The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease.


:Alcoholic liver disease (ALD) encompasses hepatic steatosis, which may progress to alcoholic hepatitis, fibrosis, and cirrhosis. It remains a leading cause of morbidity and mortality in the US and worldwide. The severity of liver disease correlates with plasma levels of bacterial products in patients, and experimental ALD depends on the level of gut derived bacterial products in rodents. Since intestinal decontamination and deficiency of bacterial product receptors or their downstream signaling molecules protect from alcohol-induced liver disease, bacterial translocation (BT), qualitative, and quantitative changes of the enteric microbiome are considered as being of fundamental importance in the pathogenesis of ALD. Recent enhancements in diagnostic technologies provide a better insight into these shifts. This review highlights vital events in ALD such as BT, the importance of Toll-like receptor (TLR) signaling, intestinal bacterial overgrowth (IBO), and changes in the intestinal microbiome. Furthermore, a treatment trial section of patients reviews possible future options of therapy for ALD modifying the enteric microbiome.


Front Physiol


Frontiers in physiology


Hartmann P,Chen WC,Schnabl B




Has Abstract


2012-10-11 00:00:00








  • Characterization of Protein Radicals in Arabidopsis.

    abstract::Oxidative modification of proteins in photosystem II (PSII) exposed to high light has been studied for a few decades, but the characterization of protein radicals formed by protein oxidation is largely unknown. Protein oxidation is induced by the direct reaction of proteins with reactive oxygen species known to form h...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Kumar A,Prasad A,Sedlářová M,Pospíšil P

    更新日期:2019-08-13 00:00:00

  • Short-Term Ketogenic Diet Improves Abdominal Obesity in Overweight/Obese Chinese Young Females.

    abstract::The purpose of this study was to examine the effects of a short-term ketogenic diet (KD) on body composition and cardiorespiratory fitness (CRF) in overweight/obese Chinese females. Twenty young females [age: 21.0 ± 3.7 years, weight: 65.5 ± 7.7 kg, body mass index (BMI): 24.9 ± 2.7 kg⋅m-2] consumed 4 weeks of a norma...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Kong Z,Sun S,Shi Q,Zhang H,Tong TK,Nie J

    更新日期:2020-07-28 00:00:00

  • Cannabinoid CB1 Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity.

    abstract::Gut-brain signaling controls feeding behavior and energy homeostasis; however, the underlying molecular mechanisms and impact of diet-induced obesity (DIO) on these pathways are poorly defined. We tested the hypothesis that elevated endocannabinoid activity at cannabinoid CB1 receptor (CB1Rs) in the gut of mice render...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Argueta DA,Perez PA,Makriyannis A,DiPatrizio NV

    更新日期:2019-06-11 00:00:00

  • Specialized Positioning of Myonuclei Near Cell-Cell Junctions.

    abstract::Skeletal muscles are large cells with multiple nuclei that are precisely positioned. The importance of the correct nuclear position is highlighted by the correlation between mispositioned nuclei and muscle disease (Spiro et al., 1966; Gueneau et al., 2009). Myonuclei are generally considered to be equivalent and there...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Perillo M,Folker ES

    更新日期:2018-11-01 00:00:00

  • Proton-Translocating Nicotinamide Nucleotide Transhydrogenase: A Structural Perspective.

    abstract::Nicotinamide nucleotide transhydrogenase (TH) is an enzyme complex in animal mitochondria and bacteria that utilizes the electrochemical proton gradient across membranes to drive the production of NADPH. The enzyme plays an important role in maintaining the redox balance of cells with implications in aging and a numbe...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Zhang Q,Padayatti PS,Leung JH

    更新日期:2017-12-19 00:00:00

  • Increased Serum Klotho With Age-Related Aortic Stiffness and Peripheral Vascular Resistance in Young and Middle-Aged Swine.

    abstract::The anti-aging function of Klotho gene has been implicated in age-related diseases. The physiological importance of Klotho in the progression of arterial stiffness with aging, however, remains unclear. The goal of this study is to determine the correlation of circulating Klotho with early age-related aortic stiffening...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Guo X,Kassab GS

    更新日期:2020-06-09 00:00:00

  • A Vaccinomics Approach for the Identification of Tick Protective Antigens for the Control of Ixodes ricinus and Dermacentor reticulatus Infestations in Companion Animals.

    abstract::Ticks and tick-borne pathogens affect health and welfare of companion animals worldwide, and some human tick-borne diseases are associated with exposure to domestic animals. Vaccines are the most environmentally friendly alternative to acaracides for the control of tick infestations, and to reduce the risk for tick-bo...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Contreras M,Villar M,de la Fuente J

    更新日期:2019-07-26 00:00:00

  • Controlling Parasympathetic Regulation of Heart Rate: A Gatekeeper Role for RGS Proteins in the Sinoatrial Node.

    abstract::Neurotransmitters released from sympathetic and parasympathetic nerve terminals in the sinoatrial node (SAN) exert their effects via G-protein-coupled receptors. Integration of these different G-protein signals within pacemaker cells of the SAN is critical for proper regulation of heart rate and function. For example,...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Mighiu AS,Heximer SP

    更新日期:2012-06-13 00:00:00

  • Self-Reported Periodization of Nutrition in Elite Female and Male Runners and Race Walkers.

    abstract::Athletes should achieve event-specific physiological requirements through careful periodization of training, underpinned by individualized and targeted nutrition strategies. However, evidence of whether, and how, elite endurance athletes periodize nutrition is scarce. Accordingly, elite international female (n = 67) a...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Heikura IA,Stellingwerff T,Burke LM

    更新日期:2018-12-03 00:00:00

  • Recent advances in the involvement of long non-coding RNAs in neural stem cell biology and brain pathophysiology.

    abstract::Exploration of non-coding genome has recently uncovered a growing list of formerly unknown regulatory long non-coding RNAs (lncRNAs) with important functions in stem cell pluripotency, development and homeostasis of several tissues. Although thousands of lncRNAs are expressed in mammalian brain in a highly patterned m...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Antoniou D,Stergiopoulos A,Politis PK

    更新日期:2014-04-22 00:00:00

  • Mitochondrial Reactive Oxygen Species and Kidney Hypoxia in the Development of Diabetic Nephropathy.

    abstract::The underlying mechanisms in the development of diabetic nephropathy are currently unclear and likely consist of a series of dynamic events from the early to late stages of the disease. Diabetic nephropathy is currently without curative treatments and it is acknowledged that even the earliest clinical manifestation of...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Schiffer TA,Friederich-Persson M

    更新日期:2017-04-11 00:00:00

  • Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity.

    abstract::Sudden cardiac death caused by ventricular arrhythmias is among the leading causes of mortality, with approximately half of all deaths attributed to heart disease worldwide. Periodic repolarization dynamics (PRD) is a novel marker of repolarization instability and strong predictor of death in patients post-myocardial ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Ang R,Marina N

    更新日期:2020-03-18 00:00:00

  • The Mouthparts Enriched Odorant Binding Protein 11 of the Alfalfa Plant Bug Adelphocoris lineolatus Displays a Preferential Binding Behavior to Host Plant Secondary Metabolites.

    abstract::Odorant binding proteins (OBPs) are proposed to be directly required for odorant discrimination and represent potential interesting targets for pest control. In the notoriously agricultural pest Adelphocoris lineolatus, our previous functional investigation of highly expressed antennal OBPs clearly supported this view...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Sun L,Wei Y,Zhang DD,Ma XY,Xiao Y,Zhang YN,Yang XM,Xiao Q,Guo YY,Zhang YJ

    更新日期:2016-06-01 00:00:00

  • Glutaraldehyde - A Subtle Tool in the Investigation of Healthy and Pathologic Red Blood Cells.

    abstract::Glutaraldehyde is a well-known substance used in biomedical research to fix cells. Since hemolytic anemias are often associated with red blood cell shape changes deviating from the biconcave disk shape, conservation of these shapes for imaging in general and 3D-imaging in particular, like confocal microscopy, scanning...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Abay A,Simionato G,Chachanidze R,Bogdanova A,Hertz L,Bianchi P,van den Akker E,von Lindern M,Leonetti M,Minetti G,Wagner C,Kaestner L

    更新日期:2019-05-14 00:00:00

  • Myocardial Blood Flow and Metabolic Rate of Oxygen Measurement in the Right and Left Ventricles at Rest and During Exercise Using 15O-Labeled Compounds and PET.

    abstract::Aims: Simultaneous measurement of right (RV) and left ventricle (LV) myocardial blood flow (MBF), oxygen extraction fraction (OEF), and oxygen consumption (MVO2) non-invasively in humans would provide new possibilities to understand cardiac physiology and different patho-physiological states. Methods: We developed and...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Kudomi N,Kalliokoski KK,Oikonen VJ,Han C,Kemppainen J,Sipilä HT,Knuuti J,Heinonen IHA

    更新日期:2019-06-19 00:00:00

  • Where to Step? Contributions of Stance Leg Muscle Spindle Afference to Planning of Mediolateral Foot Placement for Balance Control in Young and Old Adults.

    abstract::Stable gait requires active control of the mediolateral (ML) kinematics of the body center of mass (CoM) and the base of support (BoS) in relation to each other. Stance leg hip abductor (HA) muscle spindle afference may be used to guide contralateral swing foot placement and adequately position the BoS in relation to ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Arvin M,Hoozemans MJM,Pijnappels M,Duysens J,Verschueren SM,van Dieën JH

    更新日期:2018-08-21 00:00:00

  • Value of Blood-Based microRNAs in the Diagnosis of Acute Myocardial Infarction: A Systematic Review and Meta-Analysis.

    abstract::Background: Recent studies have shown that blood-based miRNAs are dysregulated in patients with acute myocardial infarction (AMI) and are therefore a potential tool for the diagnosis of AMI. Therefore, this study summarized and evaluated studies focused on microRNAs as novel biomarkers for the diagnosis of AMI from th...

    journal_title:Frontiers in physiology



    authors: Zhai C,Li R,Hou K,Chen J,Alzogool M,Hu Y,Zhang J,Zhang Y,Wang L,Zhang R,Cong H

    更新日期:2020-08-14 00:00:00

  • Cadherin-11 Is Required for Neural Crest Specification and Survival.

    abstract::Neural crest (NC) cells are multipotent embryonic cells that form melanocytes, craniofacial bone and cartilage, and the peripheral nervous system in vertebrates. NC cells express many cadherin proteins, which control their specification, epithelial to mesenchymal transition (EMT), migration, and mesenchymal to epithel...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Manohar S,Camacho-Magallanes A,Echeverria C Jr,Rogers CD

    更新日期:2020-10-30 00:00:00

  • Molecular Characterization of a Novel Shell Matrix Protein With PDZ Domain From Mytilus coruscus.

    abstract::Mollusk shells are products of biomineralization and possess excellent mechanical properties, and shell matrix proteins (SMPs) have important functions in shell formation. A novel SMP with a PDZ domain (PDZ-domain-containing-protein-1, PDCP-1) was identified from the shell matrices of Mytilus coruscus. In this study, ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Sun Q,Jiang Y,Yan X,Fan M,Zhang X,Xu H,Liao Z

    更新日期:2020-10-02 00:00:00

  • Alteration in Taste Perception in Cancer: Causes and Strategies of Treatment.

    abstract::The sense of taste is responsible for the detection and ingestion of food to cover energetic requirements in health and disease. The change in taste perception might lead to malnutrition that is usually one of the frequent causes of morbidity and mortality in patients with cancer. In this review, we summarize the mech...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Murtaza B,Hichami A,Khan AS,Ghiringhelli F,Khan NA

    更新日期:2017-03-08 00:00:00

  • Efficacy of Stochastic Vestibular Stimulation to Improve Locomotor Performance During Adaptation to Visuomotor and Somatosensory Distortion.

    abstract::Astronauts exposed to microgravity face sensorimotor challenges affecting balance control when readapting to Earth's gravity upon return from spaceflight. Small amounts of electrical noise applied to the vestibular system have been shown to improve balance control during standing and walking under discordant sensory c...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Temple DR,De Dios YE,Layne CS,Bloomberg JJ,Mulavara AP

    更新日期:2018-03-29 00:00:00

  • Marine Mammals' NMDA Receptor Structure: Possible Adaptation to High Pressure Environment.

    abstract::Divers that are exposed to high pressure (HP) above 1.1 MPa suffer from High Pressure Neurological Syndrome (HPNS), which is implicated with central nervous system (CNS) malfunction. Marine mammals performing extended and deep breath-hold dives are exposed to almost 20 MPa without apparent HPNS symptoms. N-methyl-D-as...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Bliznyuk A,Golan H,Grossman Y

    更新日期:2018-11-22 00:00:00

  • Echolocation by the harbour porpoise: life in coastal waters.

    abstract::The harbor porpoise is one of the smallest and most widely spread of all toothed whales. They are found abundantly in coastal waters all around the northern hemisphere. They are among the 11 species known to use high frequency sonar of relative narrow bandwidth. Their narrow biosonar beam helps isolate echoes from pre...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Miller LA,Wahlberg M

    更新日期:2013-04-15 00:00:00

  • To Flex or Rest: Does Adding No-Load Isometric Actions to the Inter-Set Rest Period in Resistance Training Enhance Muscular Adaptations? A Randomized-Controlled Trial.

    abstract::We aimed to investigate the effects of resistance training (RT) combined with no-load isometric actions (iso-holds) during the inter-set recovery period versus RT that involves passive inter-set rest on muscular strength, muscular hypertrophy, and muscular endurance in resistance-trained men. Twenty-seven resistance-t...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Schoenfeld BJ,Grgic J,Contreras B,Delcastillo K,Alto A,Haun C,De Souza EO,Vigotsky AD

    更新日期:2020-01-15 00:00:00

  • Insecticidal Effects of Hemocoelic Delivery of Bacillus thuringiensis Cry Toxins in Achaea janata Larvae.

    abstract::Insecticidal effects of Bacillus thuringiensis Cry toxins in hemocoel of larvae have not been properly evaluated. In the present study, hemocoelic injection of four representative Cry toxins i.e., Cry1Aa, Cry1Ab, Cry1Ac, and DOR5 to an economically important lepidopteran insect pest Achaea janata, induced larval morta...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Ningshen TJ,Chauhan VK,Dhania NK,Dutta-Gupta A

    更新日期:2017-05-10 00:00:00

  • High Glucose Suppresses Keratinocyte Migration Through the Inhibition of p38 MAPK/Autophagy Pathway.

    abstract::Wound healing is delayed frequently in patients with diabetes. Proper keratinocyte migration is an essential step during re-epithelialization. Impaired keratinocyte migration is a critical underlying factor responsible for the deficiency of diabetic wound healing, which is mainly attributed to the hyperglycemic state....

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Li L,Zhang J,Zhang Q,Zhang D,Xiang F,Jia J,Wei P,Zhang J,Hu J,Huang Y

    更新日期:2019-01-28 00:00:00

  • An Augmented Negative Force-Frequency Relationship and Slowed Mechanical Restitution Are Associated With Increased Susceptibility to Drug-Induced Torsade de Pointes Arrhythmias in the Chronic Atrioventricular Block Dog.

    abstract::Introduction: In the chronic AV-block (CAVB) dog model, structural, contractile, and electrical remodeling occur, which predispose the heart to dofetilide-induced Torsade de Pointes (TdP) arrhythmias. Previous studies found a relation between electrical remodeling and inducibility of TdP, while structural remodeling i...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Sprenkeler DJ,Bossu A,Beekman JDM,Schoenmakers M,Vos MA

    更新日期:2018-08-08 00:00:00

  • Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart.

    abstract::Aging is associated with a decline in cardiac function due to a decreased myocardial reserve. This adverse cardiac remodeling comprises of a variety of changes, including a reduction in mitochondrial function and a decline in the expression of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Whitehead N,Gill JF,Brink M,Handschin C

    更新日期:2018-03-21 00:00:00

  • Different Types of Sounds and Their Relationship With the Electrocardiographic Signals and the Cardiovascular System - Review.

    abstract::Background: For some time now, the effects of sound, noise, and music on the human body have been studied. However, despite research done through time, it is still not completely clear what influence, interaction, and effects sounds have on human body. That is why it is necessary to conduct new research on this topic....

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Idrobo-Ávila EH,Loaiza-Correa H,van Noorden L,Muñoz-Bolaños FG,Vargas-Cañas R

    更新日期:2018-05-22 00:00:00

  • Is central dogma a global property of cellular information flow?

    abstract::The central dogma of molecular biology has come under scrutiny in recent years. Here, we reviewed high-throughput mRNA and protein expression data of Escherichia coli, Saccharomyces cerevisiae, and several mammalian cells. At both single cell and population scales, the statistical comparisons between the entire transc...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Piras V,Tomita M,Selvarajoo K

    更新日期:2012-11-23 00:00:00