Neuromuscular Electrical Stimulation: A New Therapeutic Option for Chronic Diseases Based on Contraction-Induced Myokine Secretion.

abstract：:Consistency of individual differences of animal behavior and personality in reactions to various environmental stresses among their life stages could reflect basic divergences in coping style which may affect survival, social rank, and reproductive success in the wild. However, the physiological mechanisms determining...

journal_title：Frontiers in physiology

authors： Yuan M,Chen Y,Huang Y,Lu W

更新日期：2018-05-30 00:00:00

abstract：:Odontoblast cells generated from human dental pulp stem/progenitor cells (hDPSCs) secrete reparative dentin in responds to an injury. Endogenous Wnt signaling is also activated during this process, and these Wnt-activated cells are responsible for the following repair response. R-spondin 2 (Rspo2) is a potent stem cel...

journal_title：Frontiers in physiology

authors： Gong Y,Yuan S,Sun J,Wang Y,Liu S,Guo R,Dong W,Li R

更新日期：2020-08-07 00:00:00

abstract：:The management of cancer patients is frequently complicated by the occurrence of cachexia. This is a complex syndrome that markedly impacts on quality of life as well as on tolerance and response to anticancer treatments. Loss of body weight, wasting of both adipose tissue and skeletal muscle and reduced survival rate...

journal_title：Frontiers in physiology

authors： Penna F,Ballarò R,Beltrà M,De Lucia S,García Castillo L,Costelli P

更新日期：2019-02-18 00:00:00

abstract：:Coronary microembolization (CME) is an important clinical problem, and it is related to poor outcome. The specific molecular mechanisms of CME are not fully understood. In the present study, we established a mice model of CME. Isobaric tags for relative and absolute quantitation (iTRAQ) and liquid chromatography coupl...

journal_title：Frontiers in physiology

authors： Chen A,Chen Z,Xia Y,Lu D,Jia J,Hu K,Sun A,Zou Y,Qian J,Ge J

更新日期：2018-09-19 00:00:00

abstract：:In mammals, there are two types of urea transporters; urea transporter (UT)-A and UT-B. The UT-A transporters are mainly expressed in kidney epithelial cells while UT-B demonstrates a broader distribution in kidney, heart, brain, testis, urinary tract, and other tissues. Over the past few years, multiple urea transpor...

journal_title：Frontiers in physiology

authors： Li X,Chen G,Yang B

更新日期：2012-06-26 00:00:00

abstract：:Sport-specific differences in the left ventricle (LV) of land-based athletes have been observed; however, comparisons to water-based athletes are sparse. The purpose of this study was to examine differences in LV structure and function in elite swimmers and runners. Sixteen elite swimmers [23 (2) years, 81% male, 69% ...

journal_title：Frontiers in physiology

authors： Currie KD,Coates AM,Slysz JT,Aubry RL,Whinton AK,Mountjoy ML,Millar PJ,Burr JF

更新日期：2018-11-28 00:00:00

abstract：:Renal fibrosis is characterized by progressive accumulation of extracellular matrix (ECM) proteins, resulting in loss of organ function and eventually requiring renal replacement therapy. Unfortunately, no efficacious treatment options are available to halt renal fibrosis and translational models to test pharmacologic...

journal_title：Frontiers in physiology

authors： Stribos EGD,Seelen MA,van Goor H,Olinga P,Mutsaers HAM

更新日期：2017-12-12 00:00:00

abstract：:Deep learning (DL) has attracted the attention of computational toxicologists as it offers a potentially greater power for in silico predictive toxicology than existing shallow learning algorithms. However, contradicting reports have been documented. To further explore the advantages of DL over shallow learning, we co...

journal_title：Frontiers in physiology

authors： Idakwo G,Thangapandian S,Luttrell J 4th,Zhou Z,Zhang C,Gong P

更新日期：2019-08-13 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) not only play essential roles in bone development but also are involved in embryonic growth, organogenesis cell proliferation and differentiation. However, the previous studies on the functions of shellfish BMPs genes are still very limited. To better understand its molecular structu...

journal_title：Frontiers in physiology

authors： Zhao J,Cui B,Yao H,Lin Z,Dong Y

更新日期：2020-08-28 00:00:00

abstract：:Acute beer or alcohol ingestion reduces arterial stiffness, but the dose required to reduce arterial stiffness is unclear. Therefore, this study aimed to determine the acute effects of ingesting various amounts of beer on arterial stiffness in healthy men. Nine men (20-22 years) participated, in eight trials in random...

journal_title：Frontiers in physiology

authors： Nishiwaki M,Yamaguchi T,Nishida R,Matsumoto N

更新日期：2020-08-28 00:00:00

abstract：:Previous studies report greater activation in the cortical motor network in controlling eccentric contraction (EC) than concentric contraction (CC) of human skeletal muscles despite lower activation level of the muscle associated with EC. It is unknown, however, whether the strength of functional coupling between the ...

journal_title：Frontiers in physiology

authors： Yao WX,Jiang Z,Li J,Jiang C,Franlin CG,Lancaster JL,Huang Y,Yue GH

更新日期：2016-11-15 00:00:00

abstract：:Astronauts exposed to microgravity face sensorimotor challenges affecting balance control when readapting to Earth's gravity upon return from spaceflight. Small amounts of electrical noise applied to the vestibular system have been shown to improve balance control during standing and walking under discordant sensory c...

journal_title：Frontiers in physiology

authors： Temple DR,De Dios YE,Layne CS,Bloomberg JJ,Mulavara AP

更新日期：2018-03-29 00:00:00

abstract：:Objective: Neuromuscular injury prevention programs (IPP) can reduce injury rate by about 40% in youth sport. Multimodal IPP include, for instance, balance, strength, power, and agility exercises. Our systematic review and meta-analysis aimed to evaluate the effects of multimodal IPP on neuromuscular performance in yo...

journal_title：Frontiers in physiology

authors： Faude O,Rössler R,Petushek EJ,Roth R,Zahner L,Donath L

更新日期：2017-10-12 00:00:00

abstract：:In this study, we analyzed the role of mammalian STE20-like protein kinase 2 (Mst2), a serine-threonine protein kinase, in Lipopolysaccharides (LPS)-mediated inflammation and apoptosis in the H9C2 cardiomyocytes. Mst2 mRNA and protein levels were significantly upregulated in the LPS-treated H9C2 cardiomyocytes. LPS tr...

journal_title：Frontiers in physiology

authors： Tian Y,Song H,Qin W,Ding Z,Zhang Y,Shan W,Jin D

更新日期：2020-08-06 00:00:00

abstract：:Hypoxic exercise may represent a novel therapeutic strategy to reduce and prevent obesity through the regulation of lipid metabolism. During hypoxic exercise, the targeting of peroxisome proliferator-activated receptor gamma (PPARγ) by miR-27b has been proposed to be one of the mechanisms involved in the modulation of...

journal_title：Frontiers in physiology

authors： Wang X,Lu Y,Zhu L,Zhang H,Feng L

更新日期：2020-08-31 00:00:00

abstract：:The two forms of inorganic arsenic, arsenate (AsV) and arsenite (AsIII), are easily taken up by the cells of the plant root. Once in the cell, AsV can be readily converted to AsIII, the more toxic of the two forms. AsV and AsIII both disrupt plant metabolism, but through distinct mechanisms. AsV is a chemical analog o...

journal_title：Frontiers in physiology

authors： Finnegan PM,Chen W

更新日期：2012-06-06 00:00:00

abstract：:Ontologies and standards are very important parts of today's bioscience research. With the rapid increase of biological knowledge, they provide mechanisms to better store and represent data in a controlled and structured way, so that scientists can share the data, and utilize a wide variety of software and tools to ma...

journal_title：Frontiers in physiology

authors： Mi H,Thomas PD

更新日期：2011-02-21 00:00:00

abstract：:Exercise is known to improve many aspects of human health, including modulation of the immune system and inflammatory status. It is generally understood that exercise reduces inflammation, but there are missing links in terms of understanding the mechanisms as well as the differences between exercise modalities. N-gly...

journal_title：Frontiers in physiology

authors： Tijardović M,Marijančević D,Bok D,Kifer D,Lauc G,Gornik O,Keser T

更新日期：2019-12-20 00:00:00

abstract：:In insects, locomotion is the result of rhythm generating thoracic circuits and their modulation by sensory reflexes and by inputs from the two head ganglia, the cerebral and the gnathal ganglia (GNG), which act as higher order neuronal centers playing different functions in the initiation, goal-direction, and mainten...

journal_title：Frontiers in physiology

authors： Emanuel S,Kaiser M,Pflueger HJ,Libersat F

更新日期：2020-02-21 00:00:00

abstract：:Telomeres are genomic complex at the end of chromosomes that protects the DNA and telomere length (TL) is related to several age-related diseases, lifespan, and cancer. On the other hand, cancer is a multifactorial disease that is responsible for reduce the quality of life and kills millions of people every year. Both...

journal_title：Frontiers in physiology

authors： Nomikos NN,Nikolaidis PT,Sousa CV,Papalois AE,Rosemann T,Knechtle B

更新日期：2018-12-18 00:00:00

abstract：:The mechanisms of atrial fibrillation (AF) are a challenging research topic. The rotor hypothesis states that the AF is sustained by a reentrant wave that propagates around an unexcited core. Cardiac tissue heterogeneities, both structural and cellular, play an important role during fibrillatory dynamics, so that the ...

journal_title：Frontiers in physiology

authors： Ugarte JP,Tobón C,Lopes AM,Machado JAT

更新日期：2018-07-24 00:00:00

abstract：:The mealworm beetle, Tenebrio molitor, is currently considered as a pest when infesting stored grains or grain products. However, mealworms are now being promoted as a beneficial insect because their high nutrient content makes them a viable food source and because they are capable of degrading polystyrene and plastic...

journal_title：Frontiers in physiology

authors： Vigneron A,Jehan C,Rigaud T,Moret Y

更新日期：2019-03-12 00:00:00

abstract：Introduction:MTHFR methylation status is associated with microvascular complications in diabetes, but the factors influencing this profile remain unknown. Objective:The aim of this study was to evaluate the influence of physical activity level and nutritional status on the methylation profile of the MTHFR gene in pati...

journal_title：Frontiers in physiology

authors： Diniz TG,Silva AS,Dos Santos Nunes MK,Ribeiro MD,Filho JM,do Nascimento RAF,Gomes CNAP,Evangelista IWQ,de Oliveira NFP,Persuhn DC

更新日期：2021-01-12 00:00:00

abstract：:Background: Understanding the microscopic dynamics of the beating heart has been challenging due to the technical nature of imaging with micrometer resolution while the heart moves. The development of multiphoton microscopy has made in vivo, cell-resolved measurements of calcium dynamics and vascular function possible...

journal_title：Frontiers in physiology

authors： Jones JS,Small DM,Nishimura N

更新日期：2018-07-31 00:00:00

abstract：Background:Perturbation of endothelial function in people with cystic fibrosis (CF) has been reported, which may be associated with endothelial cell expression of the cystic fibrosis transmembrane conductance regulator (CFTR). Previous reports indicate that CFTR activity upregulates endothelial barrier function, endoth...

journal_title：Frontiers in physiology

authors： Khalaf M,Scott-Ward T,Causer A,Saynor Z,Shepherd A,Górecki D,Lewis A,Laight D,Shute J

更新日期：2020-07-29 00:00:00

abstract：:Gut-brain signaling controls feeding behavior and energy homeostasis; however, the underlying molecular mechanisms and impact of diet-induced obesity (DIO) on these pathways are poorly defined. We tested the hypothesis that elevated endocannabinoid activity at cannabinoid CB1 receptor (CB1Rs) in the gut of mice render...

journal_title：Frontiers in physiology

authors： Argueta DA,Perez PA,Makriyannis A,DiPatrizio NV

更新日期：2019-06-11 00:00:00

abstract：:Several Octopodidae species have a great potential for the diversification of worldwide aquaculture. Unfortunately, the lack of stress-related biomarkers in this taxon results an obstacle for its maintenance in conditions where animal welfare is of paramount relevance. In this study, we made a first approach to uncove...

journal_title：Frontiers in physiology

authors： Barragán-Méndez C,Sobrino I,Marín-Rincón A,Fernández-Boo S,Costas B,Mancera JM,Ruiz-Jarabo I

更新日期：2019-06-25 00:00:00

abstract：:Background: Measuring the extent to which renal artery stenosis (RAS) alters renal haemodynamics may permit precision medicine by physiologically guided revascularization. This currently requires invasive intra-arterial pressure measurement with associated risks and is rarely performed. The present proof-of-concept st...

journal_title：Frontiers in physiology

authors： Mandaltsi A,Grytsan A,Odudu A,Kadziela J,Morris PD,Witkowski A,Ellam T,Kalra P,Marzo A

更新日期：2018-08-17 00:00:00

abstract：:Ameloblasts are ectoderm-derived cells that produce an extracellular enamel matrix that mineralizes to form enamel. The development and use of immortalized cell lines, with a stable phenotype, is an important contribution to biological studies as it allows for the investigation of molecular activities without the cont...

journal_title：Frontiers in physiology

authors： Sarkar J,Simanian EJ,Tuggy SY,Bartlett JD,Snead ML,Sugiyama T,Paine ML

更新日期：2014-07-25 00:00:00

abstract：:Cells expressing bitter taste receptors (T2Rs or Tas2rs) in extraoral tissues are considered to be chemosensory cells mediating protective responses to potentially harmful or even antiinflammatory or antimicrobial compounds. In a previous study the activity of the Tas2R143/Tas2R135/Tas2r126 cluster promoter in the sto...

journal_title：Frontiers in physiology

authors： Widmayer P,Partsch V,Pospiech J,Kusumakshi S,Boehm U,Breer H

更新日期：2020-02-07 00:00:00