Abstract：
:Throughout the world, drug and alcohol use has a clear adolescent onset (Degenhardt et al., 2008). Alcohol continues to be the most popular drug among teens and emerging adults, with almost a third of 12th graders and 40% of college students reporting recent binge drinking (Johnston et al., 2009, 2010), and marijuana (MJ) is the second most popular drug in teens (Johnston et al., 2010). The initiation of drug use is consistent with an overall increase in risk-taking behaviors during adolescence that coincides with significant neurodevelopmental changes in both gray and white matter (Giedd et al., 1996a; Paus et al., 1999; Sowell et al., 1999, 2002, 2004; Gogtay et al., 2004; Barnea-Goraly et al., 2005; Lenroot and Giedd, 2006). Animal studies have suggested that compared to adults, adolescents may be particularly vulnerable to the neurotoxic effects of drugs, especially alcohol and MJ (see Schneider and Koch, 2003; Barron et al., 2005; Monti et al., 2005; Cha et al., 2006; Rubino et al., 2009; Spear, 2010). In this review, we will provide a detailed overview of studies that examined the impact of early adolescent onset of alcohol and MJ use on neurocognition (e.g., Ehrenreich et al., 1999; Wilson et al., 2000; Tapert et al., 2002a; Hartley et al., 2004; Fried et al., 2005; Townshend and Duka, 2005; Medina et al., 2007a; McQueeny et al., 2009; Gruber et al., 2011, 2012; Hanson et al., 2011; Lisdahl and Price, 2012), with a special emphasis on recent prospective longitudinal studies (e.g., White et al., 2011; Hicks et al., 2012; Meier et al., 2012). Finally, we will explore potential clinical and public health implications of these findings.
journal_name
Front Psychiatryjournal_title
Frontiers in psychiatryauthors
Lisdahl KM,Gilbart ER,Wright NE,Shollenbarger Sdoi
10.3389/fpsyt.2013.00053subject
Has Abstractpub_date
2013-07-01 00:00:00pages
53issn
1664-0640journal_volume
4pub_type
杂志文章abstract：:Background: Catatonic phenomena such as stupor, mutism, stereotypy, echolalia, echopraxia, affective flattening, psychomotor deficits, and social withdrawal are characteristic symptoms of both schizophrenia and autism spectrum disorders (ASD), suggesting overlapping pathophysiological similarities such as altered glut...
journal_title：Frontiers in psychiatry
pub_type：
doi：10.3389/fpsyt.2019.00224
更新日期：2019-04-12 00:00:00
abstract：:Neuroimaging holds the promise that it may one day aid the clinical assessment of individual psychiatric patients. However, the vast majority of studies published so far have been based on average differences between groups, which do not permit accurate inferences at the level of the individual. We examined the potent...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2013.00187
更新日期：2014-01-29 00:00:00
abstract：Introduction:Visual impairment (VI) is associated with a variety of comorbidities including physical and mental health in industrial countries. Our aim is to examine associations between self-reported impairment and depressive symptoms in the German population. Methods:The point prevalence of self-reported VI in Germa...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2018.00114
更新日期：2018-04-09 00:00:00
abstract：:Introduction: Previous studies have indicated that changes in the concentration of glutamate and related metabolites may mediate the progression of addiction in patients with methamphetamine (MA) use disorders. In the present study, we utilized magnetic resonance spectroscopy (MRS) to investigate absolute glutamate co...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2018.00368
更新日期：2018-08-31 00:00:00
abstract：:Objectives: Marginalization-related diminished returns (MDRs) refer to weaker health effects of educational attainment for socially marginalized groups compared to the socially privileged groups. Most of the existing literature on MDRs, however, has focused on marginalization due to race, ethnicity, and sexual orienta...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2020.535624
更新日期：2020-11-27 00:00:00
abstract：:Following the severe attacks by the so-called "Islamic State of Iraq and Syria" on the Yazidi population, which started in summer 2014, the state government of Baden-Württemberg, Germany, funded a Special-Quota Project to bring 1,000 very ill or left-behind women and children who were being held hostage to 22 cities a...
journal_title：Frontiers in psychiatry
pub_type：
doi：10.3389/fpsyt.2017.00282
更新日期：2017-12-13 00:00:00
abstract：:Objective: Predicting who will be a placebo responder is a prerequisite to maximize placebo effects in pain treatment and to minimize them in clinical trials. First evidence exists that genetics could affect placebo effects. However, a classical twin study to estimate the relative contribution of genetic influences co...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2019.00679
更新日期：2019-09-18 00:00:00
abstract：:The treatment of heroin addiction is a complex process involving changes in addictive behavior and brain functioning. The goal of this study was to explore the brain default mode network (DMN) functional connectivity using resting-state functional magnetic resonance imaging (rs-fMRI) and decision-making performance ba...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2019.00381
更新日期：2019-06-06 00:00:00
abstract：:A feature of human culture is that we can learn to consume chemical compounds, derived from natural plants or synthetic fabrication, for their psychoactive effects. These drugs change the mental state and/or the behavioral performance of an individual and can be instrumentalized for various purposes. After the emergen...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章,评审
doi：10.3389/fpsyt.2017.00152
更新日期：2017-08-18 00:00:00
abstract：:Our study aims to explore the risk factors for suicidal ideation and their interaction among the elderly in nursing homes in Hunan province, China. A cross-sectional study was conducted among the elderly in nursing homes in Hunan Province. Twenty-four nursing homes were selected by multistage cluster random sampling, ...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2020.00339
更新日期：2020-04-30 00:00:00
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journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2016.00191
更新日期：2016-11-30 00:00:00
abstract：INTRODUCTION:Multivariate machine learning methods can be used to classify groups of schizophrenia patients and controls using structural magnetic resonance imaging (MRI). However, machine learning methods to date have not been extended beyond classification and contemporaneously applied in a meaningful way to clinical...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2012.00053
更新日期：2012-06-01 00:00:00
abstract：:Autism spectrum disorder (ASD) is a behaviorally defined disorder that is now thought to affect approximately 1 in 69 children in the United States. In most cases, the etiology is unknown, but several studies point to the interaction of genetic predisposition with environmental factors. The immune system is thought to...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2019.00612
更新日期：2019-09-11 00:00:00
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journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2011.00035
更新日期：2011-06-07 00:00:00
abstract：Introduction:Psychosocial stressors may worsen psychotic symptoms in schizophrenia, while social support could protect against the effects of stress in schizophrenia. Hypothalamus-pituitary-adrenal axis dysfunction has been associated with schizophrenia. Hair cortisol concentrations (HCC) allow assessment of cumulative...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2020.572656
更新日期：2020-09-24 00:00:00
abstract：:Classical conditioning was suggested as a mechanism of placebo effects in the 1950s. It was then challenged by response expectancy theory, which proposed that classical conditioning is just one of the means by which expectancies are acquired and changed. According to that account, placebo effects induced by classical ...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2019.00449
更新日期：2019-06-25 00:00:00
abstract：UNLABELLED:Collecting information about the prevalence of cannabis use is necessary but not sufficient for understanding the size, dynamics, and outcomes associated with cannabis markets. This paper uses two data sets describing cannabis consumption in the United States and Europe to highlight (1) differences in infere...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2013.00138
更新日期：2013-11-06 00:00:00
abstract：:[This corrects the article DOI: 10.3389/fpsyt.2019.00786.]. ...
journal_title：Frontiers in psychiatry
pub_type： 已发布勘误
doi：10.3389/fpsyt.2019.00900
更新日期：2019-12-17 00:00:00
abstract：:The aim of this study is to explore the changes and clinical significance of serum C3, C4, hypersensitive C-reactive protein (hsCRP) and uric acid (UA) in patients of bipolar disorder (BD). In this case-control study, we recruited 141 BD patients from The Second Xiangya Hospital, Central South University, and 151 age ...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2018.00381
更新日期：2018-08-21 00:00:00
abstract：:Background: The impact of the ongoing COVID-19 pandemic on vulnerable groups like patients suffering from substance use disorders is expected to be tremendous, and corresponding concerns were raised early on by many experts around the world. Psychosocial distress, financial insecurities and physiological problems asso...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2020.620612
更新日期：2020-12-16 00:00:00
abstract：:Baclofen, particularly high-dose baclofen, has recently emerged as a treatment of major interest for alcohol-dependence. However, baclofen has many potentially dangerous side effects, and the maximal dose of baclofen that may be used is a matter of discussion. Here, the author analyses the medical charts of the last 1...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2014.00143
更新日期：2014-10-10 00:00:00
abstract：:Situational awareness is especially important to decision-making in health care. Comprehending the situation is crucial for anticipating any change in the environment and delivering optimal care. The objective of this study was to evaluate the effects of a training to increase situational awareness and mutual care des...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2020.570786
更新日期：2020-11-26 00:00:00
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journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2016.00098
更新日期：2016-06-13 00:00:00
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journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2018.00087
更新日期：2018-03-21 00:00:00
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journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2010.00153
更新日期：2011-01-07 00:00:00
abstract：:Down syndrome (DS) is associated with intellectual disability and an ultra-high risk of developing dementia. Informant ratings are invaluable to assess abilities and related changes in adults with DS, particularly for those with more severe intellectual disabilities and/or cognitive decline. We previously developed th...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2019.00158
更新日期：2019-04-16 00:00:00
abstract：:Prenatal infections have been linked to the development of schizophrenia (SCZ) and other neurodevelopmental disorders in the offspring, and work in animal models indicates that this is to occur through the maternal inflammatory response triggered by infection. Several studies in animal models demonstrated that acute i...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章,评审
doi：10.3389/fpsyt.2020.00852
更新日期：2020-08-21 00:00:00
abstract：:Suicidality is highly prevalent in patients at clinical high risk (CHR) for psychosis. Childhood adversities and trauma are generally predictive of suicidality. However, the differential effects of adversity/trauma-domains and CHR-criteria, i.e., ultra-high risk and basic symptom criteria, on suicidality remain unclea...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2017.00242
更新日期：2017-11-20 00:00:00
abstract：:Co-design, defined as collective creativity across the entire design process, can lead to the development of interventions that are more engaging, satisfying, and useful to potential users. However, using this methodology within the research arena requires a shift from traditional practice. Co-design of eHealth interv...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章,评审
doi：10.3389/fpsyt.2018.00481
更新日期：2018-10-18 00:00:00
abstract：:Butyrylcholinesterase (BChE) efficiently hydrolyzes acetylcholine (ACh) at high concentrations when acetylcholinesterase (AChE) is substrate-inhibited. Recent studies have shown that BChE also has a function that is independent of ACh, but it has not been fully explored. Low BChE expression is accompanied with higher ...
journal_title：Frontiers in psychiatry
pub_type： 杂志文章
doi：10.3389/fpsyt.2020.564843
更新日期：2020-09-11 00:00:00
