Bumetanide As a Candidate Treatment for Behavioral Problems in Tuberous Sclerosis Complex.

abstract：BACKGROUND:Amnestic mild cognitive impairment (aMCI) is considered to be the transitional stage between healthy aging and Alzheimer's disease (AD). Moreover, aMCI individuals with additional impairment in one or more non-memory cognitive domains are at higher risk of conversion to AD. Hence accurate identification of t...

journal_title：Frontiers in neurology

authors： Raamana PR,Wen W,Kochan NA,Brodaty H,Sachdev PS,Wang L,Beg MF

更新日期：2014-05-21 00:00:00

abstract：:Objective: The platelet-to-lymphocyte ratio (PLR) is a new marker of atherosclerotic inflammation and has been identified as a predictive factor in cardiovascular diseases, but its significance in patients with acute ischaemic stroke (AIS) who have undergone intravenous thrombolysis (IVT) is still unknown. Methods: Co...

journal_title：Frontiers in neurology

authors： Xu JH,He XW,Li Q,Liu JR,Zhuang MT,Huang FF,Bao GS

更新日期：2019-11-13 00:00:00

abstract：:Inconclusive results have been reported in studies investigating the association between the brain-derived neurotrophic factor (BDNF) rs6265 polymorphism and migraine. In the present study, we conducted a systematic review and meta-analysis on the published data in order to quantitatively estimate the relationship bet...

journal_title：Frontiers in neurology

authors： Terrazzino S,Cargnin S,Viana M,Sances G,Tassorelli C

更新日期：2017-05-01 00:00:00

abstract：:During neurorehabilitation, clinical measurements are widely adopted to evaluate behavioral improvements after treatment. However, it is not able to identify or monitor the change of central nervous system (CNS) of each individual patient. Resting-state functional magnetic resonance imaging (rs-fMRI) has been widely u...

journal_title：Frontiers in neurology

authors： Ge Y,Pan Y,Wu Q,Dou W

更新日期：2019-11-01 00:00:00

abstract：:Importance: Coronavirus disease 2019 (COVID-19) is a newly emerging infectious disease that has caused a global pandemic. The presenting symptoms are mainly respiratory symptom, yet studies have reported nervous system involvement in the disease. A systematic review and meta-analysis of these studies are required to u...

journal_title：Frontiers in neurology

authors： Pinzon RT,Wijaya VO,Buana RB,Al Jody A,Nunsio PN

更新日期：2020-05-29 00:00:00

abstract：:The Boston Carpal Tunnel Questionnaire (BCTQ) is a scale that has been developed specifically for carpal tunnel syndrome (CTS). It consists of the Functional Status Scale (FSS) and the Symptom Severity Scale (SSS). It is the most widely used patient reported outcome measure in CTS and has been validated in many langua...

journal_title：Frontiers in neurology

authors： De Kleermaeker FGCM,Levels M,Verhagen WIM,Meulstee J

更新日期：2019-11-07 00:00:00

abstract：OBJECTIVES:Use of oral contraceptive pills (OCP) increases the risk of cerebral venous sinus thrombosis (CVST). Whether this risk varies by type, duration, and other forms of hormonal contraceptives is largely unknown. This systematic review and meta-analysis update the current state of knowledge. METHODS:We performed...

journal_title：Frontiers in neurology

authors： Amoozegar F,Ronksley PE,Sauve R,Menon BK

更新日期：2015-02-02 00:00:00

abstract：:Functional connectivity maps using resting-state functional magnetic resonance imaging (rs-fMRI) can closely resemble task fMRI activation patterns, suggesting that resting-state brain activity may predict task-evoked activation or behavioral performance. However, this conclusion was mostly drawn upon a healthy popula...

journal_title：Frontiers in neurology

authors： Hu J,Du J,Xu Q,Yang F,Zeng F,Dai XJ,Liu X,Lu G,Zhang Z

更新日期：2017-07-19 00:00:00

abstract：:This study reports the case of an acoustic shock injury (ASI), which did not result in a significant hearing loss, but was followed by manifold chronic symptoms both within (tinnitus, otalgia, tingling in the ear, tension in the ear, and red tympanum) and outside the ears (blocked nose, pain in the neck/temporal regio...

journal_title：Frontiers in neurology

authors： Londero A,Charpentier N,Ponsot D,Fournier P,Pezard L,Noreña AJ

更新日期：2017-08-16 00:00:00

abstract：:Cerebral ischemia is the leading cause of morbidity and mortality following aneurysmal subarachnoid hemorrhage (SAH). Although 70% of the patients show angiographic vasospasm only 30% develop symptomatic vasospasm defined as delayed cerebral ischemia (DCI). Early detection and management of reversible ischemia is of c...

journal_title：Frontiers in neurology

authors： Rostami E,Engquist H,Johnson U,Howells T,Ronne-Engström E,Nilsson P,Hillered L,Lewén A,Enblad P

更新日期：2014-06-02 00:00:00

abstract：:Object: Predicting whether intramedullary slitlike cavity (SC) will worsen over time or remain stable is an outstanding clinical challenge. The aim of this study was to identify early features of SC (clinical and magnetic resonance imaging [MRI] findings). Methods: We prospectively included all patients referred to ou...

journal_title：Frontiers in neurology

authors： Faillot M,Morar S,Delphine S,El-Mendili M,Ducreux D,Parker F,Aghakhani N

更新日期：2020-06-12 00:00:00

abstract：:Infections in the post-acute phase of cerebral ischaemia impede optimal recovery by exacerbating morbidity and mortality. Our review aims to reconcile the increased infection susceptibility of patients post-stroke by consolidating our understanding of compartmentalised alterations to systemic immunity. Mounting eviden...

journal_title：Frontiers in neurology

authors： Krishnan S,Lawrence CB

更新日期：2019-07-02 00:00:00

abstract：:Background: Cognitive impairments in temporal lobe epilepsy (TLE) patients has been described as a chronically progressive feature of the disease. However, how severe recurrent seizures modify neuronal circuits in the human brain and subsequently degrade cognitive function, remains largely unknown. Here, we aimed to i...

journal_title：Frontiers in neurology

authors： Qin L,Jiang W,Zheng J,Zhou X,Zhang Z,Liu J

更新日期：2020-07-21 00:00:00

abstract：:Non-linear relations of brain amyloid beta (Aβ) with task- based functional connectivity (tbFC) measured with functional magnetic resonance imaging (fMRI) have been reported in late middle age. Our objective was to examine the association between brain Aβ and resting-state functional connectivity (rsFC) in late middle...

journal_title：Frontiers in neurology

authors： Tahmi M,Rippon B,Palta P,Soto L,Ceballos F,Pardo M,Sherwood G,Hernandez G,Arevalo R,He H,Sedaghat A,Arabshahi S,Teresi J,Moreno H,Brickman AM,Razlighi QR,Luchsinger JA

更新日期：2020-10-06 00:00:00

abstract：:There is a need for biomarkers for amyotrophic lateral sclerosis (ALS), to support the diagnosis of the disease, to predict disease progression and to track disease activity and treatment responses. Over the last decade multiple studies have investigated the potential of neurofilament levels, both in cerebrospinal flu...

journal_title：Frontiers in neurology

authors： Poesen K,Van Damme P

更新日期：2019-01-18 00:00:00

abstract：:This study aimed to assess the efficacy and safety of self-designed Ningxin Anshen (NXAS) Formula for post-ischemic stroke insomnia of blood-deficient and liver-heat syndrome. Ninety patients were randomized into NXAS group, Placebo group and Zopiclone group. Patients in the NXAS group, Placebo group and Zopiclone gro...

journal_title：Frontiers in neurology

authors： Dai N,Li Y,Sun J,Li F,Xiong H

更新日期：2020-11-09 00:00:00

abstract：:Takotsubo cardiomyopathy (TTC) is an acute and reversible cardiac wall motion abnormality of the left myocardium. Although many studies focused on etiology, diagnostic and treatment of TTC, precise clinical guidelines on TTC are not available. Research revealed emotional and physical triggering factors of TTC and emph...

journal_title：Frontiers in neurology

authors： Buchmann SJ,Lehmann D,Stevens CE

更新日期：2019-08-22 00:00:00

abstract：:Cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 are two crucial mediators contributing to blood-brain barrier (BBB) damage during cerebral ischemia. However, it is not known whether MMP-9 activation is involved in COX-2-mediated BBB disruption in ischemic stroke. In this study, we hypothesized that genetic...

journal_title：Frontiers in neurology

authors： Yang C,Yang Y,DeMars KM,Rosenberg GA,Candelario-Jalil E

更新日期：2020-08-20 00:00:00

abstract：:Magnetic resonance imaging (MRI) is a non-destructive technique that is capable of localizing pathologies and assessing other anatomical features (e.g., tissue volume, microstructure, and white matter connectivity) in postmortem, ex vivo human brains. However, when brains are removed from the skull and cerebrospinal f...

journal_title：Frontiers in neurology

authors： Shatil AS,Matsuda KM,Figley CR

更新日期：2016-11-29 00:00:00

abstract：:Previous consensus statements on sports concussion have highlighted the importance of Attention Deficit Hyperactivity Disorder (ADHD) and loss of consciousness (LOC) as risk factors related to concussion management. The present study investigated how self-reported history of either ADHD diagnosis or history of previou...

journal_title：Frontiers in neurology

authors： Kaye S,Sundman MH,Hall EE,Williams E,Patel K,Ketcham CJ

更新日期：2019-04-24 00:00:00

abstract：:Background: Elderly patients account for 30% of acute ischemic stroke (AIS) but are under-represented in randomized controlled trials of endovascular thrombectomy (EVT). Meta-analysis of "real world" studies evaluating 90-day outcomes in elderly patients ≥80 years have been limited to small numbers undergoing EVT with...

journal_title：Frontiers in neurology

authors： Sharobeam A,Cordato DJ,Manning N,Cheung A,Wenderoth J,Cappelen-Smith C

更新日期：2019-03-20 00:00:00

abstract：:Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal muscle-initiated crosstalk with other tissues is accomplished though the secretion of myokines, protein hormones which can exert autoc...

journal_title：Frontiers in neurology

authors： Delezie J,Handschin C

更新日期：2018-08-24 00:00:00

abstract：:Introduction: Eslicarbazepine acetate (ESL) is an antiepileptic drug approved as monotherapy or add-on for the treatment of epilepsy with seizures of focal onset. ESL owns a good profile in terms of efficacy and tolerability, but its effects on EEG activity and connectivity are unknown. The purpose of this study was t...

journal_title：Frontiers in neurology

authors： Pellegrino G,Mecarelli O,Pulitano P,Tombini M,Ricci L,Lanzone J,Brienza M,Davassi C,Di Lazzaro V,Assenza G

更新日期：2018-12-11 00:00:00

abstract：:Background and aims: The pathophysiology of hippocampal enlarged perivascular spaces (H-EPVS) and its relationship to cognitive impairment is largely unknown. This study aimed to investigate the relationship between H-EPVS and cognition in non-dementic elderly population. Methods: A total of 109 subjects were prospect...

journal_title：Frontiers in neurology

authors： Sim JE,Park MS,Shin HY,Jang HS,Won HH,Seo SW,Seo WK,Kim BJ,Kim GM

更新日期：2020-09-29 00:00:00

abstract：:Traumatic brain injury (TBI) is a major medical crisis without any FDA-approved pharmacological therapies that have been demonstrated to improve functional outcomes. It has been argued that discovery of disease-relevant biomarkers might help to guide successful clinical trials for TBI. Major advances in mass spectrome...

journal_title：Frontiers in neurology

authors： Guingab-Cagmat JD,Cagmat EB,Hayes RL,Anagli J

更新日期：2013-05-31 00:00:00

abstract：:Background: Prolonged static whole-body roll-tilt has been shown to bias estimates of the direction of gravity when assessed by static paradigms such as the subjective visual vertical and the subjective haptic vertical. Objective: We hypothesized that these shifts are paradigm-independent and thus predicted a post-til...

journal_title：Frontiers in neurology

authors： Wedtgrube A,Bockisch CJ,Straumann D,Tarnutzer AA

更新日期：2020-10-15 00:00:00

abstract：:Quantitative mapping of the magnetic susceptibility and the effective transverse relaxation rate (R2*) are suitable to assess the iron content in distinct brain regions. In this prospective, explorative study the iron accumulation in deep gray matter nuclei (DGM) in myotonic dystrophy type 1 (DM1) and 2 (DM2) and its ...

journal_title：Frontiers in neurology

authors： Ates S,Deistung A,Schneider R,Prehn C,Lukas C,Reichenbach JR,Schneider-Gold C,Bellenberg B

更新日期：2019-12-13 00:00:00

abstract：:We describe the case of one patient with pure sporadic hemiplegic migraine (SHM) with a novel ATP1A2 gene variant and a large patent foramen ovale (PFO) with atrial septal aneurysm. In hemiplegic migraine (HM), the relationship between incomplete penetrance, environmental triggers, and phenotypic expression is underde...

journal_title：Frontiers in neurology

authors： Perrotta A,Gambardella S,Ambrosini A,Anastasio MG,Albano V,Fornai F,Pierelli F

更新日期：2018-05-17 00:00:00

abstract：:Background: In functional movement disorders, explicit movements are impaired, while implicit movements are preserved. Furthermore, there is evidence that the sense of agency is abnormal. Aim: We aimed to investigate how motor responses and sense of agency were affected by subliminal or supraliminal cues in people wit...

journal_title：Frontiers in neurology

authors： Huys AML,Edwards MJ,Bhatia KP,Haggard P

更新日期：2020-09-11 00:00:00

abstract：BACKGROUND:Spinocerebellar ataxia type 2 (SCA2) is an inherited and still incurable neurodegenerative disorder. Evidence suggests that pro-oxidant agents as well as factors involved in antioxidant cellular defenses are part of SCA2 physiopathology. AIM:To assess the influence of superoxide dismutase (SOD3) and catalas...

journal_title：Frontiers in neurology

authors： Almaguer-Gotay D,Almaguer-Mederos LE,Aguilera-Rodríguez R,Rodríguez-Labrada R,Cuello-Almarales D,Estupiñán-Domínguez A,Velázquez-Pérez LC,González-Zaldívar Y,Vázquez-Mojena Y

更新日期：2017-06-13 00:00:00