Gene × Environment interactions in autism spectrum disorders: role of epigenetic mechanisms.

abstract：Background:From birth, the human propensity to selectively attend and respond to critical super-stimuli forms the basis of future socio-emotional development and health. In particular, the first super-stimuli to preferentially engage and elicit responses in the healthy newborn are the physical touch, voice and face/eye...

journal_title：Frontiers in psychiatry

authors： Doyle FL,Mendoza Diaz A,Eapen V,Frick PJ,Kimonis ER,Hawes DJ,Moul C,Richmond JL,Mehta D,Sareen S,Morgan BG,Dadds MR

更新日期：2020-06-19 00:00:00

abstract：:Background: Approach and avoidance motivation have been thoroughly studied in common mental disorders, which are prevalent in the military context. Approach/avoidance motivational dispositions underlie emotion responses and are thought to influence emotion dysregulation. However, studies on the mediating role of emoti...

journal_title：Frontiers in psychiatry

authors： Wang X,Zhang R,Chen X,Liu K,Wang L,Zhang J,Liu X,Feng Z

更新日期：2019-03-22 00:00:00

abstract：:Introduction: People with psychosis show impairments in cognitive flexibility, a phenomenon that is still poorly understood. In this study, we tested if there were differences in cognitive and metacognitive processes related to rigidity in patients with psychosis. We compared individuals with dichotomous interpersonal...

journal_title：Frontiers in psychiatry

authors： García-Mieres H,Usall J,Feixas G,Ochoa S

更新日期：2020-11-26 00:00:00

abstract：:Alcohol is one of the leading risk factors for global disease burden and overconsumption leads to a wide variety of negative consequences in everyday life. Digital interventions have shown small positive effects in contributing to reductions in problematic use. Specific research on smartphone apps is sparse and the fe...

journal_title：Frontiers in psychiatry

authors： Berman AH,Molander O,Tahir M,Törnblom P,Gajecki M,Sinadinovic K,Andersson C

更新日期：2020-05-27 00:00:00

abstract：:Incarceration affects the lives of many African American men and often leads to poverty, ill health, violence, and a decreased quality of life. There has been an unprecedented increase in incarceration among African American males since 1970. In 2009, the incarceration rate among black males was 6.7 times that of whit...

journal_title：Frontiers in psychiatry

authors： Mukku VK,Benson TG,Alam F,Richie WD,Bailey RK

更新日期：2012-11-12 00:00:00

abstract：Objective:To explore the attitudes and factors in seeking professional psychological help among a Chinese community-dwelling population in order to promote positive help-seeking behaviors and better utilization of mental health services. Methods:Using system and simple random sampling with Kish selection table methods...

journal_title：Frontiers in psychiatry

authors： Chen P,Liu XJ,Wang XQ,Yang BX,Ruan J,Liu Z

更新日期：2020-05-14 00:00:00

abstract：:Introduction: Previous studies on internet gaming disorder (IGD) have reported an association between personality traits and impulsive or problematic use of the internet or internet games, but the results obtained were inconsistent. Our study's hypothesis was that personality traits are associated with the individual'...

journal_title：Frontiers in psychiatry

authors： Seong W,Hong JS,Kim S,Kim SM,Han DH

更新日期：2019-08-28 00:00:00

abstract：:Despite being a commonly used protocol to treat major depressive disorder (MDD), the underlying mechanism of repetitive transcranial magnetic stimulation (rTMS) on dorsolateral prefrontal cortex (DLPFC) remains unclear. In the current study, we investigated the resting-state fMRI data of 100 healthy subjects by explor...

journal_title：Frontiers in psychiatry

authors： Ishida T,Dierks T,Strik W,Morishima Y

更新日期：2020-08-20 00:00:00

abstract：:Impaired manual dexterity is commonly observed in schizophrenia. However, a quantitative description of key sensorimotor components contributing to impaired dexterity is lacking. Whether the key components of dexterity are differentially affected and how they relate to clinical characteristics also remains unclear. We...

journal_title：Frontiers in psychiatry

authors： Térémetz M,Carment L,Brénugat-Herne L,Croca M,Bleton JP,Krebs MO,Maier MA,Amado I,Lindberg PG

更新日期：2017-07-10 00:00:00

abstract：:Recent evidence suggests that epigenetic mechanisms play a role in psychiatric diseases. In this study, we considered rats with neonatal ventral hippocampal lesions (NVHL) that are currently used for modeling neurodevelopmental aspects of schizophrenia. Contribution of epigenetic regulation to the effects of the lesio...

journal_title：Frontiers in psychiatry

authors： Sandner G,Host L,Angst MJ,Guiberteau T,Guignard B,Zwiller J

更新日期：2011-01-07 00:00:00

abstract：Background/Hypotheses:As risk factors for nonsuicidal self-injury (NSSI), most studies highlight the importance of internalising disorders, while only a few researches show the connection between externalising disorders and NSSI. Although some papers have introduced the idea that increasing prevalence rates of NSSI are...

journal_title：Frontiers in psychiatry

authors： Mészáros G,Győri D,Horváth LO,Szentiványi D,Balázs J

更新日期：2020-08-14 00:00:00

abstract：Background:Previous studies suggested bipolar disorder caused an aberrant alteration in the insular, putamen, and left superior frontal gyrus, which are the main components of the hate circuit. However, the relationship between the hate circuit and the pathophysiologic substrate underlying different phases of bipolar d...

journal_title：Frontiers in psychiatry

authors： Fan Z,Yang J,Zeng C,Xi C,Wu G,Guo S,Xue Z,Liu Z,Tao H

更新日期：2020-10-27 00:00:00

abstract：Objectives:Schizophrenia (SZ) is a complex psychiatric disorder that has a strong genetic basis. Dystrobrevin-binding protein 1 (DTNBP1) is one of the genes thought to be pivotal in regulating the glutamatergic system. Studies have suggested that variations in DTNBP1 confer susceptibility to SZ and clinical symptoms. H...

journal_title：Frontiers in psychiatry

authors： Yang Y,Zhang L,Guo D,Zhang L,Yu H,Liu Q,Su X,Shao M,Song M,Zhang Y,Ding M,Lu Y,Liu B,Li W,Yue W,Fan X,Yang G,Lv L

更新日期：2020-05-25 00:00:00

abstract：:Prolonged bedtime smartphone use is often associated with poor sleep quality and daytime dysfunction. In addition, the unstructured nature of smartphones may lead to excessive and uncontrolled use, which can be a cardinal feature of problematic smartphone use. This study was designed to investigate functional connecti...

journal_title：Frontiers in psychiatry

authors： Paik SH,Park CH,Kim JY,Chun JW,Choi JS,Kim DJ

更新日期：2019-07-23 00:00:00

abstract：:Objective: We aimed to conduct a comparative analysis of the psychological stress experienced by healthcare workers, frontline workers, and the general public and to assess the factors associated with psychological stress in each of these groups. Methods: We conducted an online survey targeting healthcare workers, fro...

journal_title：Frontiers in psychiatry

authors： Luan R,Pu W,Dai L,Yang R,Wang P

更新日期：2020-12-01 00:00:00

abstract：:THE MIRROR SYSTEM HYPOTHESIS AND INVESTIGATIONS OF BIRDSONG ARE REVIEWED IN RELATION TO THE SIGNIFICANCE FOR THE DEVELOPMENT OF HUMAN SYMBOLIC AND LANGUAGE CAPACITY, IN TERMS OF THREE FUNDAMENTAL FORMS OF COGNITIVE REFERENCE: iconic, indexical, and symbolic. Mirror systems are initially iconic but can progress to inde...

journal_title：Frontiers in psychiatry

authors： Levy F

更新日期：2012-01-11 00:00:00

abstract：:Objective: Predicting who will be a placebo responder is a prerequisite to maximize placebo effects in pain treatment and to minimize them in clinical trials. First evidence exists that genetics could affect placebo effects. However, a classical twin study to estimate the relative contribution of genetic influences co...

journal_title：Frontiers in psychiatry

authors： Weimer K,Hahn E,Mönnikes N,Herr AK,Stengel A,Enck P

更新日期：2019-09-18 00:00:00

abstract：:The most replicated neuroanatomical finding in autism is the tendency toward brain overgrowth, especially in younger children. Research shows that both gray and white matter are enlarged. Proposed mechanisms underlying brain enlargement include abnormal inflammatory and neurotrophic signals that lead to excessive, abe...

journal_title：Frontiers in psychiatry

authors： Sokol DK,Maloney B,Westmark CJ,Lahiri DK

更新日期：2019-04-10 00:00:00

abstract：Background:Anorexia nervosa (AN) is characterized by severe malnutrition as well as inefficiencies in neurocognitive functioning, which are believed to contribute to the maintenance of disordered eating. The aim of this study was to examine the impact of individual cognitive remediation therapy (CRT) on neurocognition ...

journal_title：Frontiers in psychiatry

authors： Leppanen J,Adamson J,Tchanturia K

更新日期：2018-03-20 00:00:00

abstract：:Mental imagery, seeing with the mind's eyes, can induce stronger positive as well as negative affect compared to verbal processing. Given this emotion-amplifying effect, it appears likely that mental images play an important role in affective disorders. According to the subcomponents model of depression, depressed moo...

journal_title：Frontiers in psychiatry

authors： Görgen SM,Joormann J,Hiller W,Witthöft M

更新日期：2015-07-07 00:00:00

abstract：:The view that anatomically distinct memory systems differentially contribute to the development of drug addiction and relapse has received extensive support. The present brief review revisits this hypothesis as it was originally proposed 20 years ago (1) and highlights several recent developments. Extensive research e...

journal_title：Frontiers in psychiatry

authors： Goodman J,Packard MG

更新日期：2016-02-25 00:00:00

abstract：:Alcohol use disorder (AUD) is a devastating public health problem in which both genetic and environmental factors play a role. Growing evidence supports that epigenetic regulation is one major mechanism in neuroadaptation that contributes to development of AUD. Meanwhile, epigenetic patterns can be modified by various...

journal_title：Frontiers in psychiatry

authors： Chen J,Hutchison KE,Bryan AD,Filbey FM,Calhoun VD,Claus ED,Lin D,Sui J,Du Y,Liu J

更新日期：2018-11-15 00:00:00

abstract：:Excessive glutamate release has been linked to stress and many neurodegenerative diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or glutamatergic dysfunction as playing an important role in the development of many major psychiatric disorders (e.g., schizophrenia, bipolar disorder, and maj...

journal_title：Frontiers in psychiatry

authors： Li CT,Yang KC,Lin WC

更新日期：2019-01-24 00:00:00

abstract：Background:Prepulse inhibition (PPI) of the acoustic startle reflex is an operational measure of sensorimotor gating. The findings on PPI deficits in bipolar disorder (BD) are inconsistent among studies due to various confounding factors such as gender. This study aimed to assess sensorimotor gating deficits in patient...

journal_title：Frontiers in psychiatry

authors： Matsuo J,Ota M,Hidese S,Teraishi T,Hori H,Ishida I,Hiraishi M,Kunugi H

更新日期：2018-04-18 00:00:00

abstract：:Translational research aiming to elucidate mediators and moderators of placebo and nocebo effects is highly relevant. This experimental study tested effects of a brief progressive muscle relaxation (PMR) exercise, designed to alter psychobiological stress parameters, on the magnitude of placebo and nocebo effects in a...

journal_title：Frontiers in psychiatry

authors： Elsenbruch S,Roderigo T,Enck P,Benson S

更新日期：2019-03-21 00:00:00

abstract：:The aim of this study is to explore the changes and clinical significance of serum C3, C4, hypersensitive C-reactive protein (hsCRP) and uric acid (UA) in patients of bipolar disorder (BD). In this case-control study, we recruited 141 BD patients from The Second Xiangya Hospital, Central South University, and 151 age ...

journal_title：Frontiers in psychiatry

authors： Yang X,Tao H,Xiao L,Li C,Tang Y,Liu Y

更新日期：2018-08-21 00:00:00

abstract：:The consumption of drugs during young adulthood may be particularly detrimental given important neurodevelopmental changes occurring during this period. As impulsivity may lead to substance use and substance use to the commission of seemingly impulsive acts, an improved understanding of the relationship between alcoho...

journal_title：Frontiers in psychiatry

authors： Balodis IM,Potenza MN,Olmstead MC

更新日期：2010-10-21 00:00:00

abstract：Background:Disorganization of semantic memory in patients with schizophrenia has been studied by referring to their category fluency performance. Recently, data-mining techniques such as singular value decomposition (SVD) analysis have been reported to be effective in elucidating the latent semantic memory structure in...

journal_title：Frontiers in psychiatry

authors： Sumiyoshi C,Fujino H,Sumiyoshi T,Yasuda Y,Yamamori H,Fujimoto M,Hashimoto R

更新日期：2018-03-21 00:00:00

abstract：:Social cognition has become recognized as an important driver of functional outcomes and overall recovery in patients with schizophrenia, mediating the relationship between neurocognition and social functioning. Since antipsychotic therapy targeting remission of clinical symptoms has been shown to have a limited impac...

journal_title：Frontiers in psychiatry

authors： Javed A,Charles A

更新日期：2018-04-24 00:00:00

abstract：:Suicide is the most severe consequence of depression which has become a leading cause of disability and a global disease burden. Recent evidence indicates a central role of small molecules in the pathogenesis of depression and associated suicidal behaviors. However, there lacks a systemic exploration of small molecule...

journal_title：Frontiers in psychiatry

authors： Liu S

更新日期：2020-04-16 00:00:00