Gait Disorders Questionnaire-Promising Tool for Virtual Reality Designing in Patients With Parkinson's Disease.

Abstract:

:Background: Gait disorders (GD) are frequent and disabling symptoms in patients with Parkinson's disease, mostly because they significantly limit mobility and often lead to fear of falls or actual falls. Nowadays, rehabilitation is considered to be the most effective nonpharmacological approach to reduce risk of falls. Using paradigms in virtual reality (VR) is a promising tool in neurorehabilitation because of the potential improvement in motor learning and improvement in daily functioning by replicating everyday real-life scenarios. Objective: To identify the most prevalent everyday situations which impair gait in PD that could be simulated in virtual reality (VR) environment. Methods: A newly developed self-report questionnaire consisting of 15 binary response items (YES/NO) encompassing everyday walking situations was administered to 62 patients diagnosed with idiopathic PD according to MDS Clinical Diagnostic Criteria. We included patients able to walk unassisted for at least 10 min and without significant cognitive impairment. Mokken Scale Analysis was used to evaluate psychometric properties of the scale. Results: Questionnaires from 58 patients were analyzed (31 men, age = 63 ± 9.9 y, disease duration = 7.02 ± 4.03 y, LEDD = 1115 ± 549.4 mg, H&Y = 2.4 ± 0.6). Only 10 items (out of 15) were identified as scalable and these were included in Gait Disorders Questionnaire (GDQ). The most prevalent trigger of gait disorders was walking under time pressure, followed by gait in crowded places and walking while dual-tasking. The total score of GDQ significantly correlated with the disease duration (rs = 0.347, p = 0.008) and modified H&Y staging (rs = 0.288, p = 0.028). Conclusion: With the use of GDQ we identified the most prevalent everyday transition activities that provoke gait disorders in patients with PD. The results may be useful for further development and systematic application of VR paradigms for physiotherapy of PD patients.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Kosutzka Z,Kusnirova A,Hajduk M,Straka I,Minar M,Valkovic P

doi

10.3389/fneur.2019.01024

subject

Has Abstract

pub_date

2019-09-24 00:00:00

pages

1024

issn

1664-2295

journal_volume

10

pub_type

杂志文章
  • Isolated Cervical Dystonia: Management and Barriers to Care.

    abstract::Background: Cervical dystonia (CD) is a rare disorder, and health care providers might be unfamiliar with its presentation, thus leading to delay in the initial diagnosis. The lack of awareness displays the need to highlight the clinical features and treatment in cervical dystonia. In our cohort, we have identified an...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.591418

    authors: Supnet ML,Acuna P,Carr SJ,Kristoper de Guzman J,Al Qahtani X,Multhaupt-Buell T,Francoeur T,Aldykiewicz GE,Alluri PR,Campion L,Paul L,Ozelius L,Penney EB,Stephen CD,Dy-Hollins M,Sharma N

    更新日期:2020-11-27 00:00:00

  • Case Report: Extreme Levels of Serum S-100B in a Patient with Chronic Subdural Hematoma.

    abstract::The protein S-100B is a biomarker increasingly used within neurosurgery and neurointensive care. As a relatively sensitive, yet unspecific, indicator of CNS pathology, potential sources of error must be clearly understood when interpreting serum S-100B levels. This case report studied the course of a 46-year-old gentl...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2012.00170

    authors: Persson ME,Thelin EP,Bellander BM

    更新日期:2012-12-05 00:00:00

  • Short-Term Test-Retest Reliability of Electrically Evoked Cortical Auditory Potentials in Adult Cochlear Implant Recipients.

    abstract::Background: Late latency auditory evoked potentials (LLAEPs) provide objective evidence of an individual's central auditory processing abilities. Electrically evoked cortical auditory evoked potentials (eCAEPs) are a type of LLAEP that provides an objective measure of aided speech perception and auditory processing ab...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00305

    authors: Pike M,Biagio-de Jager L,le Roux T,Hofmeyr LM

    更新日期:2020-04-28 00:00:00

  • Assessing the Safety of Craniotomy for Resection of Primary Central Nervous System Lymphoma: A Nationwide Inpatient Sample Analysis.

    abstract:BACKGROUND:Unlike many other central nervous system (CNS) tumors, the surgical management of primary central nervous system lymphomas (PCNSL) is traditionally limited by diagnostic biopsy. Studies that predate the use of modern neurosurgical techniques have reported a prohibitive operative morbidity for this surgery. T...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2017.00478

    authors: Yun J,Yang J,Cloney M,Mehta A,Singh S,Iwamoto FM,Neugut AI,Sonabend AM

    更新日期:2017-09-12 00:00:00

  • Alterations Functional Connectivity in Temporal Lobe Epilepsy and Their Relationships With Cognitive Function: A Longitudinal Resting-State fMRI Study.

    abstract::Background: Cognitive impairments in temporal lobe epilepsy (TLE) patients has been described as a chronically progressive feature of the disease. However, how severe recurrent seizures modify neuronal circuits in the human brain and subsequently degrade cognitive function, remains largely unknown. Here, we aimed to i...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00625

    authors: Qin L,Jiang W,Zheng J,Zhou X,Zhang Z,Liu J

    更新日期:2020-07-21 00:00:00

  • Predictive factors of neurological complications and one-month mortality after liver transplantation.

    abstract:BACKGROUND:Neurological complications are common after orthotopic liver transplantation (OLT). We aimed to characterize the risk factors associated with neurological complications and mortality among patients who underwent OLT in the post-model for end-stage liver disease (MELD) era. METHODS:In a retrospective review,...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2014.00275

    authors: Fu KA,DiNorcia J,Sher L,Velani SA,Akhtar S,Kalayjian LA,Sanossian N

    更新日期:2014-12-17 00:00:00

  • Parkinson's Disease Dementia and Dementia with Lewy Bodies Have Similar Neuropsychological Profiles.

    abstract::Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are common causes of dementia worldwide. Although considered separate entities based on the relative temporal onset of motor symptoms vs. diagnosis of dementia, it is unknown if these diseases truly have distinct cognitive profiles. We hypothesized...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00123

    authors: Aldridge GM,Birnschein A,Denburg NL,Narayanan NS

    更新日期:2018-03-12 00:00:00

  • Prolonged Static Whole-Body Roll-Tilt and Optokinetic Stimulation Significantly Bias the Subjective Postural Vertical in Healthy Human Subjects.

    abstract::Background: Prolonged static whole-body roll-tilt has been shown to bias estimates of the direction of gravity when assessed by static paradigms such as the subjective visual vertical and the subjective haptic vertical. Objective: We hypothesized that these shifts are paradigm-independent and thus predicted a post-til...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.595975

    authors: Wedtgrube A,Bockisch CJ,Straumann D,Tarnutzer AA

    更新日期:2020-10-15 00:00:00

  • MRI screening for chronic anticoagulation in atrial fibrillation.

    abstract::Anticoagulation is highly effective in preventing stroke due to atrial fibrillation, but numerous studies have demonstrated low utilization of anticoagulation for these patients. Assessment of clinicians' attitudes on this topic indicate that fear of intracerebral hemorrhage (ICH), rather than appreciation of anticoag...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2013.00137

    authors: Fisher M

    更新日期:2013-10-04 00:00:00

  • Bumetanide As a Candidate Treatment for Behavioral Problems in Tuberous Sclerosis Complex.

    abstract:BACKGROUND:Recent studies indicate excitatory GABA action in and around tubers in patients with tuberous sclerosis complex (TSC). This may contribute to recurrent seizures and behavioral problems that may be treated by agents that enhance GABAergic transmission by influencing chloride regulation. CASE PRESENTATION:Her...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2017.00469

    authors: Vlaskamp C,Poil SS,Jansen F,Linkenkaer-Hansen K,Durston S,Oranje B,Bruining H

    更新日期:2017-09-08 00:00:00

  • A Case-Controlled Pilot Study on Rhythmic Auditory Stimulation-Assisted Gait Training and Conventional Physiotherapy in Patients With Parkinson's Disease Submitted to Deep Brain Stimulation.

    abstract::Deep brain stimulation (DBS) is indicated when motor disturbances in patients with idiopathic Parkinson's disease (PD) are refractory to current treatment options and significantly impair quality of life. However, post-DBS rehabilitation is essential, with particular regard to gait. Rhythmic auditory stimulation (RAS)...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00794

    authors: Naro A,Pignolo L,Sorbera C,Latella D,Billeri L,Manuli A,Portaro S,Bruschetta D,Calabrò RS

    更新日期:2020-08-04 00:00:00

  • Parkinson's Disease Caregiver Strain in Singapore.

    abstract::Background: Caregiver strain is recognized globally with Parkinson's disease (PD). Comparatively little is understood about caregiver burden and strain in Asia. Objective: To investigate caregiver strain for families living with PD in Singapore, in light of international data. Methods: Ninety-four caregivers were recr...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.00455

    authors: Tan SB,Williams AF,Tan EK,Clark RB,Morris ME

    更新日期:2020-06-23 00:00:00

  • Consecutive Slides on Axial View Is More Effective Than Transversal Diameter to Differentiate Mechanisms of Single Subcortical Infarctions in the Lenticulostriate Artery Territory.

    abstract::Objective: Lipohyalinosis or atherosclerosis might be responsible for single subcortical infarctions (SSIs); however, ways of differentiating between the two clinically remain uncertain. We aimed to investigate whether consecutive slides on axial view or transversal diameter is more effective to differentiate mechanis...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00336

    authors: Cao Y,Zhang M,Zhou L,Yao M,Peng B,Zhu Y,Ni J,Cui L

    更新日期:2019-04-09 00:00:00

  • Parkinson's disease rigidity: relation to brain connectivity and motor performance.

    abstract:OBJECTIVE:(1) To determine the brain connectivity pattern associated with clinical rigidity scores in Parkinson's disease (PD) and (2) to determine the relation between clinically assessed rigidity and quantitative metrics of motor performance. BACKGROUND:Rigidity, the resistance to passive movement, is exacerbated in...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2013.00067

    authors: Baradaran N,Tan SN,Liu A,Ashoori A,Palmer SJ,Wang ZJ,Oishi MM,McKeown MJ

    更新日期:2013-06-05 00:00:00

  • Lower Functional Connectivity in Vestibular-Limbic Networks in Individuals With Subclinical Agoraphobia.

    abstract::Background: Agoraphobia was described in 1871 as a condition of fear-related alterations in spatial orientation and locomotor control triggered by places or situations that might cause a patient to panic and feel trapped. In contemporary nosology, however, this original concept of agoraphobia was split into two diagno...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00874

    authors: Indovina I,Conti A,Lacquaniti F,Staab JP,Passamonti L,Toschi N

    更新日期:2019-08-13 00:00:00

  • Identification of the Early Stage of Alzheimer's Disease Using Structural MRI and Resting-State fMRI.

    abstract::Accurate prediction of the early stage of Alzheimer's disease (AD) is important but very challenging. The goal of this study was to utilize predictors for diagnosis conversion to AD based on integrating resting-state functional MRI (rs-fMRI) connectivity analysis and structural MRI (sMRI). We included 177 subjects in ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00904

    authors: Hojjati SH,Ebrahimzadeh A,Babajani-Feremi A

    更新日期:2019-08-30 00:00:00

  • HLA Polymorphism Affects Risk of de novo Mutation of dystrophin Gene and Clinical Severity of Duchenne Muscular Dystrophy in a Southern Chinese Population.

    abstract::Immune-mediated pathology has been thought to be an important factor contributing to Duchenne muscular dystrophy (DMD). Allele frequencies of certain HLA types are known to differ between patients with dystrophinopathies and healthy controls with low-resolution HLA gene typing data in limit reports. Using Polymerase c...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00970

    authors: Li H,Xiao L,Wang L,Lin J,Luo M,Chen M,He R,Zhu Y,Zhang C

    更新日期:2018-11-15 00:00:00

  • Temporal Discrimination: Mechanisms and Relevance to Adult-Onset Dystonia.

    abstract::Temporal discrimination is the ability to determine that two sequential sensory stimuli are separated in time. For any individual, the temporal discrimination threshold (TDT) is the minimum interval at which paired sequential stimuli are perceived as being asynchronous; this can be assessed, with high test-retest and ...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2017.00625

    authors: Conte A,McGovern EM,Narasimham S,Beck R,Killian O,O'Riordan S,Reilly RB,Hutchinson M

    更新日期:2017-11-28 00:00:00

  • Spontaneous behavior in noise and silence: a possible new measure to assess tinnitus in Guinea pigs.

    abstract::This study describes two experiments that were conducted in search for a behavioral paradigm to test for tinnitus in guinea pigs. Conditioning paradigms are available to determine the presence of tinnitus in animals and are based on the assumption that tinnitus impairs their ability to detect silent intervals in conti...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2014.00207

    authors: Heeringa AN,Agterberg MJ,van Dijk P

    更新日期:2014-10-15 00:00:00

  • Pathomechanisms of a CLCN1 Mutation Found in a Russian Family Suffering From Becker's Myotonia.

    abstract::Objective: Myotonia congenita (MC) is a rare muscle disease characterized by sarcolemma over-excitability inducing skeletal muscle stiffness. It can be inherited either as an autosomal dominant (Thomsen's disease) or an autosomal recessive (Becker's disease) trait. Both types are caused by loss-of-function mutations i...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2020.01019

    authors: Altamura C,Ivanova EA,Imbrici P,Conte E,Camerino GM,Dadali EL,Polyakov AV,Kurbatov SA,Girolamo F,Carratù MR,Desaphy JF

    更新日期:2020-09-04 00:00:00

  • Blood Flow and Glucose Metabolism Dissociation in the Putamen Is Predictive of Levodopa Induced Dyskinesia in Parkinson's Disease Patients.

    abstract::Background: The forefront treatment of Parkinson's disease (PD) is Levodopa. When patients are treated with Levodopa cerebral blood flow is increased while cerebral metabolic rate is decreased in key subcortical regions including the putamen. This phenomenon is especially pronounced in patients with Levodopa-induced d...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.01217

    authors: Aljuaid M,Booth S,Hobson DE,Borys A,Williams K,Katako A,Ryner L,Goertzen AL,Ko JH

    更新日期:2019-11-21 00:00:00

  • Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism.

    abstract::Numerous studies suggest that the increased activity of p38MAPK plays an important role in the abnormal immune and inflammatory response observed in the course of neurodegenerative diseases such as Alzheimer's disease. On the other hand, high levels of p38MAPK are present in the brain during normal aging, suggesting t...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00675

    authors: Martín-Segura A,Casadomé-Perales Á,Fazzari P,Mas JM,Artigas L,Valls R,Nebreda AR,Dotti CG

    更新日期:2019-06-25 00:00:00

  • Large Vessel Disease Modifies the Relationship Between Kidney Injury and Cerebral Small Vessel Disease.

    abstract::Background: Recent studies have shown that renal disease is associated with magnetic resonance imaging (MRI) markers of cerebral small vessel disease (CSVD), independent of traditional vascular risk factors. Although large artery lesions might be involved in the cerebrorenal association, evidence has been lacking. Met...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00498

    authors: Ao DH,Zhai FF,Han F,Zhou LX,Ni J,Yao M,Zhang DD,Li ML,Fan XH,Jin ZY,Cui LY,Zhang SY,Zhu YC

    更新日期:2018-06-26 00:00:00

  • Serial Cerebral Metabolic Changes in Patients With Ischemic Stroke Treated With Autologous Bone Marrow Derived Mononuclear Cells.

    abstract::Purpose: Cell-based therapy offers new opportunities for the development of novel treatments to promote tissue repair, functional restoration, and cerebral metabolic balance. N-acetylasperate (NAA), Choline (Cho), and Creatine (Cr) are three major metabolites seen on proton magnetic resonance spectroscopy (MRS) that p...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2019.00141

    authors: Haque ME,Gabr RE,George SD,Boren SB,Vahidy FS,Zhang X,Arevalo OD,Alderman S,Narayana PA,Hasan KM,Friedman ER,Sitton CW,Savitz SI

    更新日期:2019-02-25 00:00:00

  • Tradipitant in the Treatment of Motion Sickness: A Randomized, Double-Blind, Placebo-Controlled Study.

    abstract::Introduction: Novel therapies are needed for the treatment of motion sickness given the inadequate relief and bothersome and dangerous adverse effects of currently approved therapies. Neurokinin-1 (NK1) receptor antagonists have the potential to be effective in improving the symptoms of motion sickness, given the invo...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2020.563373

    authors: Polymeropoulos VM,Czeisler MÉ,Gibson MM,Anderson AA,Miglo J,Wang J,Xiao C,Polymeropoulos CM,Birznieks G,Polymeropoulos MH

    更新日期:2020-09-29 00:00:00

  • Temporal Lobe Cavernous Malformation Caused Epileptic Amnesic Episodes and Mild Cognitive Impairment.

    abstract::Neuropathological features in Alzheimer's disease (AD) are amyloid β (Aβ) deposits and neurofibrillary changes. AD is characterized by memory impairment and cognitive dysfunction, with some reports associating these impairments with hyperexcitability caused by Aβ in the medial temporal lobe. Epileptic seizures are kno...

    journal_title:Frontiers in neurology

    pub_type:

    doi:10.3389/fneur.2019.00620

    authors: Hirokawa Y,Fujimoto A,Ichikawa N,Sato K,Tanaka T,Enoki H,Otsuki Y,Okanishi T

    更新日期:2019-06-12 00:00:00

  • The Sub-Regional Functional Organization of Neocortical Irritative Epileptic Networks in Pediatric Epilepsy.

    abstract::Between seizures, irritative network generates frequent brief synchronous activity, which manifests on the EEG as interictal epileptiform discharges (IEDs). Recent insights into the mechanism of IEDs at the microscopic level have demonstrated a high variance in the recruitment of neuronal populations generating IEDs a...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00184

    authors: Janca R,Krsek P,Jezdik P,Cmejla R,Tomasek M,Komarek V,Marusic P,Jiruska P

    更新日期:2018-03-23 00:00:00

  • The Differential Effects of Repetitive Magnetic Stimulation in an In Vitro Neuronal Model of Ischemia/Reperfusion Injury.

    abstract::Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive therapy that has been implicated in treatment of serious neurological disorders. However, the neurobiological mechanisms underlying the effects of rTMS remain unclear. Therefore, this study examined the differential effects of repetitive magnetic st...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2018.00050

    authors: Baek A,Kim JH,Pyo S,Jung JH,Park EJ,Kim SH,Cho SR

    更新日期:2018-02-13 00:00:00

  • Relationship between Sleep Duration and Risk Factors for Stroke.

    abstract::Stroke is a leading cause of death and disability worldwide. While various risk factors have been identified, sleep has only been considered a risk factor more recently. Various epidemiologic studies have associated stroke with sleep such as sleep duration, and laboratory and clinical studies have proposed various und...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章,评审

    doi:10.3389/fneur.2017.00392

    authors: Phua CS,Jayaram L,Wijeratne T

    更新日期:2017-08-08 00:00:00

  • High prevalence of chronic pituitary and target-organ hormone abnormalities after blast-related mild traumatic brain injury.

    abstract::Studies of traumatic brain injury from all causes have found evidence of chronic hypopituitarism, defined by deficient production of one or more pituitary hormones at least 1 year after injury, in 25-50% of cases. Most studies found the occurrence of posttraumatic hypopituitarism (PTHP) to be unrelated to injury sever...

    journal_title:Frontiers in neurology

    pub_type: 杂志文章

    doi:10.3389/fneur.2012.00011

    authors: Wilkinson CW,Pagulayan KF,Petrie EC,Mayer CL,Colasurdo EA,Shofer JB,Hart KL,Hoff D,Tarabochia MA,Peskind ER

    更新日期:2012-02-07 00:00:00