Abstract：
:It is assumed that a properly timed circadian clock enhances fitness, but only few studies have truly demonstrated this in animals. We raised each of the three classical Drosophila period mutants for >50 generations in the laboratory in competition with wildtype flies. The populations were either kept under a conventional 24-h day or under cycles that matched the mutant's natural cycle, i.e., a 19-h day in the case of per s mutants and a 29-h day for per l mutants. The arrhythmic per0 mutants were grown together with wildtype flies under constant light that renders wildtype flies similar arrhythmic as the mutants. In addition, the mutants had to compete with wildtype flies for two summers in two consecutive years under outdoor conditions. We found that wildtype flies quickly outcompeted the mutant flies under the 24-h laboratory day and under outdoor conditions, but per l mutants persisted and even outnumbered the wildtype flies under the 29-h day in the laboratory. In contrast, per s and per0 mutants did not win against wildtype flies under the 19-h day and constant light, respectively. Our results demonstrate that wildtype flies have a clear fitness advantage in terms of fertility and offspring survival over the period mutants and - as revealed for per l mutants - this advantage appears maximal when the endogenous period resonates with the period of the environment. However, the experiments indicate that per l and per s persist at low frequencies in the population even under the 24-h day. This may be a consequence of a certain mating preference of wildtype and heterozygous females for mutant males and time differences in activity patterns between wildtype and mutants.
journal_name
Front Physioljournal_title
Frontiers in physiologyauthors
Horn M,Mitesser O,Hovestadt T,Yoshii T,Rieger D,Helfrich-Förster Cdoi
10.3389/fphys.2019.01374subject
Has Abstractpub_date
2019-11-01 00:00:00pages
1374issn
1664-042Xjournal_volume
10pub_type
杂志文章abstract：:Connexin hemichannels, which are plasma membrane hexameric channels (connexons) composed of connexin protein protomers, have been implicated in a host of physiological processes and pathological conditions. A number of single point pathological mutations impart a "leaky" character to the affected hemichannels, i.e., m...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.00392
更新日期：2019-06-11 00:00:00
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pub_type： 杂志文章
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更新日期：2020-10-06 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
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更新日期：2019-09-27 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00822
更新日期：2017-11-17 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2012.00217
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00220
更新日期：2017-04-12 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.01477
更新日期：2019-12-12 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2013.00135
更新日期：2013-06-07 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00279
更新日期：2017-05-05 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2019.00763
更新日期：2019-06-25 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2016.00002
更新日期：2016-01-26 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2016.00643
更新日期：2016-12-26 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2019.01463
更新日期：2019-11-28 00:00:00
abstract：:Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in different genes mainly encoding myofilament proteins and therefore called a "disease of the sarcomere." Despite the discovery of sarcomere protein mutations linked to HCM almost 30 years ago, the cellular mechanisms responsible for the deve...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2020.00107
更新日期：2020-03-10 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00340
更新日期：2017-05-24 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2020.00494
更新日期：2020-05-29 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2020.00631
更新日期：2020-07-09 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.00761
更新日期：2018-07-03 00:00:00
abstract：:Mitochondria are the major source of superoxide radicals and superoxide overproduction contributes to cardiovascular diseases and metabolic disorders. Endothelial dysfunction and diminished nitric oxide levels are early steps in the development of these pathological conditions. It is known that physiological productio...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00907
更新日期：2017-11-07 00:00:00
abstract：:[This corrects the article DOI: 10.3389/fphys.2016.00593.]. ...
journal_title：Frontiers in physiology
pub_type： 杂志文章,已发布勘误
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更新日期：2019-05-22 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.00370
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pub_type： 杂志文章
doi：10.3389/fphys.2016.00086
更新日期：2016-03-29 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2014.00370
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2020.00121
更新日期：2020-02-25 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.01786
更新日期：2018-12-12 00:00:00
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pub_type： 杂志文章
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更新日期：2019-12-10 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章,评审
doi：10.3389/fphys.2017.00952
更新日期：2017-11-27 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.00236
更新日期：2018-03-16 00:00:00
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journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2018.00724
更新日期：2018-07-27 00:00:00
abstract：:FXYD proteins are important regulators of Na+/K+-ATPase (NKA) activity in mammals. As an inhabitant of estuaries, the pufferfish (Tetraodon nigroviridis) responds to ambient salinity changes with efficient osmoregulation, including alterations in branchial, and renal NKA activities. Previous studies on teleostean FXYD...
journal_title：Frontiers in physiology
pub_type： 杂志文章
doi：10.3389/fphys.2017.00576
更新日期：2017-08-08 00:00:00
