Have we missed that neural vasodilator mechanisms may contribute to exercise hyperemia at onset of voluntary exercise?

abstract：:Advances in the development of voltage sensitive dyes and Ca(2+) sensors in combination with innovative microscopy techniques allowed researchers to perform functional measurements with an unprecedented spatial and temporal resolution. At the moment, one of the shortcomings of available technologies is their incapabil...

journal_title：Frontiers in physiology

authors： Crocini C,Coppini R,Ferrantini C,Pavone FS,Sacconi L

更新日期：2014-10-20 00:00:00

abstract：:Pluripotency in human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) is regulated by three transcription factors-OCT3/4, SOX2, and NANOG. To fully exploit the therapeutic potential of these cells it is essential to have a good mechanistic understanding of the maintenance of self-renewal and pl...

journal_title：Frontiers in physiology

authors： Peterson H,Abu Dawud R,Garg A,Wang Y,Vilo J,Xenarios I,Adjaye J

更新日期：2013-10-28 00:00:00

abstract：:Chronic kidney disease (CKD) can have an insidious onset because there is a gradual decline in nephron number throughout life. There may be no overt symptoms of renal dysfunction until about two thirds or more of the nephrons have been destroyed and glomerular filtration rate (GFR) falls to below 25% of normal (often ...

journal_title：Frontiers in physiology

authors： Lumbers ER,Kandasamy Y,Delforce SJ,Boyce AC,Gibson KJ,Pringle KG

更新日期：2020-07-16 00:00:00

abstract：:Aim: Combined use of herbal medicines in patients underwent dual antiplatelet therapy (DAPT) might cause bleeding or thrombosis because herbal medicines with anti-platelet activities may exhibit interactions with DAPT. In this study, we tried to use a feedback system control (FSC) optimization technique to optimize do...

journal_title：Frontiers in physiology

authors： Liu W,Li YL,Feng MT,Zhao YW,Ding X,He B,Liu X

更新日期：2018-05-04 00:00:00

abstract：:Leucine-rich repeat containing protein 10 (LRRC10) is a cardiomyocyte-specific member of the Leucine-rich repeat containing (LRRC) protein superfamily with critical roles in cardiac function and disease pathogenesis. Recent studies have identified LRRC10 mutations in human idiopathic dilated cardiomyopathy (DCM) and L...

journal_title：Frontiers in physiology

authors： Brody MJ,Lee Y

更新日期：2016-08-03 00:00:00

abstract：:A primary goal of enamel research is to understand and potentially treat or prevent enamel defects related to amelogenesis imperfecta (AI). Rodents are ideal models to assist our understanding of how enamel is formed because they are easily genetically modified, and their continuously erupting incisors display all sta...

journal_title：Frontiers in physiology

authors： Pugach MK,Gibson CW

更新日期：2014-09-17 00:00:00

abstract：:Patients undergoing the complex treatment for hematological malignancies are exposed to a high physiological and psychological distress inducing fatigue and physical inactivity. In line with cancer-related metabolic changes patients are predisposed for skeletal muscle mass loss that leads to a functional decline, affe...

journal_title：Frontiers in physiology

authors： Schink K,Reljic D,Herrmann HJ,Meyer J,Mackensen A,Neurath MF,Zopf Y

更新日期：2018-12-18 00:00:00

abstract：:The central dogma of molecular biology has come under scrutiny in recent years. Here, we reviewed high-throughput mRNA and protein expression data of Escherichia coli, Saccharomyces cerevisiae, and several mammalian cells. At both single cell and population scales, the statistical comparisons between the entire transc...

journal_title：Frontiers in physiology

authors： Piras V,Tomita M,Selvarajoo K

更新日期：2012-11-23 00:00:00

abstract：:Erythropoietin (Epo) is an indispensable erythropoietic hormone primarily produced from renal Epo-producing cells (REPs). Epo production in REPs is tightly regulated in a hypoxia-inducible manner to maintain tissue oxygen homeostasis. Insufficient Epo production by REPs causes renal anemia and anemia associated with c...

journal_title：Frontiers in physiology

authors： Souma T,Suzuki N,Yamamoto M

更新日期：2015-06-03 00:00:00

abstract：:Recent progress in high-throughput data acquisition has shifted the focus from data generation to processing and understanding of how to integrate collected information. Context specific reconstruction based on generic genome scale models like ReconX or HMR has the potential to become a diagnostic and treatment tool t...

journal_title：Frontiers in physiology

authors： Pacheco MP,Pfau T,Sauter T

更新日期：2016-01-22 00:00:00

abstract：:Many disease fighting strategies have focused on the generation of NK cells, since they constitute the main immune barrier against cancer and intracellular pathogens such as viruses. Therefore, a predictive model for the development of NK cells would constitute a useful tool to test several hypotheses regarding the pr...

journal_title：Frontiers in physiology

authors： Liquitaya-Montiel AJ,Mendoza L

更新日期：2018-08-02 00:00:00

abstract：:With the advent of high-throughput technologies, the field of systems biology has amassed an abundance of "omics" data, quantifying thousands of cellular components across a variety of scales, ranging from mRNA transcript levels to metabolite quantities. Methods are needed to not only integrate this omics data but to ...

journal_title：Frontiers in physiology

authors： Blazier AS,Papin JA

更新日期：2012-08-06 00:00:00

abstract：:During formation of the secondary palate in mammalian embryos, two vertically oriented palatal shelves rapidly elevate into a horizontal position above the tongue, meet at the midline, and fuse to form a single entity. Previous observations suggested that elevation occurs by a simple 90° rotation of the palatal shelve...

journal_title：Frontiers in physiology

authors： Chiquet M,Blumer S,Angelini M,Mitsiadis TA,Katsaros C

更新日期：2016-09-07 00:00:00

abstract：:The upcoming exploration missions will imply a much longer duration than any of the missions flown so far. In these missions, physiological adaptation to the new environment leads to changes in different body systems, such as the cardiovascular and musculoskeletal systems, metabolic and neurobehavioral health and immu...

journal_title：Frontiers in physiology

authors： Turroni S,Magnani M,Kc P,Lesnik P,Vidal H,Heer M

更新日期：2020-09-08 00:00:00

abstract：:Cataract, the loss of ocular lens transparency, accounts for ∼50% of worldwide blindness and has been associated with water and solute transport dysfunction across lens cellular barriers. We show that neutral amino acid antiporter LAT2 (Slc7a8) and uniporter TAT1 (Slc16a10) are expressed on mouse ciliary epithelium an...

journal_title：Frontiers in physiology

authors： Knöpfel EB,Vilches C,Camargo SMR,Errasti-Murugarren E,Stäubli A,Mayayo C,Munier FL,Miroshnikova N,Poncet N,Junza A,Bhattacharya SS,Prat E,Berry V,Berger W,Heon E,Moore AT,Yanes Ó,Nunes V,Palacín M,Verrey F,Kloecke

更新日期：2019-06-04 00:00:00

abstract：:Gravity has remained constant during animal evolution and the neural sensory systems detecting acceleration forces have remained remarkably conserved among vertebrates. The utricular organ senses the sum of inertial force due to head translation and head tilt relative to gravitational vertical. Change in gravitational...

journal_title：Frontiers in physiology

authors： Boyle R,Popova Y,Varelas J

更新日期：2018-10-22 00:00:00

abstract：:Social attachment formed by filial imprinting in newborn chicks undergoes a process of memory consolidation that involves rearrangement of its neural storage substrates. In the first 3 h after imprinting it depends on the integrity of the intermediate medial mesopallium (IMM) and beyond that time on unidentified memor...

journal_title：Frontiers in physiology

authors： Tiunova AA,Komissarova NV,Anokhin KV

更新日期：2019-03-29 00:00:00

abstract：:Atherosclerosis is the leading cause of death worldwide. Over the past two decades, it has been clearly recognized that atherosclerosis is an inflammatory disease of the arterial wall. Accumulating data from animal experiments have supported this hypothesis, however, clinical applications making use of this knowledge ...

journal_title：Frontiers in physiology

authors： Linden F,Domschke G,Erbel C,Akhavanpoor M,Katus HA,Gleissner CA

更新日期：2014-11-21 00:00:00

abstract：:Current scientific debates center on the impact of lipids and mitochondrial function on diverse aspects of human health, nutrition and disease, among them the association of lipotoxicity with the onset of insulin resistance in skeletal muscle, and with heart dysfunction in obesity and diabetes. Mitochondria play a fun...

journal_title：Frontiers in physiology

authors： Aon MA,Bhatt N,Cortassa SC

更新日期：2014-07-31 00:00:00

abstract：:Purpose: To determine if acute slow breathing at 6 breaths/min would improve baroreflex sensitivity (BRS) and heart rate variability (HRV), and lower blood pressure (BP) in adults after stroke. Methods: Twelve individuals completed two randomized study visits where they performed a 15-min bout of breathing exercises a...

journal_title：Frontiers in physiology

authors： Larson M,Chantigian DP,Asirvatham-Jeyaraj N,Van de Winckel A,Keller-Ross ML

更新日期：2020-10-30 00:00:00

abstract：:The need for radiotherapy personalization is now widely recognized, however, it would require considerations not only on the probability of control and survival of the tumor, but also on the possible toxic effects, on the quality of the expected life and the economic efficiency of the treatment. In this paper, we prop...

journal_title：Frontiers in physiology

authors： Belfatto A,Jereczek-Fossa BA,Baroni G,Cerveri P

更新日期：2018-10-15 00:00:00

abstract：:Singlet oxygen generated in a type II photodynamic action, due to its limited lifetime (1 μs) and reactive distance (<10 nm), could regulate live cell function nanoscopically. The genetically-encoded protein photosensitizers (engineered fluorescent proteins such as KillerRed, TagRFP, and flavin-binding proteins such a...

journal_title：Frontiers in physiology

authors： Jiang HN,Li Y,Cui ZJ

更新日期：2017-04-04 00:00:00

abstract：:Preeclampsia, a pregnancy-specific disorder, presents a major health problem during gestation, but is also associated with increased risk for cardiovascular complications in later life. We aimed to investigate whether chronic stress experience and preeclampsia may have additive adverse effects on the cardiac ability t...

journal_title：Frontiers in physiology

authors： Lackner HK,Moertl MG,Schmid-Zalaudek K,Lucovnik M,Weiss EM,Kolovetsiou-Kreiner V,Papousek I

更新日期：2018-09-03 00:00:00

abstract：:Resting-state EEG signals undergo rapid transition processes (RTPs) that glue otherwise stationary epochs. We study the fractal properties of RTPs in space and time, supporting the hypothesis that the brain works at a critical state. We discuss how the global intermittent dynamics of collective excitations is linked t...

journal_title：Frontiers in physiology

authors： Allegrini P,Paradisi P,Menicucci D,Gemignani A

更新日期：2010-09-15 00:00:00

abstract：:The emergence of new cardiac diagnostics and therapeutics of the heart has given rise to the challenging field of virtual design and testing of technologies in a patient-specific environment. Given the recent advances in medical imaging, computational power and mathematical algorithms, patient-specific cardiac models ...

journal_title：Frontiers in physiology

authors： Zhong L,Zhang JM,Su B,Tan RS,Allen JC,Kassab GS

更新日期：2018-06-26 00:00:00

abstract：:Myocardial electrical impedance is a biophysical property of the heart that is influenced by the intrinsic structural characteristics of the tissue. Therefore, the structural derangements elicited in a chronic myocardial infarction should cause specific changes in the local systolic-diastolic myocardial impedance, but...

journal_title：Frontiers in physiology

authors： Amorós-Figueras G,Jorge E,García-Sánchez T,Bragós R,Rosell-Ferrer J,Cinca J

更新日期：2016-08-31 00:00:00

abstract：:The cell-division cycle (CDC) is driven by cyclin-dependent kinases (CDKs). Mathematical models based on molecular networks, as revealed by molecular and genetic studies, have reproduced the oscillatory behavior of CDK activity. Thus, one basic system for representing the CDC is a biochemical oscillator (CDK oscillato...

journal_title：Frontiers in physiology

authors： Arata Y,Takagi H

更新日期：2019-08-19 00:00:00

abstract：:Background: The severity of wildland fires is increasing due to continually hotter and drier summers. Firefighters are required to make life altering decisions on the fireground, which requires analytical thinking, problem solving, and situational awareness. This study aimed to determine the effects of very hot (45°C;...

journal_title：Frontiers in physiology

authors： Williams-Bell FM,Aisbett B,Murphy BA,Larsen B

更新日期：2017-10-24 00:00:00

abstract：:To determine the level of hypoxia from which muscle activation (MA) is reduced during incremental exercise to exhaustion (IE), and the role played by PIO2 in this process, ten volunteers (21 ± 2 years) performed four IE in severe acute hypoxia (SAH) (PIO2 = 73 mmHg). Upon exhaustion, subjects were asked to continue ex...

journal_title：Frontiers in physiology

authors： Torres-Peralta R,Losa-Reyna J,Morales-Alamo D,González-Izal M,Pérez-Suárez I,Ponce-González JG,Izquierdo M,Calbet JA

更新日期：2016-08-17 00:00:00

abstract：:The aim of this study was to investigate the effects of two consecutive Crossfit® training sessions (24 h apart) designed to enhance work-capacity that involved both cardiovascular and muscular exercises on cytokines, muscle power, blood lactate and glucose. Nine male members of the CrossFit® community (age 26.7 ± 6.6...

journal_title：Frontiers in physiology

authors： Tibana RA,de Almeida LM,Frade de Sousa NM,Nascimento Dda C,Neto IV,de Almeida JA,de Souza VC,Lopes Mde F,Nobrega Ode T,Vieira DC,Navalta JW,Prestes J

更新日期：2016-06-28 00:00:00