Abstract：
PURPOSE:We investigated if oral ingestion of ibuprofen influenced leucocyte recruitment and infiltration following an acute bout of traditional resistance exercise Methods: Sixteen male subjects were divided into two groups that received the maximum over-the-counter dose of ibuprofen (1200mg d(-1)) or a similarly administered placebo following lower body resistance exercise. Muscle biopsies were taken from m.vastus lateralis and blood serum samples were obtained before and immediately after exercise, and at 3 and 24 h after exercise. Muscle cross-sections were stained with antibodies against neutrophils (CD66b and MPO) and macrophages (CD68). Muscle damage was assessed via creatine kinase and myoglobin in blood serum samples, and muscle soreness was rated on a ten-point pain scale. RESULTS:The resistance exercise protocol stimulated a significant increase in the number of CD66b(+) and MPO(+) cells when measured 3 h post exercise. Serum creatine kinase, myoglobin and subjective muscle soreness all increased post-exercise. Muscle leucocyte infiltration, creatine kinase, myoglobin and subjective muscle soreness were unaffected by ibuprofen treatment when compared to placebo. There was also no association between increases in inflammatory leucocytes and any other marker of cellular muscle damage. CONCLUSION:Ibuprofen administration had no effect on the accumulation of neutrophils, markers of muscle damage or muscle soreness during the first 24 h of post-exercise muscle recovery.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Vella L,Markworth JF,Paulsen G,Raastad T,Peake JM,Snow RJ,Cameron-Smith D,Russell APdoi
10.3389/fphys.2016.00086subject
Has Abstractpub_date
2016-03-29 00:00:00pages
86issn
1664-042Xjournal_volume
7pub_type
杂志文章abstract：:Microbiopsies of human skeletal muscle are increasingly adopted by physiologists for a variety of experimental assays given the reduced invasiveness of this procedure compared to the classic Bergstrom percutaneous biopsy technique. However, a recent report demonstrated lower mitochondrial respiration in saponin-permea...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2015.00360
更新日期：2015-12-18 00:00:00
abstract：Purpose:This study aimed to evaluate effects of remote ischemic preconditioning (RIPC) on myocardial injury in patients undergoing off-pump coronary artery bypass graft surgery (OPCABG). Methods:Sixty-five patients scheduled for the OPCABG were randomly assigned to control (n = 32) or RIPC group (n = 33). All patients...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.00495
更新日期：2019-04-29 00:00:00
abstract：:Ameloblasts are ectoderm-derived cells that produce an extracellular enamel matrix that mineralizes to form enamel. The development and use of immortalized cell lines, with a stable phenotype, is an important contribution to biological studies as it allows for the investigation of molecular activities without the cont...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2014.00277
更新日期：2014-07-25 00:00:00
abstract：:Developing new methods to treat heart diseases is always a focus for basic research and clinical applications. Existing drugs have strong side-effects and also require lifetime administration for patients. Recent attempts of using nanoparticles (NPs) in treating atherosclerosis in animals and some heart diseases such ...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.00642
更新日期：2018-05-29 00:00:00
abstract：:We explored the metagenomic, metabolomic and trace metal makeup of intestinal microbiota and environment in healthy male participants during the run-in (5 day) and the following three 21-day interventions: normoxic bedrest (NBR), hypoxic bedrest (HBR) and hypoxic ambulation (HAmb) which were carried out within a contr...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.00198
更新日期：2018-03-13 00:00:00
abstract：:RNAi is applied as a new and safe method for pest control in agriculture but efficiency and specificity of delivery of dsRNA trigger remains a critical issue. Various agents have been proposed to augment dsRNA delivery, such as engineered micro-organisms and synthetic nanoparticles, but the use of viruses has received...
journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2017.00399
更新日期：2017-06-14 00:00:00
abstract：:Leucine-rich repeat containing protein 10 (LRRC10) is a cardiomyocyte-specific member of the Leucine-rich repeat containing (LRRC) protein superfamily with critical roles in cardiac function and disease pathogenesis. Recent studies have identified LRRC10 mutations in human idiopathic dilated cardiomyopathy (DCM) and L...
journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2016.00337
更新日期：2016-08-03 00:00:00
abstract：:Aims: Simultaneous measurement of right (RV) and left ventricle (LV) myocardial blood flow (MBF), oxygen extraction fraction (OEF), and oxygen consumption (MVO2) non-invasively in humans would provide new possibilities to understand cardiac physiology and different patho-physiological states. Methods: We developed and...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.00741
更新日期：2019-06-19 00:00:00
abstract：:Long non-coding RNAs (lncRNAs) play important roles in transcriptional and post-transcriptional regulation. However, little is currently known about the mechanisms by which they regulate skeletal muscle development in the chicken. In this study, we used RNA sequencing to profile the leg muscle transcriptome (lncRNA an...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2016.00687
更新日期：2017-01-09 00:00:00
abstract：:In our digitized society, advanced information and communication technology and highly interactive work environments impose high demands on cognitive capacity. Optimal workload conditions are important for assuring employee's health and safety of other persons. This is particularly relevant in safety-critical occupati...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2020.00300
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abstract：:The development of durable ventricular assist devices (VADs) has improved mortality rates and quality of life in patients with end stage heart failure. While the use of VADs has increased dramatically in recent years, there is limited experience with VAD implantation in patients with complex congenital heart disease (...
journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2017.00131
更新日期：2017-05-09 00:00:00
abstract：PURPOSE:The aim of present investigation was to evaluate marginal bone level after 5-year follow-up of implants placed in healed ridges and fresh extraction sockets in maxilla with immediate loading protocol. MATERIALS AND METHODS:Thirty-six patients in need of a single-tooth replacement in the anterior maxilla receiv...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2014.00029
更新日期：2014-01-31 00:00:00
abstract：:The year 2002 marked the tercentenary of Antonie van Leeuwenhoek's discovery of desiccation tolerance in animals. This remarkable phenomenon to sustain 'life' in the absence of water can be revived upon return of hydrating conditions. Today, coping with climate change-related factors, especially temperature-humidity i...
journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2018.01843
更新日期：2018-12-21 00:00:00
abstract：:This work investigates the effect of arterial bifurcation angulation on atherosclerosis development through in-silico simulations of coupled cell dynamics. The computational model presented here combines cellular pathways, fluid dynamics, and physiologically-realistic vessel geometries as observed in the human vascula...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.01528
更新日期：2018-10-31 00:00:00
abstract：:Advances in the development of voltage sensitive dyes and Ca(2+) sensors in combination with innovative microscopy techniques allowed researchers to perform functional measurements with an unprecedented spatial and temporal resolution. At the moment, one of the shortcomings of available technologies is their incapabil...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2014.00403
更新日期：2014-10-20 00:00:00
abstract：:Autophagy, or cellular self-eating, is a tightly regulated cellular pathway the main purpose of which is lysosomal degradation and subsequent recycling of cytoplasmic material to maintain normal cellular homeostasis. Defects in autophagy are linked to a variety of pathological states, including cancer. Cancer is the d...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2013.00272
更新日期：2013-10-02 00:00:00
abstract：:The impact of peritoneal dialysis (PD) associated peritonitis on peritoneal membrane integrity is incompletely understood. Children are particularly suited to address this question, since they are largely devoid of preexisting tissue damage and life-style related alterations. Within the International Peritoneal Bioban...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.00356
更新日期：2019-04-02 00:00:00
abstract：:In our previous study, we reported a high temperature adapted strain (HTAS) of the predatory mite Neoseiulus barkeri was artificially selected via a long-term heat acclimation (35°C) and frequent heat hardenings. To understand the molecular basis of heat acclimation, 'omics' analyses were performed to compare the diff...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2020.00426
更新日期：2020-04-29 00:00:00
abstract：:[This corrects the article on p. 354 in vol. 10, PMID: 30984032.]. ...
journal_title：Frontiers in physiology
pub_type： 已发布勘误
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更新日期：2020-08-12 00:00:00
abstract：:Single-channel kinetics has proven a powerful tool to reveal information about the gating mechanisms that control the opening and closing of ion channels. This introductory review focuses on the gating of large conductance Ca(2+)- and voltage-activated K(+) (BK or Slo1) channels at the single-channel level. It starts ...
journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2014.00532
更新日期：2015-01-21 00:00:00
abstract：:In insects, locomotion is the result of rhythm generating thoracic circuits and their modulation by sensory reflexes and by inputs from the two head ganglia, the cerebral and the gnathal ganglia (GNG), which act as higher order neuronal centers playing different functions in the initiation, goal-direction, and mainten...
journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2020.00135
更新日期：2020-02-21 00:00:00
abstract：:The anti-aging function of Klotho gene has been implicated in age-related diseases. The physiological importance of Klotho in the progression of arterial stiffness with aging, however, remains unclear. The goal of this study is to determine the correlation of circulating Klotho with early age-related aortic stiffening...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2020.00591
更新日期：2020-06-09 00:00:00
abstract：:Cycling test such Wingate anaerobic test (WAnT) is used to measure anaerobic power (AP), but not anaerobic capacity (AC, i.e., the metabolic energy demand). However, in sports that do not involve cycling movements (Karate), the continuous jump for 30 s (vertical jumps for 30 s) has been extensively used to measure ana...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.00543
更新日期：2018-05-15 00:00:00
abstract：:Objective: The aim of the present study was to elucidate the effects of Mindfulness-based interventions (MBIs) on salivary cortisol levels in healthy adult populations. Method: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs), published between January 1980 and June 2015 in Pub...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2016.00471
更新日期：2016-10-19 00:00:00
abstract：:Treatment with ionizing radiation (IR) remains the cornerstone of therapy for multiple cancer types, including disseminated and aggressive diseases in the palliative setting. Radiotherapy efficacy could be improved in combination with drugs that regulate the ubiquitin-proteasome system (UPS), many of which are current...
journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2019.01144
更新日期：2019-10-01 00:00:00
abstract：:Large-conductance calcium-activated potassium (BK) channels are currently considered as vital players in a variety of renal physiological processes. In podocytes, BK channels become active in response to stimuli that increase local cytosolic Ca(2+), possibly secondary to activation of slit diaphragm TRPC6 channels by ...
journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2016.00248
更新日期：2016-06-21 00:00:00
abstract：:Octopamine (OA) is a prominent neuromodulator of invertebrate nervous systems, influencing multiple physiological processes. Among its many roles in insects are the initiation and maintenance of various rhythmic behaviors. Here, the neuromodulatory effects of OA on the components of the locust stomatogastric nervous s...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2012.00288
更新日期：2012-07-20 00:00:00
abstract：:Genetically modified mice provide a number of models for studying cardiac channelopathies related to cardiac Na(+) channel (SCN5A) abnormalities. We review key pathophysiological features in these murine models that may underlie clinical features observed in sinus node dysfunction and progressive cardiac conduction di...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2012.00234
更新日期：2012-07-06 00:00:00
abstract：:[This corrects the article on p. 528 in vol. 7, PMID: 27899896.]. ...
journal_title：Frontiers in physiology
pub_type： 已发布勘误
doi：10.3389/fphys.2016.00670
更新日期：2017-01-05 00:00:00
abstract：:Directed cell migration is essential all along an individual's life, from embryogenesis to tissue repair and cancer metastasis. Thus, due to its biomedical relevance, directed cell migration is currently under intense research. Directed cell migration has been shown to be driven by an assortment of external biasing cu...
journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2020.586432
更新日期：2020-11-25 00:00:00
