Are mouse models of asthma appropriate for investigating the pathogenesis of airway hyper-responsiveness?

abstract：:Huanglian Jiedu decoction (HLJDD) has been used in the clinical treatment of inflammatory conditions. To clarify the mechanism of its comprehensive anti-inflammatory activities, the correlation between lipid homeostasis and the TLR4/MyD88 signaling pathway in zebrafish was established in the present study. In the lipo...

journal_title：Frontiers in physiology

authors： Zhou J,Gu X,Fan X,Zhou Y,Wang H,Si N,Yang J,Bian B,Zhao H

更新日期：2019-09-26 00:00:00

abstract：:AF is a heterogeneous rhythm disorder that is related to a wide spectrum of etiologies and has broad clinical presentations. Mechanisms underlying AF are complex and remain incompletely understood despite extensive research. They associate interactions between triggers, substrate and modulators including ionic and ana...

journal_title：Frontiers in physiology

authors： Cheniti G,Vlachos K,Pambrun T,Hooks D,Frontera A,Takigawa M,Bourier F,Kitamura T,Lam A,Martin C,Dumas-Pommier C,Puyo S,Pillois X,Duchateau J,Klotz N,Denis A,Derval N,Jais P,Cochet H,Hocini M,Haissaguerre M,Sache

更新日期：2018-10-17 00:00:00

abstract：:The mealworm beetle, Tenebrio molitor, is currently considered as a pest when infesting stored grains or grain products. However, mealworms are now being promoted as a beneficial insect because their high nutrient content makes them a viable food source and because they are capable of degrading polystyrene and plastic...

journal_title：Frontiers in physiology

authors： Vigneron A,Jehan C,Rigaud T,Moret Y

更新日期：2019-03-12 00:00:00

abstract：:Glucagon counterregulation (GCR) protects against hypoglycemia, but is impaired in type 1 diabetes (T1DM). A model-based analysis of in vivo animal data predicts that the GCR defects are linked to basal hyperglucagonemia. To test this hypothesis we studied the relationship between basal glucagon (BasG) and the GCR res...

journal_title：Frontiers in physiology

authors： Farhy LS,Chan A,Breton MD,Anderson SM,Kovatchev BP,McCall AL

更新日期：2012-02-28 00:00:00

abstract：:Breast cancer is the most common type of cancer among women and despite recent advances in the medical field, there are still some inherent limitations in the currently used screening techniques. The radiological interpretation of screening X-ray mammograms often leads to over-diagnosis and, as a consequence, to unnec...

journal_title：Frontiers in physiology

authors： Gerasimova E,Audit B,Roux SG,Khalil A,Gileva O,Argoul F,Naimark O,Arneodo A

更新日期：2014-05-08 00:00:00

abstract：:This study aimed to evaluate the effect of the stretch-shortening cycle (SSC) on different portions of the force-velocity (F-V) relationship in older adults with and without chronic obstructive pulmonary disease (COPD), and to assess its association with physical function. The participants were 26 older adults with CO...

journal_title：Frontiers in physiology

authors： Navarro-Cruz R,Alcazar J,Rodriguez-Lopez C,Losa-Reyna J,Alfaro-Acha A,Ara I,García-García FJ,Alegre LM

更新日期：2019-03-26 00:00:00

abstract：:Background: Measuring the extent to which renal artery stenosis (RAS) alters renal haemodynamics may permit precision medicine by physiologically guided revascularization. This currently requires invasive intra-arterial pressure measurement with associated risks and is rarely performed. The present proof-of-concept st...

journal_title：Frontiers in physiology

authors： Mandaltsi A,Grytsan A,Odudu A,Kadziela J,Morris PD,Witkowski A,Ellam T,Kalra P,Marzo A

更新日期：2018-08-17 00:00:00

abstract：:Liver cirrhosis (LC) is the final usual outcome of liver damage induced by various chronic liver diseases. Because of asymptomatic nature of LC, it is usually diagnosed at late and advanced stages, and patients are easy to miss the best timing for treatment. Thus, the early detection of LC is needed. In the prospectiv...

journal_title：Frontiers in physiology

authors： Yoo HJ,Jung KJ,Kim M,Kim M,Kang M,Jee SH,Choi Y,Lee JH

更新日期：2019-11-19 00:00:00

abstract：:The main purpose of the present study was to investigate the effect of frequency, thereby increasing training volume, of resistance training on body composition, inflammation markers, lipid and glycemic profile in healthy older individuals (age range 65-75 year). Ninety-two healthy participants were randomly assigned ...

journal_title：Frontiers in physiology

authors： Ihalainen JK,Inglis A,Mäkinen T,Newton RU,Kainulainen H,Kyröläinen H,Walker S

更新日期：2019-02-01 00:00:00

abstract：:Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19 inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation and disease processes like thrombosis, atherosclerosis, and lung injury. In endothelial cells, mitochondria regulate these inflammatory pathways ...

journal_title：Frontiers in physiology

authors： Chang R,Mamun A,Dominic A,Le NT

更新日期：2021-01-15 00:00:00

abstract：:Short bowel syndrome (SBS) is characterized by severe intestinal malabsorption following restrictive surgery. The objective of this study was to determine the functional contribution of SBS-microbiota after resection. It is well-known that SBS-microbiota displayed specific features with a prevalence of Lactobacillus, ...

journal_title：Frontiers in physiology

authors： Gillard L,Mayeur C,Robert V,Pingenot I,Le Beyec J,Bado A,Lepage P,Thomas M,Joly F

更新日期：2017-04-19 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphys.2020.00302.]. ...

journal_title：Frontiers in physiology

authors： Semple C,Riveros D,Nagy JA,Rutkove SB,Mortreux M

更新日期：2020-07-03 00:00:00

abstract：:To excrete body nitrogen waste and regulate electrolyte and fluid balance, the kidney has developed into an energy factory with only second to the heart in mitochondrial content in the body to meet the high-energy demand and regulate homeostasis. Energy supply from the renal mitochondria majorly depends on lipid metab...

journal_title：Frontiers in physiology

authors： Lin PH,Duann P

更新日期：2020-09-03 00:00:00

abstract：:The rare opportunity to study a human fetus showing bilateral clefting of the lower lip along with other associated anomalies resembling those of the equally rare Pena-Shokeir phenotype prompts this report. The scarcity of reports on bilateral clefts of the lower lip has strengthened the conventional understanding or,...

journal_title：Frontiers in physiology

authors： Vastardis H,Spyropoulos MN,Burdi AR

更新日期：2012-08-24 00:00:00

abstract：:Chronic pressure overload can result in ventricular hypertrophy and eventually diastolic dysfunction. In normal myocardium, the time from peak tension to 50% relaxation of isolated cardiac myocardium is not directly determined by the time for calcium decline. This study aims to determine whether the time for calcium d...

journal_title：Frontiers in physiology

authors： Monasky MM,Torres CAA,Janssen PML

更新日期：2017-12-04 00:00:00

abstract：:Background: Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) is highly effective in alleviating motor symptoms of Parkinson's disease (PD) which are not optimally controlled by dopamine replacement therapy. Clinical studies and reports suggest that STN-DBS may result in increased impulsivity and de novo impulse co...

journal_title：Frontiers in physiology

authors： Mandali A,Chakravarthy VS,Rajan R,Sarma S,Kishore A

更新日期：2016-11-29 00:00:00

abstract：:Background: Hypoxia represents both an outcome of cardiopulmonary diseases and a trigger for severe pulmonary complications as pulmonary hypertension. Because nitric oxide (NO) is a critical mediator in the development of pulmonary hypertension, the modulators of its downstream function may become target of pharmacolo...

journal_title：Frontiers in physiology

authors： Nydegger C,Martinelli C,Di Marco F,Bulfamante G,von Segesser L,Tozzi P,Samaja M,Milano G

更新日期：2018-03-27 00:00:00

abstract：:While it is widely known that marine mammals possess adaptations which allow them to make repetitive and extended dives to great depths without suffering ill effects seen in humans, the response of marine mammal immune cells to diving is unknown. Renewed interest in marine mammal dive physiology has arisen due to repo...

journal_title：Frontiers in physiology

authors： Thompson LA,Romano TA

更新日期：2015-05-06 00:00:00

abstract：:Chaste is an open-source C++ library for computational biology that has well-developed cardiac electrophysiology tissue simulation support. In this paper, we introduce the features available for performing cardiac electrophysiology action potential simulations using a wide range of models from the Physiome repository....

journal_title：Frontiers in physiology

authors： Cooper J,Spiteri RJ,Mirams GR

更新日期：2015-01-06 00:00:00

abstract：:Hallucinations - compelling perceptions of stimuli that aren't really there - occur in many psychiatric and neurological disorders, and are triggered by certain drugs of abuse. Despite their clinical importance, the neuronal mechanisms giving rise to hallucinations are poorly understood, in large part due to the absen...

journal_title：Frontiers in physiology

authors： Lee AH,Brandon CL,Wang J,Frost WN

更新日期：2018-06-25 00:00:00

abstract：:Background: It is known that the respiration-modulated photoplethysmographic (PPG) signals could be used to derive respiratory frequency (RF) and that PPG signals could be measured from different body sites. However, the accuracy of RF derived from PPG signals of different body sites has not been comprehensively inves...

journal_title：Frontiers in physiology

authors： Hartmann V,Liu H,Chen F,Hong W,Hughes S,Zheng D

更新日期：2019-06-18 00:00:00

abstract：:Alcoholic liver disease (ALD) encompasses hepatic steatosis, which may progress to alcoholic hepatitis, fibrosis, and cirrhosis. It remains a leading cause of morbidity and mortality in the US and worldwide. The severity of liver disease correlates with plasma levels of bacterial products in patients, and experimental...

journal_title：Frontiers in physiology

authors： Hartmann P,Chen WC,Schnabl B

更新日期：2012-10-11 00:00:00

abstract：:Mollusk shells are products of biomineralization and possess excellent mechanical properties, and shell matrix proteins (SMPs) have important functions in shell formation. A novel SMP with a PDZ domain (PDZ-domain-containing-protein-1, PDCP-1) was identified from the shell matrices of Mytilus coruscus. In this study, ...

journal_title：Frontiers in physiology

authors： Sun Q,Jiang Y,Yan X,Fan M,Zhang X,Xu H,Liao Z

更新日期：2020-10-02 00:00:00

abstract：:The free-fall of orbital spaceflight effectively removes the gravitational vector used as a primary spatial orientation reference on Earth. Sustained absence of this reference drives adaptive changes in the internal perception-action models of the central nervous system (CNS), most notably in the processing of the ves...

journal_title：Frontiers in physiology

authors： Ozdemir RA,Goel R,Reschke MF,Wood SJ,Paloski WH

更新日期：2018-11-27 00:00:00

abstract：:Previous studies reported enhanced cerebrovascular CO2 reactivity upon ascent to high altitude using linear models. However, there is evidence that this response may be sigmoidal in nature. Moreover, it was speculated that these changes at high altitude are mediated by alterations in acid-base buffering. Accordingly, ...

journal_title：Frontiers in physiology

authors： Fan JL,Subudhi AW,Duffin J,Lovering AT,Roach RC,Kayser B

更新日期：2016-01-08 00:00:00

abstract：:Single-channel kinetics has proven a powerful tool to reveal information about the gating mechanisms that control the opening and closing of ion channels. This introductory review focuses on the gating of large conductance Ca(2+)- and voltage-activated K(+) (BK or Slo1) channels at the single-channel level. It starts ...

journal_title：Frontiers in physiology

authors： Geng Y,Magleby KL

更新日期：2015-01-21 00:00:00

abstract：:Skeletal muscles are large cells with multiple nuclei that are precisely positioned. The importance of the correct nuclear position is highlighted by the correlation between mispositioned nuclei and muscle disease (Spiro et al., 1966; Gueneau et al., 2009). Myonuclei are generally considered to be equivalent and there...

journal_title：Frontiers in physiology

authors： Perillo M,Folker ES

更新日期：2018-11-01 00:00:00

abstract：:Voltage gated potassium channels (KV) are membrane proteins that allow selective flow of K+ ions in a voltage-dependent manner. These channels play an important role in several excitable cells as neurons, cardiomyocytes, and vascular smooth muscle. Over the last 20 years, it has been shown that omega-3 polyunsaturated...

journal_title：Frontiers in physiology

authors： Moreno C,de la Cruz A,Valenzuela C

更新日期：2016-11-24 00:00:00

abstract：:Yeast-like symbiotes (YLS), harbored in the abdomen fat-body cells of the rice brown planthopper (BPH), Nilaparvata lugens Stål (Hemiptera: Delphacidae), are vital to the growth and reproduction of their host. It is feasible to manipulate BPH infestation on rice by inhibiting YLS using fungicide. In this study, the fu...

journal_title：Frontiers in physiology

authors： Shentu X,Wang X,Xiao Y,Yu X

更新日期：2019-02-11 00:00:00

abstract：:Aim: mircoRNAs (miRNAs), small non-coding RNAs regulating gene expression, are stably secreted into the blood and circulating miRNAs (c-miRNAs) may play an important role in cell-cell communication. Furthermore, c-miRNAs might serve as novel biomarkers of the current vascular cell status. Here, we examined how the lev...

journal_title：Frontiers in physiology

authors： Wahl P,Wehmeier UF,Jansen FJ,Kilian Y,Bloch W,Werner N,Mester J,Hilberg T

更新日期：2016-12-26 00:00:00