更新日期:2013-09-26 00:00:00

  • Insights on the Role of Putative Muscle-Derived Factors on Pancreatic Beta Cell Function.

    abstract::Skeletal muscle is a main target of insulin action that plays a pivotal role in postprandial glucose disposal. Importantly, skeletal muscle insulin sensitivity relates inversely with pancreatic insulin secretion, which prompted the hypothesis of the existence of a skeletal muscle-pancreas crosstalk mediated through an...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Mizgier ML,Fernández-Verdejo R,Cherfan J,Pinget M,Bouzakri K,Galgani JE

    更新日期:2019-08-08 00:00:00

  • Mammalian STE20-Like Kinase 2 Promotes Lipopolysaccharides-Mediated Cardiomyocyte Inflammation and Apoptosis by Enhancing Mitochondrial Fission.

    abstract::In this study, we analyzed the role of mammalian STE20-like protein kinase 2 (Mst2), a serine-threonine protein kinase, in Lipopolysaccharides (LPS)-mediated inflammation and apoptosis in the H9C2 cardiomyocytes. Mst2 mRNA and protein levels were significantly upregulated in the LPS-treated H9C2 cardiomyocytes. LPS tr...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Tian Y,Song H,Qin W,Ding Z,Zhang Y,Shan W,Jin D

    更新日期:2020-08-06 00:00:00

  • Acute-Stress Biomarkers in Three Octopodidae Species After Bottom Trawling.

    abstract::Several Octopodidae species have a great potential for the diversification of worldwide aquaculture. Unfortunately, the lack of stress-related biomarkers in this taxon results an obstacle for its maintenance in conditions where animal welfare is of paramount relevance. In this study, we made a first approach to uncove...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Barragán-Méndez C,Sobrino I,Marín-Rincón A,Fernández-Boo S,Costas B,Mancera JM,Ruiz-Jarabo I

    更新日期:2019-06-25 00:00:00

  • Resting state MEG oscillations show long-range temporal correlations of phase synchrony that break down during finger movement.

    abstract::The capacity of the human brain to interpret and respond to multiple temporal scales in its surroundings suggests that its internal interactions must also be able to operate over a broad temporal range. In this paper, we utilize a recently introduced method for characterizing the rate of change of the phase difference...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Botcharova M,Berthouze L,Brookes MJ,Barnes GR,Farmer SF

    更新日期:2015-06-17 00:00:00

  • Where to Step? Contributions of Stance Leg Muscle Spindle Afference to Planning of Mediolateral Foot Placement for Balance Control in Young and Old Adults.

    abstract::Stable gait requires active control of the mediolateral (ML) kinematics of the body center of mass (CoM) and the base of support (BoS) in relation to each other. Stance leg hip abductor (HA) muscle spindle afference may be used to guide contralateral swing foot placement and adequately position the BoS in relation to ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Arvin M,Hoozemans MJM,Pijnappels M,Duysens J,Verschueren SM,van Dieën JH

    更新日期:2018-08-21 00:00:00

  • Bone resorption: an actor of dental and periodontal development?

    abstract::Dental and periodontal tissue development is a complex process involving various cell-types. A finely orchestrated network of communications between these cells is implicated. During early development, communications between cells from the oral epithelium and the underlying mesenchyme govern the dental morphogenesis w...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Gama A,Navet B,Vargas JW,Castaneda B,Lézot F

    更新日期:2015-11-05 00:00:00

  • Partial Amino Acid Metabolism and Glutamine Synthesis as the Ammonia Defensive Strategies During Aerial Exposure in Chinese Loach Paramisgurnus dabryanus.

    abstract::The Paramisgurnus dabryanus was exposed to air to assess the changes in plasma, liver and muscle free amino acid (FAA) contents. The FAA concentrations in plasma, liver and muscle of P. dabryanus were significantly affected by aerial exposure (P < 0.05). After 12 h of aerial exposure, the plasma glutamate contents inc...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Zhang YL,Wang GY,Zhang ZH,Xie YY,Jin H,Dong ZR

    更新日期:2019-01-29 00:00:00

  • Acute Effects of Different Exercise Protocols on the Circulating Vascular microRNAs -16, -21, and -126 in Trained Subjects.

    abstract::Aim: mircoRNAs (miRNAs), small non-coding RNAs regulating gene expression, are stably secreted into the blood and circulating miRNAs (c-miRNAs) may play an important role in cell-cell communication. Furthermore, c-miRNAs might serve as novel biomarkers of the current vascular cell status. Here, we examined how the lev...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Wahl P,Wehmeier UF,Jansen FJ,Kilian Y,Bloch W,Werner N,Mester J,Hilberg T

    更新日期:2016-12-26 00:00:00

  • Personalized Cardiovascular Disease Prediction and Treatment-A Review of Existing Strategies and Novel Systems Medicine Tools.

    abstract::Cardiovascular disease (CVD) continues to constitute the leading cause of death globally. CVD risk stratification is an essential tool to sort through heterogeneous populations and identify individuals at risk of developing CVD. However, applications of current risk scores have recently been shown to result in conside...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Björnson E,Borén J,Mardinoglu A

    更新日期:2016-01-26 00:00:00

  • AltitudeOmics: Baroreflex Sensitivity During Acclimatization to 5,260 m.

    abstract::Introduction: Baroreflex sensitivity (BRS) is essential to ensure rapid adjustment to variations in blood pressure (BP). Little is known concerning the adaptive responses of BRS during acclimatization to high altitude at rest and during exercise. Methods: Twenty-one healthy sea-level residents were tested near sea lev...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Bourdillon N,Yazdani S,Subudhi AW,Lovering AT,Roach RC,Vesin JM,Kayser B

    更新日期:2018-06-21 00:00:00

  • Anti-inflammatory Effects of Fungal Metabolites in Mouse Intestine as Revealed by In vitro Models.

    abstract::Inflammatory bowel diseases (IBD), which include Crohn's disease and ulcerative colitis, are chronic inflammatory disorders that can affect the whole gastrointestinal tract or the colonic mucosal layer. Current therapies aiming to suppress the exaggerated immune response in IBD largely rely on compounds with non-satis...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Schreiber D,Marx L,Felix S,Clasohm J,Weyland M,Schäfer M,Klotz M,Lilischkis R,Erkel G,Schäfer KH

    更新日期:2017-08-07 00:00:00

  • Alteration of pancreatic cancer cell functions by tumor-stromal cell interaction.

    abstract::Pancreatic cancer shows a characteristic tissue structure called desmoplasia, which consists of dense fibrotic stroma surrounding cancer cells. Interactions between pancreatic cancer cells and stromal cells promote invasive growth of cancer cells and establish a specific microenvironment such as hypoxia which further ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Hamada S,Masamune A,Shimosegawa T

    更新日期:2013-11-01 00:00:00

  • Glutaraldehyde - A Subtle Tool in the Investigation of Healthy and Pathologic Red Blood Cells.

    abstract::Glutaraldehyde is a well-known substance used in biomedical research to fix cells. Since hemolytic anemias are often associated with red blood cell shape changes deviating from the biconcave disk shape, conservation of these shapes for imaging in general and 3D-imaging in particular, like confocal microscopy, scanning...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Abay A,Simionato G,Chachanidze R,Bogdanova A,Hertz L,Bianchi P,van den Akker E,von Lindern M,Leonetti M,Minetti G,Wagner C,Kaestner L

    更新日期:2019-05-14 00:00:00

  • Model-Supported Radiotherapy Personalization: In silico Test of Hyper- and Hypo-Fractionation Effects.

    abstract::The need for radiotherapy personalization is now widely recognized, however, it would require considerations not only on the probability of control and survival of the tumor, but also on the possible toxic effects, on the quality of the expected life and the economic efficiency of the treatment. In this paper, we prop...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Belfatto A,Jereczek-Fossa BA,Baroni G,Cerveri P

    更新日期:2018-10-15 00:00:00

  • Arsenic toxicity: the effects on plant metabolism.

    abstract::The two forms of inorganic arsenic, arsenate (AsV) and arsenite (AsIII), are easily taken up by the cells of the plant root. Once in the cell, AsV can be readily converted to AsIII, the more toxic of the two forms. AsV and AsIII both disrupt plant metabolism, but through distinct mechanisms. AsV is a chemical analog o...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Finnegan PM,Chen W

    更新日期:2012-06-06 00:00:00

  • The Role of Leucine-Rich Repeat Containing Protein 10 (LRRC10) in Dilated Cardiomyopathy.

    abstract::Leucine-rich repeat containing protein 10 (LRRC10) is a cardiomyocyte-specific member of the Leucine-rich repeat containing (LRRC) protein superfamily with critical roles in cardiac function and disease pathogenesis. Recent studies have identified LRRC10 mutations in human idiopathic dilated cardiomyopathy (DCM) and L...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Brody MJ,Lee Y

    更新日期:2016-08-03 00:00:00

  • Salbutamol Worsens the Autonomic Nervous System Dysfunction of Children With Sickle Cell Disease.

    abstract:Background:Sickle cell disease (SCD) patients with asthma have an increased rate of vaso-occlusive crisis (VOC) and acute chest syndrome (ACS) episodes when compared to those without asthma. We hypothesized that either asthma diagnosis or bronchodilator treatment might aggravate SCD via their modulating effect on the a...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Bokov P,El Jurdi H,Denjoy I,Peiffer C,Medjahdi N,Holvoet L,Benkerrou M,Delclaux C

    更新日期:2020-02-26 00:00:00

  • Hepatocellular carcinoma: a systems biology perspective.

    abstract::Hepatocellular carcinomas (HCCs) have different etiology and heterogenic genomic alterations lead to high complexity. The molecular features of HCC have largely been studied by gene expression and proteome profiling focusing on the correlations between the expression of specific markers and clinical data. Integration ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: D'Alessandro LA,Meyer R,Klingmüller U

    更新日期:2013-02-25 00:00:00

  • Determination of the Maximum Velocity of Filaments in the in vitro Motility Assay.

    abstract::The in vitro motility assay (IVMA) is a powerful tool commonly used in basic muscle research and for drug screenings with the aim to find treatment options for neuromuscular disorders. In brief, the sliding movement of fluorescence-labeled actin filaments on myosin motor proteins is recorded, and the sliding velocity ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Bopp N,Scheid LM,Fink RHA,Rohr K

    更新日期:2019-03-27 00:00:00

  • Physiological Levels of Nitric Oxide Diminish Mitochondrial Superoxide. Potential Role of Mitochondrial Dinitrosyl Iron Complexes and Nitrosothiols.

    abstract::Mitochondria are the major source of superoxide radicals and superoxide overproduction contributes to cardiovascular diseases and metabolic disorders. Endothelial dysfunction and diminished nitric oxide levels are early steps in the development of these pathological conditions. It is known that physiological productio...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Dikalov SI,Mayorov VI,Panov AV

    更新日期:2017-11-07 00:00:00

  • Limb-Specific Features and Asymmetry of Nerve Conduction Velocity and Nerve Trunk Size in Human.

    abstract::This study aimed to simultaneously examine the differences of human nerve conduction velocity (NCV) and nerve cross-sectional area (nCSA) between the upper and lower limbs and between different regions of the upper and lower limbs. Thirty healthy subjects volunteered for the study. NCV and nCSA of the ulnar and tibial...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Nobue A,Kunimasa Y,Tsuneishi H,Sano K,Oda H,Ishikawa M

    更新日期:2020-12-03 00:00:00

  • Prediction of outcome and selection of the liver transplantat candidate in acute liver failure.

    abstract::Acute liver failure (ALF) is characterized by a sudden and severe deterioration of liver function, typically mirrored by a marked increase of the international normalized ratio (INR) and hepatic encephalopathy (HE). Due to various possible causes hepatocytes get damaged via either apoptotic or necrotic pathways. Antic...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Hadem J,Strassburg CP,Manns MP

    更新日期:2012-08-28 00:00:00