Grafting Neural Stem and Progenitor Cells Into the Hippocampus of Juvenile, Irradiated Mice Normalizes Behavior Deficits.

abstract：:Mutations of the voltage-gated sodium channel SCN8A have been identified in approximately 1% of nearly 1,500 children with early-infantile epileptic encephalopathies (EIEE) who have been tested by DNA sequencing. EIEE caused by mutation of SCN8A is designated EIEE13 (OMIM #614558). Affected children have seizure onset...

journal_title：Frontiers in neurology

authors： Wagnon JL,Meisler MH

更新日期：2015-05-15 00:00:00

abstract：:Background: Mild traumatic brain injuries (mTBIs) are a significant social, sport, and military health issue. In spite of advances in the clinical management of these injuries, the underlying pathophysiology is not well-understood. There is a critical need to advance objective biomarkers, allowing the identification a...

journal_title：Frontiers in neurology

authors： Raikes AC,Bajaj S,Dailey NS,Smith RS,Alkozei A,Satterfield BC,Killgore WDS

更新日期：2018-06-20 00:00:00

abstract：:Background: This study aims to investigate the association between blood pressure (BP) at the time of recanalization and hemorrhagic transformation in large vessel occlusion (LVO) patients following mechanical thrombectomy (MT) with general anesthesia. Methods: We retrospectively reviewed our data base for patients wi...

journal_title：Frontiers in neurology

authors： Cheng H,Xu C,Jin X,Chen Y,Zheng X,Shi F,He X,Hao Y,Jiang Y,Zhang J,Chen Z

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND:The neural constraints underlying hemiparetic gait dysfunction are associated with abnormal kinetic outflow and altered muscle synergy structure. Recent evidence from our lab implicates the lesioned hemisphere in mediating the expression of abnormally coupled hip adduction and knee extension synergy, suggest...

journal_title：Frontiers in neurology

authors： Tan AQ,Dhaher YY

更新日期：2017-08-07 00:00:00

abstract：:Penetrating brain trauma commonly results in occult neurovascular injury. Detailed cerebrovascular imaging can evaluate the relationship of intracranial foreign bodies to major vascular structures, assess for traumatic pseudoaneurysms, and ensure hemostasis during surgical removal. We report a case of a self-inflicted...

journal_title：Frontiers in neurology

authors： Rennert RC,Steinberg JA,Sack J,Pannell JS,Khalessi AA

更新日期：2016-07-14 00:00:00

abstract：OBJECTIVE:Dizziness is a common reason patients present to doctors, but effective diagnostic tests and treatments for dizziness are underused. The internet is a way to disseminate medical information and is emerging as an intervention platform. The objective of this study was to describe internet searches for dizziness...

journal_title：Frontiers in neurology

authors： Kerber KA,Skolarus LE,Callaghan BC,Zheng K,Zhang Y,An LC,Burke JF

更新日期：2014-04-16 00:00:00

abstract：:Gross motor impairments are common after stroke, but efficient and motivating therapies for these impairments are scarce. We present an innovative musical sonification therapy, especially designed to retrain patients' gross motor functions. Sonification should motivate patients and provide additional sensory input inf...

journal_title：Frontiers in neurology

authors： Scholz DS,Rohde S,Nikmaram N,Brückner HP,Großbach M,Rollnik JD,Altenmüller EO

更新日期：2016-06-30 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), which is TNF receptor superfamily member, contributes to several diseases pathogenesis. The aim of this research was to investigate the relevance of serum TRAIL protein levels and mRNA expression in peripheral blood mononuclear cells (PBMC) of pati...

journal_title：Frontiers in neurology

authors： Tufekci KU,Vurgun U,Yigitaslan O,Keskinoglu P,Yaka E,Kutluk K,Genc S

更新日期：2018-03-05 00:00:00

abstract：:Background: Automated ASPECTS has the potential of reducing interobserver variability in the determination of early ischemic changes. We aimed to assess the performance of an automated ASPECTS vs. ASPECTS interpreted for sent CT images on WhatsApp and to correlate these results with the outcome. Materials and Methods:...

journal_title：Frontiers in neurology

authors： Mansour OY,Ramadan I,Abdo A,Hamdi M,Eldeeb H,Marouf H,Elsalamawy D,Elfatatry A,Elnekidy A,Reda MI

更新日期：2020-05-19 00:00:00

abstract：OBJECTIVE:Rotational vestibular function declines with age resulting in saccades as a compensatory mechanism to improve impaired gaze stability. Small reductions in rotational vestibulo-ocular reflex (VOR) gain that would be considered clinically normal have been associated with compensatory saccades. We evaluated whet...

journal_title：Frontiers in neurology

authors： Anson ER,Bigelow RT,Carey JP,Xue QL,Studenski S,Schubert MC,Weber KP,Agrawal Y

更新日期：2016-07-18 00:00:00

abstract：:Purpose: We are aiming to build a supervised machine learning-based classifier, in order to preoperatively distinguish focal cortical dysplasia (FCD) from glioneuronal tumors (GNTs) in patients with epilepsy. Methods: This retrospective study was comprised of 96 patients who underwent epilepsy surgery, with the final ...

journal_title：Frontiers in neurology

authors： Guo Y,Liu Y,Ming W,Wang Z,Zhu J,Chen Y,Yao L,Ding M,Shen C

更新日期：2020-11-24 00:00:00

abstract：:Background: Listeria rhombencephalitis, infection of the brainstem with Listeria monocytogenes, occurs mainly in humans and farmed ruminants and is associated with high fatality rates. Small ruminants (goats and sheep) are a large animal model due to neuropathological similarities. The purpose of this study was to def...

journal_title：Frontiers in neurology

authors： Precht C,Vermathen P,Henke D,Staudacher A,Lauper J,Seuberlich T,Oevermann A,Schweizer-Gorgas D

更新日期：2020-12-14 00:00:00

abstract：:Objective: The platelet-to-lymphocyte ratio (PLR) is a new marker of atherosclerotic inflammation and has been identified as a predictive factor in cardiovascular diseases, but its significance in patients with acute ischaemic stroke (AIS) who have undergone intravenous thrombolysis (IVT) is still unknown. Methods: Co...

journal_title：Frontiers in neurology

authors： Xu JH,He XW,Li Q,Liu JR,Zhuang MT,Huang FF,Bao GS

更新日期：2019-11-13 00:00:00

abstract：:Study Objectives: To clarify the effects of sleep duration on stroke and stroke subtypes, we adopted a Mendelian randomization (MR) approach to evaluate their causal relationship. Methods: A genome-wide association study including 446,118 participants from UK biobank was used to identify instruments for short sleep, l...

journal_title：Frontiers in neurology

authors： Lu H,Wu PF,Li RZ,Zhang W,Huang GX

更新日期：2020-10-07 00:00:00

abstract：:The evidence demonstrating the benefits of exercise is indisputable for healthy subjects, and more recently, it is growing for Parkinson's disease (PD) patients. Due to its easy access, low cost, social facilitation and, above all, the symptomatic effect, clinical exercise may have a profound impact on PD management. ...

journal_title：Frontiers in neurology

authors： Bouça-Machado R,Venturelli M,Tinazzi M,Schena F,Ferreira JJ

更新日期：2020-04-02 00:00:00

abstract：:Background: Most travelers experience Jet Lag Disorder (JLD) symptoms due to misalignment of their circadian rhythms with respect to the new time zone. We assessed the efficacy and safety of tasimelteon (HETLIOZ®) in healthy participants using a laboratory model of JLD induced by an 8-h phase advance of the sleep-wake...

journal_title：Frontiers in neurology

authors： Polymeropoulos CM,Mohrman MA,Keefe MS,Brzezynski JL,Wang J,Prokosch LS,Polymeropoulos VM,Xiao C,Birznieks G,Polymeropoulos MH

更新日期：2020-07-09 00:00:00

abstract：:Glaucoma is a multifactorial syndrome in which the development of pro-apoptotic signals are the causes for retinal ganglion cell (RGC) loss. Most of the research progress in the glaucoma field have been based on experimentally inducible glaucoma animal models, which provided results about RGC loss after either the cra...

journal_title：Frontiers in neurology

authors： Tirendi S,Saccà SC,Vernazza S,Traverso C,Bassi AM,Izzotti A

更新日期：2020-12-01 00:00:00

abstract：:Poststroke depression (PSD) is the most prevalent psychiatric disorder after stroke, which is independently correlated with negative clinical outcome. The identification of specific biomarkers could help to increase the sensitivity of PSD diagnosis and elucidate its pathophysiological mechanisms. The aim of current st...

journal_title：Frontiers in neurology

authors： Levada OA,Troyan AS

更新日期：2018-07-16 00:00:00

abstract：:Exposure of the brain to brief, non-harmful seizures can activate protective mechanisms that temporarily generate a damage-refractory state. This process, termed epileptic tolerance, is associated with large-scale down-regulation of gene expression. Polycomb group (PcG) proteins are master controllers of gene silencin...

journal_title：Frontiers in neurology

authors： Reynolds JP,Miller-Delaney SF,Jimenez-Mateos EM,Sano T,McKiernan RC,Simon RP,Henshall DC

更新日期：2015-03-10 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative genetic disorder characterized by motor, cognitive, and psychiatric symptoms. It is well established that regular physical activity supports brain health, benefiting cognitive function, mental health as well as brain structure and plasticity. Exercis...

journal_title：Frontiers in neurology

authors： Paré MF,Jasmin BJ

更新日期：2017-09-27 00:00:00

abstract：:This study reports the case of an acoustic shock injury (ASI), which did not result in a significant hearing loss, but was followed by manifold chronic symptoms both within (tinnitus, otalgia, tingling in the ear, tension in the ear, and red tympanum) and outside the ears (blocked nose, pain in the neck/temporal regio...

journal_title：Frontiers in neurology

authors： Londero A,Charpentier N,Ponsot D,Fournier P,Pezard L,Noreña AJ

更新日期：2017-08-16 00:00:00

abstract：:Injuries to the immature optic radiation (OR) are associated with thinning of the retinal nerve fiber layer and corresponding visual field (VF) defects. The aim of the current study was to seek evidence for causal retrograde trans-synaptic degeneration by exploring the correspondence between the localization and exten...

journal_title：Frontiers in neurology

authors： Lennartsson F,Nilsson M,Flodmark O,Jacobson L,Larsson J

更新日期：2018-05-07 00:00:00

abstract：:Preterm-born infants frequently suffer from an array of neurological damage, collectively termed encephalopathy of prematurity (EoP). They also have an increased risk of presenting with a neurodevelopmental disorder (e.g., autism spectrum disorder; attention deficit hyperactivity disorder) later in life. It is hypothe...

journal_title：Frontiers in neurology

authors： Fleiss B,Gressens P,Stolp HB

更新日期：2020-07-14 00:00:00

abstract：BACKGROUND:Persistent postural-perceptual dizziness (PPPD) is a common functional vestibular disorder characterized by persistent symptoms of non-vertiginous dizziness and unsteadiness that are exacerbated by upright posture, self-motion, and exposure to complex or moving visual stimuli. Recent physiologic and neuroima...

journal_title：Frontiers in neurology

authors： Riccelli R,Passamonti L,Toschi N,Nigro S,Chiarella G,Petrolo C,Lacquaniti F,Staab JP,Indovina I

更新日期：2017-10-17 00:00:00

abstract：:Background: Gait disorders (GD) are frequent and disabling symptoms in patients with Parkinson's disease, mostly because they significantly limit mobility and often lead to fear of falls or actual falls. Nowadays, rehabilitation is considered to be the most effective nonpharmacological approach to reduce risk of falls...

journal_title：Frontiers in neurology

authors： Kosutzka Z,Kusnirova A,Hajduk M,Straka I,Minar M,Valkovic P

更新日期：2019-09-24 00:00:00

abstract：:Purpose: Cardiac [123I]metaiodobenzylguanidine scintigraphy (123I-MIBG), reflecting postganglionic cardiac autonomic denervation, is proposed for early detection of Parkinson's disease (PD; reduced tracer uptake) and separation from Multiple System Atrophy (MSA; preserved tracer uptake). However, several recent studie...

journal_title：Frontiers in neurology

authors： Skowronek C,Zange L,Lipp A

更新日期：2019-02-26 00:00:00

abstract：BACKGROUND AND PURPOSE:Although the presence of cavitating lacunes on brain imaging may have prognostic implications, the modifiable risk factors underlying these frequently observed lesions are not completely understood. We sought to determine if fasting and post-challenge triglycerides associate with cavitating lacun...

journal_title：Frontiers in neurology

authors： Leonards CO,Wang L,Fiebach JB,Endres M,Ebinger M

更新日期：2013-07-10 00:00:00

abstract：:Fatigue is one of the most disabling side effects in people with multiple sclerosis. While this fact is well known, there has been a remarkable lack of progress in determining the pathophysiological mechanisms behind fatigue and the establishment of effective treatments. The main barrier has been the lack of a unified...

journal_title：Frontiers in neurology

authors： Rudroff T,Kindred JH,Ketelhut NB

更新日期：2016-08-02 00:00:00

abstract：:Background: Caregiver strain is recognized globally with Parkinson's disease (PD). Comparatively little is understood about caregiver burden and strain in Asia. Objective: To investigate caregiver strain for families living with PD in Singapore, in light of international data. Methods: Ninety-four caregivers were recr...

journal_title：Frontiers in neurology

authors： Tan SB,Williams AF,Tan EK,Clark RB,Morris ME

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND:Recent studies indicate excitatory GABA action in and around tubers in patients with tuberous sclerosis complex (TSC). This may contribute to recurrent seizures and behavioral problems that may be treated by agents that enhance GABAergic transmission by influencing chloride regulation. CASE PRESENTATION:Her...

journal_title：Frontiers in neurology

authors： Vlaskamp C,Poil SS,Jansen F,Linkenkaer-Hansen K,Durston S,Oranje B,Bruining H

更新日期：2017-09-08 00:00:00