Emergence of melioidosis in the Indian Ocean region: Two new cases and a literature review.

abstract：:The global spread of vector-borne diseases remains a worrying public health threat, raising the need for development of new combat strategies for vector control. Knowledge of vector ecology can be exploited in this regard, including plant feeding; a critical resource that mosquitoes of both sexes rely on for survival ...

journal_title：PLoS neglected tropical diseases

authors： Nyasembe VO,Tchouassi DP,Pirk CWW,Sole CL,Torto B

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:Clinical relevance of nontuberculous mycobacteria (NTM) is increasing worldwide including in Saudi Arabia. A high species diversity of NTM's has been noticed in a recent study. However, the identification in diagnostic laboratories is mostly limited to common species. The impact of NTM species diversity on c...

journal_title：PLoS neglected tropical diseases

authors： Varghese B,Enani M,Shoukri M,AlThawadi S,AlJohani S,Al-Hajoj S

更新日期：2017-01-11 00:00:00

abstract：BACKGROUND:Third-stage larvae (L3) of the canine hookworm, Ancylostoma caninum, undergo arrested development preceding transmission to a host. Many of the mRNAs up-regulated at this stage are likely to encode proteins that facilitate the transition from a free-living to a parasitic larva. The initial phase of mammalian...

journal_title：PLoS neglected tropical diseases

authors： Datu BJ,Gasser RB,Nagaraj SH,Ong EK,O'Donoghue P,McInnes R,Ranganathan S,Loukas A

更新日期：2008-01-09 00:00:00

abstract：BACKGROUND:Carrion' disease, caused by Bartonella bacilliformis, remains truly neglected due to its focal geographical nature. A wide spectrum of clinical manifestations, including asymptomatic bacteremia, and lack of a sensitive diagnostic test can potentially lead to a spread of the disease into non-endemic regions w...

journal_title：PLoS neglected tropical diseases

authors： Angkasekwinai N,Atkins EH,Johnson RN,Grieco JP,Ching WM,Chao CC

更新日期：2014-12-18 00:00:00

abstract：:Leprosy is a persistent infectious disease caused by Mycobacterium leprae that still affects over 200,000 new patients annually. The host genetic background is an important risk factor for leprosy susceptibility and the PARK2 gene is a replicated leprosy susceptibility candidate gene. The protein product of PARK2, Par...

journal_title：PLoS neglected tropical diseases

authors： de Léséleuc L,Orlova M,Cobat A,Girard M,Huong NT,Ba NN,Thuc NV,Truman R,Spencer JS,Adams L,Thai VH,Alcais A,Schurr E

更新日期：2013-01-01 00:00:00

abstract：:Erythema nodosum leprosum (ENL), or type 2 lepra reaction, is a multi-system immune-mediated complication in patients with multibacillary leprosy, frequently associated with chronicity and recurrences. Management of ENL requires high doses of oral corticosteroids, which may not be universally effective and pose seriou...

journal_title：PLoS neglected tropical diseases

authors： Upputuri B,Pallapati MS,Tarwater P,Srikantam A

更新日期：2020-10-09 00:00:00

abstract：BACKGROUND:The diagnosis of Strongyloides stercoralis (S. stercoralis) infection is hampered by the suboptimal sensitivity of fecal-based tests. Serological methods are believed to be more sensitive, although assessing their accuracy is difficult because of the lack of sensitivity of a fecal-based reference ("gold") st...

journal_title：PLoS neglected tropical diseases

authors： Bisoffi Z,Buonfrate D,Sequi M,Mejia R,Cimino RO,Krolewiecki AJ,Albonico M,Gobbo M,Bonafini S,Angheben A,Requena-Mendez A,Muñoz J,Nutman TB

更新日期：2014-01-09 00:00:00

abstract：BACKGROUND:Buruli ulcer (BU) is a chronic necrotizing infectious skin disease caused by Mycobacterium ulcerans. The treatment with BU-specific antibiotics is initiated after clinical suspicion based on the WHO clinical and epidemiological criteria. This study aimed to estimate the predictive values of these criteria an...

journal_title：PLoS neglected tropical diseases

authors： Ayelo GA,Sopoh GE,Houezo JG,Fiodessihoue R,Affolabi D,Dossou AD,Barogui YT,Wadagni AAC,Agossadou DC,Hasker E,Portaels F,de Jong BC,Eddyani M

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:Leishmaniasis is a complex disease in which clinical outcome depends on factors such as parasite species, host genetics and immunity and vector species. In Brazil, Leishmania (Viannia) braziliensis is a major etiological agent of cutaneous (CL) and mucosal leishmaniasis (MCL), a disfiguring form of the disea...

journal_title：PLoS neglected tropical diseases

authors： Alves-Ferreira EV,Toledo JS,De Oliveira AH,Ferreira TR,Ruy PC,Pinzan CF,Santos RF,Boaventura V,Rojo D,López-Gonzálvez Á,Rosa JC,Barbas C,Barral-Netto M,Barral A,Cruz AK

更新日期：2015-09-14 00:00:00

abstract：BACKGROUND:The history of Chagas disease control in Peru and many other nations is marked by scattered and poorly documented vector control campaigns. The complexities of human migration and sporadic control campaigns complicate evaluation of the burden of Chagas disease and dynamics of Trypanosoma cruzi transmission. ...

journal_title：PLoS neglected tropical diseases

authors： Delgado S,Castillo Neyra R,Quispe Machaca VR,Ancca Juárez J,Chou Chu L,Verastegui MR,Moscoso Apaza GM,Bocángel CD,Tustin AW,Sterling CR,Comrie AC,Náquira C,Cornejo del Carpio JG,Gilman RH,Bern C,Levy MZ

更新日期：2011-02-22 00:00:00

abstract：BACKGROUND:Traditional faecal-based methods have poor sensitivity for the detection of S. stercoralis, therefore are inadequate for post-treatment evaluation of infected patients who should be carefully monitored to exclude the persistence of the infection. In a previous study, we demonstrated high accuracy of five ser...

journal_title：PLoS neglected tropical diseases

authors： Buonfrate D,Sequi M,Mejia R,Cimino RO,Krolewiecki AJ,Albonico M,Degani M,Tais S,Angheben A,Requena-Mendez A,Muñoz J,Nutman TB,Bisoffi Z

更新日期：2015-02-10 00:00:00

abstract：BACKGROUND:Cure after treatment for human African trypanosomiasis (HAT) is assessed by examination of the cerebrospinal fluid every 6 months, for a total period of 2 years. So far, no markers for cure or treatment failure have been identified in blood. Trypanosome-specific antibodies are detectable in blood by the Card...

journal_title：PLoS neglected tropical diseases

authors： Lejon V,Ngoyi DM,Boelaert M,Büscher P

更新日期：2010-01-26 00:00:00

abstract：BACKGROUND:Protozoan parasites of the genus Leishmania cause a large spectrum of clinical manifestations known as Leishmaniases. These diseases are increasingly important public health problems in many countries both within and outside endemic regions. Thus, an accurate differential diagnosis is extremely relevant for ...

journal_title：PLoS neglected tropical diseases

authors： Zampieri RA,Laranjeira-Silva MF,Muxel SM,Stocco de Lima AC,Shaw JJ,Floeter-Winter LM

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:Human cysticercosis is a zoonotic disease causing severe health disorders and even death. While prevalence data become available worldwide, incidence rate and cumulative incidence figures are lacking, which limits the understanding of the Taenia solium epidemiology. METHODOLOGY/PRINCIPAL FINDINGS:A seroepid...

journal_title：PLoS neglected tropical diseases

authors： Coral-Almeida M,Rodríguez-Hidalgo R,Celi-Erazo M,García HH,Rodríguez S,Devleesschauwer B,Benítez-Ortiz W,Dorny P,Praet N

更新日期：2014-05-22 00:00:00

abstract：BACKGROUND:Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is an emerging cause of pneumonia-derived sepsis in the tropics. The gut microbiota supports local mucosal immunity and is increasingly recognized as a protective mediator in host defenses against systemic infection. Here, we aimed...

journal_title：PLoS neglected tropical diseases

authors： Lankelma JM,Birnie E,Weehuizen TAF,Scicluna BP,Belzer C,Houtkooper RH,Roelofs JJTH,de Vos AF,van der Poll T,Budding AE,Wiersinga WJ

更新日期：2017-04-19 00:00:00

abstract：BACKGROUND:Predictive models can serve as early warning systems and can be used to forecast future risk of various infectious diseases. Conventionally, regression and time series models are used to forecast dengue incidence, using dengue surveillance (e.g., case counts) and weather data. However, these models may be li...

journal_title：PLoS neglected tropical diseases

authors： Benedum CM,Shea KM,Jenkins HE,Kim LY,Markuzon N

更新日期：2020-10-16 00:00:00

abstract：:Intracerebral microhemorrhages (CMHs) are small foci of hemorrhages in the cerebrum. Acute infections induced by some intracellular pathogens, including rickettsia, can result in CMHs. Annexin a2 (ANXA2) has been documented to play a functional role during intracellular bacterial adhesion. Here we report that ANXA2-kn...

journal_title：PLoS neglected tropical diseases

authors： Su Z,Chang Q,Drelich A,Shelite T,Judy B,Liu Y,Xiao J,Zhou C,He X,Jin Y,Saito T,Tang S,Soong L,Wakamiya M,Fang X,Bukreyev A,Ksiazek T,Russell WK,Gong B

更新日期：2020-07-20 00:00:00

abstract：:Post-kala-azar dermal leishmaniasis (PKDL) is clinical outcome of visceral leishmaniasis (VL) and is thought to be the potential reservoir of parasite. Miltefosine (MF) is the only oral drug existing for treatment of post-kala-azar dermal leishmaniasis (PKDL). Increased miltefosine tolerance in clinical isolates of Le...

journal_title：PLoS neglected tropical diseases

authors： Topno RK,Rabi Das VN,Kumar M,Madhukar M,Pandey K,Verma N,Agrawal K,Lal CS,Siddiqui NA,Bimal S,Das P

更新日期：2020-03-23 00:00:00

abstract：:The progression and variation of pathology during infections can be due to components from both host or pathogen, and/or the interaction between them. The influence of host genetic variation on disease pathology during infections with trypanosomes has been well studied in recent years, but the role of parasite genetic...

journal_title：PLoS neglected tropical diseases

authors： Morrison LJ,Tait A,McLellan S,Sweeney L,Turner CM,MacLeod A

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Hosts repeatedly bitten by sand flies develop antibodies against sand fly saliva and screening of these immunoglobulins can be employed to estimate the risk of Leishmania transmission, to indicate the feeding preferences of sand flies, or to evaluate the effectiveness of vector control campaigns. Previously,...

journal_title：PLoS neglected tropical diseases

authors： Sima M,Ferencova B,Bhattacharyya T,Miles MA,Litvinov SV,Hailu A,Baneth G,Volf P

更新日期：2019-01-24 00:00:00

abstract：:Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU) disease, is unique amongst human pathogens in its capacity to produce a lipid toxin called mycolactone. While previous studies have demonstrated that bacterially-released mycolactone diffuses beyond infection foci, the spatiotemporal distribution of myco...

journal_title：PLoS neglected tropical diseases

authors： Colucci-Guyon E,Rifflet A,Saint-Auret S,da Costa A,Boucontet L,Laval T,Prehaud C,Blanchard N,Levraud JP,Boneca IG,Demangel C,Guenin-Macé L

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:There are health risks associated with wastewater and fecal sludge management and use, but little is known about the magnitude, particularly in rapidly growing urban settings of low- and middle-income countries. We assessed the point-prevalence and risk factors of intestinal parasite infections in people wit...

journal_title：PLoS neglected tropical diseases

authors： Fuhrimann S,Winkler MS,Kabatereine NB,Tukahebwa EM,Halage AA,Rutebemberwa E,Medlicott K,Schindler C,Utzinger J,Cissé G

更新日期：2016-03-03 00:00:00

abstract：BACKGROUND:This paper presents the development of an agent-based model (ABM) to incorporate climatic drivers which affect tsetse fly (G. m. morsitans) population dynamics, and ultimately disease transmission. The model was used to gain a greater understanding of how tsetse populations fluctuate seasonally, and investig...

journal_title：PLoS neglected tropical diseases

authors： Alderton S,Macleod ET,Anderson NE,Palmer G,Machila N,Simuunza M,Welburn SC,Atkinson PM

更新日期：2018-02-09 00:00:00

abstract：OBJECTIVES:To assess if a probabilistic model could be used to estimate the combined prevalence of infection with any species of intestinal nematode worm when only the separate prevalence of each species is reported, and to estimate the extent to which simply taking the highest individual species prevalence underestima...

journal_title：PLoS neglected tropical diseases

authors： de Silva N,Hall A

更新日期：2010-04-13 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF) is targeted for global elimination through treatment of entire at-risk populations with repeated annual mass drug administration (MDA). Essential for program success is defining and confirming the appropriate endpoint for MDA when transmission is presumed to have reached a level low...

journal_title：PLoS neglected tropical diseases

authors： Chu BK,Deming M,Biritwum NK,Bougma WR,Dorkenoo AM,El-Setouhy M,Fischer PU,Gass K,Gonzalez de Peña M,Mercado-Hernandez L,Kyelem D,Lammie PJ,Flueckiger RM,Mwingira UJ,Noordin R,Offei Owusu I,Ottesen EA,Pavluck A,Pilotte

更新日期：2013-12-05 00:00:00

abstract：:West Nile Fever is a zoonotic disease caused by a mosquito-borne flavivirus, WNV. By its clinical sensitivity to the disease, the horse is a useful sentinel of infection. Because of the virus' low-level, short-term viraemia in horses, the primary tools used to diagnose WNV are serological tests. Inter-laboratory profi...

journal_title：PLoS neglected tropical diseases

authors： Beck C,Lowenski S,Durand B,Bahuon C,Zientara S,Lecollinet S

更新日期：2017-09-15 00:00:00

abstract：BACKGROUND:Deposition of complement factors on Mycobacterium leprae may enhance phagocytosis. Such deposition may occur through the lectin pathway of complement. Three proteins of the lectin pathway are produced from the gene MASP1: Mannan-binding lectin-associated serine protease 1 (MASP-1) and MASP-3 and mannan-bindi...

journal_title：PLoS neglected tropical diseases

authors： Weinschutz Mendes H,Boldt ABW,von Rosen Seeling Stahlke E,Jensenius JC,Thiel S,Messias-Reason IJT

更新日期：2020-04-02 00:00:00

abstract：BACKGROUND:Envenoming by viper snakes constitutes an important public health problem in Brazil and other developing countries. Local hemorrhage is an important symptom of these accidents and is correlated with the action of snake venom metalloproteinases (SVMPs). The degradation of vascular basement membrane has been p...

journal_title：PLoS neglected tropical diseases

authors： Baldo C,Jamora C,Yamanouye N,Zorn TM,Moura-da-Silva AM

更新日期：2010-06-29 00:00:00

abstract：BACKGROUND:Oncomelania hupensis is the unique intermediate host of Schistosoma japonicum, which causes schistosomiasis endemic in the Far East, and especially in mainland China. O. hupensis largely determines the parasite's geographical range. How O. hupensis's genetic diversity is distributed geographically in mainlan...

journal_title：PLoS neglected tropical diseases

authors： Zhao QP,Jiang MS,Littlewood DT,Nie P

更新日期：2010-03-02 00:00:00

abstract：BACKGROUND:The World Health Organization now recommends semiannual mass drug administration (MDA) of albendazole with integrated vector management as an option for eliminating lymphatic filariasis (LF) in areas of loiasis-endemic countries where it may not be safe to use diethylcarbamazine or ivermectin in MDA programs...

journal_title：PLoS neglected tropical diseases

authors： Pion SDS,Chesnais CB,Awaca-Uvon NP,Vlaminck J,Abdou A,Kunyu-Shako B,Kuyangisa Simuna G,Tambwe JP,Weil GJ,Boussinesq M

更新日期：2020-06-23 00:00:00