Abstract：
:Obesity is characterized by an excessive increase in body mass, leading to endothelial damage that may favor the development of erectile dysfunction (ED). ED is defined as the inability to achieve or maintain a penile erection long enough to have a sexual intercourse. In this context, different ED models were developed, however the high price of special animals or the long period to establish the disease has limited studies in this field. Therefore, this study proposed to establish and characterize a novel model of ED in rats associated to a hypercaloric diet consumption. Animals were randomly divided into control group (CG), which received a standard diet, and obese group (OG), fed with a hypercaloric diet during 8 weeks. Rat's erectile function was evaluated in vivo and in vitro. Food and caloric intake of OG were reduced compared to CG, due to an increased diet energy efficiency. However, OG presented an increased body mass, inguinal, retroperitoneal and epididymal adipose tissues, as well as body adiposity index at the end of experimental protocol. In erectile function analysis, there was a decrease in the number and the latency of penile erections in OG. Additionally, the contractile reactivity of corpus cavernosum was increased in OG, favoring penile detumescence and related to a reduced nitric oxide bioavailability and an increased in contractile prostaglandins levels as a consequence of endothelial damage. Moreover, the endothelium-relaxation reactivity of corpus cavernosum was attenuated in OG associated to the oxidative stress. Thus, it was provided a model for advances in sexual dysfunction field and drug discovery for ED treatment.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
de Souza ILL,Barros BC,de Oliveira GA,Queiroga FR,Toscano LT,Silva AS,Silva PM,Interaminense LFL,Cavalcante FA,da Silva BAdoi
10.3389/fphys.2017.00760subject
Has Abstractpub_date
2017-10-04 00:00:00pages
760issn
1664-042Xjournal_volume
8pub_type
杂志文章abstract：:Chaste is an open-source C++ library for computational biology that has well-developed cardiac electrophysiology tissue simulation support. In this paper, we introduce the features available for performing cardiac electrophysiology action potential simulations using a wide range of models from the Physiome repository....
journal_title：Frontiers in physiology
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pub_type： 杂志文章
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更新日期：2019-04-24 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.3389/fphys.2013.00183
更新日期：2013-07-30 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.00267
更新日期：2019-03-22 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.00558
更新日期：2018-05-28 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2019.01243
更新日期：2019-10-01 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2020.00828
更新日期：2020-08-05 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2014.00127
更新日期：2014-04-09 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.01528
更新日期：2018-10-31 00:00:00
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journal_title：Frontiers in physiology
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doi：10.3389/fphys.2016.00260
更新日期：2016-06-28 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2013.00023
更新日期：2013-02-15 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00393
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journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
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journal_title：Frontiers in physiology
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doi：10.3389/fphys.2016.00201
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journal_title：Frontiers in physiology
pub_type： 杂志文章
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journal_title：Frontiers in physiology
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doi：10.3389/fphys.2019.01477
更新日期：2019-12-12 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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更新日期：2013-09-26 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2013.00393
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pub_type： 杂志文章,评审
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.01093
更新日期：2018-08-14 00:00:00
