Hepatocellular carcinoma: a systems biology perspective.

abstract：:Previous studies reported enhanced cerebrovascular CO2 reactivity upon ascent to high altitude using linear models. However, there is evidence that this response may be sigmoidal in nature. Moreover, it was speculated that these changes at high altitude are mediated by alterations in acid-base buffering. Accordingly, ...

journal_title：Frontiers in physiology

authors： Fan JL,Subudhi AW,Duffin J,Lovering AT,Roach RC,Kayser B

更新日期：2016-01-08 00:00:00

abstract：:Cardiac autonomic function can be quantified through mean heart rate (HR) or heart rate variability (HRV). Numerous studies have supported the utility of different HRV parameters as indicators of cardiorespiratory fitness (CRF). However, HR has recently shown to be a stronger predictor of CRF than HRV in healthy young...

journal_title：Frontiers in physiology

authors： Plaza-Florido A,Migueles JH,Mora-Gonzalez J,Molina-Garcia P,Rodriguez-Ayllon M,Cadenas-Sanchez C,Esteban-Cornejo I,Solis-Urra P,de Teresa C,Gutiérrez Á,Michels N,Sacha J,Ortega FB

更新日期：2019-05-07 00:00:00

abstract：:Defects in mid-facial development, including cleft lip/palate, account for a large number of human birth defects annually. In many cases, aberrant gene expression results in either a reduction in the number of neural crest cells (NCCs) that reach the frontonasal region and form much of the facial skeleton or subsequen...

journal_title：Frontiers in physiology

authors： Ding HL,Hooper JE,Batzel P,Eames BF,Postlethwait JH,Artinger KB,Clouthier DE

更新日期：2016-07-14 00:00:00

abstract：:Skeletal muscles are large cells with multiple nuclei that are precisely positioned. The importance of the correct nuclear position is highlighted by the correlation between mispositioned nuclei and muscle disease (Spiro et al., 1966; Gueneau et al., 2009). Myonuclei are generally considered to be equivalent and there...

journal_title：Frontiers in physiology

authors： Perillo M,Folker ES

更新日期：2018-11-01 00:00:00

abstract：:The knowledge of possible acute and long-term health effects of aerosols inhaled from electronic cigarettes (ECs) is still limited partially due to incomplete awareness of physical phenomena related to EC-aerosol dynamics. This short review discusses the basic processes of aerosol transformation (dynamics) upon inhala...

journal_title：Frontiers in physiology

authors： Sosnowski TR,Odziomek M

更新日期：2018-07-09 00:00:00

abstract：:We have isolated dental pulp cells (DPCs) from three healthy (hDPCs) and three carious (cDPCs) donors and shown that compared to hDPCs cells isolated from superficial carious lesions show higher clonogenic potential; show an equivalent proportion of cells with putative stem cell surface markers; show enhanced matrix m...

journal_title：Frontiers in physiology

authors： Alkharobi H,Beattie J,Meade J,Devine D,El-Gendy R

更新日期：2017-04-28 00:00:00

abstract：:As opposed to the standard tolerogenic apoptosis, immunogenic cell death (ICD) constitutes a type of cellular demise that elicits an adaptive immune response. ICD has been characterized in malignant cells following cytotoxic interventions, such as chemotherapy or radiotherapy. Briefly, ICD of cancer cells releases som...

journal_title：Frontiers in physiology

authors： Checcoli A,Pol JG,Naldi A,Noel V,Barillot E,Kroemer G,Thieffry D,Calzone L,Stoll G

更新日期：2020-11-12 00:00:00

abstract：:Studies of palate development are motivated by the all too common incidence of cleft palate, a birth defect that imposes a tremendous health burden and can leave lasting disfigurement. Although, mechanistic studies of palate growth and fusion have focused on growth factors such as Transforming Growth Factor ß-3 (Tgfß3...

journal_title：Frontiers in physiology

authors： Benson MD,Serrano MJ

更新日期：2012-09-26 00:00:00

abstract：:Planarians undergo continuous body size remodeling under starvation or during regeneration. This process likely involves autophagy and autophagic cell death, but this hypothesis is supported by few studies. To test this hypothesis, we cloned and characterized autophagy-related gene 7 (Atg7) from the planarian Dugesia ...

journal_title：Frontiers in physiology

authors： Ma K,Zhang Y,Song G,Wu M,Chen G

更新日期：2018-09-04 00:00:00

abstract：:Obesity is a multi-factor chronic disease caused by the mixed influence of genetics, environments and an imbalance of energy intake and expenditure. Due to lifestyle changes, modern society sees a rapid increase in obesity occurrence along with an aggravated risk of metabolic syndromes in the general population, inclu...

journal_title：Frontiers in physiology

authors： Xu L,Zhao W,Wang D,Ma X

更新日期：2018-07-06 00:00:00

abstract：:Determining individual health status is of great importance for a better understanding of life history trade-offs between growth, reproduction, and maintenance. However, existing immunological methods are invasive and therefore not suitable for investigating health status in wild populations. Thus, there is an urgent ...

journal_title：Frontiers in physiology

authors： Behringer V,Stevens JM,Leendertz FH,Hohmann G,Deschner T

更新日期：2017-02-06 00:00:00

abstract：:Myokines are peptides known to modulate brain neuroplasticity, adipocyte metabolism, bone mineralization, endothelium repair and cell growth arrest in colon and breast cancer, among other processes. Repeated skeletal muscle contraction induces the production and secretion of myokines, which have a wide range of functi...

journal_title：Frontiers in physiology

authors： Sanchis-Gomar F,Lopez-Lopez S,Romero-Morales C,Maffulli N,Lippi G,Pareja-Galeano H

更新日期：2019-11-28 00:00:00

abstract：:Intermittent hypoxia (IH), characterized as cyclic episodes of short-period hypoxia followed by normoxia, occurs in many physiological and pathophysiological conditions such as pregnancy, athlete, obstructive sleep apnea, and asthma. Hypoxia can induce autophagy, which is activated in response to protein aggregates, i...

journal_title：Frontiers in physiology

authors： Chang JC,Hu WF,Lee WS,Lin JH,Ting PC,Chang HR,Shieh KR,Chen TI,Yang KT

更新日期：2019-08-07 00:00:00

abstract：:Swimming induced pulmonary edema (SIPE) is a complication that can occur during exercise with the possibility of misdiagnosis and can quickly become life threatening; however, medical literature infrequently describes SIPE. Therefore, the aim of this review was to analyse all individual cases diagnosed with SIPE as re...

journal_title：Frontiers in physiology

authors： Grünig H,Nikolaidis PT,Moon RE,Knechtle B

更新日期：2017-08-31 00:00:00

abstract：:Inflammation-induced impaired function of vascular endothelium may cause leakage of plasma proteins that can lead to edema. Proteins may leave the vascular lumen through two main paracellular and transcellular pathways. As the first involves endothelial cell (EC) junction proteins and the second caveolae formation, th...

journal_title：Frontiers in physiology

authors： Muradashvili N,Tyagi R,Lominadze D

更新日期：2012-05-31 00:00:00

abstract：:We aimed to investigate the effects of resistance training (RT) combined with no-load isometric actions (iso-holds) during the inter-set recovery period versus RT that involves passive inter-set rest on muscular strength, muscular hypertrophy, and muscular endurance in resistance-trained men. Twenty-seven resistance-t...

journal_title：Frontiers in physiology

authors： Schoenfeld BJ,Grgic J,Contreras B,Delcastillo K,Alto A,Haun C,De Souza EO,Vigotsky AD

更新日期：2020-01-15 00:00:00

abstract：:In the chronic stage of myocardial infarction, a significant number of patients develop life-threatening ventricular tachycardias (VT) due to the arrhythmogenic nature of the remodeled myocardium. Radiofrequency ablation (RFA) is a common procedure to isolate reentry pathways across the infarct scar that are responsib...

journal_title：Frontiers in physiology

authors： Lopez-Perez A,Sebastian R,Izquierdo M,Ruiz R,Bishop M,Ferrero JM

更新日期：2019-05-15 00:00:00

abstract：:Many drugs investigated for the treatment of glioblastoma (GBM) have had disappointing clinical trial results. Efficacy of these agents is dependent on adequate delivery to sensitive tumor cell populations, which is limited by the blood-brain barrier (BBB). Additionally, tumor heterogeneity can lead to subpopulations ...

journal_title：Frontiers in physiology

authors： Massey SC,Urcuyo JC,Marin BM,Sarkaria JN,Swanson KR

更新日期：2020-08-21 00:00:00

abstract：:At a fundamental level most genes, signaling pathways, biological functions and organ systems are highly conserved between man and all vertebrate species. Leveraging this conservation, researchers are increasingly using the experimental advantages of the amphibian Xenopus to model human disease. The online Xenopus res...

journal_title：Frontiers in physiology

authors： Nenni MJ,Fisher ME,James-Zorn C,Pells TJ,Ponferrada V,Chu S,Fortriede JD,Burns KA,Wang Y,Lotay VS,Wang DZ,Segerdell E,Chaturvedi P,Karimi K,Vize PD,Zorn AM

更新日期：2019-02-26 00:00:00

abstract：:Mouse Embryonic Stem Cells (ESCs) are pluripotent mammalian cells derived from the Inner Cell Mass (ICM) of mouse blastocysts, which give rise to all three embryonic germ layers both in vivo and in vitro. Mouse ESCs have a distinct epigenetic landscape and a more decondensed chromatin compared to differentiated cells....

journal_title：Frontiers in physiology

authors： Karnavas T,Pintonello L,Agresti A,Bianchi ME

更新日期：2014-08-28 00:00:00

abstract：:Human physiological signals are inherently rhythmic and have a hallmark feature in that even distant intrasignal measurements are related to each other. This relationship is termed long-range correlation and has been recognized as an indicator of the optimal state of the observed physiological systems, among which the...

journal_title：Frontiers in physiology

authors： Ravi DK,Marmelat V,Taylor WR,Newell KM,Stergiou N,Singh NB

更新日期：2020-06-23 00:00:00

abstract：Objective:Develop an automated approach to detect flash (<1.0 s) or prolonged (>2.0 s) capillary refill time (CRT) that correlates with clinician judgment by applying several supervised machine learning (ML) techniques to pulse oximeter plethysmography data. Materials and Methods:Data was collected in the Pediatric In...

journal_title：Frontiers in physiology

authors： Hunter RB,Jiang S,Nishisaki A,Nickel AJ,Napolitano N,Shinozaki K,Li T,Saeki K,Becker LB,Nadkarni VM,Masino AJ

更新日期：2020-10-06 00:00:00

abstract：:The microbes in the gastrointestinal tract are separated from the host by a single layer of intestinal epithelial cells (IECs) that plays pivotal roles in maintaining homeostasis by absorbing nutrients and providing a physical and immunological barrier to potential pathogens. Preservation of homeostasis requires the c...

journal_title：Frontiers in physiology

authors： Burgueño JF,Fritsch J,Santander AM,Brito N,Fernández I,Pignac-Kobinger J,Conner GE,Abreu MT

更新日期：2019-12-12 00:00:00

abstract：:Microbiopsies of human skeletal muscle are increasingly adopted by physiologists for a variety of experimental assays given the reduced invasiveness of this procedure compared to the classic Bergstrom percutaneous biopsy technique. However, a recent report demonstrated lower mitochondrial respiration in saponin-permea...

journal_title：Frontiers in physiology

authors： Hughes MC,Ramos SV,Turnbull PC,Nejatbakhsh A,Baechler BL,Tahmasebi H,Laham R,Gurd BJ,Quadrilatero J,Kane DA,Perry CG

更新日期：2015-12-18 00:00:00

abstract：:Exhaled breath carbon monoxide (eCO) is a candidate biomarker for non-invasive assessment of oxidative stress and respiratory diseases. Standard end-tidal CO analysis, however, cannot distinguish, whether eCO reflects endogenous CO production, lung diffusion properties or exogenous sources, and is unable to resolve a ...

journal_title：Frontiers in physiology

authors： Ghorbani R,Blomberg A,Schmidt FM

更新日期：2018-07-30 00:00:00

abstract：:Excitatory and inhibitory junction potentials of circular smooth muscle cells in guinea pig ileum and colon are suppressed 30-90 min after setting up in vitro preparations. We have previously shown this "unresponsive" period is associated with a transient loss of dye coupling between smooth muscle cells, which subsequ...

journal_title：Frontiers in physiology

authors： Carbone SE,Wattchow DA,Spencer NJ,Hibberd TJ,Brookes SJ

更新日期：2014-08-22 00:00:00

abstract：:Teeth and dentitions contain many morphological characters which give them a particularly important weight in comparative anatomy, systematics, physiology and ecology. As teeth are organs that contain the hardest mineralized tissues vertebrates can produce, their fossil remains are abundant and the study of their anat...

journal_title：Frontiers in physiology

authors： Bertin TJC,Thivichon-Prince B,LeBlanc ARH,Caldwell MW,Viriot L

更新日期：2018-11-21 00:00:00

abstract：:The study was conducted to compare and evaluate effects of four different macro-algaes on growth, immune response, and intestinal microbiota of Litopenaeus vannamei. In the rearing trial 1, shrimp were fed five diets containing four sources of macro-algaes for 8 weeks, named D1 (without macro-algae), D2 (Porphyra hait...

journal_title：Frontiers in physiology

authors： Niu J,Xie JJ,Guo TY,Fang HH,Zhang YM,Liao SY,Xie SW,Liu YJ,Tian LX

更新日期：2019-01-09 00:00:00

abstract：:Background: The modulation of arachidonic acid (AA) metabolism pathway is identified in metabolic alterations after hypoxia exposure, but its biological function is controversial. We aimed at integrating plasma metabolomic and transcriptomic approaches to systematically explore the roles of the AA metabolism pathway i...

journal_title：Frontiers in physiology

authors： Liu C,Liu B,Liu L,Zhang EL,Sun BD,Xu G,Chen J,Gao YQ

更新日期：2018-03-16 00:00:00

abstract：:Reticuloendothelial macrophages engulf ∼0.2 trillion senescent erythrocytes daily in a process called erythrophagocytosis (EP). This critical mechanism preserves systemic heme-iron homeostasis by regulating red blood cell (RBC) catabolism and iron recycling. Although extensive work has demonstrated the various effects...

journal_title：Frontiers in physiology

authors： Catala A,Youssef LA,Reisz JA,Dzieciatkowska M,Powers NE,Marchetti C,Karafin M,Zimring JC,Hudson KE,Hansen KC,Spitalnik SL,D'Alessandro A

更新日期：2020-04-30 00:00:00