First isolation and genetic characterization of pseudocowpox virus from cattle in Japan.

abstract：:While improved drug regimens have greatly enhanced outcomes for patients with chronic viral infection, antiviral therapy is still not ideal due to drug toxicities, treatment costs, primary drug failure and emergent resistance. New antiviral agents, alternative treatment strategies and a better understanding of viral p...

journal_title：Virology journal

authors： Sallie R

更新日期：2007-03-13 00:00:00

abstract：BACKGROUND:The human immunodeficiency virus type 1(HIV-1) is a complex retrovirus and the causative agent of acquired immunodeficiency syndrome (AIDS). The HIV-1 Vpu protein is an oligomeric integral membrane protein essential for particle release, viral load and CD4 degradation. In silico models show Vpu to form penta...

journal_title：Virology journal

authors： Hussain A,Das SR,Tanwar C,Jameel S

更新日期：2007-08-29 00:00:00

abstract：BACKGROUND:In mammals, interleukin 2 (IL-2) has been shown to decrease replication or attenuate pathogenicity of numerous viral pathogens (herpes simplex virus, vaccinia virus, human respiratory syncytial virus, human immunodeficiency virus) by activating natural killer cells (NK), cytotoxic T lymphocytes and expanding...

journal_title：Virology journal

authors： Susta L,Diel DG,Courtney S,Cardenas-Garcia S,Sundick RS,Miller PJ,Brown CC,Afonso CL

更新日期：2015-08-08 00:00:00

abstract：BACKGROUND:Torquetenovirus (TTV) belongs to Anelloviridae family, infects nearly all people indefinitely without causing overt disease establishing a fine and successful interaction with the host. Increasing evidence have shown some human viruses exploit extracellular vesicles thereby helping viral persistence in the h...

journal_title：Virology journal

authors： Martelli F,Macera L,Spezia PG,Medici C,Pistello M,Guasti D,Romagnoli P,Maggi F,Giannecchini S

更新日期：2018-09-20 00:00:00

abstract：BACKGROUND:Pseudorabies virus (PRV) of the family Herpesviridae is the causative agent of Aujeszky's disease. Attenuation of PRV by serial passaging in vitro is a well-established method; however, the dynamic variations occurring on viral genome during this process have not been characterized. METHODS:Genome sequencin...

journal_title：Virology journal

authors： Ye C,Wu J,Tong W,Shan T,Cheng X,Xu J,Liang C,Zheng H,Li G,Tong G

更新日期：2018-12-29 00:00:00

abstract：BACKGROUND:Patchouli alcohol (PA) is a tricyclic sesquiterpene extracted from Pogostemonis Herba, which is a traditional Chinese medicine used for therapy of inflammatory diseases. Recent studies have shown that PA has various pharmacological activities, including anti-bacterial and anti-viral effects. METHODS:In this...

journal_title：Virology journal

authors： Yu Y,Zhang Y,Wang S,Liu W,Hao C,Wang W

更新日期：2019-12-23 00:00:00

abstract：BACKGROUND:The Urabe AM9 vaccine strain of mumps virus contains two variants of V protein: VWT (of HN-A1081 viral population) and VGly (of HN-G1081). The V protein is a promoting factor of viral replication by blocking the IFN antiviral pathway. FINDINGS:We studied the relationship between V protein variants and IFN-α...

journal_title：Virology journal

authors： Rosas-Murrieta NH,Santos-López G,Reyes-Leyva J,Jurado FS,Herrera-Camacho I

更新日期：2011-05-13 00:00:00

abstract：BACKGROUND:Foot-and-mouth disease (FMD) is a highly contagious disease of livestock which causes severe economic loss in cloven-hoofed animals. Vaccination is still a major strategy in developing countries to control FMD. Currently, inactivated vaccine of FMDV has been used in many countries with limited success and sa...

journal_title：Virology journal

authors： Cao Y,Lu Z,Sun P,Fu Y,Tian F,Hao X,Bao H,Liu X,Liu Z

更新日期：2011-02-23 00:00:00

abstract：BACKGROUND:SEN virus is a blood-borne, circular ssDNA virus and possessing nine genotypes (A to I). Among nine genotypes, SENV-D and SENV-H genotypes have the strong link with patients with unknown (none-A to E) hepatitis infections. Infection with blood-borne viruses is the second important cause of death in thalassem...

journal_title：Virology journal

authors： Karimi-Rastehkenari A,Bouzari M

更新日期：2010-01-02 00:00:00

abstract：:Bats have been recognized as the natural reservoirs of a large variety of viruses. Special attention has been paid to bat coronaviruses as the two emerging coronaviruses which have caused unexpected human disease outbreaks in the 21st century, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Re...

journal_title：Virology journal

authors： Hu B,Ge X,Wang LF,Shi Z

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:A novel reassortant H7N9 influenza A virus has crossed the species barrier from poultry to cause human infections in China in 2013 and 2014. Rapid detection of the novel H7N9 virus is important to detect this virus in poultry and reduce the risk of an epidemic in birds or humans. FINDINGS:In this study, a m...

journal_title：Virology journal

authors： Xu X,Bao H,Ma Y,Sun J,Zhao Y,Wang Y,Shi J,Zeng X,Li Y,Wang X,Chen H

更新日期：2015-04-30 00:00:00

abstract：BACKGROUND:This study aimed at reseaching the immune effect of porcine circovirus type 2 (PCV2) DNA vaccine containing CpG motif on mice. METHODS:A total of 40 6-week-old female BALB/c mice were randomly divided into four groups which were immunized by 18CpG-pVAX1-ORF2, pVAX1-ORF2, pVAX1 and PBS, respectively, and imm...

journal_title：Virology journal

authors： Li J,Yu J,Xu S,Shi J,Xu S,Wu X,Fu F,Peng Z,Zhang L,Zheng S,Yuan X,Cong X,Sun W,Cheng K,Du Y,Wu J,Wang J

更新日期：2016-11-14 00:00:00

abstract：BACKGROUND:More than a decade after the outbreak of human coronaviruses (HCoVs) SARS in Guangdong province and Hong Kong SAR of China in 2002, there is still no reoccurrence, but the evolution and recombination of the coronaviruses in this region are still unknown. Therefore, surveillance on the prevalence and the viru...

journal_title：Virology journal

authors： Liu P,Shi L,Zhang W,He J,Liu C,Zhao C,Kong SK,Loo JFC,Gu D,Hu L

更新日期：2017-11-22 00:00:00

abstract：BACKGROUND:Construction of conditionally-replicative Adenovirus (CRAd) is complex and time-consuming. While homologous recombination (HR) using a two-plasmid system in bacteria is commonly used to generate CRAds, alternative methods may be required when HR fails. Previously, in vitro ligation has been suggested to faci...

journal_title：Virology journal

authors： Haviv YS

更新日期：2009-02-07 00:00:00

abstract：BACKGROUND:During the pandemic [Influenza A(H1N1)pdm09] period in 2009-2010, an influenza A (Inf-A) virus with H1N2 subtype (designated as A/Eastern India/N-1289/2009) was detected from a 25 years old male from Mizoram (North-eastern India). OBJECTIVE:To characterize full genome of the H1N2 influenza virus. METHODS:F...

journal_title：Virology journal

authors： Mukherjee TR,Agrawal AS,Chakrabarti S,Chawla-Sarkar M

更新日期：2012-10-11 00:00:00

abstract：BACKGROUND:Infection with Chikungunya alphavirus (CHIKV) can cause severe arthralgia and chronic arthritis in humans with persistence of the virus in perivascular macrophages of the synovial membrane by mechanisms largely ill-characterized. FINDINGS:We herein analysed the innate immune response (cytokine and programme...

journal_title：Virology journal

authors： Kumar S,Jaffar-Bandjee MC,Giry C,Connen de Kerillis L,Merits A,Gasque P,Hoarau JJ

更新日期：2012-12-19 00:00:00

abstract：BACKGROUND:The mechanisms through which the avian influenza virus H5N1 modulate the host's innate immune defense during invasion, remains incompletely understood. RIG-I as a pattern recognition receptor plays an important role in mediating innate immune response induced by influenza virus. So, modulating RIG-I might be...

journal_title：Virology journal

authors： Mi Z,Ma Y,Tong Y

更新日期：2012-08-03 00:00:00

abstract：BACKGROUND:RNA viruses are characterized by high rate of mutations mainly due to the lack of proofreading repair activities associated with its RNA-dependent RNA-polymerase (RdRp). In case of arboviruses, this phenomenon has lead to the existence of mixed population of genomic variants within the host called quasi-spec...

journal_title：Virology journal

authors： Jain J,Mathur K,Shrinet J,Bhatnagar RK,Sunil S

更新日期：2016-06-02 00:00:00

abstract：BACKGROUND:Highly-pathogenic avian influenza (HPAI) H5N1 and Newcastle disease (ND) viruses are the two most important poultry viruses in the world, with the ability to cause classic central nervous system dysfunction in poultry and migratory birds. To elucidate the mechanisms of neurovirulence caused by these viruses,...

journal_title：Virology journal

authors： Balasubramaniam VR,Wai TH,Omar AR,Othman I,Hassan SS

更新日期：2012-02-23 00:00:00

abstract：BACKGROUND:Emergence and re-emergence of porcine epidemic diarrhea virus (PEDV) in North America, Asia and Europe has caused severe economic loss to the global swine industry. However, the virome of PEDV infected pigs and its effect on disease severity remains unknown. The advancements of sequencing technology have mad...

journal_title：Virology journal

authors： Chen Q,Wang L,Zheng Y,Zhang J,Guo B,Yoon KJ,Gauger PC,Harmon KM,Main RG,Li G

更新日期：2018-05-25 00:00:00

abstract：BACKGROUND:Chikungunya virus (CHIKV) is a mosquito-borne, arthrogenic Alphavirus that causes large epidemics in Africa, South-East Asia and India. Recently, CHIKV has been transmitted to humans in Southern Europe by invading and now established Asian tiger mosquitoes. To study the processing of envelope proteins E1 and...

journal_title：Virology journal

authors： Metz SW,Geertsema C,Martina BE,Andrade P,Heldens JG,van Oers MM,Goldbach RW,Vlak JM,Pijlman GP

更新日期：2011-07-15 00:00:00

abstract：BACKGROUND:Resonant microwave absorption has been proposed in the literature to excite the vibrational states of microorganisms in an attempt to destroy them. But it is extremely difficult to transfer microwave excitation energy to the vibrational energy of microorganisms due to severe absorption of water in this spect...

journal_title：Virology journal

authors： Tsen KT,Tsen SW,Chang CL,Hung CF,Wu TC,Kiang JG

更新日期：2007-06-05 00:00:00

abstract：:Hepatitis C virus (HCV) is endemic worldwide, and it causes cirrhosis and other complications that often lead to death; nevertheless, our knowledge of the disease and its mechanisms is limited. HCV is most common in underdeveloped nations, including many in Africa and Asia. The virus is usually transmitted by parenter...

journal_title：Virology journal

authors： Aman W,Mousa S,Shiha G,Mousa SA

更新日期：2012-03-02 00:00:00

abstract：BACKGROUND:Acute gastroenteritis caused by bacteria, virus and parasite is an important cause of childhood morbidity and mortality in developing countries. Rotavirus and norovirus have been recognized as the most common pathogens causing acute gastroenteritis among children. However, there is still no valuable data abo...

journal_title：Virology journal

authors： Sai L,Sun J,Shao L,Chen S,Liu H,Ma L

更新日期：2013-10-08 00:00:00

abstract：BACKGROUND:Subviral particles of hepatitis B virus (HBV) composed of L protein deletion variants with the 48 N-terminal amino acids of preS joined to the N-terminus of S protein (1-48preS/S) induced broadly neutralizing antibodies after immunization of mice with a Semliki Forest virus vector. A practical limitation for...

journal_title：Virology journal

authors： Niedre-Otomere B,Bogdanova A,Bruvere R,Ose V,Gerlich WH,Pumpens P,Glebe D,Kozlovska T

更新日期：2013-02-25 00:00:00

abstract：BACKGROUND:Norovirus is one of the most common causes of nonbacterial gastroenteritis in humans. Rapid spread by contaminated food and person-to-person transmission through the fecal-oral route are characteristics of norovirus epidemiology and result in high morbidity in vulnerable patient populations. Therefore, detec...

journal_title：Virology journal

authors： Lee SG,Lee SH,Park SW,Suh CI,Jheong WH,Oh S,Paik SY

更新日期：2011-05-26 00:00:00

abstract：BACKGROUND:Cell culture adaptation of very virulent infectious bursal disease virus (vvIBDV) was shown to be mainly associated with the VP2 capsid protein residues 253, 279, and 284. The single mutation A284T proved critical for cell culture tropism, but did not confer efficient virus replication, which at least requir...

journal_title：Virology journal

authors： Ben Abdeljelil N,Khabouchi N,Kassar S,Miled K,Boubaker S,Ghram A,Mardassi H

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Influenza A virus infects not only humans, but also other species including avian and swine. If a novel influenza A subtype acquires the ability to spread between humans efficiently, it could cause the next pandemic. Therefore it is necessary to understand the evolutionary processes of influenza A viruses in...

journal_title：Virology journal

authors： Furuse Y,Suzuki A,Kamigaki T,Oshitani H

更新日期：2009-05-29 00:00:00

abstract：BACKGROUND:Foot-and mouth disease (FMD) is an acute, febrile, and contagious vesicular disease affecting cloven-hoofed animals. Some animals may become persistent infected carriers when they contact FMD virus (FMDV), and persistent infected animals are a dangerous factor to cause FMD outbreak. FINDINGS:300 OP (oesopha...

journal_title：Virology journal

authors： Bao HF,Li D,Sun P,Zhou Q,Hu J,Bai XW,Fu YF,Lu ZJ,Liu ZX

更新日期：2011-12-14 00:00:00

abstract：BACKGROUND:Infection by any one of 15 high risk human papillomavirus (hrHPV) types causes most invasive cervical cancers. Their oncogenic genome is encapsidated by L1 (major) and L2 (minor) coat proteins. Current HPV prophylactic vaccines are composed of L1 virus-like particles (VLP) that elicit type restricted immunit...

journal_title：Virology journal

authors： Wu WH,Alkutkar T,Karanam B,Roden RB,Ketner G,Ibeanu OA

更新日期：2015-09-11 00:00:00