Huntington's Disease and Striatal Signaling.

abstract：:A60, the mouse monoclonal antibody against the neuronal nuclear protein (NeuN), is the most widely used neuronal marker in neuroscience research and neuropathological assays. Previous studies identified fragments of A60-immunoprecipitated protein as Synapsin I (Syn I), suggesting the antibody will demonstrate cross im...

journal_title：Frontiers in neuroanatomy

authors： Mao S,Xiong G,Zhang L,Dong H,Liu B,Cohen NA,Cohen AS

更新日期：2016-05-13 00:00:00

abstract：:Dendritic spines are micron-sized protrusions that harbor the majority of excitatory synapses in the central nervous system. The head of the spine is connected to the dendritic shaft by a 50-400 nm thin membrane tube, called the spine neck, which has been hypothesized to confine biochemical and electric signals within...

journal_title：Frontiers in neuroanatomy

authors： Adrian M,Kusters R,Wierenga CJ,Storm C,Hoogenraad CC,Kapitein LC

更新日期：2014-12-04 00:00:00

abstract：:Recent studies have supported the relation between mitochondrial functions and degenerative disorders related to ageing, such as Alzheimer's and Parkinson's diseases. Since these studies have exposed the need for detailed and high-resolution analysis of physical alterations in mitochondria, it is necessary to be able ...

journal_title：Frontiers in neuroanatomy

authors： Xiao C,Chen X,Li W,Li L,Wang L,Xie Q,Han H

更新日期：2018-11-02 00:00:00

abstract：:Pathways arising from the ventral tegmental area (VTA) release dopamine and other neurotransmitters during the expectation and achievement of reward, and are regarded as central links of the brain networks that create drive, pleasure, and addiction. While the global pattern of VTA projections is well-known, the actual...

journal_title：Frontiers in neuroanatomy

authors： Aransay A,Rodríguez-López C,García-Amado M,Clascá F,Prensa L

更新日期：2015-05-19 00:00:00

abstract：:Traditionally, the impact of evolution on the central nervous system has been studied by comparing the sizes of brain regions between species. However, more recent work has demonstrated that environmental factors, such as sensory experience, modulate brain region sizes intraspecifically, clouding the distinction betwe...

journal_title：Frontiers in neuroanatomy

authors： Hall ZJ,Tropepe V

更新日期：2020-03-18 00:00:00

abstract：:A subset of monoamine neurons releases glutamate as a cotransmitter due to presence of the vesicular glutamate transporters VGLUT2 or VGLUT3. In addition to mediating vesicular loading of glutamate, it has been proposed that VGLUT3 enhances serotonin (5-HT) vesicular loading by the vesicular monoamine transporter (VMA...

journal_title：Frontiers in neuroanatomy

authors： Voisin AN,Mnie-Filali O,Giguère N,Fortin GM,Vigneault E,El Mestikawy S,Descarries L,Trudeau LÉ

更新日期：2016-04-12 00:00:00

abstract：:The striatum and the subthalamic nucleus (STN) are the main entry doors for extrinsic inputs to reach the basal ganglia (BG) circuitry. The cerebral cortex, thalamus and brainstem are the key sources of glutamatergic inputs to these nuclei. There is anatomical, functional and neurochemical evidence that glutamatergic ...

journal_title：Frontiers in neuroanatomy

authors： Villalba RM,Mathai A,Smith Y

更新日期：2015-09-25 00:00:00

abstract：:Drug addiction is a severe neuropsychiatric disorder characterized by loss of control over motivated behavior. The need for effective treatments mandates a greater understanding of the causes and identification of new therapeutic targets for drug development. Drugs of abuse subjugate normal reward-related behavior to ...

journal_title：Frontiers in neuroanatomy

authors： Philibin SD,Hernandez A,Self DW,Bibb JA

更新日期：2011-09-20 00:00:00

abstract：:Dendritic spines are key components of a variety of microcircuits and they represent the majority of postsynaptic targets of glutamatergic axon terminals in the brain. The present article will focus on the discovery of dendritic spines, which was possible thanks to the application of the Golgi technique to the study o...

journal_title：Frontiers in neuroanatomy

authors： DeFelipe J

更新日期：2015-03-05 00:00:00

abstract：:Birds use various vocalizations to communicate with one another, and some are acquired through learning. So far, three families of birds (songbirds, parrots, and hummingbirds) have been identified as having vocal learning ability. Previously, we found that cadherins, a large family of cell-adhesion molecules, show voc...

journal_title：Frontiers in neuroanatomy

authors： Matsunaga E,Okanoya K

更新日期：2011-04-20 00:00:00

abstract：:Why do neurons have dendritic spines? This question-the heart of what Yuste calls "the spine problem"-presupposes that why-questions of this sort have scientific answers: that empirical findings can favor or count against claims about why neurons have spines. Here we show how such questions can receive empirical answe...

journal_title：Frontiers in neuroanatomy

authors： Malanowski S,Craver CF

更新日期：2014-09-10 00:00:00

abstract：:Until recently it was widely believed that the ability of female mammals (with the likely exception of women) to identify and seek out a male breeding partner relied on the detection of non-volatile male pheromones by the female's vomeronasal organ (VNO) and their subsequent processing by a neural circuit that include...

journal_title：Frontiers in neuroanatomy

authors： Baum MJ

更新日期：2012-06-05 00:00:00

abstract：:Choline acetyltransferase (ChAT), the enzyme synthesizing acetylcholine (ACh), has an exon-skipping splice variant which is expressed preferentially in the peripheral nervous system (PNS) and thus termed peripheral ChAT (pChAT). A rabbit antiserum previously produced against rat pChAT (rpChAT) has been used for immuno...

journal_title：Frontiers in neuroanatomy

authors： Bellier JP,Yuan PQ,Mukaisho K,Tooyama I,Taché Y,Kimura H

更新日期：2019-04-16 00:00:00

abstract：:Immunohistochemistry (IHC) is a valuable method for identifying discrete neurochemical molecules by the interaction of target antigens with validated antibodies tagged with a visible label (e.g., peroxidase). We have developed an immunostaining method that is highly sensitive in detection of neurochemical antigens. Ou...

journal_title：Frontiers in neuroanatomy

authors： Goto S,Morigaki R,Okita S,Nagahiro S,Kaji R

更新日期：2015-03-03 00:00:00

abstract：:Gaze changes involving the eyes and head are orchestrated by brainstem gaze centers found within the superior colliculus (SC), paramedian pontine reticular formation (PPRF), and medullary reticular formation (MdRF). The mesencephalic reticular formation (MRF) also plays a role in gaze. It receives a major input from t...

journal_title：Frontiers in neuroanatomy

authors： Perkins E,May PJ,Warren S

更新日期：2014-01-10 00:00:00

abstract：:Sevoflurane is widely used in adult and pediatric patients during clinical surgeries. Although studies have shown that exposure to sevoflurane impairs solfactory memory after an operation, the neuropathological changes underlying this effect are not clear. This study detected the effect of sevoflurane exposure on the ...

journal_title：Frontiers in neuroanatomy

authors： Yang J,Chen J,Cai G,Lu R,Sun T,Luo T,Wu S,Ling S

更新日期：2016-06-24 00:00:00

abstract：:Enough species have now been subject to systematic quantitative analysis of the relationship between the morphology and cellular composition of their brain that patterns begin to emerge and shed light on the evolutionary path that led to mammalian brain diversity. Based on an analysis of the shared and clade-specific ...

journal_title：Frontiers in neuroanatomy

authors： Herculano-Houzel S,Manger PR,Kaas JH

更新日期：2014-08-11 00:00:00

abstract：:Calcium stores in neurons are heterogeneous in compartmentalization and molecular composition. Danio rerio (zebrafish) is an animal model with a simply folded cerebellum similar in cellular organization to that of mammals. The aim of the study was to identify new endoplasmic reticulum (ER) calcium store markers in zeb...

journal_title：Frontiers in neuroanatomy

authors： Furlan S,Campione M,Murgia M,Mosole S,Argenton F,Volpe P,Nori A

更新日期：2020-04-21 00:00:00

abstract：:The neural circuits involved in mediating complex behaviors are being rapidly elucidated using various newly developed and powerful anatomical and molecular techniques, providing insights into the neural basis for anxiety disorders, depression, addiction, and dysfunctional social behaviors. Many of these behaviors and...

journal_title：Frontiers in neuroanatomy

authors： Santos FN,Pereira CW,Sánchez-Pérez AM,Otero-García M,Ma S,Gundlach AL,Olucha-Bordonau FE

更新日期：2016-04-07 00:00:00

abstract：:Dopamine (DA) modulates the effects of amino acid neurotransmitters (AANs), including GABA and glutamate, in motor, visual, olfactory, and reward systems (Hnasko et al., 2010; Stuber et al., 2010; Hnasko and Edwards, 2012). The results suggest that DA may play a similar modulatory role in the auditory pathways. Previo...

journal_title：Frontiers in neuroanatomy

authors： Fyk-Kolodziej BE,Shimano T,Gafoor D,Mirza N,Griffith RD,Gong TW,Holt AG

更新日期：2015-07-22 00:00:00

abstract：:The thalamocingulate tract is a key component of the Papez circuit that connects the anterior thalamic nucleus (ATN) to the cingulum bundle. While the other white matter connections, consisting of the fornix, cingulum bundle and mammillothalamic tract, were well defined in Papez's original 1937 paper, the anatomy of t...

journal_title：Frontiers in neuroanatomy

authors： Weininger J,Roman E,Tierney P,Barry D,Gallagher H,Murphy P,Levins KJ,O'Keane V,O'Hanlon E,Roddy DW

更新日期：2019-02-18 00:00:00

abstract：:Adult born neurons in the hippocampus show species-specific differences in their numbers, the pace of their maturation and their spatial distribution. Here, we present quantitative data on adult hippocampal neurogenesis in a New World primate, the common marmoset (Callithrix jacchus) that demonstrate parts of the line...

journal_title：Frontiers in neuroanatomy

authors： Amrein I,Nosswitz M,Slomianka L,van Dijk RM,Engler S,Klaus F,Raineteau O,Azim K

更新日期：2015-06-29 00:00:00

abstract：:Human inducible pluripotent stem cells (hiPSCs) hold a large potential for disease modeling. hiPSC-derived human astrocyte and neuronal cultures permit investigations of neural signaling pathways with subcellular resolution. Combinatorial cultures, and three-dimensional (3-D) embryonic bodies (EBs) enlarge the scope o...

journal_title：Frontiers in neuroanatomy

authors： Rakotoson I,Delhomme B,Djian P,Deeg A,Brunstein M,Seebacher C,Uhl R,Ricard C,Oheim M

更新日期：2019-08-20 00:00:00

abstract：:Anatomically distinct areas within the basal ganglia encode flexible- and stable-value memories for visual objects (Hikosaka et al., 2014), but an important question remains: do they receive inputs from the same or different brain areas or neurons? To answer this question, we first located flexible and stable value-co...

journal_title：Frontiers in neuroanatomy

authors： Griggs WS,Kim HF,Ghazizadeh A,Costello MG,Wall KM,Hikosaka O

更新日期：2017-11-24 00:00:00

abstract：:Involuntary movements or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson's disease. Dyskinesia is, ultimately, experienced by the vast majority of the patients. Despite the importance of this problem, little was known about the cause of dyskinesia, a situation that has dramatically ...

journal_title：Frontiers in neuroanatomy

authors： Barroso-Chinea P,Bezard E

更新日期：2010-09-14 00:00:00

abstract：:Experiments in several species have identified direct projections to the medial geniculate nucleus (MG) from cells in subcollicular auditory nuclei. Moreover, many cochlear nucleus cells that project to the MG send collateral projections to the inferior colliculus (IC) (Schofield et al., 2014). We conducted three expe...

journal_title：Frontiers in neuroanatomy

authors： Schofield BR,Mellott JG,Motts SD

更新日期：2014-07-18 00:00:00

abstract：:Species-typical patterns of grouping have profound impacts on many aspects of physiology and behavior. However, prior to our recent studies in estrildid finches, neural mechanisms that titrate species-typical group-size preferences, independent of other aspects of social organization (e.g., mating system and parental ...

journal_title：Frontiers in neuroanatomy

authors： Goodson JL,Kingsbury MA

更新日期：2011-03-02 00:00:00

abstract：:In human prefrontal cortex (PFC), ~85% of γ-aminobutyric acid (GABA)-expressing neurons can be subdivided into non-overlapping groups by the presence of calbindin (CB), calretinin (CR) or parvalbumin (PV). Substantial research has focused on the differences in the laminar locations of the cells bodies of these neurons...

journal_title：Frontiers in neuroanatomy

authors： Fish KN,Rocco BR,Lewis DA

更新日期：2018-02-16 00:00:00

abstract：:Early telencephalic development involves the migration of diverse cell types that can be identified by specific molecular markers. Most prominent among them are Cajal-Retzius (CR) cells that emanate mainly from the cortical hem and to a lesser extent from rostrolateral, septal and caudo-medial regions. One additional ...

journal_title：Frontiers in neuroanatomy

authors： Frade-Pérez MD,Miquelajáuregui A,Varela-Echavarría A

更新日期：2017-11-01 00:00:00

abstract：:Despite many structural and functional aspects of the brain organization have been extensively studied in neuroscience, we are still far from a clear understanding of the intricate structure-function interactions occurring in the multi-layered brain architecture, where billions of different neurons are involved. Altho...

journal_title：Frontiers in neuroanatomy

authors： Ullo S,Nieus TR,Sona D,Maccione A,Berdondini L,Murino V

更新日期：2014-11-20 00:00:00