Abstract:
:Ischemic stroke places an increasing burden on individuals, families, and societies around the world. However, effective therapies or drugs for ischemic stroke are lacking. Therefore, animal models mimicking ischemic stroke in humans are of great value for preclinical experiments. middle cerebral artery occlusion (MCAO) in mice or rats and subsequent 2,3,5-triphenyltetrazolium chloride (TTC) staining of brain sections are common methods in the study of experimental animal ischemic stroke. In this study, we present and assess the utility of the semi-automated analysis of the TTC staining (SAT) software program, a novel, small, user-friendly, and free software program, in the quantification of the infarct size in rodent brain sections, with TTC staining, by analyzing images captured by cell phones or scan systems. We performed MCAO and TTC staining in adult mice. We then utilized the SAT software and Image J to analyze the infarct size in the brain sections with TTC staining and compared the findings of the two analysis methods. We found that the data on infarct size from SAT and from Image J were comparable, suggesting that the SAT software could be an alternative option to Image J in the evaluation of ischemic stroke.
journal_name
Front Neuroscijournal_title
Frontiers in neuroscienceauthors
Shi XF,Ai H,Lu W,Cai Fdoi
10.3389/fnins.2019.00102subject
Has Abstractpub_date
2019-02-12 00:00:00pages
102eissn
1662-4548issn
1662-453Xjournal_volume
13pub_type
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journal_title:Frontiers in neuroscience
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abstract::The GABAergic neurons in the lateral pontine tegmentum (LPT) play key roles in the regulation of sleep and locomotion. The dysfunction of the LPT is related to neurological disorders such as rapid eye movement sleep behavior disorder and ocular flutter. However, the whole-brain neural connectivity to LPT GABAergic neu...
journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2019.00375
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journal_title:Frontiers in neuroscience
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doi:10.3389/fnins.2013.00077
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doi:10.3389/fnins.2020.00424
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pub_type: 杂志文章
doi:10.3389/fnins.2012.00192
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pub_type: 杂志文章
doi:10.3389/fnins.2017.00488
更新日期:2017-09-15 00:00:00
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journal_title:Frontiers in neuroscience
pub_type: 杂志文章
doi:10.3389/fnins.2019.01004
更新日期:2019-09-18 00:00:00
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journal_title:Frontiers in neuroscience
pub_type: 杂志文章
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journal_title:Frontiers in neuroscience
pub_type: 杂志文章,评审
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journal_title:Frontiers in neuroscience
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