Abstract:
:The rare opportunity to study a human fetus showing bilateral clefting of the lower lip along with other associated anomalies resembling those of the equally rare Pena-Shokeir phenotype prompts this report. The scarcity of reports on bilateral clefts of the lower lip has strengthened the conventional understanding or, perhaps even dogma that the lower lip and jaw develop from the progressive midline merging of just two mandibular prominences in the embryo. On the basis of observations stemming from this case report, it is proposed that yet another developmental event or process (in addition to the midline merging of the mandibular prominences) may be operable in the normal morphogenesis of the lower lip and anterior mandibular region. The bilateral paramedian clefting observed provides evidence that another distinct developmental region, a small medial process complements mandibular morphogenesis.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Vastardis H,Spyropoulos MN,Burdi ARdoi
10.3389/fphys.2012.00333subject
Has Abstractpub_date
2012-08-24 00:00:00pages
333issn
1664-042Xjournal_volume
3pub_type
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pub_type: 杂志文章,评审
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journal_title:Frontiers in physiology
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doi:10.3389/fphys.2012.00253
更新日期:2012-07-20 00:00:00
abstract::The cell-division cycle (CDC) is driven by cyclin-dependent kinases (CDKs). Mathematical models based on molecular networks, as revealed by molecular and genetic studies, have reproduced the oscillatory behavior of CDK activity. Thus, one basic system for representing the CDC is a biochemical oscillator (CDK oscillato...
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pub_type: 杂志文章,评审
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