A Model of Synaptic Reconsolidation.

Abstract:

:Reconsolidation of memories has mostly been studied at the behavioral and molecular level. Here, we put forward a simple extension of existing computational models of synaptic consolidation to capture hippocampal slice experiments that have been interpreted as reconsolidation at the synaptic level. The model implements reconsolidation through stabilization of consolidated synapses by stabilizing entities combined with an activity-dependent reservoir of stabilizing entities that are immune to protein synthesis inhibition (PSI). We derive a reduced version of our model to explore the conditions under which synaptic reconsolidation does or does not occur, often referred to as the boundary conditions of reconsolidation. We find that our computational model of synaptic reconsolidation displays complex boundary conditions. Our results suggest that a limited resource of hypothetical stabilizing molecules or complexes, which may be implemented by protein phosphorylation or different receptor subtypes, can underlie the phenomenon of synaptic reconsolidation.

journal_name

Front Neurosci

authors

Kastner DB,Schwalger T,Ziegler L,Gerstner W

doi

10.3389/fnins.2016.00206

subject

Has Abstract

pub_date

2016-05-18 00:00:00

pages

206

eissn

1662-4548

issn

1662-453X

journal_volume

10

pub_type

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