A simple method to reconstruct firing rates from dendritic calcium signals.

Abstract:

:Calcium imaging using fluorescent reporters is the most widely used optical approach to investigate activity in intact neuronal circuits with single-cell resolution. Calcium signals, however, are often difficult to interpret, especially if the desired output quantity is membrane voltage or instantaneous firing rates. Combining dendritic intracellular electrophysiology and multi-photon calcium imaging in vivo, we recently investigated the relationship between optical signals recorded with the fluorescent calcium indicator Oregon Green BAPTA-1 (OGB-1) and spike output in principal neurons in the locust antennal lobe. We derived from these experiments a simple, empirical and easily adaptable method requiring minimal calibration to reconstruct firing rates from calcium signals with good accuracy and 50-ms temporal resolution.

journal_name

Front Neurosci

authors

Moreaux L,Laurent G

doi

10.3389/neuro.01.032.2008

subject

Has Abstract

pub_date

2008-12-15 00:00:00

pages

176-85

issue

2

eissn

1662-4548

issn

1662-453X

journal_volume

2

pub_type

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