Abstract:
:An increase in calorie consumption is associated with the recent rise in obesity prevalence. However, our current understanding of the effects of nutrient excess on major metabolic pathways appears insufficient to develop safe and effective metabolic interventions to prevent obesity. Hence, we sought to identify systemic metabolic changes caused by nutrient excess and to determine how endothelial nitric oxide synthase (eNOS)-which has anti-obesogenic properties-affects systemic metabolism by measuring plasma metabolites. Wild-type (WT) and eNOS transgenic (eNOS-TG) mice were placed on low fat or high fat diets for 6 weeks, and plasma metabolites were measured using an unbiased metabolomic approach. High fat feeding in WT mice led to significant increases in fat mass, which was associated with significantly lower plasma levels of 1,5-anhydroglucitol, lysophospholipids, 3-dehydrocarnitine, and bile acids, as well as branched chain amino acids (BCAAs) and their metabolites. Plasma levels of several lipids including sphingomyelins, stearoylcarnitine, dihomo-linoleate and metabolites associated with oxidative stress were increased by high fat diet. In comparison with low fat-fed WT mice, eNOS-TG mice showed lower levels of several free fatty acids, but in contrast, the levels of bile acids, amino acids, and BCAA catabolites were increased. When placed on a high fat diet, eNOS overexpressing mice showed remarkably higher levels of plasma bile acids and elevated levels of plasma BCAAs and their catabolites compared with WT mice. Treatment with GW4064, an inhibitor of bile acid synthesis, decreased plasma bile acid levels but was not sufficient to reverse the anti-obesogenic effects of eNOS overexpression. These findings reveal unique metabolic changes in response to high fat diet and eNOS overexpression and suggest that the anti-obesity effects of eNOS are likely independent of changes in the bile acid pool.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Sansbury BE,Bhatnagar A,Hill BGdoi
10.3389/fphys.2014.00453subject
Has Abstractpub_date
2014-11-25 00:00:00pages
453issn
1664-042Xjournal_volume
5pub_type
杂志文章abstract::The epidemics of obesity and diabetes mellitus are associated with an increased incidence of both atrial fibrillation (AF), the most common sustained arrhythmia in adults, and sudden cardiac death (SCD). Obesity and DM are known to have adverse effects on cardiac structure and function. The pathologic mechanisms are t...
journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2018.01847
更新日期:2019-01-07 00:00:00
abstract::The effect of Withania somnifera a medicinal plant seed extract was tested against lesser mulberry pyralid, a potential pest of mulberry. The mulberry leaves were used for silk production in rural areas of northern Iran. The extract was administered orally by leaf dipping method in two lower (5%W/V) and higher (15%W/V...
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pub_type: 杂志文章
doi:10.3389/fphys.2020.00908
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2012.00010
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2016.00155
更新日期:2016-05-02 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2017.00945
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pub_type: 杂志文章
doi:10.3389/fphys.2018.01086
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pub_type: 杂志文章
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doi:10.3389/fphys.2020.00562
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2018.01328
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.3389/fphys.2019.00688
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pub_type: 杂志文章
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journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2018.01656
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pub_type: 杂志文章
doi:10.3389/fphys.2020.00490
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journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2018.01728
更新日期:2018-12-04 00:00:00
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pub_type: 杂志文章,已发布勘误
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更新日期:2020-02-11 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2012.00121
更新日期:2012-05-03 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2013.00266
更新日期:2013-09-30 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章,已发布勘误
doi:10.3389/fphys.2019.00669
更新日期:2019-05-28 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2018.00175
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journal_title:Frontiers in physiology
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doi:10.3389/fphys.2012.00376
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2014.00327
更新日期:2014-08-26 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2020.00254
更新日期:2020-04-07 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2020.00426
更新日期:2020-04-29 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2018.01515
更新日期:2018-10-30 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章,评审
doi:10.3389/fphys.2020.00774
更新日期:2020-07-15 00:00:00
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journal_title:Frontiers in physiology
pub_type: 杂志文章
doi:10.3389/fphys.2018.00922
更新日期:2018-07-12 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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