Abstract:
:Although the olfactory sense has always been considered with less interest than the visual, auditive or somatic senses, it does plays a major role in our ordinary life, with important implication in dangerous situations or in social and emotional behaviors. Traditional Diffusion Tensor signal model and related tractography have been used in the past years to reconstruct the cranial nerves, including the olfactory nerve (ON). However, no supplementary information with regard to the pathways of the olfactory network have been provided. Here, by using the more advanced Constrained Spherical Deconvolution (CSD) diffusion model, we show for the first time in vivo and non-invasively that, in healthy humans, the olfactory system has a widely distributed anatomical network to several cortical regions as well as to many subcortical structures. Although the present study focuses on an healthy sample size, a similar approach could be applied in the near future to gain important insights with regard to the early involvement of olfaction in several neurodegenerative disorders.
journal_name
Front Neuroanatjournal_title
Frontiers in neuroanatomyauthors
Milardi D,Cacciola A,Calamuneri A,Ghilardi MF,Caminiti F,Cascio F,Andronaco V,Anastasi G,Mormina E,Arrigo A,Bruschetta D,Quartarone Adoi
10.3389/fnana.2017.00032subject
Has Abstractpub_date
2017-04-10 00:00:00pages
32issn
1662-5129journal_volume
11pub_type
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