Cerebral vs. Cardiovascular Responses to Exercise in Type 2 Diabetic Patients.

Abstract:

:The human brain is constantly active and even small limitations to cerebral blood flow (CBF) may be critical for preserving oxygen and substrate supply, e.g., during exercise and hypoxia. Exhaustive exercise evokes a competition for the supply of oxygenated blood between the brain and the working muscles, and inability to increase cardiac output sufficiently during exercise may jeopardize cerebral perfusion of relevance for diabetic patients. The challenge in diabetes care is to optimize metabolic control to slow progression of vascular disease, but likely because of a limited ability to increase cardiac output, these patients perceive aerobic exercise to be more strenuous than healthy subjects and that limits the possibility to apply physical activity as a preventive lifestyle intervention. In this review, we consider the effects of functional activation by exercise on the brain and how it contributes to understanding the control of CBF with the limited exercise tolerance experienced by type 2 diabetic patients. Whether a decline in cerebral oxygenation and thereby reduced neural drive to working muscles plays a role for "central" fatigue during exhaustive exercise is addressed in relation to brain's attenuated vascular response to exercise in type 2 diabetic subjects.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Kim YS,van der Ster BJP,Brassard P,Secher NH,van Lieshout JJ

doi

10.3389/fphys.2020.583155

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

583155

issn

1664-042X

journal_volume

11

pub_type

杂志文章,评审
  • The Influence of Mid-Event Deception on Psychophysiological Status and Pacing Can Persist across Consecutive Disciplines and Enhance Self-paced Multi-modal Endurance Performance.

    abstract::Purpose: To examine the effects of deceptively aggressive bike pacing on performance, pacing, and associated physiological and perceptual responses during simulated sprint-distance triathlon. Methods: Ten non-elite, competitive male triathletes completed three simulated sprint-distance triathlons (0.75 km swim, 500 kJ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00006

    authors: Taylor D,Smith MF

    更新日期:2017-01-24 00:00:00

  • Supervised Machine Learning Applied to Automate Flash and Prolonged Capillary Refill Detection by Pulse Oximetry.

    abstract:Objective:Develop an automated approach to detect flash (<1.0 s) or prolonged (>2.0 s) capillary refill time (CRT) that correlates with clinician judgment by applying several supervised machine learning (ML) techniques to pulse oximeter plethysmography data. Materials and Methods:Data was collected in the Pediatric In...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.564589

    authors: Hunter RB,Jiang S,Nishisaki A,Nickel AJ,Napolitano N,Shinozaki K,Li T,Saeki K,Becker LB,Nadkarni VM,Masino AJ

    更新日期:2020-10-06 00:00:00

  • β-adrenergic receptor responsiveness in aging heart and clinical implications.

    abstract::Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle inotropic reserve related to increased vascular afterload, arterial-ventricular load mismatching, physical deconditioning and impaired autonomic regulation (the so called "β-adrenergic desensitization"). Adrenergic responsiven...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2013.00396

    authors: Ferrara N,Komici K,Corbi G,Pagano G,Furgi G,Rengo C,Femminella GD,Leosco D,Bonaduce D

    更新日期:2014-01-09 00:00:00

  • The Role of Carotid Sinus Nerve Input in the Hypoxic-Hypercapnic Ventilatory Response in Juvenile Rats.

    abstract::In juvenile rats, the carotid body (CB) is the primary sensor of oxygen (O2) and a secondary sensor of carbon dioxide (CO2) in the blood. The CB communicates to the respiratory pattern generator via the carotid sinus nerve, which terminates within the commissural nucleus tractus solitarius (cNTS). While this is not th...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.613786

    authors: Getsy PM,Coffee GA,Lewis SJ

    更新日期:2020-12-17 00:00:00

  • Integrated Analysis of Long Non-coding RNAs (LncRNAs) and mRNA Expression Profiles Reveals the Potential Role of LncRNAs in Skeletal Muscle Development of the Chicken.

    abstract::Long non-coding RNAs (lncRNAs) play important roles in transcriptional and post-transcriptional regulation. However, little is currently known about the mechanisms by which they regulate skeletal muscle development in the chicken. In this study, we used RNA sequencing to profile the leg muscle transcriptome (lncRNA an...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00687

    authors: Li Z,Ouyang H,Zheng M,Cai B,Han P,Abdalla BA,Nie Q,Zhang X

    更新日期:2017-01-09 00:00:00

  • Specialized Positioning of Myonuclei Near Cell-Cell Junctions.

    abstract::Skeletal muscles are large cells with multiple nuclei that are precisely positioned. The importance of the correct nuclear position is highlighted by the correlation between mispositioned nuclei and muscle disease (Spiro et al., 1966; Gueneau et al., 2009). Myonuclei are generally considered to be equivalent and there...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01531

    authors: Perillo M,Folker ES

    更新日期:2018-11-01 00:00:00

  • Identification of Wolbachia-Responsive miRNAs in the Small Brown Planthopper, Laodelphax striatellus.

    abstract::Laodelphax striatellus is naturally infected with the Wolbachia strain wStri, which induces strong cytoplasmic incompatibility of its host. MicroRNAs (miRNAs) are a class of endogenous non-coding small RNAs that play a critical role in the regulation of gene expression at post-transcriptional level in various biologic...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00928

    authors: Liu L,Zhang KJ,Rong X,Li YY,Liu H

    更新日期:2019-07-24 00:00:00

  • Designing Brains for Pain: Human to Mollusc.

    abstract::There is compelling evidence that the "what it feels like" subjective experience of sensory stimuli arises in the cerebral cortex in both humans as well as mammalian experimental animal models. Humans are alone in their ability to verbally communicate their experience of the external environment. In other species, sen...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01027

    authors: Key B,Brown D

    更新日期:2018-08-02 00:00:00

  • Re-visiting the embryogenesis of the human lower lip: an overlooked paradigm.

    abstract::The rare opportunity to study a human fetus showing bilateral clefting of the lower lip along with other associated anomalies resembling those of the equally rare Pena-Shokeir phenotype prompts this report. The scarcity of reports on bilateral clefts of the lower lip has strengthened the conventional understanding or,...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00333

    authors: Vastardis H,Spyropoulos MN,Burdi AR

    更新日期:2012-08-24 00:00:00

  • Effects of Hypoxia on Erythrocyte Membrane Properties-Implications for Intravascular Hemolysis and Purinergic Control of Blood Flow.

    abstract::Intravascular hemolysis occurs in hereditary, acquired, and iatrogenic hemolytic conditions but it could be also a normal physiological process contributing to intercellular signaling. New evidence suggests that intravascular hemolysis and the associated release of adenosine triphosphate (ATP) may be an important mech...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2017.01110

    authors: Grygorczyk R,Orlov SN

    更新日期:2017-12-22 00:00:00

  • Deleting Titin's C-Terminal PEVK Exons Increases Passive Stiffness, Alters Splicing, and Induces Cross-Sectional and Longitudinal Hypertrophy in Skeletal Muscle.

    abstract::The Proline, Glutamate, Valine and Lysine-rich (PEVK) region of titin constitutes an entropic spring that provides passive tension to striated muscle. To study the functional and structural repercussions of a small reduction in the size of the PEVK region, we investigated skeletal muscles of a mouse with the constitut...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00494

    authors: van der Pijl RJ,Hudson B,Granzier-Nakajima T,Li F,Knottnerus AM,Smith J,Chung CS,Gotthardt M,Granzier HL,Ottenheijm CAC

    更新日期:2020-05-29 00:00:00

  • Different Types of Sounds and Their Relationship With the Electrocardiographic Signals and the Cardiovascular System - Review.

    abstract::Background: For some time now, the effects of sound, noise, and music on the human body have been studied. However, despite research done through time, it is still not completely clear what influence, interaction, and effects sounds have on human body. That is why it is necessary to conduct new research on this topic....

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2018.00525

    authors: Idrobo-Ávila EH,Loaiza-Correa H,van Noorden L,Muñoz-Bolaños FG,Vargas-Cañas R

    更新日期:2018-05-22 00:00:00

  • Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity.

    abstract::Sudden cardiac death caused by ventricular arrhythmias is among the leading causes of mortality, with approximately half of all deaths attributed to heart disease worldwide. Periodic repolarization dynamics (PRD) is a novel marker of repolarization instability and strong predictor of death in patients post-myocardial ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2020.00236

    authors: Ang R,Marina N

    更新日期:2020-03-18 00:00:00

  • Ephrin regulation of palate development.

    abstract::Studies of palate development are motivated by the all too common incidence of cleft palate, a birth defect that imposes a tremendous health burden and can leave lasting disfigurement. Although, mechanistic studies of palate growth and fusion have focused on growth factors such as Transforming Growth Factor ß-3 (Tgfß3...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00376

    authors: Benson MD,Serrano MJ

    更新日期:2012-09-26 00:00:00

  • Long-Term Chronic Intermittent Hypobaric Hypoxia Induces Glucose Transporter (GLUT4) Translocation Through AMP-Activated Protein Kinase (AMPK) in the Soleus Muscle in Lean Rats.

    abstract::Background: In chronic hypoxia (CH) and short-term chronic intermittent hypoxia (CIH) exposure, glycemia and insulin levels decrease and insulin sensitivity increases, which can be explained by changes in glucose transport at skeletal muscles involving GLUT1, GLUT4, Akt, and AMPK, as well as GLUT4 translocation to cel...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00799

    authors: Siques P,Brito J,Flores K,Ordenes S,Arriaza K,Pena E,León-Velarde F,López de Pablo ÁL,Gonzalez MC,Arribas S

    更新日期:2018-06-28 00:00:00

  • Reconsideration of Serial Visual Reversal Learning in Octopus (Octopus vulgaris) from a Methodological Perspective.

    abstract::Octopuses (Octopus vulgaris) are generally considered to possess extraordinary cognitive abilities including the ability to successfully perform in a serial reversal learning task. During reversal learning, an animal is presented with a discrimination problem and after reaching a learning criterion, the signs of the s...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00054

    authors: Bublitz A,Weinhold SR,Strobel S,Dehnhardt G,Hanke FD

    更新日期:2017-02-07 00:00:00

  • Modeling Interactions among Individual P2 Receptors to Explain Complex Response Patterns over a Wide Range of ATP Concentrations.

    abstract::Extracellular ATP acts on the P2X family of ligand-gated ion channels and several members of the P2Y family of G protein-coupled receptors to mediate intercellular communication among many cell types including bone-forming osteoblasts. It is known that multiple P2 receptors are expressed on osteoblasts (P2X2,5,6,7 and...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00294

    authors: Xing S,Grol MW,Grutter PH,Dixon SJ,Komarova SV

    更新日期:2016-07-13 00:00:00

  • The Variation Tendency of Polyamines Forms and Components of Polyamine Metabolism in Zoysiagrass (Zoysia japonica Steud.) to Salt Stress with Exogenous Spermidine Application.

    abstract::To understand dynamic changes in polyamines (PAs) forms and components of polyamine metabolism in zoysiagrass (Zoysia japonica Steud.) response to salt stress with exogenous spermidine (Spd) application, two Chinese zoysia cultivars, z081 and z057, were exposed to sodium chloride stress for 2, 4, 6, and 8 days. The z0...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00208

    authors: Li S,Cui L,Zhang Y,Wang Y,Mao P

    更新日期:2017-04-06 00:00:00

  • Expression of South East Asian Ovalocytic Band 3 Disrupts Erythroblast Cytokinesis and Reticulocyte Maturation.

    abstract::Southeast Asian Ovalocytosis results from a heterozygous deletion of 9 amino acids in the erythrocyte anion exchange protein AE1 (band 3). The report of the first successful birth of an individual homozygous for this mutation showed an association with severe dyserythropoietic anemia. Imaging of the proband's erythroc...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00357

    authors: Flatt JF,Stevens-Hernandez CJ,Cogan NM,Eggleston DJ,Haines NM,Heesom KJ,Picard V,Thomas C,Bruce LJ

    更新日期:2020-04-28 00:00:00

  • AltitudeOmics: Spontaneous Baroreflex Sensitivity During Acclimatization to 5,260 m: A Comparison of Methods.

    abstract:Introduction:Baroreflex sensitivity (BRS) is essential to ensure rapid adjustment to variations in blood pressure (BP). Spontaneous baroreflex function can be assessed using continuous recordings of blood pressure. The goal of this study was to compare four methods for BRS quantification [the sequence, Bernardi's (BER)...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01505

    authors: Bourdillon N,Yazdani S,Vesin JM,Subudhi AW,Lovering AT,Roach RC,Kayser B

    更新日期:2019-12-10 00:00:00

  • Trawling bats exploit an echo-acoustic ground effect.

    abstract::A water surface acts not only as an optic mirror but also as an acoustic mirror. Echolocation calls emitted by bats at low heights above water are reflected away from the bat, and hence the background clutter is reduced. Moreover, targets on the surface create an enhanced echo. Here, we formally quantified the effect ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2013.00065

    authors: Zsebok S,Kroll F,Heinrich M,Genzel D,Siemers BM,Wiegrebe L

    更新日期:2013-04-05 00:00:00

  • Positive Impact of Thermal Manipulation During Embryogenesis on Foie Gras Production in Mule Ducks.

    abstract::Animal studies have shown that very early life events may have programing effects on adult metabolism and health. In this study, we aim, for the first, time to elucidate the effects of embryonic thermal manipulation (TM) on the performance of overfed mule ducks, in particular for the production of foie gras (fatty liv...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.01495

    authors: Massimino W,Davail S,Bernadet MD,Pioche T,Tavernier A,Ricaud K,Gontier K,Bonnefont C,Manse H,Morisson M,Fauconneau B,Collin A,Panserat S,Houssier M

    更新日期:2019-12-12 00:00:00

  • Daily Intermittent Normobaric Hypoxia Over 2 Weeks Reduces BDNF Plasma Levels in Young Adults - A Randomized Controlled Feasibility Study.

    abstract::Background: The results from animal and human research indicate that acute intermittent hypoxia can enhance brain-derived neurotrophic factor (BDNF) plasma levels and gene expression. As BDNF is known to promote the differentiation of new neurons and the formation of synapses, it has been proposed to mediate adult neu...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01337

    authors: Becke A,Müller P,Dordevic M,Lessmann V,Brigadski T,Müller NG

    更新日期:2018-10-01 00:00:00

  • The impact of escitalopram on vagally mediated cardiovascular function to stress and the moderating effects of vigorous physical activity: a randomized controlled treatment study in healthy participants.

    abstract::Recent concerns over the impact of antidepressant medications, including the selective serotonin reuptake inhibitors (SSRIs), on cardiovascular function highlight the importance of research on the moderating effects of specific lifestyle factors such as physical activity. Studies in affective neuroscience have demonst...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2013.00259

    authors: Hanson CS,Outhred T,Brunoni AR,Malhi GS,Kemp AH

    更新日期:2013-09-24 00:00:00

  • Immune Defenses of a Beneficial Pest: The Mealworm Beetle, Tenebrio molitor.

    abstract::The mealworm beetle, Tenebrio molitor, is currently considered as a pest when infesting stored grains or grain products. However, mealworms are now being promoted as a beneficial insect because their high nutrient content makes them a viable food source and because they are capable of degrading polystyrene and plastic...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2019.00138

    authors: Vigneron A,Jehan C,Rigaud T,Moret Y

    更新日期:2019-03-12 00:00:00

  • Post-mortem Characterisation of a Case With an ACTG1 Variant, Agenesis of the Corpus Callosum and Neuronal Heterotopia.

    abstract::Cytoplasmic Actin Gamma 1 (ACTG1) gene variant are autosomal dominant and can cause CNS anomalies (Baraitser Winter Malformation Syndrome; BWMS). ACTG1 anomalies in offspring include agenesis of the corpus callosum (ACC) and neuronal heterotopia which are ectopic nodules of nerve cells that failed to migrate appropria...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00623

    authors: Vontell R,Supramaniam VG,Davidson A,Thornton C,Marnerides A,Holder-Espinasse M,Lillis S,Yau S,Jansson M,Hagberg HE,Rutherford MA

    更新日期:2019-05-24 00:00:00

  • Impact and management of physiological calibration in spectral analysis of blood pressure variability.

    abstract::Physiological calibration (Physiocal) improves the quality of continuous blood pressure (BP) signal from finger. However, the effects of Physiocal on spectral characteristics of systolic BP (SBP) variability are not well-known. We tested the hypothesis that the use of Physiocal may alter the results on SBP variability...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2014.00473

    authors: Kiviniemi AM,Hintsala H,Hautala AJ,Ikäheimo TM,Jaakkola JJ,Tiinanen S,Seppänen T,Tulppo MP

    更新日期:2014-12-03 00:00:00

  • Mitochondrial and cellular mechanisms for managing lipid excess.

    abstract::Current scientific debates center on the impact of lipids and mitochondrial function on diverse aspects of human health, nutrition and disease, among them the association of lipotoxicity with the onset of insulin resistance in skeletal muscle, and with heart dysfunction in obesity and diabetes. Mitochondria play a fun...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2014.00282

    authors: Aon MA,Bhatt N,Cortassa SC

    更新日期:2014-07-31 00:00:00

  • Metabolic and hormonal signatures in pre-manifest and manifest Huntington's disease patients.

    abstract::Huntington's disease (HD) is an inherited neurodegenerative disorder typified by involuntary body movements, and psychiatric and cognitive abnormalities. Many HD patients also exhibit metabolic changes including progressive weight loss and appetite dysfunction. Here we have investigated metabolic function in pre-manif...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2014.00231

    authors: Wang R,Ross CA,Cai H,Cong WN,Daimon CM,Carlson OD,Egan JM,Siddiqui S,Maudsley S,Martin B

    更新日期:2014-06-23 00:00:00

  • Nitric Oxide and Oxidative Stress Changes at Depth in Breath-Hold Diving.

    abstract:Background:Several mechanisms allow humans to resist the extreme conditions encountered during breath-hold diving. Available nitric oxide (NO) is one of the major contributors to such complex adaptations at depth and oxidative stress is one of the major collateral effects of diving. Due to technical difficulties, these...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.609642

    authors: Cialoni D,Brizzolari A,Samaja M,Bosco G,Paganini M,Pieri M,Lancellotti V,Marroni A

    更新日期:2021-01-07 00:00:00