Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes.

Abstract:

:Our team has been a pioneer in harvesting extracellular vesicles (EVs) enriched for neuronal origin from peripheral blood and using them as a biomarker discovery platform for neurological disorders. This methodology has demonstrated excellent diagnostic and predictive performance for Alzheimer's and other neurodegenerative diseases in multiple studies, providing a strong proof of concept for this approach. Here, we describe our methodology in detail and offer further evidence that isolated EVs are enriched for neuronal origin. In addition, we present evidence that EVs enriched for neuronal origin represent a more sensitive and accurate base for biomarkers than plasma, serum, or non-enriched total plasma EVs. Finally, we proceed to investigate the protein content of EVs enriched for neuronal origin and compare it with other relevant enriched and non-enriched populations of plasma EVs. Neuronal-origin enriched plasma EVs contain higher levels of signaling molecules of great interest for cellular metabolism, survival, and repair, which may be useful as biomarkers and to follow response to therapeutic interventions in a mechanism-specific manner.

journal_name

Front Neurosci

authors

Mustapic M,Eitan E,Werner JK Jr,Berkowitz ST,Lazaropoulos MP,Tran J,Goetzl EJ,Kapogiannis D

doi

10.3389/fnins.2017.00278

subject

Has Abstract

pub_date

2017-05-22 00:00:00

pages

278

eissn

1662-4548

issn

1662-453X

journal_volume

11

pub_type

杂志文章
  • Brain dynamics that correlate with effects of learning on auditory distance perception.

    abstract::Accuracy in auditory distance perception can improve with practice and varies for sounds differing in familiarity. Here, listeners were trained to judge the distances of English, Bengali, and backwards speech sources pre-recorded at near (2-m) and far (30-m) distances. Listeners' accuracy was tested before and after t...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00396

    authors: Wisniewski MG,Mercado E 3rd,Church BA,Gramann K,Makeig S

    更新日期:2014-12-09 00:00:00

  • Encoding of Sucrose's Palatability in the Nucleus Accumbens Shell and Its Modulation by Exteroceptive Auditory Cues.

    abstract::Although the palatability of sucrose is the primary reason for why it is over consumed, it is not well understood how it is encoded in the nucleus accumbens shell (NAcSh), a brain region involved in reward, feeding, and sensory/motor transformations. Similarly, untouched are issues regarding how an external auditory s...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00265

    authors: Villavicencio M,Moreno MG,Simon SA,Gutierrez R

    更新日期:2018-05-04 00:00:00

  • Improving Real-Time Lower Limb Motor Imagery Detection Using tDCS and an Exoskeleton.

    abstract::The aim of this work was to test if a novel transcranial direct current stimulation (tDCS) montage boosts the accuracy of lower limb motor imagery (MI) detection by using a real-time brain-machine interface (BMI) based on electroencephalographic (EEG) signals. The tDCS montage designed was composed of two anodes and o...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00757

    authors: Rodríguez-Ugarte M,Iáñez E,Ortiz M,Azorín JM

    更新日期:2018-10-23 00:00:00

  • Modulation of Illusory Auditory Perception by Transcranial Electrical Stimulation.

    abstract::The aim of the present study was to test whether transcranial electrical stimulation can modulate illusory perception in the auditory domain. In two separate experiments we applied transcranial Direct Current Stimulation (anodal/cathodal tDCS, 2 mA; N = 60) and high-frequency transcranial Random Noise Stimulation (hf-...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00351

    authors: Prete G,D'Anselmo A,Tommasi L,Brancucci A

    更新日期:2017-06-20 00:00:00

  • Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders.

    abstract::The Golgi apparatus is a dynamic organelle involved in processing and sorting of lipids and proteins. In neurons, the Golgi apparatus is important for the development of axons and dendrites and maintenance of their highly complex polarized morphology. The motor protein complex cytoplasmic dynein has an important role ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2015.00397

    authors: Jaarsma D,Hoogenraad CC

    更新日期:2015-10-26 00:00:00

  • Pretreatment With Risperidone Ameliorates Systemic LPS-Induced Oxidative Stress in the Cortex and Hippocampus.

    abstract::Risperidone (RIS), an atypical antipsychotic has been found to show anti-inflammatory effect against lipopolysaccharide (LPS)-induced inflammation. In vitro study has revealed that RIS inhibits the LPS-induced reactive oxygen species (ROS) formation. We investigated the antioxidant effects of RIS on LPS-induced oxidat...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00384

    authors: Al-Amin MM,Choudhury MFR,Chowdhury AS,Chowdhury TR,Jain P,Kazi M,Alkholief M,Alshehri SM,Reza HM

    更新日期:2018-06-08 00:00:00

  • ATP as a multi-target danger signal in the brain.

    abstract::ATP is released in an activity-dependent manner from different cell types in the brain, fulfilling different roles as a neurotransmitter, neuromodulator, in astrocyte-to-neuron communication, propagating astrocytic responses and formatting microglia responses. This involves the activation of different ATP P2 receptors...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2015.00148

    authors: Rodrigues RJ,Tomé AR,Cunha RA

    更新日期:2015-04-28 00:00:00

  • Robust Candidates for Language Development and Evolution Are Significantly Dysregulated in the Blood of People With Williams Syndrome.

    abstract::Williams syndrome (WS) is a clinical condition, involving cognitive deficits and an uneven language profile, which has been the object of intense inquiry over the last decades. Although WS results from the hemideletion of around two dozen genes in chromosome 7, no gene has yet been probed to account for, or contribute...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00258

    authors: Benítez-Burraco A,Kimura R

    更新日期:2019-03-26 00:00:00

  • Dysregulated Long Non-coding RNAs in Parkinson's Disease Contribute to the Apoptosis of Human Neuroblastoma Cells.

    abstract::The molecular mechanism underlying Parkinson's disease (PD), an increasingly common neurodegenerative disease, remains unclear. Long non-coding RNA (lncRNA) plays essential roles in gene expression and human diseases. We hypothesize that lncRNAs are involved in neuronal degeneration of PD. Using microarray, we identif...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01320

    authors: Fan Y,Li J,Yang Q,Gong C,Gao H,Mao Z,Yuan X,Zhu S,Xue Z

    更新日期:2019-12-13 00:00:00

  • Topography of the complete corticopontine projection: from experiments to principal Maps.

    abstract::The mammalian brain is characterized by orderly spatial distribution of its cellular components, commonly referred to as topographical organization. The topography of cortical and subcortical maps is thought to represent functional or computational properties. In the present investigation, we have studied map transfor...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.01.1.1.016.2007

    authors: Leergaard TB,Bjaalie JG

    更新日期:2007-10-15 00:00:00

  • μ-Rhythm Extracted With Personalized EEG Filters Correlates With Corticospinal Excitability in Real-Time Phase-Triggered EEG-TMS.

    abstract::Ongoing brain activity has been implicated in the modulation of cortical excitability. The combination of electroencephalography (EEG) and transcranial magnetic stimulation (TMS) in a real-time triggered setup is a novel method for testing hypotheses about the relationship between spontaneous neuronal oscillations, co...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00954

    authors: Schaworonkow N,Caldana Gordon P,Belardinelli P,Ziemann U,Bergmann TO,Zrenner C

    更新日期:2018-12-13 00:00:00

  • Decoding Speech With Integrated Hybrid Signals Recorded From the Human Ventral Motor Cortex.

    abstract::Restoration of speech communication for locked-in patients by means of brain computer interfaces (BCIs) is currently an important area of active research. Among the neural signals obtained from intracranial recordings, single/multi-unit activity (SUA/MUA), local field potential (LFP), and electrocorticography (ECoG) a...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00221

    authors: Ibayashi K,Kunii N,Matsuo T,Ishishita Y,Shimada S,Kawai K,Saito N

    更新日期:2018-04-05 00:00:00

  • Anle138b Partly Ameliorates Motor Deficits Despite Failure of Neuroprotection in a Model of Advanced Multiple System Atrophy.

    abstract::The neurodegenerative disorder multiple system atrophy (MSA) is characterized by autonomic failure, cerebellar ataxia and parkinsonism in any combination associated with predominantly oligodendroglial α-synuclein (α-syn) aggregates (glial cytoplasmic inclusions = GCIs). To date, there is no effective disease modifying...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00099

    authors: Fellner L,Kuzdas-Wood D,Levin J,Ryazanov S,Leonov A,Griesinger C,Giese A,Wenning GK,Stefanova N

    更新日期:2016-03-10 00:00:00

  • Anti-microRNAs as Novel Therapeutic Agents in the Clinical Management of Alzheimer's Disease.

    abstract::Overview- One hundred and ten years since its first description Alzheimer's disease (AD) still retains its prominent status: (i) as the industrialized world's number one cause of age-related intellectual impairment and cognitive decline; (ii) as this country's most rapidly expanding socioeconomic and healthcare concer...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00059

    authors: Zhao Y,Alexandrov PN,Lukiw WJ

    更新日期:2016-02-25 00:00:00

  • A PCR-Based Method for RNA Probes and Applications in Neuroscience.

    abstract::In situ hybridization (ISH) is a powerful technique that is used to detect the localization of specific nucleic acid sequences for understanding the organization, regulation, and function of genes. However, in most cases, RNA probes are obtained by in vitro transcription from plasmids containing specific promoter elem...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00266

    authors: Hua R,Yu S,Liu M,Li H

    更新日期:2018-05-02 00:00:00

  • Advances in Nano Neuroscience: From Nanomaterials to Nanotools.

    abstract::During the last decades, neuroscientists have increasingly exploited a variety of artificial, de-novo synthesized materials with controlled nano-sized features. For instance, a renewed interest in the development of prostheses or neural interfaces was driven by the availability of novel nanomaterials that enabled the ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2018.00953

    authors: Pampaloni NP,Giugliano M,Scaini D,Ballerini L,Rauti R

    更新日期:2019-01-15 00:00:00

  • SpiLinC: Spiking Liquid-Ensemble Computing for Unsupervised Speech and Image Recognition.

    abstract::In this work, we propose a Spiking Neural Network (SNN) consisting of input neurons sparsely connected by plastic synapses to a randomly interlinked liquid, referred to as Liquid-SNN, for unsupervised speech and image recognition. We adapt the strength of the synapses interconnecting the input and liquid using Spike T...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00524

    authors: Srinivasan G,Panda P,Roy K

    更新日期:2018-08-23 00:00:00

  • Modulation of Auditory Spatial Attention by Angry Prosody: An fMRI Auditory Dot-Probe Study.

    abstract::Emotional stimuli have been shown to modulate attentional orienting through signals sent by subcortical brain regions that modulate visual perception at early stages of processing. Fewer studies, however, have investigated a similar effect of emotional stimuli on attentional orienting in the auditory domain together w...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00216

    authors: Ceravolo L,Frühholz S,Grandjean D

    更新日期:2016-05-12 00:00:00

  • Spatio-Temporal Dynamics of Intrinsic Networks in Functional Magnetic Imaging Data Using Recurrent Neural Networks.

    abstract::We introduce a novel recurrent neural network (RNN) approach to account for temporal dynamics and dependencies in brain networks observed via functional magnetic resonance imaging (fMRI). Our approach directly parameterizes temporal dynamics through recurrent connections, which can be used to formulate blind source se...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00600

    authors: Hjelm RD,Damaraju E,Cho K,Laufs H,Plis SM,Calhoun VD

    更新日期:2018-09-20 00:00:00

  • Impact of Traumatic Brain Injury on Neurogenesis.

    abstract::New neurons are generated in the hippocampal dentate gyrus from early development through adulthood. Progenitor cells and immature granule cells in the subgranular zone are responsive to changes in their environment; and indeed, a large body of research indicates that neuronal interactions and the dentate gyrus milieu...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.01014

    authors: Ngwenya LB,Danzer SC

    更新日期:2019-01-09 00:00:00

  • Working Memory Network Changes in ALS: An fMRI Study.

    abstract::We used amyotrophic lateral sclerosis (ALS) as a model of prefrontal dysfunction in order to re-assess the potential neuronal substrates of two sub processes of working memory, namely information storage and filtering. To date it is unclear which exact neuronal networks sustain these two processes and the prefrontal c...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00158

    authors: Vellage AK,Veit M,Kobeleva X,Petri S,Vielhaber S,Müller NG

    更新日期:2016-04-19 00:00:00

  • The Role of Astrocytes in the Generation, Migration, and Integration of New Neurons in the Adult Olfactory Bulb.

    abstract::In mammals, new neurons in the adult olfactory bulb originate from a pool of neural stem cells in the subventricular zone of the lateral ventricles. Adult-born cells play an important role in odor information processing by adjusting the neuronal network to changing environmental conditions. Olfactory bulb neurogenesis...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2016.00149

    authors: Gengatharan A,Bammann RR,Saghatelyan A

    更新日期:2016-04-05 00:00:00

  • Preferred Tempo and Low-Audio-Frequency Bias Emerge From Simulated Sub-cortical Processing of Sounds With a Musical Beat.

    abstract::Prior research has shown that musical beats are salient at the level of the cortex in humans. Yet below the cortex there is considerable sub-cortical processing that could influence beat perception. Some biases, such as a tempo preference and an audio frequency bias for beat timing, could result from sub-cortical proc...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00349

    authors: Zuk NJ,Carney LH,Lalor EC

    更新日期:2018-05-29 00:00:00

  • Resting-State Functional Connectivity Estimated With Hierarchical Bayesian Diffuse Optical Tomography.

    abstract::Resting-state functional connectivity (RSFC) has been generally assessed with functional magnetic resonance imaging (fMRI) thanks to its high spatial resolution. However, fMRI has several disadvantages such as high cost and low portability. In addition, fMRI may not be appropriate for people with metal or electronic i...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00032

    authors: Aihara T,Shimokawa T,Ogawa T,Okada Y,Ishikawa A,Inoue Y,Yamashita O

    更新日期:2020-01-31 00:00:00

  • Neural Correlates of Familiarity in Music Listening: A Systematic Review and a Neuroimaging Meta-Analysis.

    abstract::Familiarity in music has been reported as an important factor modulating emotional and hedonic responses in the brain. Familiarity and repetition may increase the liking of a piece of music, thus inducing positive emotions. Neuroimaging studies have focused on identifying the brain regions involved in the processing o...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00686

    authors: Freitas C,Manzato E,Burini A,Taylor MJ,Lerch JP,Anagnostou E

    更新日期:2018-10-05 00:00:00

  • Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation.

    abstract::Atrial fibrillation (AF) is one of the cardiovascular risk factors for dementia. Several longitudinal studies have reported an association between AF and dementia independently of stroke history. Although the mechanisms underlying this association are not fully understood, proposed mechanisms include cerebral hypoperf...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2019.00018

    authors: Silva RMFLD,Miranda CM,Liu T,Tse G,Roever L

    更新日期:2019-01-31 00:00:00

  • Gender-typical olfactory regulation of sexual behavior in goldfish.

    abstract::It is known that olfaction is essential for the occurrence of sexual behavior in male goldfish. Sex pheromones from ovulatory females elicit male sexual behavior, chasing, and sperm releasing act. In female goldfish, ovarian prostaglandin F2α (PGF) elicits female sexual behavior, egg releasing act. It has been conside...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00091

    authors: Kawaguchi Y,Nagaoka A,Kitami A,Mitsuhashi T,Hayakawa Y,Kobayashi M

    更新日期:2014-04-30 00:00:00

  • A framework to analyze cerebral mean diffusivity using surface guided diffusion mapping in diffusion tensor imaging.

    abstract::The mean diffusivity (MD) value has been used to describe microstructural properties in Diffusion Tensor Imaging (DTI) in cortical gray matter (GM). Recently, researchers have applied a cortical surface generated from the T1-weighted volume. When the DTI data are analyzed using the cortical surface, it is important to...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00236

    authors: Kwon OH,Park H,Seo SW,Na DL,Lee JM

    更新日期:2015-07-14 00:00:00

  • Contralateral Inhibition of Click- and Chirp-Evoked Human Compound Action Potentials.

    abstract::Cochlear outer hair cells (OHC) receive direct efferent feedback from the caudal auditory brainstem via the medial olivocochlear (MOC) bundle. This circuit provides the neural substrate for the MOC reflex, which inhibits cochlear amplifier gain and is believed to play a role in listening in noise and protection from a...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00189

    authors: Smith SB,Lichtenhan JT,Cone BK

    更新日期:2017-04-04 00:00:00

  • Estrogen Protects Neurotransmission Transcriptome During Status Epilepticus.

    abstract::Women with epilepsy commonly have premature onset of menopause. The decrease in estrogen levels is associated with increased occurrence of neurodegenerative processes and cognitive decline. Previously, we found that estradiol (E2) replacement in ovariectomized (OVX) female rats significantly reduced the seizure-relate...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00332

    authors: Iacobas DA,Iacobas S,Nebieridze N,Velíšek L,Velíšková J

    更新日期:2018-06-20 00:00:00