Therapeutic potential of mGluR5 targeting in Alzheimer's disease.

abstract：:In the brain, glucose homeostasis of extracellular fluid is crucial to the point that systems specifically dedicated to glucose sensing are found in areas involved in energy regulation and feeding behavior. Olfaction is a major sensory modality regulating food consumption. Nutritional status in turn modulates olfactor...

journal_title：Frontiers in neuroscience

authors： Al Koborssy D,Palouzier-Paulignan B,Salem R,Thevenet M,Romestaing C,Julliard AK

更新日期：2014-10-29 00:00:00

abstract：:Auditory recognition memory in non-human primates differs from recognition memory in other sensory systems. Monkeys learn the rule for visual and tactile delayed matching-to-sample within a few sessions, and then show one-trial recognition memory lasting 10-20 min. In contrast, monkeys require hundreds of sessions to ...

journal_title：Frontiers in neuroscience

authors： Muñoz-López M,Insausti R,Mohedano-Moriano A,Mishkin M,Saunders RC

更新日期：2015-05-18 00:00:00

abstract：:The goal of our research was to develop a compound computational model that predicts the "opposite" effects of the alternating aftereffects stimuli, such as the "color dove illusion" (Barkan and Spitzer, 2017), and the "filling in the afterimage after the image" (van Lier et al., 2009). The model is based on a filling...

journal_title：Frontiers in neuroscience

authors： Cohen-Duwek H,Spitzer H

更新日期：2018-08-17 00:00:00

abstract：UNLABELLED:α2-adrenoceptors (α2AR) lower central sympathetic output and peripheral catecholamine release, and may therefore prevent sympathetic hyperactivity and hypertension. The α2AR are dysfunctional in male spontaneously hypertensive rats (SHR). Premenopausal females are less hypertensive than males. The purpose of...

journal_title：Frontiers in neuroscience

authors： Berg T

更新日期：2016-03-30 00:00:00

abstract：:Motor recovery following nerve transfer surgery depends on the successful re-innervation of the new target muscle by regenerating axons. Cortical plasticity and motor relearning also play a major role during functional recovery. Successful neuromuscular rehabilitation requires detailed afferent feedback. Surface elect...

journal_title：Frontiers in neuroscience

authors： Sturma A,Hruby LA,Prahm C,Mayer JA,Aszmann OC

更新日期：2018-12-04 00:00:00

abstract：Objective:Magnetic resonance-guided focused ultrasound surgery (MRgFUS) lesioning is a new treatment for brain disorders. However, the skull is a major barrier of ultrasound sonication in MRgFUS because it has an irregular surface and varies its size and shape among individuals. We recently developed the concept of sku...

journal_title：Frontiers in neuroscience

authors： Chang KW,Rachmilevitch I,Chang WS,Jung HH,Zadicario E,Prus O,Chang JW

更新日期：2021-01-12 00:00:00

abstract：:The formation of the six-layered structure of the mammalian cortex via the inside-out pattern of neuronal migration is fundamental to neocortical functions. Extracellular cues such as Reelin induce intracellular signaling cascades through the protein phosphorylation. Migrating neurons also have intrinsic machineries t...

journal_title：Frontiers in neuroscience

authors： Ohshima T

更新日期：2015-01-13 00:00:00

abstract：:The mean diffusivity (MD) value has been used to describe microstructural properties in Diffusion Tensor Imaging (DTI) in cortical gray matter (GM). Recently, researchers have applied a cortical surface generated from the T1-weighted volume. When the DTI data are analyzed using the cortical surface, it is important to...

journal_title：Frontiers in neuroscience

authors： Kwon OH,Park H,Seo SW,Na DL,Lee JM

更新日期：2015-07-14 00:00:00

abstract：:The analysis of spontaneous functional connectivity (sFC) reveals the statistical connections between regions of the brain consistent with underlying functional communication networks within the brain. In this work, we describe the implementation of a complete all-to-all network analysis of resting state neuronal acti...

journal_title：Frontiers in neuroscience

authors： Schmidt BT,Ghuman AS,Huppert TJ

更新日期：2014-06-11 00:00:00

abstract：:While brain stimulation techniques have been examined as treatment options for chronic tinnitus for many years, they have recently been extended to multimodal treatment approaches. As chronic tinnitus is often accompanied by comorbid muscular tension in the neck and back, we performed a one-arm pilot study to explore ...

journal_title：Frontiers in neuroscience

authors： Vielsmeier V,Schecklmann M,Schlee W,Kreuzer PM,Poeppl TB,Rupprecht R,Langguth B,Lehner A

更新日期：2018-02-20 00:00:00

abstract：:Cognitive control of emotions depends on intermodular long-distance communications. However, negative connections between connector hubs are removed by traditional hard-thresholding approach in graph-theoretical research. Using soft-thresholding approach to reserve negative links, we explore time-varying features of c...

journal_title：Frontiers in neuroscience

authors： Zhang W,Chen J,Ren G,Tang F,Liu Q,Li H

更新日期：2019-10-25 00:00:00

abstract：:Our team has been a pioneer in harvesting extracellular vesicles (EVs) enriched for neuronal origin from peripheral blood and using them as a biomarker discovery platform for neurological disorders. This methodology has demonstrated excellent diagnostic and predictive performance for Alzheimer's and other neurodegener...

journal_title：Frontiers in neuroscience

authors： Mustapic M,Eitan E,Werner JK Jr,Berkowitz ST,Lazaropoulos MP,Tran J,Goetzl EJ,Kapogiannis D

更新日期：2017-05-22 00:00:00

abstract：:Openness to experience (OTE) has relatively stable and heritable characteristics. Previous studies have used candidate gene approaches to explore the genetic mechanisms of OTE, but genome-wide polygenic scores have a greater genetic effect than other genetic analysis methods, and previous studies have never examined t...

journal_title：Frontiers in neuroscience

authors： Ren Z,Liu C,Meng J,Liu Q,Shi L,Wu X,Song L,Qiu J

更新日期：2021-01-11 00:00:00

abstract：:Neural oscillations in the alpha band (7-13 Hz) are commonly associated with disengagement of visual attention. However, recent studies have also associated alpha with processes of attentional control and stability. We addressed this issue in previous experiments by delivering transcranial alternating current stimulat...

journal_title：Frontiers in neuroscience

authors： Clayton MS,Yeung N,Cohen Kadosh R

更新日期：2018-02-13 00:00:00

abstract：:Self-control exertion on an initial task has been associated with impaired performance on subsequent physical tasks also requiring self-control; an effect suggested to be mediated by changes in perceptions of pain and motivation. However, the effects of spending longer on the initial self-control task are unknown. Thi...

journal_title：Frontiers in neuroscience

authors： Boat R,Hunte R,Welsh E,Dunn A,Treadwell E,Cooper SB

更新日期：2020-10-08 00:00:00

abstract：:Selection of the time-window mainly affects the effectiveness of piecewise feature extraction procedures. We present an enhanced bag-of-patterns representation that allows capturing the higher-level structures of brain dynamics within a wide window range. So, we introduce augmented instance representations with extend...

journal_title：Frontiers in neuroscience

authors： Collazos-Huertas D,Caicedo-Acosta J,Castaño-Duque GA,Acosta-Medina CD

更新日期：2020-02-25 00:00:00

abstract：:Postganglionic sympathetic axons in awake healthy human subjects, regardless of their identity as muscle vasoconstrictor, cutaneous vasoconstrictor, or sudomotor neurons, discharge with a low firing probability (∼30%), generate low firing rates (∼0.5 Hz) and typically fire only once per cardiac interval. The purpose o...

journal_title：Frontiers in neuroscience

authors： Macefield VG

更新日期：2011-12-06 00:00:00

abstract：:Prior research has shown that during development, there is increased segregation between, and increased integration within, prototypical resting-state functional brain networks. Functional networks are typically defined by static functional connectivity over extended periods of rest. However, little is known about how...

journal_title：Frontiers in neuroscience

authors： Rosenberg BM,Mennigen E,Monti MM,Kaiser RH

更新日期：2020-12-08 00:00:00

abstract：:Calcium imaging using fluorescent reporters is the most widely used optical approach to investigate activity in intact neuronal circuits with single-cell resolution. Calcium signals, however, are often difficult to interpret, especially if the desired output quantity is membrane voltage or instantaneous firing rates. ...

journal_title：Frontiers in neuroscience

authors： Moreaux L,Laurent G

更新日期：2008-12-15 00:00:00

abstract：:Stereotactic electroencephalogaphy (sEEG) utilizes localized, penetrating depth electrodes to measure electrophysiological brain activity. It is most commonly used in the identification of epileptogenic zones in cases of refractory epilepsy. The implanted electrodes generally provide a sparse sampling of a unique set ...

journal_title：Frontiers in neuroscience

authors： Herff C,Krusienski DJ,Kubben P

更新日期：2020-02-27 00:00:00

abstract：:The Artificial Intelligence (AI) revolution foretold of during the 1960s is well underway in the second decade of the twenty first century. Its period of phenomenal growth likely lies ahead. AI-operated machines and technologies will extend the reach of Homo sapiens far beyond the biological constraints imposed by evo...

journal_title：Frontiers in neuroscience

authors： Krichmar JL,Severa W,Khan MS,Olds JL

更新日期：2019-06-27 00:00:00

abstract：:In this work, we present a neuromorphic architecture for head pose estimation and scene representation for the humanoid iCub robot. The spiking neuronal network is fully realized in Intel's neuromorphic research chip, Loihi, and precisely integrates the issued motor commands to estimate the iCub's head pose in a neuro...

journal_title：Frontiers in neuroscience

authors： Kreiser R,Renner A,Leite VRC,Serhan B,Bartolozzi C,Glover A,Sandamirskaya Y

更新日期：2020-06-23 00:00:00

abstract：:Hardware-based spiking neural networks (SNNs) inspired by a biological nervous system are regarded as an innovative computing system with very low power consumption and massively parallel operation. To train SNNs with supervision, we propose an efficient on-chip training scheme approximating backpropagation algorithm ...

journal_title：Frontiers in neuroscience

authors： Kwon D,Lim S,Bae JH,Lee ST,Kim H,Seo YT,Oh S,Kim J,Yeom K,Park BG,Lee JH

更新日期：2020-07-07 00:00:00

abstract：:Ischemic stroke places an increasing burden on individuals, families, and societies around the world. However, effective therapies or drugs for ischemic stroke are lacking. Therefore, animal models mimicking ischemic stroke in humans are of great value for preclinical experiments. middle cerebral artery occlusion (MCA...

journal_title：Frontiers in neuroscience

authors： Shi XF,Ai H,Lu W,Cai F

更新日期：2019-02-12 00:00:00

abstract：:Developments of new strategies to restore vision and improving on current strategies by harnessing new advancements in material and electrical sciences, and biological and genetic-based technologies are of upmost health priorities around the world. Federal and private entities are spending billions of dollars on visua...

journal_title：Frontiers in neuroscience

authors： Farnum A,Pelled G

更新日期：2020-02-18 00:00:00

abstract：:Maternal overnutrition modulates body weight, development of metabolic failure and, potentially, neurodegenerative susceptibility in the offspring. Overnutrition sets a chronic pro-inflammatory profile that integrates peripheral and central immune activation nodes, damaging neuronal physiology and survival. Innate imm...

journal_title：Frontiers in neuroscience

authors： Cárdenas-Tueme M,Montalvo-Martínez L,Maldonado-Ruiz R,Camacho-Morales A,Reséndez-Pérez D

更新日期：2020-02-04 00:00:00

abstract：:Several works have demonstrated that visual experience plays a critical role in the development of allocentric spatial coding. Indeed, while children with a typical development start to code space by relying on allocentric landmarks from the first year of life, blind children remain anchored to an egocentric perspecti...

journal_title：Frontiers in neuroscience

authors： Martolini C,Cappagli G,Luparia A,Signorini S,Gori M

更新日期：2020-06-16 00:00:00

abstract：:The R47H coding variant of the triggering receptor expressed on myeloid cells-2 (TREM2) increases the risk of Alzheimer's disease (AD) similar to apolipoprotein E4. TREM2 R47H has recently been shown to have impaired binding to damage-associated lipid or apolipoprotein ligands. However, it is not known how this R47H v...

journal_title：Frontiers in neuroscience

authors： Park JS,Ji IJ,Kim DH,An HJ,Yoon SY

更新日期：2017-01-18 00:00:00

abstract：:Adult neurogenesis is a tightly regulated process continuously taking place in the central nervous system of most mammalian species. In neuroscience research, transgenic animals bearing the tamoxifen-inducible CreERT2-Lox system are widely used. In this study, we made use of a Nestin-CreERT2/R26R-YFP transgenic mouse ...

journal_title：Frontiers in neuroscience

authors： Rotheneichner P,Romanelli P,Bieler L,Pagitsch S,Zaunmair P,Kreutzer C,König R,Marschallinger J,Aigner L,Couillard-Després S

更新日期：2017-02-01 00:00:00

abstract：:Newborn neurons are continuously added to the hippocampal dentate gyrus throughout adulthood. In this review, we analyze the maturational stages that newborn granule neurons go through, with a focus on their unique morphological features during each stage under both physiological and pathological circumstances. In add...

journal_title：Frontiers in neuroscience

authors： Llorens-Martín M,Rábano A,Ávila J

更新日期：2016-01-19 00:00:00