SAT: Free Software for the Semi-Automated Analysis of Rodent Brain Sections With 2,3,5-Triphenyltetrazolium Chloride Staining.


:Ischemic stroke places an increasing burden on individuals, families, and societies around the world. However, effective therapies or drugs for ischemic stroke are lacking. Therefore, animal models mimicking ischemic stroke in humans are of great value for preclinical experiments. middle cerebral artery occlusion (MCAO) in mice or rats and subsequent 2,3,5-triphenyltetrazolium chloride (TTC) staining of brain sections are common methods in the study of experimental animal ischemic stroke. In this study, we present and assess the utility of the semi-automated analysis of the TTC staining (SAT) software program, a novel, small, user-friendly, and free software program, in the quantification of the infarct size in rodent brain sections, with TTC staining, by analyzing images captured by cell phones or scan systems. We performed MCAO and TTC staining in adult mice. We then utilized the SAT software and Image J to analyze the infarct size in the brain sections with TTC staining and compared the findings of the two analysis methods. We found that the data on infarct size from SAT and from Image J were comparable, suggesting that the SAT software could be an alternative option to Image J in the evaluation of ischemic stroke.


Front Neurosci


Shi XF,Ai H,Lu W,Cai F




Has Abstract


2019-02-12 00:00:00










  • Depression Affects Intrinsic Brain Activity in Patients With Mild Cognitive Impairment.

    abstract::Numerous observational studies have shown that depressive symptoms are common in individuals with mild cognitive impairment (MCI) who have a higher rate of progress to dementia. However, it is still uncertain whether there are any differences between MCI patients with and without depression symptom in their brain func...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Yu Y,Li Z,Lin Y,Yu J,Peng G,Zhang K,Jia X,Luo B

    更新日期:2019-12-17 00:00:00

  • Effects of Noise on the Behavioral and Neural Categorization of Speech.

    abstract::We investigated whether the categorical perception (CP) of speech might also provide a mechanism that aids its perception in noise. We varied signal-to-noise ratio (SNR) [clear, 0 dB, -5 dB] while listeners classified an acoustic-phonetic continuum (/u/ to /a/). Noise-related changes in behavioral categorization were ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Bidelman GM,Bush LC,Boudreaux AM

    更新日期:2020-02-27 00:00:00

  • Integrating early results on ventral striatal gamma oscillations in the rat.

    abstract::A vast literature implicates the ventral striatum in the processing of reward-related information and in mediating the impact of such information on behavior. It is characterized by heterogeneity at the local circuit, connectivity, and functional levels. A tool for dissecting this complex structure that has received r...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: van der Meer MA,Kalenscher T,Lansink CS,Pennartz CM,Berke JD,Redish AD

    更新日期:2010-09-15 00:00:00

  • Functional Segregation of Human Brain Networks Across the Lifespan: An Exploratory Analysis of Static and Dynamic Resting-State Functional Connectivity.

    abstract::Prior research has shown that during development, there is increased segregation between, and increased integration within, prototypical resting-state functional brain networks. Functional networks are typically defined by static functional connectivity over extended periods of rest. However, little is known about how...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Rosenberg BM,Mennigen E,Monti MM,Kaiser RH

    更新日期:2020-12-08 00:00:00

  • Overview of Brain-to-Gut Axis Exposed to Chronic CNS Bacterial Infection(s) and a Predictive Urinary Metabolic Profile of a Brain Infected by Mycobacterium tuberculosis.

    abstract::A new paradigm in neuroscience has recently emerged - the brain-gut axis (BGA). The contemporary focus in this paradigm has been gut → brain ("bottom-up"), in which the gut-microbiome, and its perturbations, affects one's psychological state-of-mind and behavior, and is pivotal in neurodegenerative disorders. The emer...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Isaiah S,Loots DT,Solomons R,van der Kuip M,Tutu Van Furth AM,Mason S

    更新日期:2020-04-21 00:00:00

  • Effects of Music Training on Inhibitory Control and Associated Neural Networks in School-Aged Children: A Longitudinal Study.

    abstract::Inhibitory control, the ability to suppress an immediate dominant response, has been shown to predict academic and career success, socioemotional wellbeing, wealth, and physical health. Learning to play a musical instrument engages various sensorimotor processes and draws on cognitive capacities including inhibition a...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Hennessy SL,Sachs ME,Ilari B,Habibi A

    更新日期:2019-10-16 00:00:00

  • Elbow Matching Accuracy in Young and Elderly Humans under Unusual Mechanical Constraints.

    abstract::Experiment was carried out to study the proprioception accuracy of elderly (61-83 years old) and young (22-36 years old) subjects during contralateral elbow matching in sagittal plane. The subjects performed the task under ordinary condition and under experimental condition (matching forearm attached to the rocking cy...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Talis VL,Levik YS

    更新日期:2016-11-16 00:00:00

  • Predictable enriched environment prevents development of hyper-emotionality in the VPA rat model of autism.

    abstract::Understanding the effects of environmental stimulation in autism can improve therapeutic interventions against debilitating sensory overload, social withdrawal, fear and anxiety. Here, we evaluate the role of environmental predictability on behavior and protein expression, and inter-individual differences, in the valp...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Favre MR,La Mendola D,Meystre J,Christodoulou D,Cochrane MJ,Markram H,Markram K

    更新日期:2015-06-02 00:00:00

  • Diabetic Polyneuropathy Is Associated With Pathomorphological Changes in Human Dorsal Root Ganglia: A Study Using 3T MR Neurography.

    abstract::Diabetic neuropathy (DPN) is one of the most severe and yet most poorly understood complications of diabetes mellitus. In vivo imaging of dorsal root ganglia (DRG), a key structure for the understanding of DPN, has been restricted to animal studies. These have shown a correlation of decreased DRG volume with neuropath...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Jende JME,Kender Z,Rother C,Alvarez-Ramos L,Groener JB,Pham M,Morgenstern J,Oikonomou D,Hahn A,Juerchott A,Kollmer J,Heiland S,Kopf S,Nawroth PP,Bendszus M,Kurz FT

    更新日期:2020-09-25 00:00:00

  • Circadian adaptations to meal timing: neuroendocrine mechanisms.

    abstract::Circadian rhythms of behavior and physiology are generated by central and peripheral circadian oscillators entrained by periodic environmental or physiological stimuli. A master circadian pacemaker in the hypothalamic suprachiasmatic nucleus (SCN) is directly entrained by daily light-dark (LD) cycles, and coordinates ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Patton DF,Mistlberger RE

    更新日期:2013-10-14 00:00:00

  • A framework for plasticity implementation on the SpiNNaker neural architecture.

    abstract::Many of the precise biological mechanisms of synaptic plasticity remain elusive, but simulations of neural networks have greatly enhanced our understanding of how specific global functions arise from the massively parallel computation of neurons and local Hebbian or spike-timing dependent plasticity rules. For simulat...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Galluppi F,Lagorce X,Stromatias E,Pfeiffer M,Plana LA,Furber SB,Benosman RB

    更新日期:2015-01-20 00:00:00

  • Reduction in Parasympathetic Tone During Sleep in Children With Habitual Snoring.

    abstract::Introduction: Changes in the autonomic nervous system due to Obstructive Sleep Apnea (OSA) during the life span have been described. Some pediatric studies have shown cardiovascular effects in children who do not fit the criteria for OSA; namely children with mild sleep disordered breathing. Objective: We investigated...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Lopes MC,Spruyt K,Azevedo-Soster L,Rosa A,Guilleminault C

    更新日期:2019-01-10 00:00:00

  • Electrochemistry of Graphene Nanoplatelets Printed Electrodes for Cortical Direct Current Stimulation.

    abstract::Possible risks stemming from the employment of novel, micrometer-thin printed electrodes for direct current neural stimulation are discussed. To assess those risks, electrochemical methods are used, including cyclic voltammetry, square-wave voltammetry, and electrochemical impedance spectroscopy. Experiments were cond...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Pepłowski A,Rathi S,Piotrkowski B,Ziółkowski R,Janczak D,Krzemiński J,Brosch M,Jakubowska M

    更新日期:2020-10-29 00:00:00

  • Transcutaneous Vagus Nerve Stimulation (tVNS) and the Dynamics of Visual Bistable Perception.

    abstract::Transcutaneous vagus nerve stimulation (tVNS) is widely used for clinical applications, but its mechanism of action is poorly understood. One candidate pathway that might mediate the effects of tVNS is an increase in GABAergic neurotransmission. In this study, we investigated the effect of tVNS on visual bistable perc...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Keute M,Boehrer L,Ruhnau P,Heinze HJ,Zaehle T

    更新日期:2019-03-08 00:00:00

  • Reduced Responses of Submucous Neurons from Irritable Bowel Syndrome Patients to a Cocktail Containing Histamine, Serotonin, TNFα, and Tryptase (IBS-Cocktail).

    abstract:BACKGROUND AND AIMS:Malfunctions of enteric neurons are believed to play an important role in the pathophysiology of irritable bowel syndrome (IBS). Our aim was to investigate whether neuronal activity in biopsies from IBS patients is altered in comparison to healthy controls (HC). METHODS:Activity of human submucous ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Ostertag D,Buhner S,Michel K,Pehl C,Kurjak M,Götzberger M,Schulte-Frohlinde E,Frieling T,Enck P,Phillip J,Schemann M

    更新日期:2015-12-16 00:00:00

  • Identification of Alzheimer's EEG With a WVG Network-Based Fuzzy Learning Approach.

    abstract::A novel analytical framework combined fuzzy learning and complex network approaches is proposed for the identification of Alzheimer's disease (AD) with multichannel scalp-recorded electroencephalograph (EEG) signals. Weighted visibility graph (WVG) algorithm is first applied to transform each channel EEG into network ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Yu H,Zhu L,Cai L,Wang J,Liu J,Wang R,Zhang Z

    更新日期:2020-07-21 00:00:00

  • Toward the Understanding of Topographical and Spectral Signatures of Infant Movement Artifacts in Naturalistic EEG.

    abstract::Electroencephalography (EEG) is perhaps the most widely used brain-imaging technique for pediatric populations. However, EEG signals are prone to distortion by motion. Compared to adults, infants' motion is both more frequent and less stereotypical yet motion effects on the infant EEG signal are largely undocumented. ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Georgieva S,Lester S,Noreika V,Yilmaz MN,Wass S,Leong V

    更新日期:2020-04-28 00:00:00

  • GEMINs: potential therapeutic targets for spinal muscular atrophy?

    abstract::The motor neuron degenerative disease spinal muscular atrophy (SMA) remains one of the most frequently inherited causes of infant mortality. Afflicted patients loose the survival motor neuron 1 (SMN1) gene but retain one or more copies of SMN2, a homolog that is incorrectly spliced. Primary treatment strategies for SM...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审


    authors: Borg R,Cauchi RJ

    更新日期:2014-10-15 00:00:00

  • Structural and Functional Brain Connectivity Changes Between People With Abdominal and Non-abdominal Obesity and Their Association With Behaviors of Eating Disorders.

    abstract::Abdominal obesity is important for understanding obesity, which is a worldwide medical problem. We explored structural and functional brain differences in people with abdominal and non-abdominal obesity by using multimodal neuroimaging and up-to-date analysis methods. A total of 274 overweight people, whose body mass ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Park BY,Lee MJ,Kim M,Kim SH,Park H

    更新日期:2018-10-11 00:00:00

  • Experimental Traumatic Brain Injury Induces Chronic Glutamatergic Dysfunction in Amygdala Circuitry Known to Regulate Anxiety-Like Behavior.

    abstract::Up to 50% of traumatic brain injury (TBI) survivors demonstrate persisting and late-onset anxiety disorders indicative of limbic system dysregulation, yet the pathophysiology underlying the symptoms is unclear. We hypothesize that the development of TBI-induced anxiety-like behavior in an experimental model of TBI is ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Beitchman JA,Griffiths DR,Hur Y,Ogle SB,Bromberg CE,Morrison HW,Lifshitz J,Adelson PD,Thomas TC

    更新日期:2020-01-21 00:00:00

  • Habituation of the Interlimb Reflex (ILR) Over the Biceps Brachii Muscle After Electrical Stimuli Over the Sural Nerve.

    abstract::Up to now relatively little is known about interlimb reflexes (ILR). Especially it is not well known whether ILR may habituate or not to subsequent stimuli. The main aim of the present investigation was to explore the short term habituation behavior of ILR. The electromyogram was recorded over the tonically active bic...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Alaid S,Emmer A,Kornhuber ME

    更新日期:2019-10-23 00:00:00

  • Is it stress? The role of stress related systems in chronic food restriction-induced augmentation of heroin seeking in the rat.

    abstract::Drug addiction is a chronic disease characterized by recurring episodes of abstinence and relapse. The precise mechanisms underlying this pattern are yet to be elucidated, but stress is thought to be a major factor in relapse. Recently, we reported that rats under withdrawal and exposed to a mild chronic stressor, pro...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Sedki F,Abbas Z,Angelis S,Martin J,D'Cunha T,Shalev U

    更新日期:2013-06-06 00:00:00

  • Functional genomic analysis and neuroanatomical localization of miR-2954, a song-responsive sex-linked microRNA in the zebra finch.

    abstract::Natural experience can cause complex changes in gene expression in brain centers for cognition and perception, but the mechanisms that link perceptual experience and neurogenomic regulation are not understood. MicroRNAs (miRNAs or miRs) have the potential to regulate large gene expression networks, and a previous stud...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Lin YC,Balakrishnan CN,Clayton DF

    更新日期:2014-12-16 00:00:00

  • A core circuit module for cost/benefit decision.

    abstract::A simple circuit for cost-benefit decision derived from behavioral and neural studies of the predatory sea-slug Pleurobranchaea may closely resemble that upon which the more complex valuation and decision processes of the social vertebrates are built. The neuronal natures of the pathways in the connectionist model com...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Hirayama K,Catanho M,Brown JW,Gillette R

    更新日期:2012-08-31 00:00:00

  • Alpha-Synuclein Continues to Enhance SNARE-Dependent Vesicle Docking at Exorbitant Concentrations.

    abstract::Recently, Parkinson's disease-associated α-synuclein (αS) has emerged as an important regulator for SNARE-dependent vesicle fusion. However, it is controversial if excessive accumulation of αS, even in the absence of aggregation, impairs neurotransmission. Here we use a single vesicle fusion assay with ms time resolut...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Hawk BJD,Khounlo R,Shin YK

    更新日期:2019-03-21 00:00:00

  • Functional organization and adaptability of a decision-making network in aplysia.

    abstract::Whereas major insights into the neuronal basis of adaptive behavior have been gained from the study of automatic behaviors, including reflexive and rhythmic motor acts, the neural substrates for goal-directed behaviors in which decision-making about action selection and initiation are crucial, remain poorly understood...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Nargeot R,Simmers J

    更新日期:2012-07-26 00:00:00

  • Transcutaneous Vagus Nerve Stimulation May Enhance Only Specific Aspects of the Core Executive Functions. A Randomized Crossover Trial.

    abstract:Background:Individuals are able to perform goal-directed behaviors thanks to executive functions. According to the neurovisceral integration model, executive functions are upregulated by brain areas such as the prefrontal and cingulate cortices, which are also crucially involved in controlling cardiac vagal activity. A...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Borges U,Knops L,Laborde S,Klatt S,Raab M

    更新日期:2020-05-25 00:00:00

  • Test-Retest Reliability of Diffusion Measures Extracted Along White Matter Language Fiber Bundles Using HARDI-Based Tractography.

    abstract::High angular resolution diffusion imaging (HARDI)-based tractography has been increasingly used in longitudinal studies on white matter macro- and micro-structural changes in the language network during language acquisition and in language impairments. However, test-retest reliability measurements are essential to asc...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Boukadi M,Marcotte K,Bedetti C,Houde JC,Desautels A,Deslauriers-Gauthier S,Chapleau M,Boré A,Descoteaux M,Brambati SM

    更新日期:2019-01-14 00:00:00

  • Auditory Perceptual Learning for Speech Perception Can be Enhanced by Audiovisual Training.

    abstract::Speech perception under audiovisual (AV) conditions is well known to confer benefits to perception such as increased speed and accuracy. Here, we investigated how AV training might benefit or impede auditory perceptual learning of speech degraded by vocoding. In Experiments 1 and 3, participants learned paired associa...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Bernstein LE,Auer ET Jr,Eberhardt SP,Jiang J

    更新日期:2013-03-18 00:00:00

  • A Comparison of Regularization Methods in Forward and Backward Models for Auditory Attention Decoding.

    abstract::The decoding of selective auditory attention from noninvasive electroencephalogram (EEG) data is of interest in brain computer interface and auditory perception research. The current state-of-the-art approaches for decoding the attentional selection of listeners are based on linear mappings between features of sound s...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章


    authors: Wong DDE,Fuglsang SA,Hjortkjær J,Ceolini E,Slaney M,de Cheveigné A

    更新日期:2018-08-07 00:00:00