Targeting Inflammation and Downstream Protein Metabolism in Sarcopenia: A Brief Up-Dated Description of Concurrent Exercise and Leucine-Based Multimodal Intervention.


:Sarcopenia is defined as the progressive loss of muscle mass with age, and poses a serious threat to the physiological and psychological health of the elderly population with consequential economic and social burdens. Chronic low-grade inflammation plays a central role in the development of sarcopenia such that it alters cellular protein metabolism to favor proteolysis over synthesis, and thereby accelerates muscular atrophy. The purpose of this review is to highlight how exercise and nutrition intervention strategies can attenuate or treat sarcopenia. Resistance exercise increases not only muscle mass but also muscle strength, while aerobic exercise is able to ameliorate the age-related metabolic disorders. Concurrent exercise training integrates the advantages of both aerobic and resistance exercise, and may exert a significant synergistic effect in the aging organism. Higher protein intakes rich in the amino acid leucine appear to restore skeletal muscle protein metabolism balance by rescuing protein synthesis in older adults. There is good reason to believe that a multimodal treatment, a combination of exercise and increased leucine consumption in the diet, can combat some of the muscle loss associated with aging. Future research is needed to consolidate these findings to humans, and to further clarify to what extent and by which mechanisms protein metabolism might be directly involved in sarcopenia pathogenesis and the multimodal treatment responses.


Front Physiol


Frontiers in physiology


Xia Z,Cholewa J,Zhao Y,Shang HY,Yang YQ,Araújo Pessôa K,Su QS,Lima-Soares F,Zanchi NE




Has Abstract


2017-06-22 00:00:00








  • Sport-Specific Assessment of the Effectiveness of Neuromuscular Training in Young Athletes.

    abstract::Neuromuscular training in young athletes improves performance and decreases the risk of injuries during sports activities. These effects are primarily ascribed to the enhancement of muscle strength and power but also balance, speed and agility. However, most studies have failed to demonstrate significant improvement i...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Zemková E,Hamar D

    更新日期:2018-04-11 00:00:00

  • Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) in Human Lung Microvascular Endothelial Cells Controls Oxidative Stress, Reactive Oxygen-Mediated Cell Signaling and Inflammatory Responses.

    abstract:Background:Perturbation of endothelial function in people with cystic fibrosis (CF) has been reported, which may be associated with endothelial cell expression of the cystic fibrosis transmembrane conductance regulator (CFTR). Previous reports indicate that CFTR activity upregulates endothelial barrier function, endoth...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Khalaf M,Scott-Ward T,Causer A,Saynor Z,Shepherd A,Górecki D,Lewis A,Laight D,Shute J

    更新日期:2020-07-29 00:00:00

  • Patients with Chronic Obstructive Pulmonary Disease Suffer from Worse Periodontal Health-Evidence from a Meta-Analysis.

    abstract::Background and Objective: It is widely accepted that there is an association between chronic obstructive pulmonary disease (COPD) and periodontitis. However, whether the periodontal status of the COPD patients is worse than that of the non-COPD subjects is seldom assessed. The findings currently available are inconsis...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Shi Q,Zhang B,Xing H,Yang S,Xu J,Liu H

    更新日期:2018-01-25 00:00:00

  • Coexisting Frailty With Heart Failure.

    abstract::People over 65 years of age constitute over 80% of patients with heart failure (HF) and the incidence of HF is 10 per 1,000 in people aged above 65 years. Approximately 25% of older patients with HF exhibit evidence of frailty. Frail patients with cardiovascular disease (CVD) have a worse prognosis than non-frail pati...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Uchmanowicz I,Nessler J,Gobbens R,Gackowski A,Kurpas D,Straburzynska-Migaj E,Kałuzna-Oleksy M,Jankowska EA

    更新日期:2019-07-03 00:00:00

  • A Personalized Signature and Chronotherapy-Based Platform for Improving the Efficacy of Sepsis Treatment.

    abstract::Sepsis remains a major therapeutic challenge and is associated with a high rate of morbidity and mortality. It is a dynamic condition in which multiple parameters change over time, rendering it difficult to overcome the various injurious responses, which worsen the prognosis in these patients. The prognosis of sepsis ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Kenig A,Ilan Y

    更新日期:2019-12-19 00:00:00

  • Nitric Oxide Has a Concentration-Dependent Effect on the Cell Cycle Acting via EIN2 in Arabidopsis thaliana Cultured Cells.

    abstract::Ethylene is known to influence the cell cycle (CC) via poorly characterized roles whilst nitric oxide (NO) has well-established roles in the animal CC but analogous role(s) have not been reported for plants. As NO and ethylene signaling events often interact we examined their role in CC in cultured cells derived from ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Novikova GV,Mur LA,Nosov AV,Fomenkov AA,Mironov KS,Mamaeva AS,Shilov ES,Rakitin VY,Hall MA

    更新日期:2017-03-10 00:00:00

  • Validity and Reliability of the 30-s Continuous Jump for Anaerobic Power and Capacity Assessment in Combat Sport.

    abstract::Cycling test such Wingate anaerobic test (WAnT) is used to measure anaerobic power (AP), but not anaerobic capacity (AC, i.e., the metabolic energy demand). However, in sports that do not involve cycling movements (Karate), the continuous jump for 30 s (vertical jumps for 30 s) has been extensively used to measure ana...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Čular D,Ivančev V,Zagatto AM,Milić M,Beslija T,Sellami M,Padulo J

    更新日期:2018-05-15 00:00:00

  • Neuromuscular Adaptations to Multimodal Injury Prevention Programs in Youth Sports: A Systematic Review with Meta-Analysis of Randomized Controlled Trials.

    abstract::Objective: Neuromuscular injury prevention programs (IPP) can reduce injury rate by about 40% in youth sport. Multimodal IPP include, for instance, balance, strength, power, and agility exercises. Our systematic review and meta-analysis aimed to evaluate the effects of multimodal IPP on neuromuscular performance in yo...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Faude O,Rössler R,Petushek EJ,Roth R,Zahner L,Donath L

    更新日期:2017-10-12 00:00:00

  • Modeling the Interactions Between Sodium Channels Provides Insight Into the Negative Dominance of Certain Channel Mutations.

    abstract:Background:Nav1.5 cardiac Na+ channel mutations can cause arrhythmogenic syndromes. Some of these mutations exert a dominant negative effect on wild-type channels. Recent studies showed that Na+ channels can dimerize, allowing coupled gating. This leads to the hypothesis that allosteric interactions between Na+ channel...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Hichri E,Selimi Z,Kucera JP

    更新日期:2020-11-05 00:00:00

  • Sirtuin1 Role in the Melatonin Protective Effects Against Obesity-Related Heart Injury.

    abstract::Obesity is a worldwide epidemic disease that induces important structural and functional changes to the heart and predisposes a patient to devastating cardiac complications. Sirtuin1 (SIRT1) has been found to have roles in regulating cardiac function, but whether it can help in cardioprotection is not clear. The aim o...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Favero G,Franco C,Stacchiotti A,Rodella LF,Rezzani R

    更新日期:2020-03-11 00:00:00

  • Being Anxious, Thinking Positively: The Effect of Emotional Context on Respiratory Sensory Gating.

    abstract::Respiratory sensory gating function has been found decreased by induced negative emotion in healthy adults. The increased ratio of the respiratory-related evoked potential (RREP) N1 peak amplitude for the second occlusion (S2) vs. the first occlusion (S1), S2/S1, is indicative of such decreased respiratory sensory gat...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Chan PY,Cheng CH,Jhu YJ,Chen CL,von Leupoldt A

    更新日期:2016-02-16 00:00:00

  • The Environmental Plasticity of Diverse Body Color Caused by Extremely Long Photoperiods and High Temperature in Saccharosydne procerus (Homoptera: Delphacidae).

    abstract::Melanization reflects not only body color variation but also environmental plasticity. It is a strategy that helps insects adapt to environmental change. Different color morphs may have distinct life history traits, e.g., development time, growth rate, and body weight. The green slender planthopper Saccharosydne proce...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Yin H,Shi Q,Shakeel M,Kuang J,Li J

    更新日期:2016-09-12 00:00:00

  • A Novel Data-Driven Boolean Model for Genetic Regulatory Networks.

    abstract::A Boolean model is a simple, discrete and dynamic model without the need to consider the effects at the intermediate levels. However, little effort has been made into constructing activation, inhibition, and protein decay networks, which could indicate the direct roles of a gene (or its synthesized protein) as an acti...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Chen L,Kulasiri D,Samarasinghe S

    更新日期:2018-09-25 00:00:00

  • Measuring energy metabolism in the mouse - theoretical, practical, and analytical considerations.

    abstract::The mouse is one of the most important model organisms for understanding human genetic function and disease. This includes characterization of the factors that influence energy expenditure and dysregulation of energy balance leading to obesity and its sequelae. Measuring energy metabolism in the mouse presents a chall...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Speakman JR

    更新日期:2013-03-14 00:00:00

  • Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's Disease.

    abstract::In aged subjects, late-onset Alzheimer's disease (LOAD) starts in the lateral entorhinal allocortex where a failure of clearance mechanisms triggers an accumulation of neurotoxic amyloid-β42 oligomers (Aβ42-os). In neurons and astrocytes, Aβ42-os enhance the transcription of Aβ precursor protein (APP) and β-secretase/...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Chiarini A,Armato U,Liu D,Dal Prà I

    更新日期:2016-04-26 00:00:00

  • Identification of displaced endometrial glands and embryonic duct remnants in female fetal reproductive tract: possible pathogenetic role in endometriotic and pelvic neoplastic processes.

    abstract:BACKGROUND:Recent findings strongly promoted the hypothesis that common pelvic gynecological diseases including endometriosis and ovarian neoplasia may develop de novo from ectopic endometrial-like glands and/or embryonic epithelial remnants. To verify the frequency, the anatomical localization and the phenotype of mis...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Bouquet de Jolinière J,Ayoubi JM,Lesec G,Validire P,Goguin A,Gianaroli L,Dubuisson JB,Feki A,Gogusev J

    更新日期:2012-12-03 00:00:00

  • The Circadian Clock Improves Fitness in the Fruit Fly, Drosophila melanogaster.

    abstract::It is assumed that a properly timed circadian clock enhances fitness, but only few studies have truly demonstrated this in animals. We raised each of the three classical Drosophila period mutants for >50 generations in the laboratory in competition with wildtype flies. The populations were either kept under a conventi...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Horn M,Mitesser O,Hovestadt T,Yoshii T,Rieger D,Helfrich-Förster C

    更新日期:2019-11-01 00:00:00

  • Developmental Potential of Abnormally Fertilized Oocytes and the Associated Clinical Outcomes.

    abstract::This study aims to investigate the embryo development potential of extending the culture of abnormally fertilized zygotes with no pronuclear (0PN), monopronuclear (1PN), and poor-quality day 3 embryos and to determine the associated clinical outcomes. This is a retrospective study performed between January 2014 and Ma...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Chen X,Shi S,Mao J,Zou L,Yu K

    更新日期:2020-11-04 00:00:00

  • Nociceptors as chronic drivers of pain and hyperreflexia after spinal cord injury: an adaptive-maladaptive hyperfunctional state hypothesis.

    abstract::Spinal cord injury (SCI) causes chronic peripheral sensitization of nociceptors and persistent generation of spontaneous action potentials (SA) in peripheral branches and the somata of hyperexcitable nociceptors within dorsal root ganglia (DRG). Here it is proposed that SCI triggers in numerous nociceptors a persisten...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Walters ET

    更新日期:2012-08-02 00:00:00

  • Entropy Analysis of RR-Time Series From Stress Tests.

    abstract::The RR-interval time series or tachograms obtained from electrocardiograms have been widely studied since they reflect the cardiac variability, and this is an indicative of the health status of a person. The tachogram can be seen as a highly non-linear and complex time series, and therefore, should be analyzed with no...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Solís-Montufar EE,Gálvez-Coyt G,Muñoz-Diosdado A

    更新日期:2020-08-12 00:00:00

  • Longitudinal analysis of arterial blood pressure and heart rate response to acute behavioral stress in rats with type 1 diabetes mellitus and in age-matched controls.

    abstract::We recorded via telemetry the arterial blood pressure (BP) and heart rate (HR) response to classical conditioning following the spontaneous onset of autoimmune diabetes in BBDP/Wor rats vs. age-matched, diabetes-resistant control (BBDR/Wor) rats. Our purpose was to evaluate the autonomic regulatory responses to an acu...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Randall DC,Speakman RO,Silcox DL,Brown LV,Brown DR,Gong MC,Patwardhan A,Reynolds LR,Karounos DG,Burgess DE,Anigbogu CN

    更新日期:2011-08-27 00:00:00

  • Linear and Nonlinear Analyses of the Cardiac Autonomic Control in Children With Developmental Coordination Disorder: A Case-Control Study.

    abstract::Children with Developmental Coordination Disorder (DCD) and children at risk for DCD (r-DCD) present motor impairments interfering in their school, leisure and daily activities. In addition, these children may have abnormalities in their cardiac autonomic control, which together with their motor impairments, restrict ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Cavalcante Neto JL,Zamunér AR,Moreno BC,Silva E,Tudella E

    更新日期:2018-03-22 00:00:00

  • Sedentary Behavior Is Only Marginally Associated with Physical Function in Adults Aged 40-75 Years-the Maastricht Study.

    abstract::Background: In an aging population, regular physical activity (PA) and exercise have been recognized as important factors in maintaining physical function and thereby preventing loss of independence and disability. However, (older) adults spent the majority of their day sedentary and therefore insight into the consequ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: van der Velde JHPM,Savelberg HHCM,van der Berg JD,Sep SJS,van der Kallen CJH,Dagnelie PC,Schram MT,Henry RMA,Reijven PLM,van Geel TACM,Stehouwer CDA,Koster A,Schaper NC

    更新日期:2017-04-25 00:00:00

  • Odorant Receptors and Odorant-Binding Proteins as Insect Pest Control Targets: A Comparative Analysis.

    abstract::Recently, two alternative targets in insect periphery nerve system have been explored for environmentally-friendly approaches in insect pest management, namely odorant-binding proteins (OBPs) and odorant receptors (ORs). Located in insect antennae, OBPs are thought to be involved in the transport of odorants to ORs fo...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: Venthur H,Zhou JJ

    更新日期:2018-08-24 00:00:00

  • Metabolic Reprogramming of Mouse Bone Marrow Derived Macrophages Following Erythrophagocytosis.

    abstract::Reticuloendothelial macrophages engulf ∼0.2 trillion senescent erythrocytes daily in a process called erythrophagocytosis (EP). This critical mechanism preserves systemic heme-iron homeostasis by regulating red blood cell (RBC) catabolism and iron recycling. Although extensive work has demonstrated the various effects...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Catala A,Youssef LA,Reisz JA,Dzieciatkowska M,Powers NE,Marchetti C,Karafin M,Zimring JC,Hudson KE,Hansen KC,Spitalnik SL,D'Alessandro A

    更新日期:2020-04-30 00:00:00

  • Arabidopsis Mutant bik1 Exhibits Strong Resistance to Plasmodiophora brassicae.

    abstract::Botrytis-induced kinase1 (BIK1), a receptor-like cytoplasmic kinase, plays an important role in resistance against pathogens and insects in Arabidopsis thaliana. However, it remains unknown whether BIK1 functions against Plasmodiophora brassicae, an obligate biotrophic protist that attacks cruciferous plants and induc...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Chen T,Bi K,He Z,Gao Z,Zhao Y,Fu Y,Cheng J,Xie J,Jiang D

    更新日期:2016-09-13 00:00:00

  • Gonad-Specific Transcriptomes Reveal Differential Expression of Gene and miRNA Between Male and Female of the Discus Fish (Symphysodon aequifasciatus).

    abstract::The discus fish (Symphysodon aequifasciatus) is an ornamental fish that is well-known around the world. In artificial reproduction, they must be matched by one male and one female, whereas phenotype investigation indicated that there are no significant differences in appearance between males and females, which causes ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Fu Y,Xu Z,Wen B,Gao J,Chen Z

    更新日期:2020-08-11 00:00:00

  • Age and Sex Differences in Hearts of Soluble Epoxide Hydrolase Null Mice.

    abstract::Biological aging is an inevitable part of life that has intrigued individuals for millennia. The progressive decline in biological systems impacts cardiac function and increases vulnerability to stress contributing to morbidity and mortality in aged individuals. Yet, our understanding of the molecular, biochemical and...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Jamieson KL,Keshavarz-Bahaghighat H,Darwesh AM,Sosnowski DK,Seubert JM

    更新日期:2020-02-07 00:00:00

  • Cardiovascular and Metabolic Responses to the Ingestion of Caffeinated Herbal Tea: Drink It Hot or Cold?

    abstract::Aim: Tea is usually consumed at two temperatures (as hot tea or as iced tea). However, the importance of drink temperature on the cardiovascular system and on metabolism has not been thoroughly investigated. The purpose of this study was to compare the cardiovascular, metabolic and cutaneous responses to the ingestion...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章


    authors: Maufrais C,Sarafian D,Dulloo A,Montani JP

    更新日期:2018-04-06 00:00:00

  • Prevention, Reduction and Repair of Brain Injury of the Preterm Infant.

    abstract::Periventricular-intraventricular hemorrhages (PIVH) and (diffuse) white matter injury (WMI) are the most important acquired brain lesions of the very and extremely prematurely born neonate. Both carry a high risk for death or adverse neurodevelopmental outcome. The first part of the review discusses the standard of ca...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审


    authors: van Bel F,Vaes J,Groenendaal F

    更新日期:2019-03-20 00:00:00