Abstract:
:Tissue inhibitor of metalloproteinase 3 (TIMP3) is unique among the four TIMPs due to its extracellular matrix (ECM)-binding property and broad range of inhibitory substrates that includes matrix metalloproteinases (MMPs), a disintegrin and metalloproteinases (ADAMs), and ADAM with thrombospondin motifs (ADAMTSs). In addition to its metalloproteinase-inhibitory function, TIMP3 can interact with proteins in the extracellular space resulting in its multifarious functions. TIMP3 mRNA has a long 3' untranslated region (UTR) which is a target for numerous microRNAs. TIMP3 levels are reduced in various cardiovascular diseases, and studies have shown that TIMP3 replenishment ameliorates the disease, suggesting a therapeutic potential for TIMP3 in cardiovascular diseases. While significant efforts have been made in identifying the effector targets of TIMP3, the regulatory mechanism for the expression of this multi-functional TIMP has been less explored. Here, we provide an overview of TIMP3 gene structure, transcriptional and post-transcriptional regulators (transcription factors and microRNAs), protein structure and partners, its role in cardiovascular pathology and its application as therapy, while also drawing reference from TIMP3 function in other diseases.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Fan D,Kassiri Zdoi
10.3389/fphys.2020.00661subject
Has Abstractpub_date
2020-06-16 00:00:00pages
661issn
1664-042Xjournal_volume
11pub_type
杂志文章,评审abstract::Defects in mid-facial development, including cleft lip/palate, account for a large number of human birth defects annually. In many cases, aberrant gene expression results in either a reduction in the number of neural crest cells (NCCs) that reach the frontonasal region and form much of the facial skeleton or subsequen...
journal_title:Frontiers in physiology
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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abstract::Research on the effects of climate change in the marine environment continues to accelerate, yet we know little about the effects of multiple climate drivers in more complex, ecologically relevant settings - especially in sub-tropical and tropical systems. In marine ecosystems, climate change (warming and freshening f...
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journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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doi:10.3389/fphys.2018.00301
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更新日期:2019-06-06 00:00:00
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