Impaired Levels of Gangliosides in the Corpus Callosum of Huntington Disease Animal Models.

abstract：:People generally prefer risky options, which have fully specified outcome probabilities, to ambiguous options, which have unspecified probabilities. This preference, formalized in economics, is strong enough that people will reliably prefer a risky option to an ambiguous option with a greater expected value. Explanati...

journal_title：Frontiers in neuroscience

authors： Hayden BY,Heilbronner SR,Platt ML

更新日期：2010-09-17 00:00:00

abstract：:Abdominal obesity is important for understanding obesity, which is a worldwide medical problem. We explored structural and functional brain differences in people with abdominal and non-abdominal obesity by using multimodal neuroimaging and up-to-date analysis methods. A total of 274 overweight people, whose body mass ...

journal_title：Frontiers in neuroscience

authors： Park BY,Lee MJ,Kim M,Kim SH,Park H

更新日期：2018-10-11 00:00:00

abstract：:Thymoma is a tumor originating from thymic gland, frequently manifesting with paraneoplastic neurological disorders. Its association with paraneoplastic dysautonomia is relatively uncommon. Here, we describe the challenging case of a 71 year-old female who developed subacute autonomic failure with digestive pseudo-obs...

journal_title：Frontiers in neuroscience

authors： Ricigliano VAG,Fossati B,Saraceno L,Cavalli M,Bazzigaluppi E,Meola G

更新日期：2018-01-24 00:00:00

abstract：:Perinatal asphyxia (PA) is a clinical condition brought by a birth temporary oxygen deprivation associated with long-term damage in the corpus striatum, one of the most compromised brain areas. Palmitoylethanolamide (PEA) is a neuromodulator well known for its protective effects in brain injury models, including PA, a...

journal_title：Frontiers in neuroscience

authors： Udovin LD,Kobiec T,Herrera MI,Toro-Urrego N,Kusnier CF,Kölliker-Frers RA,Ramos-Hryb AB,Luaces JP,Otero-Losada M,Capani F

更新日期：2020-01-08 00:00:00

abstract：:Accumulation of misfolded proteins results in cellular stress, and is detected by specific sensors in the endoplasmic reticulum, collectively known as the unfolded protein response (UPR). It has been prominently proposed that the UPR is involved in the pathophysiology of Parkinson's disease (PD). In the present study,...

journal_title：Frontiers in neuroscience

authors： Baek JH,Mamula D,Tingstam B,Pereira M,He Y,Svenningsson P

更新日期：2019-07-05 00:00:00

abstract：:Disruption of iron homeostasis and increased glial response are known to occur in brains afflicted by Alzheimer's disease (AD). While the APP/PS1 transgenic mouse model recapitulates the hallmark amyloid-beta plaque pathology of AD, it does so in a different neuronal mileu than humans. Understanding the iron character...

journal_title：Frontiers in neuroscience

authors： Meadowcroft MD,Connor JR,Yang QX

更新日期：2015-07-23 00:00:00

abstract：:Evidence is mounting that LRRK2 function, particularly its kinase activity, is elevated in multiple forms of Parkinson's disease, both idiopathic as well as familial forms linked to mutations in the LRRK2 gene. However, sensitive quantitative markers of LRRK2 activation in clinical samples remain at the early stages o...

journal_title：Frontiers in neuroscience

authors： Rideout HJ,Chartier-Harlin MC,Fell MJ,Hirst WD,Huntwork-Rodriguez S,Leyns CEG,Mabrouk OS,Taymans JM

更新日期：2020-08-18 00:00:00

abstract：:Background: Gambling disorder (GD) is the most common behavioral addiction and shares pathophysiological and clinical features with substance use disorders (SUDs). Effective therapeutic interventions for GD are lacking. Non-invasive brain stimulation (NIBS) may represent a promising treatment option for GD. Objective:...

journal_title：Frontiers in neuroscience

authors： Zucchella C,Mantovani E,Federico A,Lugoboni F,Tamburin S

更新日期：2020-08-18 00:00:00

abstract：:Compared to standard laboratory protocols, the measurement of psychophysiological signals in real world experiments poses technical and methodological challenges due to external factors that cannot be directly controlled. To address this problem, we propose a hybrid approach based on an immersive and human accessible ...

journal_title：Frontiers in neuroscience

authors： Betella A,Zucca R,Cetnarski R,Greco A,Lanatà A,Mazzei D,Tognetti A,Arsiwalla XD,Omedas P,De Rossi D,Verschure PF

更新日期：2014-09-24 00:00:00

abstract：:Gilles de la Tourette Sydrome (TS) is a childhood onset neurodevelopmental disorder, characterized phenotypically by the presence of multiple motor and vocal tics. It is often accompanied by multiple psychiatric comorbidities, with Attention Deficit/Hyperactivity Disorder (ADHD) among the most common. The extensive co...

journal_title：Frontiers in neuroscience

authors： Tsetsos F,Padmanabhuni SS,Alexander J,Karagiannidis I,Tsifintaris M,Topaloudi A,Mantzaris D,Georgitsi M,Drineas P,Paschou P

更新日期：2016-07-22 00:00:00

abstract：:The feedback-related negativity (FRN) is a mid-frontal event-related potential (ERP) recorded in various cognitive tasks and associated with the onset of sensory feedback signaling decision outcome. Some properties of the FRN are still debated, notably its sensitivity to positive and negative reward prediction error (...

journal_title：Frontiers in neuroscience

authors： Sallet J,Camille N,Procyk E

更新日期：2013-11-14 00:00:00

abstract：:Animals must routinely deal with barriers as they move through their natural environment. These challenges require directed changes in leg movements and posture performed in the context of ever changing internal and external conditions. In particular, cockroaches use a combination of tactile and visual information to ...

journal_title：Frontiers in neuroscience

authors： Ritzmann RE,Harley CM,Daltorio KA,Tietz BR,Pollack AJ,Bender JA,Guo P,Horomanski AL,Kathman ND,Nieuwoudt C,Brown AE,Quinn RD

更新日期：2012-07-06 00:00:00

abstract：:Blood-brain barrier opening (BBBO) with pulsed Focused Ultrasound (pFUS) and microbubbles (MB) has received increasing interest as a method for neurotherapeutics of the central nervous system. In general, conventional MRI [i.e., T2w, T2∗w, gadolinium (Gd) enhanced T1w] is used to monitor the effects of pFUS+MB on BBBO...

journal_title：Frontiers in neuroscience

authors： Tu TW,Kovacs ZI,Sundby M,Witko JA,Papadakis GZ,Reid WC,Hammoud DA,Frank JA

更新日期：2020-08-25 00:00:00

abstract：:Reconsolidation of memories has mostly been studied at the behavioral and molecular level. Here, we put forward a simple extension of existing computational models of synaptic consolidation to capture hippocampal slice experiments that have been interpreted as reconsolidation at the synaptic level. The model implement...

journal_title：Frontiers in neuroscience

authors： Kastner DB,Schwalger T,Ziegler L,Gerstner W

更新日期：2016-05-18 00:00:00

abstract：:Several works have demonstrated that visual experience plays a critical role in the development of allocentric spatial coding. Indeed, while children with a typical development start to code space by relying on allocentric landmarks from the first year of life, blind children remain anchored to an egocentric perspecti...

journal_title：Frontiers in neuroscience

authors： Martolini C,Cappagli G,Luparia A,Signorini S,Gori M

更新日期：2020-06-16 00:00:00

abstract：:This paper presents a digital implementation of the Cascade of Asymmetric Resonators with Fast-Acting Compression (CAR-FAC) cochlear model. The CAR part simulates the basilar membrane's (BM) response to sound. The FAC part models the outer hair cell (OHC), the inner hair cell (IHC), and the medial olivocochlear effere...

journal_title：Frontiers in neuroscience

authors： Xu Y,Thakur CS,Singh RK,Hamilton TJ,Wang RM,van Schaik A

更新日期：2018-04-10 00:00:00

abstract：:The sleep duration of adolescents has continued to decline over the past 20 years. Sleep insufficiency is one of the most important risk factors for obesity, but the mechanisms underlying the association are unclear. Therefore, the hypothalamic-regulated mechanisms of appetite and the circadian clock gene expression w...

journal_title：Frontiers in neuroscience

authors： Sun Q,Liu Y,Wei W,Wu D,Lin R,Wen D,Jia L

更新日期：2020-09-08 00:00:00

abstract：Background:Cranial irradiation is a common therapy for the treatment of brain tumors, but unfortunately patients suffer from side effects, particularly cognitive impairment, caused by neurodegenerative and neuroinflammatory mechanisms. Finding a therapeutic agent protecting hippocampal neurons would be beneficial. Fing...

journal_title：Frontiers in neuroscience

authors： Metzdorf J,Hobloss Z,Schlevogt S,Ayzenberg I,Stahlke S,Pedreiturria X,Haupeltshofer S,Gold R,Tönges L,Kleiter I

更新日期：2019-07-09 00:00:00

abstract：:Developing new standardized tools to characterize brain recording devices is critical to evaluate neural probes and for translation to clinical use. The signal-to-noise ratio (SNR) measurement is the gold standard for quantifying the performance of brain recording devices. Given the drawbacks with the SNR measure, our...

journal_title：Frontiers in neuroscience

authors： Suarez-Perez A,Gabriel G,Rebollo B,Illa X,Guimerà-Brunet A,Hernández-Ferrer J,Martínez MT,Villa R,Sanchez-Vives MV

更新日期：2018-11-29 00:00:00

abstract：:We asked whether coordinated voluntary movement of the lower limbs could be regained in an individual having been completely paralyzed (>4 year) and completely absent of vision (>15 year) using two novel strategies-transcutaneous electrical spinal cord stimulation at selected sites over the spine as well as pharmacolo...

journal_title：Frontiers in neuroscience

authors： Gad P,Gerasimenko Y,Zdunowski S,Turner A,Sayenko D,Lu DC,Edgerton VR

更新日期：2017-06-08 00:00:00

abstract：:Vagal neurocircuits are vitally important in the co-ordination and modulation of GI reflexes and homeostatic functions. 5-hydroxytryptamine (5-HT; serotonin) is critically important in the regulation of several of these autonomic gastrointestinal (GI) functions including motility, secretion and visceral sensitivity. W...

journal_title：Frontiers in neuroscience

authors： Browning KN

更新日期：2015-10-29 00:00:00

abstract：:In mammals, new neurons in the adult olfactory bulb originate from a pool of neural stem cells in the subventricular zone of the lateral ventricles. Adult-born cells play an important role in odor information processing by adjusting the neuronal network to changing environmental conditions. Olfactory bulb neurogenesis...

journal_title：Frontiers in neuroscience

authors： Gengatharan A,Bammann RR,Saghatelyan A

更新日期：2016-04-05 00:00:00

abstract：Background:Endovascular treatment of large or giant non-saccular vertebrobasilar aneurysms (VBAs) by conventional stents is difficult and has unsatisfactory outcomes. Object:This study was performed to retrospectively analyze the safety and efficacy of a flow diverter in treating large and giant non-saccular VBAs. Me...

journal_title：Frontiers in neuroscience

authors： Wang J,Jia L,Duan Z,Wang Z,Yang X,Zhang Y,Lv M

更新日期：2019-11-28 00:00:00

abstract：:The R47H coding variant of the triggering receptor expressed on myeloid cells-2 (TREM2) increases the risk of Alzheimer's disease (AD) similar to apolipoprotein E4. TREM2 R47H has recently been shown to have impaired binding to damage-associated lipid or apolipoprotein ligands. However, it is not known how this R47H v...

journal_title：Frontiers in neuroscience

authors： Park JS,Ji IJ,Kim DH,An HJ,Yoon SY

更新日期：2017-01-18 00:00:00

abstract：:The visual system is organized in a parallel and hierarchical architecture. However, the plasticity in hierarchical neural networks is controversial across different response features and at different levels. In this study, we recorded areas 17 and 21a, earlier and intermediate stages of the visual cortex in the cat, ...

journal_title：Frontiers in neuroscience

authors： Wang J,Ni Z,Jin A,Yu T,Yu H

更新日期：2019-10-11 00:00:00

abstract：:Genes for endoplasmic reticulum (ER)-shaping proteins are among the most commonly mutated in hereditary spastic paraplegia (HSP). Mutation of these genes in model organisms can lead to disruption of the ER network. To investigate how the physiological roles of the ER might be affected by such disruption, we developed ...

journal_title：Frontiers in neuroscience

authors： Oliva MK,Pérez-Moreno JJ,O'Shaughnessy J,Wardill TJ,O'Kane CJ

更新日期：2020-08-10 00:00:00

abstract：:Evolution and development are interdependent, particularly with regard to the construction of the nervous system and its position as the machine that produces behavior. On the one hand, the processes directing development and plasticity of the brain provide avenues through which natural selection can sculpt neural cel...

journal_title：Frontiers in neuroscience

authors： Pallas SL

更新日期：2017-06-28 00:00:00

abstract：:Learning a new language requires the use of extensive neural networks and can represent a powerful tool to reorganize brain neuroplasticity. In this study, we analyze how a 4 months long second language learning program (16, 2 h sessions) can lead to functional changes in the brain of healthy elderly individuals. A la...

journal_title：Frontiers in neuroscience

authors： Bubbico G,Chiacchiaretta P,Parenti M,di Marco M,Panara V,Sepede G,Ferretti A,Perrucci MG

更新日期：2019-05-15 00:00:00

abstract：:Intracortical electrodes for brain-machine interfaces rely on intimate contact with tissues for recording signals and stimulating neurons. However, the long-term viability of intracortical electrodes in vivo is poor, with a major contributing factor being the development of a glial scar. In vivo approaches for evaluat...

journal_title：Frontiers in neuroscience

authors： Gilmour A,Poole-Warren L,Green RA

更新日期：2019-12-17 00:00:00

abstract：:Antibiotic-mediated changes to the intestinal microbiome have largely been assumed to be the basis of antibiotic-induced neurophysiological and behavioral changes. However, relatively little research has addressed whether antibiotics act directly on the host nervous system to produce these changes. We aimed to identif...

journal_title：Frontiers in neuroscience

authors： Delungahawatta T,Amin JY,Stanisz AM,Bienenstock J,Forsythe P,Kunze WA

更新日期：2017-10-20 00:00:00