A Case of Acoustic Shock with Post-trauma Trigeminal-Autonomic Activation.


:This study reports the case of an acoustic shock injury (ASI), which did not result in a significant hearing loss, but was followed by manifold chronic symptoms both within (tinnitus, otalgia, tingling in the ear, tension in the ear, and red tympanum) and outside the ears (blocked nose, pain in the neck/temporal region). We suggest that these symptoms may result from a loop involving injury to middle ear muscles, peripheral inflammatory processes, activation and sensitization of the trigeminal nerve, the autonomic nervous system, and central feedbacks. The pathophysiology of this ASI is reminiscent of that observed in post-traumatic trigeminal-autonomic cephalalgia. This framework opens new and promising perspectives on the understanding and medical management of ASI.


Front Neurol


Frontiers in neurology


Londero A,Charpentier N,Ponsot D,Fournier P,Pezard L,Noreña AJ




Has Abstract


2017-08-16 00:00:00








  • Cerebral Hemodynamic Evaluation After Cerebral Recanalization Therapy for Acute Ischemic Stroke.

    abstract::Cerebral recanalization therapy, either intravenous thrombolysis or mechanical thrombectomy, improves the outcomes in patients with acute ischemic stroke (AIS) by restoring the cerebral perfusion of the ischemic penumbra. Cerebral hemodynamic evaluation after recanalization therapy, can help identify patients with hig...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Zhang Z,Pu Y,Mi D,Liu L

    更新日期:2019-07-03 00:00:00

  • The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke.

    abstract::Background: There is very limited information on the relationship between non-alcoholic fatty liver disease (NAFLD) and the severity or functional outcomes of ischemic stroke or transient ischemic stroke (TIA). We investigated the correlation between NAFLD and stroke outcomes. Methods: NAFLD was assessed in 321 patien...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Baik M,Kim SU,Nam HS,Heo JH,Kim YD

    更新日期:2019-04-12 00:00:00

  • Contralesional Hemisphere Regulation of Transcranial Magnetic Stimulation-Induced Kinetic Coupling in the Poststroke Lower Limb.

    abstract:BACKGROUND:The neural constraints underlying hemiparetic gait dysfunction are associated with abnormal kinetic outflow and altered muscle synergy structure. Recent evidence from our lab implicates the lesioned hemisphere in mediating the expression of abnormally coupled hip adduction and knee extension synergy, suggest...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Tan AQ,Dhaher YY

    更新日期:2017-08-07 00:00:00

  • Spatial Hearing by Bilateral Cochlear Implant Users With Temporal Fine-Structure Processing.

    abstract::Several studies have demonstrated the advantages of the bilateral vs. unilateral cochlear implantation in listeners with bilateral severe to profound hearing loss. However, it remains unclear to what extent bilaterally implanted listeners have access to binaural cues, e.g., accurate processing of interaural timing dif...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Ausili SA,Agterberg MJH,Engel A,Voelter C,Thomas JP,Brill S,Snik AFM,Dazert S,Van Opstal AJ,Mylanus EAM

    更新日期:2020-09-30 00:00:00

  • TuberOus SClerosis Registry to Increase Disease Awareness: A Review on Alignment of Its Planning, Execution, and Publications With European Medicines Agency Guidelines.

    abstract::Patient registries offer a powerful and practical means of real-world data collection system for rare diseases. Many guidelines have been released to standardize patient registries, although most of them do not address issues specific to rare disease patient registries. In November 2018, the European Medicines Agency ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Marques R,Thole H,Ruiz de Morales JG

    更新日期:2020-05-15 00:00:00

  • Atherosclerosis Might Be Responsible for Branch Artery Disease: Evidence From White Matter Hyperintensity Burden in Acute Isolated Pontine Infarction.

    abstract::Objective: To investigate an MRI-based etiological classification for acute isolated pontine infarcts and to assess differences in vascular risk factors, clinical characteristics and WMH burden among the etiological subtypes. Methods: All participants from SMART cohort with DWI-proven acute isolated pontine infarcts (...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Zhou L,Yao M,Peng B,Zhu Y,Ni J,Cui L

    更新日期:2018-10-09 00:00:00

  • Sleep Duration and Stroke: A Mendelian Randomization Study.

    abstract::Study Objectives: To clarify the effects of sleep duration on stroke and stroke subtypes, we adopted a Mendelian randomization (MR) approach to evaluate their causal relationship. Methods: A genome-wide association study including 446,118 participants from UK biobank was used to identify instruments for short sleep, l...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Lu H,Wu PF,Li RZ,Zhang W,Huang GX

    更新日期:2020-10-07 00:00:00

  • Thyroid Hormones in the Brain and Their Impact in Recovery Mechanisms After Stroke.

    abstract::Thyroid hormones are of fundamental importance for brain development and essential factors to warrant brain functions throughout life. Their actions are mediated by binding to specific intracellular and membranous receptors regulating genomic and non-genomic mechanisms in neurons and populations of glial cells, respec...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Talhada D,Santos CRA,Gonçalves I,Ruscher K

    更新日期:2019-10-18 00:00:00

  • Employment Probability Trajectories Up To 10 Years After Moderate-To-Severe Traumatic Brain Injury.

    abstract::Aims: To examine trajectories of employment probability up to 10 years following moderate-to-severe traumatic brain injury (TBI) and identify significant predictors from baseline socio-demographic and injury characteristics. Methods: A longitudinal observational study followed 97 individuals with moderate-to-severe TB...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Howe EI,Andelic N,Perrin PB,Røe C,Sigurdardottir S,Arango-Lasprilla JC,Lu J,Løvstad M,Forslund MV

    更新日期:2018-12-05 00:00:00

  • Amplitudes of Pain-Related Evoked Potentials Are Useful to Detect Small Fiber Involvement in Painful Mixed Fiber Neuropathies in Addition to Quantitative Sensory Testing - An Electrophysiological Study.

    abstract::To investigate the usefulness of pain-related evoked potentials (PREP) elicited by electrical stimulation for the identification of small fiber involvement in patients with mixed fiber neuropathy (MFN). Eleven MFN patients with clinical signs of large fiber impairment and neuropathic pain and ten healthy controls unde...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Hansen N,Kahn AK,Zeller D,Katsarava Z,Sommer C,Üçeyler N

    更新日期:2015-12-07 00:00:00

  • Cell-Based Therapies for Stroke: Are We There Yet?

    abstract::Stroke is the second leading cause of death and physical disability, with a global lifetime incidence rate of 1 in 6. Currently, the only FDA approved treatment for ischemic stroke is the administration of tissue plasminogen activator (tPA). Stem cell clinical trials for stroke have been underway for close to two deca...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Krause M,Phan TG,Ma H,Sobey CG,Lim R

    更新日期:2019-06-25 00:00:00

  • What Comes First: Return to School or Return to Activity for Youth After Concussion? Maybe We Don't Have to Choose.

    abstract::Objectives: Return to School (RTS) and Return to Activity/Play (RTA) protocols are important in concussion management. Minimal evidence exists as to sequence and whether progression can occur simultaneously. Experts recommend that children/youth fully return to school before beginning RTA protocols. This study investi...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: DeMatteo CA,Randall S,Lin CA,Claridge EA

    更新日期:2019-07-23 00:00:00

  • Neurological Emergencies in Refugees.

    abstract::Objective: Health care personnel in Europe is increasingly involved in care of displaced persons from non-European countries; we investigated the spectrum of neurological disorders and medical management in refugees presenting to the emergency room (ER) of a German university hospital. Methods: We retrospectively stud...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Brinckmann MP,van Noort BM,Leithner C,Ploner CJ

    更新日期:2018-12-11 00:00:00

  • Amide Proton Transfer Weighted Imaging Shows Differences in Multiple Sclerosis Lesions and White Matter Hyperintensities of Presumed Vascular Origin.

    abstract::Objectives: To assess the ability of 3D amide proton transfer weighted (APTw) imaging based on magnetization transfer analysis to discriminate between multiple sclerosis lesions (MSL) and white matter hyperintensities of presumed vascular origin (WMH) and to compare APTw signal intensity of healthy white matter (healt...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Sartoretti E,Sartoretti T,Wyss M,Becker AS,Schwenk Á,van Smoorenburg L,Najafi A,Binkert C,Thoeny HC,Zhou J,Jiang S,Graf N,Czell D,Sartoretti-Schefer S,Reischauer C

    更新日期:2019-12-10 00:00:00

  • Historical Review of the Fluid-Percussion TBI Model.

    abstract::Traumatic brain injury (TBI) is a major health concern worldwide. Laboratory studies utilizing animal models of TBI are essential for addressing pathological mechanisms of brain injury and development of innovative treatments. Over the past 75 years, pioneering head injury researchers have devised and tested a number ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Lyeth BG

    更新日期:2016-12-02 00:00:00

  • A Cross-Study Analysis for Reproducible Sub-classification of Traumatic Brain Injury.

    abstract::Objective: To identify reproducible sub-classes of traumatic brain injury (TBI) that correlate with patient outcomes. Methods: Two TBI datasets from the Federal Interagency Traumatic Brain Injury Research (FITBIR) Informatics System were utilized, Transforming Research and Clinical Knowledge in Traumatic Brain Injury ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Si B,Dumkrieger G,Wu T,Zafonte R,Dodick DW,Schwedt TJ,Li J

    更新日期:2018-08-13 00:00:00

  • Vasculature Remodeling in a Rat Model of Cerebral Ischemia. The Fate of the BrdU-Labeled Cells Prior to Stroke.

    abstract::Despite the clinical significance of post-stroke angiogenesis, a detailed phenotypic analysis of pre-stroke vascular remodeling and post-stroke angiogenesis had not yet been done in a model of focal ischemia. In this study, using BrdU-labeling of proliferating cells and immunofluorescence of pre- and post-stroke rats,...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Surugiu R,Glavan D,Popescu M,Margaritescu O,Eugen R,Popa-Wagner A

    更新日期:2018-11-27 00:00:00

  • Money Management in Multiple Sclerosis: The Role of Cognitive, Motor, and Affective Factors.

    abstract::Introduction: Few studies have examined the motor, cognitive, and emotional factors involved in effective money management in persons with multiple sclerosis (MS). The aim of this study was to assess money management in persons MS and examine whether cognitive, motor, and emotional processes can predict money manageme...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Yael G,Nancy C,John D

    更新日期:2019-10-23 00:00:00

  • Corrigendum: Does Severity of Alzheimer's Disease Contribute to Its Responsiveness to Modifying Gut Microbiota? A Double Blind Clinical Trial.

    abstract::[This corrects the article DOI: 10.3389/fneur.2018.00662.]. ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,已发布勘误


    authors: Agahi A,Hamidi GA,Daneshvar R,Hamdieh M,Soheili M,Alinaghipour A,Taba SME,Salami M

    更新日期:2019-02-05 00:00:00

  • A Mindfulness-Based Stress Reduction Program via Group Video Conferencing for Adults With Cerebral Palsy - A Pilot Study.

    abstract::Purpose: Adults with cerebral palsy experience challenges related to lifelong disability, such as stress, fatigue, pain and emotional issues. E-health services can be delivered regardless of residence and level of functioning. The aim of this pilot study was to explore the potential benefits and feasibility of a mindf...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Høye H,Jahnsen RB,Løvstad M,Hartveit JF,Sørli H,Tornås S,Månum G

    更新日期:2020-04-03 00:00:00

  • A Persistent Primitive Hypoglossal Artery As the Sole Supply to the Brain Associated with a Basilar Bifurcation Aneurysm.

    abstract::The persistent primitive hypoglossal artery (PPHA) is the second most common persistent carotid-vertebrobasilar anastomosis, with an incidence of 0.027-0.26%. PPHAs change the hemodynamics of the carotid and vertebrobasilar system and may be associated with intracranial vascular anomalies, but basilar bifurcation aneu...

    journal_title:Frontiers in neurology



    authors: Wang M,Gu J,Lan P,Wan S,Zhou Y,Zheng X,Zhan R

    更新日期:2017-04-26 00:00:00

  • Stenosis Length and Degree Interact With the Risk of Cerebrovascular Events Related to Internal Carotid Artery Stenosis.

    abstract::Background and Purpose: Internal carotid artery stenosis (ICAS)≥70% is a leading cause of ischemic cerebrovascular events (ICVEs). However, a considerable percentage of stroke survivors with symptomatic ICAS (sICAS) have <70% stenosis with a vulnerable plaque. Whether the length of ICAS is associated with high risk of...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Elhfnawy AM,Heuschmann PU,Pham M,Volkmann J,Fluri F

    更新日期:2019-04-09 00:00:00

  • Global Hippocampal Volume Reductions and Local CA1 Shape Deformations in Amyotrophic Lateral Sclerosis.

    abstract::There is increasing evidence for hippocampal involvement in Amyotrophic Lateral Sclerosis (ALS). Recent neuroimaging studies have been focused on disease-related hippocampal volume alterations while changes in hippocampal shape have been investigated less frequently. Here, we aimed to characterize the patterns of hipp...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Machts J,Vielhaber S,Kollewe K,Petri S,Kaufmann J,Schoenfeld MA

    更新日期:2018-07-20 00:00:00

  • Macroscale White Matter Alterations Due to Traumatic Cerebral Microhemorrhages Are Revealed by Diffusion Tensor Imaging.

    abstract::With the advent of susceptibility-weighted imaging (SWI), the ability to identify cerebral microbleeds (CMBs) associated with mild traumatic brain injury (mTBI) has become increasingly commonplace. Nevertheless, the clinical significance of post-traumatic CMBs remains controversial partly because it is unclear whether...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Rostowsky KA,Maher AS,Irimia A

    更新日期:2018-11-13 00:00:00

  • Middle Meningeal Artery Embolization in Chronic Subdural Hematoma: Implications of Pathophysiology in Trial Design.

    abstract::Background: Chronic subdural hematoma (cSDH) is a debilitating condition with a high rate of recurrence after surgical evacuation. Summary: This review is focused on middle meningeal artery (MMA) embolization to treat cSDH. We discuss the underlying pathophysiology of chronic subdural hematoma and how cessation of art...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审


    authors: Moshayedi P,Liebeskind DS

    更新日期:2020-08-27 00:00:00

  • Carmustine as a Supplementary Therapeutic Option for Glioblastoma: A Systematic Review and Meta-Analysis.

    abstract::Background: Glioblastoma (GBM) is the most aggressive type of primary malignant brain tumor. Carmustine is used by intravenous injection or local implantation in the resection cavity for gliomas, including GBMs. However, the therapeutic potential of carmustine is not well-recognized. This analysis aimed to evaluate th...

    journal_title:Frontiers in neurology



    authors: Xiao ZZ,Wang ZF,Lan T,Huang WH,Zhao YH,Ma C,Li ZQ

    更新日期:2020-09-17 00:00:00

  • Persistence of Gut Microbiota Dysbiosis and Chronic Systemic Inflammation After Cerebral Infarction in Cynomolgus Monkeys.

    abstract::Background: The bidirectional interaction between the gut and brain after stroke through the immune-mediated pathway has been studied. However, the long-term effects of gut microbiota and systemic immune homeostasis after cerebral ischemia remain unclear. We examined long-term changes in the gut microbiota and systemi...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Chen Y,Liang J,Ouyang F,Chen X,Lu T,Jiang Z,Li J,Li Y,Zeng J

    更新日期:2019-06-28 00:00:00

  • Severe Blood-Brain Barrier Disruption in Cardioembolic Stroke.

    abstract:Background:Previous studies demonstrated that cardioembolism (CE) was prone to develop hemorrhagic transformation (HT), whereas hyper-permeability of blood-brain barrier (BBB) might be one reason for the development of HT. We, thus, aimed to investigate whether the BBB permeability (BBBP) was higher in CE stroke than o...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Liu C,Shi F,Chen Z,Yan S,Ding X,Lou M

    更新日期:2018-02-08 00:00:00

  • MR-Guided Focused Ultrasound Central Lateral Thalamotomy for Trigeminal Neuralgia. Single Center Experience.

    abstract::Background: Trigeminal neuralgia (TN) is a recognized pain condition the treatment of which can be very challenging. Various surgical interventions can be applied in cases of therapy-resistance to drug treatments. The central lateral thalamotomy (CLT) against neurogenic (or neuropathic) pain is based on multiarchitect...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Gallay MN,Moser D,Jeanmonod D

    更新日期:2020-04-17 00:00:00

  • Prevalence of Extrapyramidal Symptoms in In-Patients With Severe Mental Illnesses: Focus on Parkinsonism.

    abstract::Patients with severe mental illnesses may present extrapyramidal symptoms as part of a concomitant neurological disorder or secondary to medications. Extrapyramidal symptoms are frequently unrecognized, have negative consequences for adherence to treatment, negatively affect quality of life and can induce stigma. We e...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章


    authors: Roiter B,Pigato G,Antonini A

    更新日期:2020-11-10 00:00:00