Brain scaling in mammalian evolution as a consequence of concerted and mosaic changes in numbers of neurons and average neuronal cell size.

abstract：:Ketamine, a known antagonist of N-methyl-D-aspartic (NMDA) glutamate receptors, had been used as an anesthetic particularly for pediatric or for cardiac patients. Unfortunately, ketamine has become an abusive drug in many parts of the world while chronic and prolonged usage led to damages of many organs including the ...

journal_title：Frontiers in neuroanatomy

authors： Wang C,Zheng D,Xu J,Lam W,Yew DT

更新日期：2013-07-17 00:00:00

abstract：:Cortical networks are shaped by sensory experience and are most susceptible to modifications during critical periods characterized by enhanced plasticity at the structural and functional level. A system particularly well-studied in this context is the mammalian visual system. Plasticity has been documented for the som...

journal_title：Frontiers in neuroanatomy

authors： Gutzmann A,Ergül N,Grossmann R,Schultz C,Wahle P,Engelhardt M

更新日期：2014-03-11 00:00:00

abstract：:Standard stereotaxic reference systems play a key role in human brain studies. Stereotaxic coordinate systems have also been developed for experimental animals including non-human primates, dogs, and rodents. However, they are lacking for other species being relevant in experimental neuroscience including sheep. Here,...

journal_title：Frontiers in neuroanatomy

authors： Nitzsche B,Frey S,Collins LD,Seeger J,Lobsien D,Dreyer A,Kirsten H,Stoffel MH,Fonov VS,Boltze J

更新日期：2015-06-04 00:00:00

abstract：:Experiments in several species have identified direct projections to the medial geniculate nucleus (MG) from cells in subcollicular auditory nuclei. Moreover, many cochlear nucleus cells that project to the MG send collateral projections to the inferior colliculus (IC) (Schofield et al., 2014). We conducted three expe...

journal_title：Frontiers in neuroanatomy

authors： Schofield BR,Mellott JG,Motts SD

更新日期：2014-07-18 00:00:00

abstract：:Huntington's Disease (HD) is the most frequent neurodegenerative disease caused by an expansion of polyglutamines (CAG). The main clinical manifestations of HD are chorea, cognitive impairment, and psychiatric disorders. The transmission of HD is autosomal dominant with a complete penetrance. HD has a single genetic c...

journal_title：Frontiers in neuroanatomy

authors： Roze E,Cahill E,Martin E,Bonnet C,Vanhoutte P,Betuing S,Caboche J

更新日期：2011-08-23 00:00:00

abstract：:Expansion microscopy and light sheet imaging (ExLSM) provide a viable alternative to existing tissue clearing and large volume imaging approaches. The analysis of intact volumes of brain tissue presents a distinct challenge in neuroscience. Recent advances in tissue clearing and light sheet microscopy have re-addresse...

journal_title：Frontiers in neuroanatomy

authors： Düring DN,Rocha MD,Dittrich F,Gahr M,Hahnloser RHR

更新日期：2019-01-31 00:00:00

abstract：:The auditory system contains a diverse array of interconnected anatomical structures that mediate the perception of sound. The cochlear nucleus of the hindbrain serves as the initial site of convergence for auditory stimuli, while the inferior colliculus of the midbrain serves as an integration and relay station for a...

journal_title：Frontiers in neuroanatomy

authors： Brown S,Zervas M

更新日期：2017-08-22 00:00:00

abstract：:A subset of monoamine neurons releases glutamate as a cotransmitter due to presence of the vesicular glutamate transporters VGLUT2 or VGLUT3. In addition to mediating vesicular loading of glutamate, it has been proposed that VGLUT3 enhances serotonin (5-HT) vesicular loading by the vesicular monoamine transporter (VMA...

journal_title：Frontiers in neuroanatomy

authors： Voisin AN,Mnie-Filali O,Giguère N,Fortin GM,Vigneault E,El Mestikawy S,Descarries L,Trudeau LÉ

更新日期：2016-04-12 00:00:00

abstract：:Human inducible pluripotent stem cells (hiPSCs) hold a large potential for disease modeling. hiPSC-derived human astrocyte and neuronal cultures permit investigations of neural signaling pathways with subcellular resolution. Combinatorial cultures, and three-dimensional (3-D) embryonic bodies (EBs) enlarge the scope o...

journal_title：Frontiers in neuroanatomy

authors： Rakotoson I,Delhomme B,Djian P,Deeg A,Brunstein M,Seebacher C,Uhl R,Ricard C,Oheim M

更新日期：2019-08-20 00:00:00

abstract：:The distribution of vitamin D-dependent calcium-binding protein (28 kDa calbindin) was investigated in cat lumbar and sacral spinal cord segments (L1-S3). We observed specific multi-dimensional distributions over the spinal segments for small immunopositive cells in Rexed laminae II-III and medium-to-large cells of va...

journal_title：Frontiers in neuroanatomy

authors： Merkulyeva N,Veshchitskii A,Makarov F,Gerasimenko Y,Musienko P

更新日期：2016-01-28 00:00:00

abstract：:Analyses of mice carrying a deletion of the pan-neurotrophin receptor p75NTR have allowed identifying p75NTR as an important structural regulator of the hippocampus. Most of the previous analyses were done using p75NTR (ExIII) knockout mice which still express the short isoform of p75NTR. To scrutinize the role of p75...

journal_title：Frontiers in neuroanatomy

authors： Poser R,Dokter M,von Bohlen Und Halbach V,Berger SM,Busch R,Baldus M,Unsicker K,von Bohlen Und Halbach O

更新日期：2015-05-27 00:00:00

abstract：:Cortical calretinin (CR)-expressing interneurons represent a heterogeneous subpopulation of about 10-30% of GABAergic interneurons, which altogether total ca. 12-20% of all cortical neurons. In the rodent neocortex, CR cells display different somatodendritic morphologies ranging from bipolar to multipolar but the bipo...

journal_title：Frontiers in neuroanatomy

authors： Cauli B,Zhou X,Tricoire L,Toussay X,Staiger JF

更新日期：2014-06-24 00:00:00

abstract：:An increasing number of applications use the postnatal piglet model in neuroimaging studies, however, these are based primarily on T1 weighted image templates. There is a growing need for a multimodal structural brain template for a comprehensive depiction of the piglet brain, particularly given the growing applicatio...

journal_title：Frontiers in neuroanatomy

authors： Zhong J,Chen DQ,Walker M,Waspe A,Looi T,Piorkowska K,Drake JM,Hodaie M

更新日期：2016-09-27 00:00:00

abstract：:Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase). We have developed an immunostaining method that is highly sensitive in detection of neurochemical antigens. Ou...

journal_title：Frontiers in neuroanatomy

authors： Goto S,Morigaki R,Okita S,Nagahiro S,Kaji R

更新日期：2015-03-03 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder that affects about 1.5% of the global population over 65 years of age. A hallmark feature of PD is the degeneration of the dopamine (DA) neurons in the substantia nigra pars compacta (SNc) and the consequent striatal DA deficiency. Yet, the pathogenesis of PD re...

journal_title：Frontiers in neuroanatomy

authors： Blesa J,Przedborski S

更新日期：2014-12-15 00:00:00

abstract：:In mammalian cerebrum there exist two distinct types of interneurons expressing nitric oxide synthase (NOS). Type I neurons are large in size and exhibit heavy nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) histochemical reaction, while type II cells are small with light NADPH-d reactivity. The time ...

journal_title：Frontiers in neuroanatomy

authors： Liu C,Yang Y,Hu X,Li JM,Zhang XM,Cai Y,Li Z,Yan XX

更新日期：2015-02-16 00:00:00

abstract：:The anterior cingulate cortex (ACC), surrounding the genu of the corpus callosum, plays important roles in emotional processing and is functionally divided into the dorsal, perigenual, and subgenual subregions (dACC, pgACC, and sgACC, respectively). Previous studies have suggested that the pgACC and sgACC have distinc...

journal_title：Frontiers in neuroanatomy

authors： Sakata H,Kim Y,Nejime M,Konoike N,Miyachi S,Nakamura K

更新日期：2019-07-31 00:00:00

abstract：:Imaging entire mouse brains at submicron resolution has historically been a challenging undertaking and largely confined to the province of dedicated atlasing initiatives. This has limited systematic investigations into important areas of neuroscience, such as neural circuits, brain mapping and neurodegeneration. In t...

journal_title：Frontiers in neuroanatomy

authors： Amato SP,Pan F,Schwartz J,Ragan TM

更新日期：2016-03-22 00:00:00

abstract：:The striatum and the subthalamic nucleus (STN) are the main entry doors for extrinsic inputs to reach the basal ganglia (BG) circuitry. The cerebral cortex, thalamus and brainstem are the key sources of glutamatergic inputs to these nuclei. There is anatomical, functional and neurochemical evidence that glutamatergic ...

journal_title：Frontiers in neuroanatomy

authors： Villalba RM,Mathai A,Smith Y

更新日期：2015-09-25 00:00:00

abstract：:Dopamine (DA) modulates the effects of amino acid neurotransmitters (AANs), including GABA and glutamate, in motor, visual, olfactory, and reward systems (Hnasko et al., 2010; Stuber et al., 2010; Hnasko and Edwards, 2012). The results suggest that DA may play a similar modulatory role in the auditory pathways. Previo...

journal_title：Frontiers in neuroanatomy

authors： Fyk-Kolodziej BE,Shimano T,Gafoor D,Mirza N,Griffith RD,Gong TW,Holt AG

更新日期：2015-07-22 00:00:00

abstract：:Introduction: Knowledge of the neuro-anatomical architecture of the inner ear contributes to the improvement and development of cochlear and vestibular implants. The present knowledge is mainly based on two-dimensional images (histology) or derived models that simplify the complexity of this architecture. This study i...

journal_title：Frontiers in neuroanatomy

authors： van den Boogert T,van Hoof M,Handschuh S,Glueckert R,Guinand N,Guyot JP,Kingma H,Perez-Fornos A,Seppen B,Johnson Chacko L,Schrott-Fischer A,van de Berg R

更新日期：2018-05-22 00:00:00

abstract：:Really interesting new gene (RING) finger protein is a type of zinc-binding motif found in a large family of functionally distinct proteins. RING finger proteins are involved in diverse cellular processes including apoptosis, DNA repair, cell cycle, signal transduction, tumour suppressor, vesicular transport, and pero...

journal_title：Frontiers in neuroanatomy

authors： Cham KL,Soga T,Parhar IS

更新日期：2017-08-31 00:00:00

abstract：:A60, the mouse monoclonal antibody against the neuronal nuclear protein (NeuN), is the most widely used neuronal marker in neuroscience research and neuropathological assays. Previous studies identified fragments of A60-immunoprecipitated protein as Synapsin I (Syn I), suggesting the antibody will demonstrate cross im...

journal_title：Frontiers in neuroanatomy

authors： Mao S,Xiong G,Zhang L,Dong H,Liu B,Cohen NA,Cohen AS

更新日期：2016-05-13 00:00:00

abstract：:Why do neurons have dendritic spines? This question-the heart of what Yuste calls "the spine problem"-presupposes that why-questions of this sort have scientific answers: that empirical findings can favor or count against claims about why neurons have spines. Here we show how such questions can receive empirical answe...

journal_title：Frontiers in neuroanatomy

authors： Malanowski S,Craver CF

更新日期：2014-09-10 00:00:00

abstract：:Dendritic spines are key components of a variety of microcircuits and they represent the majority of postsynaptic targets of glutamatergic axon terminals in the brain. The present article will focus on the discovery of dendritic spines, which was possible thanks to the application of the Golgi technique to the study o...

journal_title：Frontiers in neuroanatomy

authors： DeFelipe J

更新日期：2015-03-05 00:00:00

abstract：:Over the last 60 years, the spotlight of research has periodically returned to the cerebellum as new techniques and insights have emerged. Because of its simple homogeneous structure, limited diversity of cell types and characteristic behavioral pathologies, the cerebellum is a natural home for studies of cell specifi...

journal_title：Frontiers in neuroanatomy

authors： Basson MA,Wingate RJ

更新日期：2013-09-03 00:00:00

abstract：:The development of light-sheet fluorescence microscopy (LSFM) has greatly expanded the experimental capabilities in many biological and biomedical research fields, enabling for example live studies of murine and zebrafish neural activity or of cell growth and division. The key feature of the method is the selective il...

journal_title：Frontiers in neuroanatomy

authors： Sancataldo G,Gavryusev V,de Vito G,Turrini L,Locatelli M,Fornetto C,Tiso N,Vanzi F,Silvestri L,Pavone FS

更新日期：2019-02-08 00:00:00

abstract：:Expression patterns of Nkx2.1 and Islet-1 (Isl1), which encode transcription factors that are key in the regionalization of the forebrain, were analyzed by combined immunohistochemical methods in young adult specimens of two lungfishes (Neoceratodus forsteri and Protopterus dolloi) and a urodele amphibian (Pleurodeles...

journal_title：Frontiers in neuroanatomy

authors： Moreno N,López JM,Morona R,Lozano D,Jiménez S,González A

更新日期：2018-05-18 00:00:00

abstract：:[This corrects the article on p. 99 in vol. 9, PMID: 26300740.]. ...

journal_title：Frontiers in neuroanatomy

authors： Hernández LF,Redgrave P,Obeso JA

更新日期：2015-11-17 00:00:00

abstract：:Although the olfactory sense has always been considered with less interest than the visual, auditive or somatic senses, it does plays a major role in our ordinary life, with important implication in dangerous situations or in social and emotional behaviors. Traditional Diffusion Tensor signal model and related tractog...

journal_title：Frontiers in neuroanatomy

authors： Milardi D,Cacciola A,Calamuneri A,Ghilardi MF,Caminiti F,Cascio F,Andronaco V,Anastasi G,Mormina E,Arrigo A,Bruschetta D,Quartarone A

更新日期：2017-04-10 00:00:00