Dysfunctional LAT2 Amino Acid Transporter Is Associated With Cataract in Mouse and Humans.

abstract：:Inflammation is a process whose main function is to fight against invading pathogens or foreign agents. Nonetheless, it is widely accepted that inflammation takes part in multiple processes in a physiological or pathophysiological context. Among these processes the inflammation has been closely related to bone metabol...

journal_title：Frontiers in physiology

authors： Alonso-Pérez A,Franco-Trepat E,Guillán-Fresco M,Jorge-Mora A,López V,Pino J,Gualillo O,Gómez R

更新日期：2018-05-08 00:00:00

abstract：:Endothelial cells have emerged as key players in SARS-CoV-2 infection and COVID-19 inflammatory pathologies. Dysfunctional endothelial cells can promote chronic inflammation and disease processes like thrombosis, atherosclerosis, and lung injury. In endothelial cells, mitochondria regulate these inflammatory pathways ...

journal_title：Frontiers in physiology

authors： Chang R,Mamun A,Dominic A,Le NT

更新日期：2021-01-15 00:00:00

abstract：Introduction:MTHFR methylation status is associated with microvascular complications in diabetes, but the factors influencing this profile remain unknown. Objective:The aim of this study was to evaluate the influence of physical activity level and nutritional status on the methylation profile of the MTHFR gene in pati...

journal_title：Frontiers in physiology

authors： Diniz TG,Silva AS,Dos Santos Nunes MK,Ribeiro MD,Filho JM,do Nascimento RAF,Gomes CNAP,Evangelista IWQ,de Oliveira NFP,Persuhn DC

更新日期：2021-01-12 00:00:00

abstract：:Local purinergic signals modulate renal tubular transport. Acute activation of renal epithelial P2 receptors causes inhibition of epithelial transport and thus, should favor increased water and salt excretion by the kidney. So far only a few studies have addressed the effects of extracellular nucleotides on ion transp...

journal_title：Frontiers in physiology

authors： Marques RD,Praetorius HA,Leipziger J

更新日期：2013-10-09 00:00:00

abstract：:Delivery of exogenous high mobility group box 1 (HMGB1) may exert a beneficial effect on myocardial ischemia-reperfusion (I/R) injury. Since the expression of vascular endothelial growth factor (VEGF) and phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) in the myocardium mediates the cardioprotective function...

journal_title：Frontiers in physiology

authors： Zhou YH,Han QF,Gao L,Sun Y,Tang ZW,Wang M,Wang W,Yao HC

更新日期：2020-01-29 00:00:00

abstract：:Early afterdepolarization (EAD) is known to cause lethal ventricular arrhythmias in long QT syndrome (LQTS). In this study, dynamical mechanisms of EAD formation in human ventricular myocytes (HVMs) were investigated using the mathematical model developed by ten Tusscher and Panfilov (Am J Physiol Heart Circ Physiol 2...

journal_title：Frontiers in physiology

authors： Kurata Y,Tsumoto K,Hayashi K,Hisatome I,Kuda Y,Tanida M

更新日期：2020-01-10 00:00:00

abstract：:Gravity has remained constant during animal evolution and the neural sensory systems detecting acceleration forces have remained remarkably conserved among vertebrates. The utricular organ senses the sum of inertial force due to head translation and head tilt relative to gravitational vertical. Change in gravitational...

journal_title：Frontiers in physiology

authors： Boyle R,Popova Y,Varelas J

更新日期：2018-10-22 00:00:00

abstract：:Background: Tissue availability of polyunsaturated fatty acids (PUFA) depends on several factors, including dietary intake, physical exercise, genetic variation, and metabolic turnover. However, there is limited evidence whether running training activity per se may influence indices associated with PUFA metabolism suc...

journal_title：Frontiers in physiology

authors： Davinelli S,Corbi G,Righetti S,Casiraghi E,Chiappero F,Martegani S,Pina R,De Vivo I,Simopoulos AP,Scapagnini G

更新日期：2019-04-26 00:00:00

abstract：:Optogenetic methods enable selective de- and hyperpolarization of cardiomyocytes expressing light-sensitive proteins within the myocardium. By using light, this technology provides very high spatial and temporal precision, which is in clear contrast to electrical stimulation. In addition, cardiomyocyte-specific expres...

journal_title：Frontiers in physiology

authors： Sasse P,Funken M,Beiert T,Bruegmann T

更新日期：2019-06-06 00:00:00

abstract：:Ginseng, the root of Panax ginseng C.A. Meyer, is one of the oldest traditional medicines and is thought to be a tonic. It has been claimed that ginseng may improve vitality and health. Recent studies have advanced ginseng pharmacology and shown that ginseng has various pharmacological effects in the nervous system. G...

journal_title：Frontiers in physiology

authors： Nah SY

更新日期：2014-03-19 00:00:00

abstract：:Autophagy, or cellular self-eating, is a tightly regulated cellular pathway the main purpose of which is lysosomal degradation and subsequent recycling of cytoplasmic material to maintain normal cellular homeostasis. Defects in autophagy are linked to a variety of pathological states, including cancer. Cancer is the d...

journal_title：Frontiers in physiology

authors： Kondratskyi A,Yassine M,Kondratska K,Skryma R,Slomianny C,Prevarskaya N

更新日期：2013-10-02 00:00:00

abstract：:We describe our development of the diffusion tensor imaging modality for the bovine ocular lens. Diffusion gradients were added to a spin-echo pulse sequence and the relevant parameters of the sequence were refined to achieve good diffusion weighting in the lens tissue, which demonstrated heterogeneous regions of diff...

journal_title：Frontiers in physiology

authors： Vaghefi E,Donaldson PJ

更新日期：2013-03-01 00:00:00

abstract：:Increased central sympathetic drive is a hallmark of several important clinical conditions including essential hypertension, heart failure, chronic kidney disease, and insulin resistance. Afferent signaling from the kidneys has been identified as an important contributor to elevated central sympathetic drive and incre...

journal_title：Frontiers in physiology

authors： Schlaich MP,Hering D,Sobotka P,Krum H,Lambert GW,Lambert E,Esler MD

更新日期：2012-02-02 00:00:00

abstract：:Due to the important biological role of red blood cells (RBCs) in vertebrates, the analysis of reshaping and dynamics of RBCs motion is a critical issue in physiology and biomechanics. In this paper the behavior of RBCs within the immature capillary plexus during embryonic development of zebrafish has been analyzed. R...

journal_title：Frontiers in physiology

authors： Djukic TR,Karthik S,Saveljic I,Djonov V,Filipovic N

更新日期：2016-10-07 00:00:00

abstract：:Laodelphax striatellus is naturally infected with the Wolbachia strain wStri, which induces strong cytoplasmic incompatibility of its host. MicroRNAs (miRNAs) are a class of endogenous non-coding small RNAs that play a critical role in the regulation of gene expression at post-transcriptional level in various biologic...

journal_title：Frontiers in physiology

authors： Liu L,Zhang KJ,Rong X,Li YY,Liu H

更新日期：2019-07-24 00:00:00

abstract：:Skeletal muscle is a main target of insulin action that plays a pivotal role in postprandial glucose disposal. Importantly, skeletal muscle insulin sensitivity relates inversely with pancreatic insulin secretion, which prompted the hypothesis of the existence of a skeletal muscle-pancreas crosstalk mediated through an...

journal_title：Frontiers in physiology

authors： Mizgier ML,Fernández-Verdejo R,Cherfan J,Pinget M,Bouzakri K,Galgani JE

更新日期：2019-08-08 00:00:00

abstract：:The rare opportunity to study a human fetus showing bilateral clefting of the lower lip along with other associated anomalies resembling those of the equally rare Pena-Shokeir phenotype prompts this report. The scarcity of reports on bilateral clefts of the lower lip has strengthened the conventional understanding or,...

journal_title：Frontiers in physiology

authors： Vastardis H,Spyropoulos MN,Burdi AR

更新日期：2012-08-24 00:00:00

abstract：:The ability to sustain submaximal exercise is largely dependent on the oxidative capacity of mitochondria within skeletal muscle, and impairments in oxidative metabolism have been implicated in many neurologic and cardiovascular pathologies. Here we review studies which have demonstrated the utility of Near-infrared s...

journal_title：Frontiers in physiology

authors： Willingham TB,McCully KK

更新日期：2017-09-14 00:00:00

abstract：:Recent concerns over the impact of antidepressant medications, including the selective serotonin reuptake inhibitors (SSRIs), on cardiovascular function highlight the importance of research on the moderating effects of specific lifestyle factors such as physical activity. Studies in affective neuroscience have demonst...

journal_title：Frontiers in physiology

authors： Hanson CS,Outhred T,Brunoni AR,Malhi GS,Kemp AH

更新日期：2013-09-24 00:00:00

abstract：:The sterile insect technique (SIT) may reduce pest populations by allowing sufficient amount of irradiation-induced sterile males to mate with wild females whilst maintaining mating ability comparable to wild males. Although the SIT methods are well understood, the optimal sterilizing dose and processing development s...

journal_title：Frontiers in physiology

authors： Cai J,Yang H,Shi S,Zhong G,Yi X

更新日期：2018-02-20 00:00:00

abstract：:Milk and dairy products are relevant components of daily diet and are part of dietary recommendation in many countries due to their content of key nutrients. However, the relatively high content of saturated fat of the milk and its extensive usage for every age group raises concerns about its potential negative health...

journal_title：Frontiers in physiology

authors： Trinchese G,Cavaliere G,Penna E,De Filippo C,Cimmino F,Catapano A,Musco N,Tudisco R,Lombardi P,Infascelli F,Messina G,Muredda L,Banni S,Monda M,Crispino M,Mollica MP

更新日期：2019-01-17 00:00:00

abstract：:In the kidney, the stimulation of renin production by the collecting duct (CD-renin) contributes to the development of hypertension. The CD is a major nephron segment for the synthesis of nitric oxide (NO), and low NO bioavailability in the renal medulla is associated with hypertension. However, it is unknown whether ...

journal_title：Frontiers in physiology

authors： Curnow AC,Gonsalez SR,Gogulamudi VR,Visniauskas B,Simon EE,Gonzalez AA,Majid DSA,Lara LS,Prieto MC

更新日期：2020-11-17 00:00:00

abstract：:Introduction: Combined antiretroviral therapy (cART) used to treat acquired immunodeficiency virus (HIV) induces a number of adverse effects, such as insulin resistance and dyslipidemia, which ultimately increases the cardiovascular risk. Advanced glycation end products (AGEs) have been implicated in the etiology of c...

journal_title：Frontiers in physiology

authors： Rodrigues KL,Borges JP,Lopes GO,Pereira ENGDS,Mediano MFF,Farinatti P,Tibiriça E,Daliry A

更新日期：2018-12-06 00:00:00

abstract：:Adipokinetic hormones (AKHs) are well known to mobilize lipids and carbohydrates for energy-consuming activities in insects. These neuropeptides exert their functions by interacting with AKH receptors (AKHRs) located on the plasma membrane of fat body cells, which regulates energy mobilization by stimulating lipolysis...

journal_title：Frontiers in physiology

authors： Lu K,Wang Y,Chen X,Zhang X,Li W,Cheng Y,Li Y,Zhou J,You K,Song Y,Zhou Q,Zeng R

更新日期：2019-01-08 00:00:00

abstract：:Purpose: Aging is associated with changes in muscle energy metabolism. Proton (1H) and phosphorous (31P) magnetic resonance spectroscopy (MRS) has been successfully applied for non-invasive investigation of skeletal muscle metabolism. The aim of this study was to detect differences in adenosine triphosphate (ATP) prod...

journal_title：Frontiers in physiology

authors： Krumpolec P,Klepochová R,Just I,Tušek Jelenc M,Frollo I,Ukropec J,Ukropcová B,Trattnig S,Krššák M,Valkovič L

更新日期：2020-06-29 00:00:00

abstract：:As clinicians attempt to understand the underlying reasons for the vulnerability of different regions of the developing brain to injury, it is apparent that little is known as to how hypoxia-ischemia may affect the cerebrovasculature in the developing infant. Most of the research investigating the pathogenesis of peri...

journal_title：Frontiers in physiology

authors： Baburamani AA,Ek CJ,Walker DW,Castillo-Melendez M

更新日期：2012-11-09 00:00:00

abstract：:Comparison of genomic sequences from diverse vertebrate species has revealed numerous highly conserved regions that do not appear to encode proteins or functional RNAs. Often these "conserved non-coding elements," or CNEs, can direct gene expression to specific tissues in transgenic models, demonstrating they have reg...

journal_title：Frontiers in physiology

authors： Turner EE,Cox TC

更新日期：2014-01-21 00:00:00

abstract：:Muscle strain is one of the most frequent sports injuries, having the rectus femoris (RF) muscle as the reported preferred site of quadriceps muscle strain. The decrease muscle stiffness could be an effective RF muscle strain prevention. In recent studies, a high-intensity static stretching intervention decreased pass...

journal_title：Frontiers in physiology

authors： Nakamura M,Sato S,Murakami Y,Kiyono R,Yahata K,Sanuki F,Yoshida R,Fukaya T,Takeuchi K

更新日期：2021-01-13 00:00:00

abstract：:Survivors of cerebral aneurysm rupture are at risk for significant morbidity and neurological deficits. Much of this is related to the effects of blood in the subarachnoid space which induces an inflammatory cascade with numerous downstream consequences. Recent clinical trials have not been able to reduce the toxic ef...

journal_title：Frontiers in physiology

authors： Blackburn SL,Kumar PT,McBride D,Zeineddine HA,Leclerc J,Choi HA,Dash PK,Grotta J,Aronowski J,Cardenas JC,Doré S

更新日期：2018-05-31 00:00:00

abstract：Objective:Varicose veins are a common problem worldwide and can cause significant impairments in health-related quality of life, but the etiology and pathogenesis remain not well defined. This study aims to elucidate transcriptomic regulations of varicose veins by detecting differentially expressed genes, pathways and ...

journal_title：Frontiers in physiology

authors： Zhang J,Nie Q,Si C,Wang C,Chen Y,Sun W,Pan L,Guo J,Kong J,Cui Y,Wang F,Fan X,Ye Z,Wen J,Liu P

更新日期：2019-03-19 00:00:00