Inflammatory therapeutic targets in coronary atherosclerosis-from molecular biology to clinical application.

abstract：:Resting-state EEG signals undergo rapid transition processes (RTPs) that glue otherwise stationary epochs. We study the fractal properties of RTPs in space and time, supporting the hypothesis that the brain works at a critical state. We discuss how the global intermittent dynamics of collective excitations is linked t...

journal_title：Frontiers in physiology

authors： Allegrini P,Paradisi P,Menicucci D,Gemignani A

更新日期：2010-09-15 00:00:00

abstract：:Cells expressing bitter taste receptors (T2Rs or Tas2rs) in extraoral tissues are considered to be chemosensory cells mediating protective responses to potentially harmful or even antiinflammatory or antimicrobial compounds. In a previous study the activity of the Tas2R143/Tas2R135/Tas2r126 cluster promoter in the sto...

journal_title：Frontiers in physiology

authors： Widmayer P,Partsch V,Pospiech J,Kusumakshi S,Boehm U,Breer H

更新日期：2020-02-07 00:00:00

abstract：:Apelin is the endogenous ligand of APJ, the orphan G protein-coupled receptor. The apelin-APJ signal transduction pathway is widely expressed in the cardiovascular system and is an important factor in cardiovascular homeostasis. This signal transduction pathway has long been related to diseases with high morbidity in ...

journal_title：Frontiers in physiology

authors： Zhou Y,Wang Y,Qiao S,Yin L

更新日期：2017-12-12 00:00:00

abstract：:Recently, we reported that Dahl salt-sensitive leptin receptor mutant (SSLepRmutant) rats exhibit dyslipidemia and renal lipid accumulation independent of hyperglycemia that progresses to chronic kidney disease (CKD). Therefore, in the current study, we examined the effects of gemfibrozil, a lipid-lowering drug (200 m...

journal_title：Frontiers in physiology

authors： Shields CA,Poudel B,McPherson KC,Brown AK,Ekperikpe US,Browning E,Sutton L,Cornelius DC,Williams JM

更新日期：2020-09-18 00:00:00

abstract：:The appearance of oxygen in the terrestrial atmosphere represented an important selective pressure for ancestral living organisms and contributed toward setting up the pace of evolutionary changes in structural and functional systems. The evolution of using oxygen for efficient energy production served as a driving fo...

journal_title：Frontiers in physiology

authors： Naudí A,Jové M,Ayala V,Portero-Otín M,Barja G,Pamplona R

更新日期：2013-12-17 00:00:00

abstract：:Acute kidney injury (AKI), which involves the loss of kidney function caused by damage to renal tubular cells, is an important public health concern. We previously showed that sirtuin (SIRT)3 protects the kidneys against mitochondrial damage by inhibiting the nucleotide-binding domain (NOD)-like receptor protein 3 (NL...

journal_title：Frontiers in physiology

authors： Zhao W,Zhang L,Chen R,Lu H,Sui M,Zhu Y,Zeng L

更新日期：2018-11-14 00:00:00

abstract：:Whether neurally-mediated vasodilatation may contribute to exercise hyperemia has not been completely understood. Bülbring and Burn (1935) found for the first time the existence of sympathetic cholinergic nerve to skeletal muscle contributing to vasodilatation in animals. Blair et al. (1959) reported that atropine-sen...

journal_title：Frontiers in physiology

authors： Matsukawa K,Ishii K,Liang N,Endo K

更新日期：2013-02-15 00:00:00

abstract：:The purpose of this study was to analyze the correlation between decompression-related physiological stress markers, given by inflammatory processes and immune system activation and changes in Heart Rate Variability, evaluating whether Heart Rate Variability can be used to estimate the physiological stress caused by t...

journal_title：Frontiers in physiology

authors： Schirato SR,El-Dash I,El-Dash V,Bizzarro B,Marroni A,Pieri M,Cialoni D,Chaui-Berlinck JG

更新日期：2020-07-03 00:00:00

abstract：:Insufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main site of hypoxic injury in the human body is the mitochondria, where oxygen acts as the final electron acceptor in the process of oxidative phosph...

journal_title：Frontiers in physiology

authors： Liu M,Galli G,Wang Y,Fan Q,Wang Z,Wang X,Xiao W

更新日期：2020-07-15 00:00:00

abstract：:Cigarette smoking causes chronic lung inflammation that is mainly regulated by redox-sensitive pathways. Our previous studies have demonstrated that cigarette smoke (CS) activates reactive oxygen species (ROS)-sensitive mitogen-activated protein kinases (MAPKs)/nuclear factor-κB (NF-κB) signaling resulting in inductio...

journal_title：Frontiers in physiology

authors： Liu MH,Lin AH,Lu SH,Peng RY,Lee TS,Kou YR

更新日期：2014-11-14 00:00:00

abstract：:Introduction: Combined antiretroviral therapy (cART) used to treat acquired immunodeficiency virus (HIV) induces a number of adverse effects, such as insulin resistance and dyslipidemia, which ultimately increases the cardiovascular risk. Advanced glycation end products (AGEs) have been implicated in the etiology of c...

journal_title：Frontiers in physiology

authors： Rodrigues KL,Borges JP,Lopes GO,Pereira ENGDS,Mediano MFF,Farinatti P,Tibiriça E,Daliry A

更新日期：2018-12-06 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) not only play essential roles in bone development but also are involved in embryonic growth, organogenesis cell proliferation and differentiation. However, the previous studies on the functions of shellfish BMPs genes are still very limited. To better understand its molecular structu...

journal_title：Frontiers in physiology

authors： Zhao J,Cui B,Yao H,Lin Z,Dong Y

更新日期：2020-08-28 00:00:00

abstract：:In addition to its roles in the maintenance of interstitial fluid homeostasis and immunosurveillance, the lymphatic system has a critical role in regulating transport of dietary lipids to the blood circulation. Recent work within the past two decades has identified an important relationship between lymphatic dysfuncti...

journal_title：Frontiers in physiology

authors： Norden PR,Kume T

更新日期：2020-05-05 00:00:00

abstract：:Spodoptera exigua and S. litura are two sympatric species in China and many other countries. Both moths employ a multiple component sex pheromone blend, including a common component Z9,E12-14:OAc, and two specific components Z9-14:OH and Z11-16:OAc for S. exigua, and one specific component Z9,E11-14:OAc for S. litura....

journal_title：Frontiers in physiology

authors： Yan Q,Liu XL,Wang YL,Tang XQ,Shen ZJ,Dong SL,Deng JY

更新日期：2019-09-27 00:00:00

abstract：:The pre-occlusal eruption brings the molars into functional occlusion and initiates tensional strains during mastication. We hypothesized that upon establishment of occlusal contact, the periodontal ligament (PDL) undergoes cell and extracellular matrix maturation to adapt to this mechanical function. The PDL of 12 Wi...

journal_title：Frontiers in physiology

authors： Denes BJ,Ait-Lounis A,Wehrle-Haller B,Kiliaridis S

更新日期：2020-03-05 00:00:00

abstract：:Obstructive sleep apnea (OSA), manifested by exposure to chronic intermittent hypoxia (CIH) and excess production of reactive oxygen species (ROS) in the airways, is associated with hyperreactive airway diseases. ROS, particularly when created by NADPH oxidase, are known to sensitize lung vagal C fibers (LVCFs), which...

journal_title：Frontiers in physiology

authors： Yang CH,Zhuang WL,Shen YJ,Lai CJ,Kou YR

更新日期：2016-05-09 00:00:00

abstract：:A sedentary lifestyle is associated with increased cardiovascular risk factors and reduced cardiac compliance when compared to a lifestyle that includes exercise training. Exercise training increases cardiac compliance in humans, but the mechanisms underlying this improvement are unknown. A major determinant of cardia...

journal_title：Frontiers in physiology

authors： Chung CS,Hiske MA,Chadha A,Mueller PJ

更新日期：2020-02-05 00:00:00

abstract：:Many disease fighting strategies have focused on the generation of NK cells, since they constitute the main immune barrier against cancer and intracellular pathogens such as viruses. Therefore, a predictive model for the development of NK cells would constitute a useful tool to test several hypotheses regarding the pr...

journal_title：Frontiers in physiology

authors： Liquitaya-Montiel AJ,Mendoza L

更新日期：2018-08-02 00:00:00

abstract：Background:Aging and changing age demographics represent critical problems of our time. Physiological functions decline with age, often ending in a systemic process that contributes to numerous impairments and age-related diseases including heart failure (HF). We aimed to analyze whether differences in composite measur...

journal_title：Frontiers in physiology

authors： Wagner J,Knaier R,Königstein K,Klenk C,Carrard J,Lichtenstein E,Scharnagl H,März W,Hanssen H,Hinrichs T,Schmidt-Trucksäss A,Arbeev K

更新日期：2020-12-15 00:00:00

abstract：:Cataract, the loss of ocular lens transparency, accounts for ∼50% of worldwide blindness and has been associated with water and solute transport dysfunction across lens cellular barriers. We show that neutral amino acid antiporter LAT2 (Slc7a8) and uniporter TAT1 (Slc16a10) are expressed on mouse ciliary epithelium an...

journal_title：Frontiers in physiology

authors： Knöpfel EB,Vilches C,Camargo SMR,Errasti-Murugarren E,Stäubli A,Mayayo C,Munier FL,Miroshnikova N,Poncet N,Junza A,Bhattacharya SS,Prat E,Berry V,Berger W,Heon E,Moore AT,Yanes Ó,Nunes V,Palacín M,Verrey F,Kloecke

更新日期：2019-06-04 00:00:00

abstract：:Trace conditioning is a form of associative learning that can be induced by presenting a conditioned stimulus (CS) and an unconditioned stimulus (US) following each other, but separated by a temporal gap. This gap distinguishes trace conditioning from classical delay conditioning, where the CS and US overlap. To bridg...

journal_title：Frontiers in physiology

authors： Dylla KV,Galili DS,Szyszka P,Lüdke A

更新日期：2013-08-23 00:00:00

abstract：:Circadian rhythms are essential for health and regulate various physiological functions. These rhythms are regulated by a negative-feedback loop involving clock genes in the suprachiasmatic nucleus (SCN) and peripheral tissues. The rate of secretion of salivary substances, ions, and water follows a circadian rhythm, h...

journal_title：Frontiers in physiology

authors： Satou R,Sato M,Kimura M,Ishizuka Y,Tazaki M,Sugihara N,Shibukawa Y

更新日期：2017-05-23 00:00:00

abstract：:The main objective of this study was to investigate the effects of the order of physical exercises on body composition, physical fitness, and cardiometabolic risk in adolescents participating in an interdisciplinary program focusing on the treatment of obesity. The final 12-week analyses involved 33 female adolescents...

journal_title：Frontiers in physiology

authors： Branco BHM,Valladares D,de Oliveira FM,Carvalho IZ,Marques DC,Coelho AA,de Oliveira LP,Bertolini SMMG

更新日期：2019-08-06 00:00:00

abstract：:Prescribing the proper resistance training (RT) program is critical to optimize skeletal muscle hypertrophy and strength. Periodization is a strategy that entails planned manipulations of training variables to maximize fitness adaptations while minimizing the risk of overtraining. Multiple meta-analyses have shown per...

journal_title：Frontiers in physiology

authors： Evans JW

更新日期：2019-01-23 00:00:00

abstract：:Cephalopod and vertebrate neural-systems are often highlighted as a traditional example of convergent evolution. Their large brains, relative to body size, and complexity of sensory-motor systems and behavioral repertoires offer opportunities for comparative analysis. Despite various attempts, questions on how cephalo...

journal_title：Frontiers in physiology

authors： Shigeno S,Andrews PLR,Ponte G,Fiorito G

更新日期：2018-07-20 00:00:00

abstract：:Obesity is characterized by an excessive increase in body mass, leading to endothelial damage that may favor the development of erectile dysfunction (ED). ED is defined as the inability to achieve or maintain a penile erection long enough to have a sexual intercourse. In this context, different ED models were develope...

journal_title：Frontiers in physiology

authors： de Souza ILL,Barros BC,de Oliveira GA,Queiroga FR,Toscano LT,Silva AS,Silva PM,Interaminense LFL,Cavalcante FA,da Silva BA

更新日期：2017-10-04 00:00:00

abstract：:Background: The possibility of non-invasively assessing load-independent parameters characterizing cardiac function is of high clinical value. Typically, these parameters are assessed during resting conditions. However, for diagnostic purposes, the parameter behavior across a physiologically relevant range of heart ra...

journal_title：Frontiers in physiology

authors： Casas B,Viola F,Cedersund G,Bolger AF,Karlsson M,Carlhäll CJ,Ebbers T

更新日期：2018-10-30 00:00:00

abstract：:Cell function and survival are controlled by intracellular signals, and modulated by surrounding cells and the extracellular environment. Connexin channels participate in these processes by mediating cell-to-cell communication. In bone cells, gap junction channels were detected in the early 1970s, and are present amon...

journal_title：Frontiers in physiology

authors： Plotkin LI

更新日期：2014-04-04 00:00:00

abstract：:Composed by a molecule of adenine and a molecule of ribose, adenosine is a paradigm of recyclable nucleoside with a multiplicity of functions that occupies a privileged position in the metabolic and regulatory contexts. Adenosine is formed continuously in intracellular and extracellular locations of all tissues. Extra...

journal_title：Frontiers in physiology

authors： Arin RM,Gorostidi A,Navarro-Imaz H,Rueda Y,Fresnedo O,Ochoa B

更新日期：2017-09-22 00:00:00

abstract：:One-third of the world's population has been infected with Mycobacterium tuberculosis (M. tuberculosis), a primary pathogen of the mammalian respiratory system, while about 10% of latent infections progress to active tuberculosis (TB), indicating that host and environmental factors may determine the outcomes such as i...

journal_title：Frontiers in physiology

authors： Luo M,Liu Y,Wu P,Luo DX,Sun Q,Zheng H,Hu R,Pandol SJ,Li QF,Han YP,Zeng Y

更新日期：2017-11-17 00:00:00