Prevention, Reduction and Repair of Brain Injury of the Preterm Infant.

Abstract:

:Periventricular-intraventricular hemorrhages (PIVH) and (diffuse) white matter injury (WMI) are the most important acquired brain lesions of the very and extremely prematurely born neonate. Both carry a high risk for death or adverse neurodevelopmental outcome. The first part of the review discusses the standard of care and latest insights with respect to prevention and/or reduction of PIVH and WMI, taking into account their etiopathogenesis which is tightly linked to (functional) immaturity of the cerebral vascular bed and nervous system and commonly encountered inflammation. The second part discusses repair of hemorrhagic- ischemic and post-inflammatory brain lesions as it is an increasingly important topic in newborn medicine. In the near future trials of trophic and (autologous or allogenic) cell-therapy in infants at risk of or demonstrating established PIVH and WMI will be started. The focus of these potential trials will be discussed.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

van Bel F,Vaes J,Groenendaal F

doi

10.3389/fphys.2019.00181

subject

Has Abstract

pub_date

2019-03-20 00:00:00

pages

181

issn

1664-042X

journal_volume

10

pub_type

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