Bipolar Mood State Reflected in Functional Connectivity of the Hate Circuit: A Resting-State Functional Magnetic Resonance Imaging Study.

Abstract:

Background:Previous studies suggested bipolar disorder caused an aberrant alteration in the insular, putamen, and left superior frontal gyrus, which are the main components of the hate circuit. However, the relationship between the hate circuit and the pathophysiologic substrate underlying different phases of bipolar disorder remain unclear. In this study, we aimed to identify group differences of resting-state functional connectivity within the hate circuit in healthy controls (HCs) and bipolar patients in different mood states. Methods:Resting-state functional magnetic resonance imaging of the brain were acquired from 54 HCs and 81 patients with bipolar disorder including 20 with bipolar mania (BM), 35 with bipolar depression (BD), and 26 with bipolar euthymia (BE). We selected bilateral insula (L.INS and R.INS), bilateral putamen (L.PUT and R.PUT), and left superior frontal gyrus (L.SFGd) as seed regions, and conducted the seed-based functional connectivity analysis to identify group differences of connectivity strength within the hate circuit. Spearman correlations were performed to evaluate the relationship between the hate circuit and manic/depressive symptoms. Results:Significant group differences of connectivity strength within the hate circuit were found in links of the R.INS-L.SFGd, R.PUT-L.SFGd, and L.INS- R.PUT after false discovery rate was corrected. The BM group showed an opposite hate circuit pattern to BD, BE, and HCs. The BD group showed decreased hate circuit connectivity in the L.INS-R.PUT compared with the BE group. No significant difference was detected among BD, BE, and HCs. Furthermore, functional connectivity of the R.INS-L.SFGd and R.PUT-L.SFGd were positively correlated with manic symptoms, while the L.INS- R.PUT was negatively correlated with depressive symptoms. Conclusions:Our preliminary findings suggest that altered functional connectivity of the hate circuit in different mood phases may be related to state markers and underpin the neuropathological basis of bipolar disorder.

journal_name

Front Psychiatry

journal_title

Frontiers in psychiatry

authors

Fan Z,Yang J,Zeng C,Xi C,Wu G,Guo S,Xue Z,Liu Z,Tao H

doi

10.3389/fpsyt.2020.556126

subject

Has Abstract

pub_date

2020-10-27 00:00:00

pages

556126

issn

1664-0640

journal_volume

11

pub_type

杂志文章
  • Efficacy, Safety, and Tolerability of Theta-Burst Stimulation in Mixed Depression: Design, Rationale, and Objectives of a Randomized, Double-Blinded, Sham-Controlled Trial.

    abstract:Introduction:Mixed-specifier mood disorders are probably a different subgroup in terms of response to treatment, socio-demographic parameters, course, and family history. Here we describe the rationale and design of a clinical trial aimed to test the efficacy, safety, and tolerability of a non-pharmacological treatment...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00435

    authors: Tavares DF,Dos Santos CGR,Valiengo LDCL,Klein I,Borrione L,Forte PM,Brunoni AR,Moreno RA

    更新日期:2020-05-15 00:00:00

  • No Laughing Matter: Presence, Consumption Trends, Drug Awareness, and Perceptions of "Hippy Crack" (Nitrous Oxide) among Young Adults in England.

    abstract::In clinical settings, nitrous oxide gas is a safe anesthetic used during childbirth, in dentistry, and to relieve anxiety in emergencies. Colloquially known as "hippy crack"' or "laughing gas," it is increasingly taken recreationally for its euphoric and relaxing effects and hallucinogenic properties. Using a self-rep...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2017.00312

    authors: Ehirim EM,Naughton DP,Petróczi A

    更新日期:2018-01-22 00:00:00

  • Resilience as a Mediator Between Interpersonal Risk Factors and Hopelessness in Depression.

    abstract::Several studies investigated the role of resilience as a mediating factor for psychopathological phenotypes. The aim of the current study is to explore the putative role of resilience as a mediator between different vulnerability factors and depressive symptoms. One hundred and fifty patients with a major depressive d...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00010

    authors: Collazzoni A,Stratta P,Pacitti F,Rossi A,Santarelli V,Bustini M,Talevi D,Socci V,Rossi R

    更新日期:2020-02-28 00:00:00

  • The Therapeutic Community: A Unique Social Psychological Approach to the Treatment of Addictions and Related Disorders.

    abstract::The evolution of the contemporary Therapeutic Community (TC) for addictions over the past 50 years may be characterized as a movement from the marginal to the mainstream of substance abuse treatment and human services. TCs currently serve a wide array of clients and their diverse problems; through advances in research...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00786

    authors: De Leon G,Unterrainer HF

    更新日期:2020-08-06 00:00:00

  • Dynamic Effects of Early Adolescent Stress on Depressive-Like Behaviors and Expression of Cytokines and JMJD3 in the Prefrontal Cortex and Hippocampus of Rats.

    abstract::Aims: Expression of inflammatory cytokines in the brain has been reported to be involved in the pathogenesis of and susceptibility to depression. Jumonji domain-containing 3 (Jmjd3), which is a histone H3 lysine 27 (H3K27) demethylase and can regulate microglial activation, has been regarded as a crucial element in th...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00471

    authors: Wang R,Wang W,Xu J,Liu D,Jiang H,Pan F

    更新日期:2018-10-11 00:00:00

  • Impact of Social Isolation on the Behavioral, Functional Profiles, and Hippocampal Atrophy Asymmetry in Dementia in Times of Coronavirus Pandemic (COVID-19): A Translational Neuroscience Approach.

    abstract::The impact of COVID-19 on the elderly is devastating, and nursing homes are struggling to provide the best care to the most fragile. The urgency and severity of the pandemic forces the use of segregation in restricted areas and confinement in individual rooms as desperate strategies to avoid the spread of disease and ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.572583

    authors: Muntsant A,Giménez-Llort L

    更新日期:2020-11-24 00:00:00

  • Effects of COVID-19 Epidemic Lockdown on Postpartum Depressive Symptoms in a Sample of Italian Mothers.

    abstract::The extraordinary health emergency of the COVID-19 pandemic represents a new challenge for mental health researchers and clinical practitioners. The related containment measures may be a risk factor for psychological distress and mood disorders, especially in at-risk populations. This study aims to explore the impact ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.589916

    authors: Spinola O,Liotti M,Speranza AM,Tambelli R

    更新日期:2020-11-17 00:00:00

  • The Associations of Emotion Coping Appraisal With Both the Cue-Outcome Contingency and Perceived Verbal Abuse Exposure.

    abstract::Previous studies have reported an association between verbal abuse in early childhood and structural and functional alterations in the young adult brain, supporting the existence of critical periods in human brain development. In addition, exposure to verbal abuse in early childhood is strongly correlated with lifetim...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00250

    authors: Shin DW,Yoon T,Jeong B

    更新日期:2019-04-16 00:00:00

  • Co-design of eHealth Interventions With Children and Young People.

    abstract::Co-design, defined as collective creativity across the entire design process, can lead to the development of interventions that are more engaging, satisfying, and useful to potential users. However, using this methodology within the research arena requires a shift from traditional practice. Co-design of eHealth interv...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2018.00481

    authors: Thabrew H,Fleming T,Hetrick S,Merry S

    更新日期:2018-10-18 00:00:00

  • Monetary Incentives Increase Metacognitive Confidence in Source Memory Performance in Patients With Schizophrenia.

    abstract:Background:Contemporary psychiatric research focuses its attention on the patient's dysfunction of metacognition in relation to the basic cognitive processes of mental activity. The current study investigated dysfunctional metacognition in relation to self-monitoring of memory in patients diagnosed with schizophrenia. ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00725

    authors: Szczepanowski R,Cichoń E,Pasieczna AH,Gawęda Ł,Rosińczuk J

    更新日期:2020-07-29 00:00:00

  • Ward Atmosphere and Patient Satisfaction in Psychiatric Hospitals With Different Ward Settings and Door Policies. Results From a Mixed Methods Study.

    abstract::Background: Open-door policies in psychiatry are discussed as a means to improve the treatment of involuntarily committed patients in various aspects. Current research on open-door policies focuses mainly on objective effects, such as the number of coercive interventions or serious incidents. The aim of the present st...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00576

    authors: Efkemann SA,Bernard J,Kalagi J,Otte I,Ueberberg B,Assion HJ,Zeiß S,Nyhuis PW,Vollmann J,Juckel G,Gather J

    更新日期:2019-08-30 00:00:00

  • Tailored-Dose Baclofen in the Management of Alcoholism: A Retrospective Study of 144 Outpatients Followed for 3 Years in a French General Practice.

    abstract::Background: More information is needed about the efficacy and safety of long-term baclofen in the treatment of alcohol use disorders. The objective of this study was to assess the effect of treatment with tailored-dose baclofen on alcohol consumption in patients with alcohol use disorders followed for 3 years after fi...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00486

    authors: Pinot J,Rigal L,Granger B,Sidorkiewicz S,Jaury P

    更新日期:2018-10-08 00:00:00

  • Language Patterns Discriminate Mild Depression From Normal Sadness and Euthymic State.

    abstract:Objectives:Deviations from typical word use have been previously reported in clinical depression, but language patterns of mild depression (MD), as distinct from normal sadness (NS) and euthymic state, are unknown. In this study, we aimed to apply the linguistic approach as an additional diagnostic key for understandin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00105

    authors: Smirnova D,Cumming P,Sloeva E,Kuvshinova N,Romanov D,Nosachev G

    更新日期:2018-04-10 00:00:00

  • The Detection of Malingering: A New Tool to Identify Made-Up Depression.

    abstract::Major depression is a high-prevalence mental disease with major socio-economic impact, for both the direct and the indirect costs. Major depression symptoms can be faked or exaggerated in order to obtain economic compensation from insurance companies. Critically, depression is potentially easily malingered, as the sym...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00249

    authors: Monaro M,Toncini A,Ferracuti S,Tessari G,Vaccaro MG,De Fazio P,Pigato G,Meneghel T,Scarpazza C,Sartori G

    更新日期:2018-06-08 00:00:00

  • Interpersonal Psychotherapy vs. Treatment as Usual for Major Depression Related to Work Stress: A Pilot Randomized Controlled Study.

    abstract::Background: Depressive disorders are among the leading causes of sick leave and long-term work incapacity in most modern countries. Work related stress is described by patients as the most common context of depression. It is vital to know what types of treatments are effective in improving work related problems and oc...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2020.00193

    authors: Schramm E,Mack S,Thiel N,Jenkner C,Elsaesser M,Fangmeier T

    更新日期:2020-03-18 00:00:00

  • Measuring Psychological Change and Predicting Recidivism Following the Swedish One-to-One Program.

    abstract::The One-to-One program aims to reduce criminal recidivism among prisoners shortly awaiting release, and among probationers. Of 1,484 program participants in Sweden, 776 contained adequate data for analysis. Pre- and post-program scores were available for the Alternative Thinking Test, Levenson's Locus of Control Scale...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00811

    authors: Berman AH,Gajecki M,Morien P,Priestley P

    更新日期:2019-11-29 00:00:00

  • Dare to delay? The impacts of adolescent alcohol and marijuana use onset on cognition, brain structure, and function.

    abstract::Throughout the world, drug and alcohol use has a clear adolescent onset (Degenhardt et al., 2008). Alcohol continues to be the most popular drug among teens and emerging adults, with almost a third of 12th graders and 40% of college students reporting recent binge drinking (Johnston et al., 2009, 2010), and marijuana ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2013.00053

    authors: Lisdahl KM,Gilbart ER,Wright NE,Shollenbarger S

    更新日期:2013-07-01 00:00:00

  • Association of frontal gray matter volume and cerebral perfusion in heroin addiction: a multimodal neuroimaging study.

    abstract::Structure and function are closely related in the healthy human brain. In patients with chronic heroin exposure, brain imaging studies have identified long-lasting changes in gray matter (GM) volume. More recently, we showed that acute application of heroin in dependent patients results in hypoperfusion of fronto-temp...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2013.00135

    authors: Denier N,Schmidt A,Gerber H,Schmid O,Riecher-Rössler A,Wiesbeck GA,Huber CG,Lang UE,Radue EW,Walter M,Borgwardt S

    更新日期:2013-10-21 00:00:00

  • Primary and Secondary Diagnoses of Gambling Disorder and Psychiatric Comorbidity in the Swedish Health Care System-A Nationwide Register Study.

    abstract::Background: Psychiatric comorbidity is common in gambling disorder, a condition with low rates of treatment seeking. There is a paucity of documented nationwide data on gambling disorder and its co-occurring psychiatric comorbidities in the health care system. Methods: This is a nationwide register-based study of all ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00426

    authors: Håkansson A,Karlsson A,Widinghoff C

    更新日期:2018-09-07 00:00:00

  • Neurocognition and Social Cognition Predicting 1-Year Outcomes in First-Episode Psychosis.

    abstract::Cognitive performance at illness onset may predict outcomes in first-episode psychosis (FEP), and the change in cognition may associate with clinical changes. Cognitive testing was administered to 54 FEP participants 2 months after entering treatment and to 39 participants after 1 year. We investigated whether baselin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.603933

    authors: Lindgren M,Holm M,Kieseppä T,Suvisaari J

    更新日期:2020-12-04 00:00:00

  • The Influence of Depression on the Psychometric Properties of the Maslach Burnout Inventory-Human Services Survey: A Cross-Sectional Study With Nursing Assistants.

    abstract::Background: The Maslach Burnout Inventory-Human Services Survey (MBI-HSS) is the most commonly used instrument to assess burnout. Although various factors have been reported to influence its validity, the influence of major depressive disorder (MDD) has not been previously considered. We developed this study to invest...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00695

    authors: Trigo TR,de Freitas CCS,Wang YP,Ribeiro FG,de Lucia MCS,Siqueira JO,Iosifescu DV,Hallak JEC,Fraguas R

    更新日期:2018-12-18 00:00:00

  • Compulsory Admission to Psychiatric Wards-Who Is Admitted, and Who Appeals Against Admission?

    abstract::Background: When persons with a mental illness present a danger to themselves or others, involuntary hospital admission can be used to initiate an immediate inpatient treatment. Often, the patients have the right to appeal against compulsory admission. These processes are implemented in most mental health-care systems...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00544

    authors: Arnold BD,Moeller J,Hochstrasser L,Schneeberger AR,Borgwardt S,Lang UE,Huber CG

    更新日期:2019-08-09 00:00:00

  • Biological Mechanisms of Cancer-Induced Depression.

    abstract::Patients with cancer are more likely to develop depression than the general population, which negatively impacts their quality of life and prognosis. In order to identify effective antidepressants catered toward cancer patients, the biology of depression in the context of cancer must be well-understood. Many theories ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2018.00299

    authors: Young K,Singh G

    更新日期:2018-07-10 00:00:00

  • Analysis of the Deleterious Single-Nucleotide Polymorphisms Associated With Antidepressant Efficacy in Major Depressive Disorder.

    abstract::Major depressive disorder (MDD) is a serious mental disease with negative effects on both mental and physical health of the patient. Currently, antidepressants are among the major ways to ease or treat MDD. However, the existing antidepressants have limited efficacy in treating MDD, with a large fraction of patients e...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00151

    authors: Xin J,Yuan M,Peng Y,Wang J

    更新日期:2020-03-18 00:00:00

  • Enhanced dopamine D1 and BDNF signaling in the adult dorsal striatum but not nucleus accumbens of prenatal cocaine treated mice.

    abstract::Previous work from our group and others utilizing animal models have demonstrated long-lasting structural and functional alterations in the meso-cortico-striatal dopamine pathway following prenatal cocaine (PCOC) treatment. We have shown that PCOC treatment results in augmented D1-induced cyclic AMP (cAMP) and cocaine...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2011.00067

    authors: Tropea TF,Kabir ZD,Kaur G,Rajadhyaksha AM,Kosofsky BE

    更新日期:2011-12-07 00:00:00

  • State-Dependent and Trait-Like Characteristics of Dysfunctional Attitudes in Patients With Major Depressive Disorder.

    abstract:Background:Studies have shown that patients with major depressive disorder (MDD) exhibit elevated dysfunctional attitudes (DAs). However, it remains controversial whether the DAs are state-dependent or trait-like features of MDD. Methods:This study recruited 172 patients and 159 healthy controls (HCs) at baseline. DAs...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00645

    authors: Liu B,Sun J,Qin X,Wang M,Lu X,Dong Q,Zhang L,Liu J,Ju Y,Wan P,Guo H,Zhao F,Zhang Y,Li L

    更新日期:2020-07-10 00:00:00

  • Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls.

    abstract:INTRODUCTION:Multivariate machine learning methods can be used to classify groups of schizophrenia patients and controls using structural magnetic resonance imaging (MRI). However, machine learning methods to date have not been extended beyond classification and contemporaneously applied in a meaningful way to clinical...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2012.00053

    authors: Greenstein D,Malley JD,Weisinger B,Clasen L,Gogtay N

    更新日期:2012-06-01 00:00:00

  • A Roadmap for Integrating Neuroscience Into Addiction Treatment: A Consensus of the Neuroscience Interest Group of the International Society of Addiction Medicine.

    abstract::Although there is general consensus that altered brain structure and function underpins addictive disorders, clinicians working in addiction treatment rarely incorporate neuroscience-informed approaches into their practice. We recently launched the Neuroscience Interest Group within the International Society of Addict...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2019.00877

    authors: Verdejo-Garcia A,Lorenzetti V,Manning V,Piercy H,Bruno R,Hester R,Pennington D,Tolomeo S,Arunogiri S,Bates ME,Bowden-Jones H,Campanella S,Daughters SB,Kouimtsidis C,Lubman DI,Meyerhoff DJ,Ralph A,Rezapour T,Tavakoli H

    更新日期:2019-12-23 00:00:00

  • Prevalence and Correlates of Psychiatric Symptoms in Minimally Verbal Children and Adolescents With ASD.

    abstract::Despite many studies documenting the prevalence of various co-occurring psychiatric symptoms in children and adults with ASD, less is known about how these symptoms relate to subtypes defined by particular phenotypic features within the ASD population. We examined the severity and prevalence of comorbid symptoms of ps...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00043

    authors: Plesa Skwerer D,Joseph RM,Eggleston B,Meyer SR,Tager-Flusberg H

    更新日期:2019-02-18 00:00:00

  • Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder.

    abstract::Major depressive disorder (MDD) is a complex psychiatric disease requiring multidisciplinary approaches to identify specific risk factors and establish more efficacious treatment strategies. Although the etiology and pathophysiology of MDD are not clear until these days, it is acknowledged that they are almost certain...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2020.00381

    authors: Shao X,Zhu G

    更新日期:2020-05-13 00:00:00