Brain scaling in mammalian evolution as a consequence of concerted and mosaic changes in numbers of neurons and average neuronal cell size.

abstract：:The neural circuits involved in mediating complex behaviors are being rapidly elucidated using various newly developed and powerful anatomical and molecular techniques, providing insights into the neural basis for anxiety disorders, depression, addiction, and dysfunctional social behaviors. Many of these behaviors and...

journal_title：Frontiers in neuroanatomy

authors： Santos FN,Pereira CW,Sánchez-Pérez AM,Otero-García M,Ma S,Gundlach AL,Olucha-Bordonau FE

更新日期：2016-04-07 00:00:00

abstract：:Rafael Lorente de Nó, the youngest of Santiago Ramón y Cajal disciples, was one of the last Century's more influential researches in neuroscience. This assay highlights two fundamental contributions of Rafael Lorente de Nó to neurobiology: the intrinsic organization of the mammalian cerebral cortex and the basic physi...

journal_title：Frontiers in neuroanatomy

authors： Larriva-Sahd JA

更新日期：2014-12-03 00:00:00

abstract：:Gestational exposure to valproic acid (VPA) is known to cause behavioral deficits of sociability, matching similar alterations in human autism spectrum disorder (ASD). Available data are scarce on the neuromorphological changes in VPA-exposed animals. Here, we focused on alterations of the dopaminergic system, which i...

journal_title：Frontiers in neuroanatomy

authors： Ádám Á,Kemecsei R,Company V,Murcia-Ramón R,Juarez I,Gerecsei LI,Zachar G,Echevarría D,Puelles E,Martínez S,Csillag A

更新日期：2020-06-05 00:00:00

abstract：:Biological impacts of light beyond vision, i.e., non-visual functions of light, signify the need to better understand light detection (or photoreception) systems in vertebrates. Photopigments, which comprise light-absorbing chromophores bound to a variety of G-protein coupled receptor opsins, are responsible for visua...

journal_title：Frontiers in neuroanatomy

authors： Hang CY,Kitahashi T,Parhar IS

更新日期：2016-04-27 00:00:00

abstract：:Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase). We have developed an immunostaining method that is highly sensitive in detection of neurochemical antigens. Ou...

journal_title：Frontiers in neuroanatomy

authors： Goto S,Morigaki R,Okita S,Nagahiro S,Kaji R

更新日期：2015-03-03 00:00:00

abstract：:Cortical networks are shaped by sensory experience and are most susceptible to modifications during critical periods characterized by enhanced plasticity at the structural and functional level. A system particularly well-studied in this context is the mammalian visual system. Plasticity has been documented for the som...

journal_title：Frontiers in neuroanatomy

authors： Gutzmann A,Ergül N,Grossmann R,Schultz C,Wahle P,Engelhardt M

更新日期：2014-03-11 00:00:00

abstract：:Hippocampal sclerosis is the most frequent pathology encountered in resected mesial temporal structures from patients with intractable temporal lobe epilepsy (TLE). Here, we have used stereological methods to compare the overall density of synapses and neurons between non-sclerotic and sclerotic hippocampal tissue obt...

journal_title：Frontiers in neuroanatomy

authors： Alonso-Nanclares L,Kastanauskaite A,Rodriguez JR,Gonzalez-Soriano J,Defelipe J

更新日期：2011-02-24 00:00:00

abstract：:Choline acetyltransferase (ChAT), the enzyme synthesizing acetylcholine (ACh), has an exon-skipping splice variant which is expressed preferentially in the peripheral nervous system (PNS) and thus termed peripheral ChAT (pChAT). A rabbit antiserum previously produced against rat pChAT (rpChAT) has been used for immuno...

journal_title：Frontiers in neuroanatomy

authors： Bellier JP,Yuan PQ,Mukaisho K,Tooyama I,Taché Y,Kimura H

更新日期：2019-04-16 00:00:00

abstract：:This study presents a tool, Neuronize, for building realistic three-dimensional models of neuronal cells from the morphological information extracted through computer-aided tracing applications. Neuronize consists of a set of methods designed to build 3D neural meshes that approximate the cell membrane at different re...

journal_title：Frontiers in neuroanatomy

authors： Brito JP,Mata S,Bayona S,Pastor L,Defelipe J,Benavides-Piccione R

更新日期：2013-06-03 00:00:00

abstract：:The radial dimension expands during central nervous system development after the proliferative neuroepithelium is molecularly patterned. The process is associated with neurogenesis, radial glia scaffolding, and migration of immature neurons into the developing mantle stratum. Radial histogenetic units, defined as a de...

journal_title：Frontiers in neuroanatomy

authors： Garcia-Calero E,Puelles L

更新日期：2020-11-10 00:00:00

abstract：:The thalamocingulate tract is a key component of the Papez circuit that connects the anterior thalamic nucleus (ATN) to the cingulum bundle. While the other white matter connections, consisting of the fornix, cingulum bundle and mammillothalamic tract, were well defined in Papez's original 1937 paper, the anatomy of t...

journal_title：Frontiers in neuroanatomy

authors： Weininger J,Roman E,Tierney P,Barry D,Gallagher H,Murphy P,Levins KJ,O'Keane V,O'Hanlon E,Roddy DW

更新日期：2019-02-18 00:00:00

abstract：:How does the size of the glial and neuronal cells that compose brain tissue vary across brain structures and species? Our previous studies indicate that average neuronal size is highly variable, while average glial cell size is more constant. Measuring whole cell sizes in vivo, however, is a daunting task. Here we use...

journal_title：Frontiers in neuroanatomy

authors： Mota B,Herculano-Houzel S

更新日期：2014-11-12 00:00:00

abstract：:Historically, the molecular and cellular mechanisms of cerebellar development were investigated through structural descriptions and studying spontaneous mutations in animal models and humans. Advances in experimental embryology, genetic engineering, and neuroimaging techniques render today the possibility to approach ...

journal_title：Frontiers in neuroanatomy

authors： Martinez S,Andreu A,Mecklenburg N,Echevarria D

更新日期：2013-06-26 00:00:00

abstract：:The development of light-sheet fluorescence microscopy (LSFM) has greatly expanded the experimental capabilities in many biological and biomedical research fields, enabling for example live studies of murine and zebrafish neural activity or of cell growth and division. The key feature of the method is the selective il...

journal_title：Frontiers in neuroanatomy

authors： Sancataldo G,Gavryusev V,de Vito G,Turrini L,Locatelli M,Fornetto C,Tiso N,Vanzi F,Silvestri L,Pavone FS

更新日期：2019-02-08 00:00:00

abstract：:Musical training can induce the functional and structural changes of the hippocampus. The hippocampus is not a homogeneous structure which can be divided into anterior and posterior parts along its longitudinal axis, and the whole-brain structural covariances of anterior (aHC) and posterior hippocampus (pHC) show dist...

journal_title：Frontiers in neuroanatomy

authors： Guo P,Li Q,Wang X,Li X,Wang S,Xie Y,Xie Y,Fu Z,Zhang X,Li S

更新日期：2020-05-19 00:00:00

abstract：:The reeler mouse has been widely used to study various aspects of cortico- and synaptogenesis, but also as a model for several neurological and neurodegenerative disorders. In contrast to development, comparably little is known about the neuronal composition and synaptic organization of the adult reeler mouse neocorte...

journal_title：Frontiers in neuroanatomy

authors： Prume M,Rollenhagen A,Lübke JHR

更新日期：2018-10-05 00:00:00

abstract：:Expansion microscopy and light sheet imaging (ExLSM) provide a viable alternative to existing tissue clearing and large volume imaging approaches. The analysis of intact volumes of brain tissue presents a distinct challenge in neuroscience. Recent advances in tissue clearing and light sheet microscopy have re-addresse...

journal_title：Frontiers in neuroanatomy

authors： Düring DN,Rocha MD,Dittrich F,Gahr M,Hahnloser RHR

更新日期：2019-01-31 00:00:00

abstract：:Involuntary movements or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson's disease. Dyskinesia is, ultimately, experienced by the vast majority of the patients. Despite the importance of this problem, little was known about the cause of dyskinesia, a situation that has dramatically ...

journal_title：Frontiers in neuroanatomy

authors： Barroso-Chinea P,Bezard E

更新日期：2010-09-14 00:00:00

abstract：:Accurate 3D reconstruction of neurons is vital for applications linking anatomy and physiology. Reconstructions are typically created using Neurolucida after biocytin histology (BH). An alternative inexpensive and fast method is to use freeware such as Neuromantic to reconstruct from fluorescence imaging (FI) stacks a...

journal_title：Frontiers in neuroanatomy

authors： Blackman AV,Grabuschnig S,Legenstein R,Sjöström PJ

更新日期：2014-07-11 00:00:00

abstract：:An increasing number of applications use the postnatal piglet model in neuroimaging studies, however, these are based primarily on T1 weighted image templates. There is a growing need for a multimodal structural brain template for a comprehensive depiction of the piglet brain, particularly given the growing applicatio...

journal_title：Frontiers in neuroanatomy

authors： Zhong J,Chen DQ,Walker M,Waspe A,Looi T,Piorkowska K,Drake JM,Hodaie M

更新日期：2016-09-27 00:00:00

abstract：:Species-typical patterns of grouping have profound impacts on many aspects of physiology and behavior. However, prior to our recent studies in estrildid finches, neural mechanisms that titrate species-typical group-size preferences, independent of other aspects of social organization (e.g., mating system and parental ...

journal_title：Frontiers in neuroanatomy

authors： Goodson JL,Kingsbury MA

更新日期：2011-03-02 00:00:00

abstract：:Emotions depend upon the integrated activity of neural networks that modulate arousal, autonomic function, motor control, and somatosensation. Brainstem nodes play critical roles in each of these networks, but prior studies of the neuroanatomic basis of emotion, particularly in the human neuropsychological literature,...

journal_title：Frontiers in neuroanatomy

authors： Venkatraman A,Edlow BL,Immordino-Yang MH

更新日期：2017-03-09 00:00:00

abstract：:Experiments in several species have identified direct projections to the medial geniculate nucleus (MG) from cells in subcollicular auditory nuclei. Moreover, many cochlear nucleus cells that project to the MG send collateral projections to the inferior colliculus (IC) (Schofield et al., 2014). We conducted three expe...

journal_title：Frontiers in neuroanatomy

authors： Schofield BR,Mellott JG,Motts SD

更新日期：2014-07-18 00:00:00

abstract：:In human prefrontal cortex (PFC), ~85% of γ-aminobutyric acid (GABA)-expressing neurons can be subdivided into non-overlapping groups by the presence of calbindin (CB), calretinin (CR) or parvalbumin (PV). Substantial research has focused on the differences in the laminar locations of the cells bodies of these neurons...

journal_title：Frontiers in neuroanatomy

authors： Fish KN,Rocco BR,Lewis DA

更新日期：2018-02-16 00:00:00

abstract：:The distribution of vitamin D-dependent calcium-binding protein (28 kDa calbindin) was investigated in cat lumbar and sacral spinal cord segments (L1-S3). We observed specific multi-dimensional distributions over the spinal segments for small immunopositive cells in Rexed laminae II-III and medium-to-large cells of va...

journal_title：Frontiers in neuroanatomy

authors： Merkulyeva N,Veshchitskii A,Makarov F,Gerasimenko Y,Musienko P

更新日期：2016-01-28 00:00:00

abstract：:Calcium stores in neurons are heterogeneous in compartmentalization and molecular composition. Danio rerio (zebrafish) is an animal model with a simply folded cerebellum similar in cellular organization to that of mammals. The aim of the study was to identify new endoplasmic reticulum (ER) calcium store markers in zeb...

journal_title：Frontiers in neuroanatomy

authors： Furlan S,Campione M,Murgia M,Mosole S,Argenton F,Volpe P,Nori A

更新日期：2020-04-21 00:00:00

abstract：:The striatum and the subthalamic nucleus (STN) are the main entry doors for extrinsic inputs to reach the basal ganglia (BG) circuitry. The cerebral cortex, thalamus and brainstem are the key sources of glutamatergic inputs to these nuclei. There is anatomical, functional and neurochemical evidence that glutamatergic ...

journal_title：Frontiers in neuroanatomy

authors： Villalba RM,Mathai A,Smith Y

更新日期：2015-09-25 00:00:00

abstract：:Most terrestrial animals demonstrate an autonomic reflex that facilitates survival during prolonged submersion under water. This diving response is characterized by bradycardia, apnea and selective increases in peripheral vascular resistance. Stimulation of the nose and nasal passages is thought to be primarily respon...

journal_title：Frontiers in neuroanatomy

authors： McCulloch PF,Lahrman KA,DelPrete B,DiNovo KM

更新日期：2018-11-13 00:00:00

abstract：:The auditory system contains a diverse array of interconnected anatomical structures that mediate the perception of sound. The cochlear nucleus of the hindbrain serves as the initial site of convergence for auditory stimuli, while the inferior colliculus of the midbrain serves as an integration and relay station for a...

journal_title：Frontiers in neuroanatomy

authors： Brown S,Zervas M

更新日期：2017-08-22 00:00:00

abstract：:The recent concept of neural genoarchitecture (or genoarchitectonics) is examined from several angles, aiming to clarify the rationale for this new approach in causal and descriptive neuroanatomy. Gene expression patterns can be used as topographic stains revealing architectonic borders that may clarify, dispute, or c...

journal_title：Frontiers in neuroanatomy

authors： Puelles L,Ferran JL

更新日期：2012-11-16 00:00:00