Abstract:
:Really interesting new gene (RING) finger protein is a type of zinc-binding motif found in a large family of functionally distinct proteins. RING finger proteins are involved in diverse cellular processes including apoptosis, DNA repair, cell cycle, signal transduction, tumour suppressor, vesicular transport, and peroxisomal biogenesis. RING finger protein 38 (RNF38) is a member of the family whose functions remain unknown. To gain insight into the putative effects of RNF38 in the central nervous system, we localised its expression. The aim of this study was to identify the neuroanatomical location(s) of rnf38 mRNA and its peptide, determine the type of RNF38-expressing cells, and measure rnf38 gene expression in the brain of male tilapia. The distributions of rnf38 mRNA and its peptide were visualised using in situ hybridisation with digoxigenin-labelled RNA antisense and immunocytochemistry, respectively. Both were identically distributed throughout the brain, including the telencephalon, preoptic area, optic tectum, hypothalamus, cerebellum, and the hindbrain. Double-labelling immunocytochemistry for RNF38 and the neuronal marker HuC/D showed that most but not all RNF38 protein was expressed in neuronal nuclei. Quantitative real-time polymerase chain reaction showed the highest level of rnf38 mRNA in the midbrain, followed by the preoptic area, cerebellum, optic tectum, telencephalon, hindbrain and hypothalamus. These findings reveal a differential spatial pattern of RNF38 in the tilapia brain, suggesting that it has potentially diverse functions related to neuronal activity.
journal_name
Front Neuroanatjournal_title
Frontiers in neuroanatomyauthors
Cham KL,Soga T,Parhar ISdoi
10.3389/fnana.2017.00072subject
Has Abstractpub_date
2017-08-31 00:00:00pages
72issn
1662-5129journal_volume
11pub_type
杂志文章abstract::Emotions depend upon the integrated activity of neural networks that modulate arousal, autonomic function, motor control, and somatosensation. Brainstem nodes play critical roles in each of these networks, but prior studies of the neuroanatomic basis of emotion, particularly in the human neuropsychological literature,...
journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
doi:10.3389/fnana.2017.00015
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abstract::Sevoflurane is widely used in adult and pediatric patients during clinical surgeries. Although studies have shown that exposure to sevoflurane impairs solfactory memory after an operation, the neuropathological changes underlying this effect are not clear. This study detected the effect of sevoflurane exposure on the ...
journal_title:Frontiers in neuroanatomy
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journal_title:Frontiers in neuroanatomy
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abstract::Experiments in several species have identified direct projections to the medial geniculate nucleus (MG) from cells in subcollicular auditory nuclei. Moreover, many cochlear nucleus cells that project to the MG send collateral projections to the inferior colliculus (IC) (Schofield et al., 2014). We conducted three expe...
journal_title:Frontiers in neuroanatomy
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2012.00003
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2012.00025
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
doi:10.3389/fnana.2014.00155
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章,评审
doi:10.3389/fnana.2015.00117
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journal_title:Frontiers in neuroanatomy
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doi:10.3389/fnana.2015.00053
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journal_title:Frontiers in neuroanatomy
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doi:10.3389/fnana.2013.00029
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pub_type: 杂志文章,评审
doi:10.3389/fnana.2017.00011
更新日期:2017-03-07 00:00:00
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journal_title:Frontiers in neuroanatomy
pub_type: 杂志文章
doi:10.3389/fnana.2014.00127
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journal_title:Frontiers in neuroanatomy
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journal_title:Frontiers in neuroanatomy
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doi:10.3389/fnana.2011.00013
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journal_title:Frontiers in neuroanatomy
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journal_title:Frontiers in neuroanatomy
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