Maternal Immune Activation and the Development of Dopaminergic Neurotransmission of the Offspring: Relevance for Schizophrenia and Other Psychoses.

Abstract:

:Prenatal infections have been linked to the development of schizophrenia (SCZ) and other neurodevelopmental disorders in the offspring, and work in animal models indicates that this is to occur through the maternal inflammatory response triggered by infection. Several studies in animal models demonstrated that acute inflammatory episodes are sufficient to trigger brain alterations in the adult offspring, especially in the mesolimbic dopamine (DA) system, involved in the pathophysiology of SCZ and other disorders involving psychosis. In the current review, we synthesize the literature on the clinical studies implicating prenatal infectious events in the development of SCZ. Then, we summarize evidence from animal models of maternal immune activation (MIA) and the behavioral and molecular alterations relevant for the function of the DAergic system. Furthermore, we discuss the evidence supporting the involvement of maternal cytokines, such as interleukin 6 (IL-6) and leptin (a hormone with effects on inflammation) in mediating the effects of MIA on the fetal brain, leading to the long-lasting effects on the offspring. In particular, IL-6 has been involved in mediating the effects of MIA animal models in the offspring through actions on the placenta, induction of IL-17a, or triggering the decrease in non-heme iron (hypoferremia). Maternal infection is very likely interacting with additional genetic and environmental risk factors in the development of SCZ; systematically investigating how these interactions produce specific phenotypes is the next step in understanding the etiology of complex psychiatric disorders.

journal_name

Front Psychiatry

journal_title

Frontiers in psychiatry

authors

Aguilar-Valles A,Rodrigue B,Matta-Camacho E

doi

10.3389/fpsyt.2020.00852

subject

Has Abstract

pub_date

2020-08-21 00:00:00

pages

852

issn

1664-0640

journal_volume

11

pub_type

杂志文章,评审
  • Comparison of Psychological Stress Levels and Associated Factors Among Healthcare Workers, Frontline Workers, and the General Public During the Novel Coronavirus Pandemic.

    abstract::Objective: We aimed to conduct a comparative analysis of the psychological stress experienced by healthcare workers, frontline workers, and the general public and to assess the factors associated with psychological stress in each of these groups. Methods: We conducted an online survey targeting healthcare workers, fro...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.583971

    authors: Luan R,Pu W,Dai L,Yang R,Wang P

    更新日期:2020-12-01 00:00:00

  • Using structural neuroimaging to make quantitative predictions of symptom progression in individuals at ultra-high risk for psychosis.

    abstract::Neuroimaging holds the promise that it may one day aid the clinical assessment of individual psychiatric patients. However, the vast majority of studies published so far have been based on average differences between groups, which do not permit accurate inferences at the level of the individual. We examined the potent...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2013.00187

    authors: Tognin S,Pettersson-Yeo W,Valli I,Hutton C,Woolley J,Allen P,McGuire P,Mechelli A

    更新日期:2014-01-29 00:00:00

  • Characteristics of Adolescents Affected by Mass Psychogenic Illness Outbreaks in Schools in Nepal: A Case-Control Study.

    abstract::This paper presents the first systematic case-control study of correlates of mass psychogenic illness (MPI) in an adolescent school population. MPI is generally construed as a dissociative phenomenon spread by social contagion to individuals who are prone to dissociation. We sought to test if the correlates of dissoci...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.493094

    authors: Sapkota RP,Brunet A,Kirmayer LJ

    更新日期:2020-11-17 00:00:00

  • Prevalence and Correlates of Psychiatric Symptoms in Minimally Verbal Children and Adolescents With ASD.

    abstract::Despite many studies documenting the prevalence of various co-occurring psychiatric symptoms in children and adults with ASD, less is known about how these symptoms relate to subtypes defined by particular phenotypic features within the ASD population. We examined the severity and prevalence of comorbid symptoms of ps...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00043

    authors: Plesa Skwerer D,Joseph RM,Eggleston B,Meyer SR,Tager-Flusberg H

    更新日期:2019-02-18 00:00:00

  • Different Trajectories of Prolonged Grief in Bereaved Family Members After Terror.

    abstract::Introduction: The loss of a loved one in a terror incident is associated with elevated risk for mental health disorders such as prolonged grief disorder (PGD) and posttraumatic stress disorder (PTSD), but the long- term adaptation after such losses are not well understood. This study aims to explore the trajectories o...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.545368

    authors: Kristensen P,Dyregrov K,Gjestad R

    更新日期:2020-10-14 00:00:00

  • Determinants of Mental Illness Among Humanitarian Migrants: Longitudinal Analysis of Findings From the First Three Waves of a Large Cohort Study.

    abstract::Background: As refugee numbers grow worldwide, understanding prevalence and determinants of mental illness in this population becomes increasingly important. Methods: We used longitudinal data to examine the initial years of resettlement in Australian refugees with a focus on ethnic-like social support. Three annual w...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00545

    authors: Cooper S,Enticott JC,Shawyer F,Meadows G

    更新日期:2019-08-02 00:00:00

  • Preliminary Indications That First Semester Students From Academic Households Exhibit Higher Hair Cortisol Concentrations Than Their Peers From Nonacademic Households.

    abstract::Previous research has extensively addressed social disparity in education using certain aspects, including the stress differences between students from nonacademic families and those from academic families during the transition from secondary school to a university. However, this issue has not yet been fully understoo...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00580

    authors: Bertrams A,Minkley N

    更新日期:2020-06-24 00:00:00

  • Corrigendum: Preventing and Reducing Coercive Measures-An Evaluation of the Implementation of the Safewards Model in Two Locked Wards in Germany.

    abstract::[This corrects the article DOI: 10.3389/fpsyt.2019.00340.]. ...

    journal_title:Frontiers in psychiatry

    pub_type: 已发布勘误

    doi:10.3389/fpsyt.2020.00162

    authors: Baumgardt J,Jäckel D,Helber-Böhlen H,Stiehm N,Morgenstern K,Voigt A,Schöppe E,Mc Cutcheon AK,Velasquez Lecca EE,Löhr M,Schulz M,Bechdolf A,Weinmann S

    更新日期:2020-03-11 00:00:00

  • Bipolar Mood State Reflected in Functional Connectivity of the Hate Circuit: A Resting-State Functional Magnetic Resonance Imaging Study.

    abstract:Background:Previous studies suggested bipolar disorder caused an aberrant alteration in the insular, putamen, and left superior frontal gyrus, which are the main components of the hate circuit. However, the relationship between the hate circuit and the pathophysiologic substrate underlying different phases of bipolar d...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.556126

    authors: Fan Z,Yang J,Zeng C,Xi C,Wu G,Guo S,Xue Z,Liu Z,Tao H

    更新日期:2020-10-27 00:00:00

  • Effect of Psychological-Behavioral Intervention on the Depression and Anxiety of COVID-19 Patients.

    abstract::The COVID-19 epidemic has caused increasing public panic and mental health stress. In this study, we explore the prevalence and factors linked to anxiety and depression in hospitalized patients with COVID-19. A total of 144 patients diagnosed with COVID-19 underwent depression and anxiety assessment by using the Hospi...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.586355

    authors: Kong X,Kong F,Zheng K,Tang M,Chen Y,Zhou J,Li Y,Diao L,Wu S,Jiao P,Su T,Dong Y

    更新日期:2020-11-20 00:00:00

  • Changes of Altruistic Behavior and Kynurenine Pathway in Late-Life Depression.

    abstract:Background:Depressive patients show less altruistic behavior. While, older adults present higher tendencies for altruism than younger adults. Depression and age are two of the influencing factors of altruism, kynurenine (KYN), and its metabolites. However, the characteristics of altruism in late-life depression (LLD) a...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00338

    authors: Wu Y,Mai N,Weng X,Liang J,Ning Y

    更新日期:2020-04-30 00:00:00

  • Memory Systems and the Addicted Brain.

    abstract::The view that anatomically distinct memory systems differentially contribute to the development of drug addiction and relapse has received extensive support. The present brief review revisits this hypothesis as it was originally proposed 20 years ago (1) and highlights several recent developments. Extensive research e...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2016.00024

    authors: Goodman J,Packard MG

    更新日期:2016-02-25 00:00:00

  • The Importance of Social Cognition in Improving Functional Outcomes in Schizophrenia.

    abstract::Social cognition has become recognized as an important driver of functional outcomes and overall recovery in patients with schizophrenia, mediating the relationship between neurocognition and social functioning. Since antipsychotic therapy targeting remission of clinical symptoms has been shown to have a limited impac...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2018.00157

    authors: Javed A,Charles A

    更新日期:2018-04-24 00:00:00

  • Neural Correlates of Own- and Other-Face Perception in Body Dysmorphic Disorder.

    abstract:Background:Body dysmorphic disorder (BDD) is characterized by an excessive preoccupation with one or more perceived flaws in one's own appearance. Previous studies provided evidence for deficits in configural and holistic processing in BDD. Preliminary evidence suggests abnormalities at an early stage of visual process...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00302

    authors: Ritter V,Kaufmann JM,Krahmer F,Wiese H,Stangier U,Schweinberger SR

    更新日期:2020-04-24 00:00:00

  • Neurobiology of cognitive remediation therapy for schizophrenia: a systematic review.

    abstract::Cognitive impairment is an important aspect of schizophrenia, where cognitive remediation therapy (CRT) is a promising treatment for improving cognitive functioning. While neurobiological dysfunction in schizophrenia has been the target of much research, the neural substrate of cognitive remediation and recovery has n...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2014.00103

    authors: Thorsen AL,Johansson K,Løberg EM

    更新日期:2014-08-15 00:00:00

  • Effectiveness of Transitional Interventions in Improving Patient Outcomes and Service Use After Discharge From Psychiatric Inpatient Care: A Systematic Review and Meta-Analysis.

    abstract::Background: The transition from psychiatric hospital to community is often hindered by challenges that influence community adjustment and continuity of care. Transitional interventions with bridging components are provided prior to discharge and continue beyond inpatient care. They provide continuity of care and may b...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2019.00969

    authors: Hegedüs A,Kozel B,Richter D,Behrens J

    更新日期:2020-01-21 00:00:00

  • Gamified, Automated Virtual Reality Exposure Therapy for Fear of Spiders: A Single-Subject Trial Under Simulated Real-World Conditions.

    abstract:Background:Virtual Reality exposure therapy (VRET) is an evidence-based treatment of phobias and recent research suggests that this applies also to self-contained, automated interventions requiring no therapist guidance. With the advent and growing adoption of consumer VR technology, automated VR intervention have the ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00116

    authors: Lindner P,Miloff A,Bergman C,Andersson G,Hamilton W,Carlbring P

    更新日期:2020-03-03 00:00:00

  • Disadvantageous Decision-Making as a Predictor of Drop-Out among Cocaine-Dependent Individuals in Long-Term Residential Treatment.

    abstract:BACKGROUND:The treatment of cocaine-dependent individuals (CDI) is substantially challenged by high drop-out rates, raising questions regarding contributing factors. Recently, a number of studies have highlighted the potential of greater focus on the clinical significance of neurocognitive impairments in treatment-seek...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2013.00149

    authors: Stevens L,Betanzos-Espinosa P,Crunelle CL,Vergara-Moragues E,Roeyers H,Lozano O,Dom G,Gonzalez-Saiz F,Vanderplasschen W,Verdejo-García A,Pérez-García M

    更新日期:2013-11-15 00:00:00

  • Personality and Psychological Factors of Problematic Internet Gamers Seeking Hospital Treatment.

    abstract::Introduction: Previous studies on internet gaming disorder (IGD) have reported an association between personality traits and impulsive or problematic use of the internet or internet games, but the results obtained were inconsistent. Our study's hypothesis was that personality traits are associated with the individual'...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00583

    authors: Seong W,Hong JS,Kim S,Kim SM,Han DH

    更新日期:2019-08-28 00:00:00

  • Corrigendum: A Brief Review of Paradigm Shifts in Prevention of Alzheimer's Disease: From Cognitive Reserve to Precision Medicine.

    abstract::[This corrects the article DOI: 10.3389/fpsyt.2019.00786.]. ...

    journal_title:Frontiers in psychiatry

    pub_type: 已发布勘误

    doi:10.3389/fpsyt.2019.00900

    authors: Hahn C,Lee CU

    更新日期:2019-12-17 00:00:00

  • Autism Spectrum Disorder and Schizophrenia Are Better Differentiated by Positive Symptoms Than Negative Symptoms.

    abstract::Autism spectrum disorder (ASD) and schizophrenia (SZ) are heterogenous neurodevelopmental disorders that overlap in symptom presentation. The purpose of this study was to specify overlapping symptom domains and to identify symptoms that can reliably differentiate adults with ASD (n = 53), SZ (n = 39), and typical deve...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00548

    authors: Trevisan DA,Foss-Feig JH,Naples AJ,Srihari V,Anticevic A,McPartland JC

    更新日期:2020-06-11 00:00:00

  • Baclofen but Not Diazepam Alleviates Alcohol-Seeking Behavior and Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Stressed Withdrawn Mice.

    abstract::This study compares the impact of repeated injections of baclofen (an agonist of GABAB receptors) or diazepam (a benzodiazepine having an agonist action on GABAA receptors) given during the alcohol-withdrawal period on the stress-induced restoration of alcohol-seeking behavior and hypothalamic-pituitary-adrenal (HPA) ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00238

    authors: Rabat Y,Henkous N,Corio M,Nogues X,Beracochea D

    更新日期:2019-04-16 00:00:00

  • Reduced intrinsic connectivity of amygdala in adults with major depressive disorder.

    abstract::Imaging studies of major depressive disorder (MDD) have demonstrated enhanced resting-state activity of the amygdala as well as exaggerated reactivity to negative emotional stimuli relative to healthy controls (HCs). However, the abnormalities in the intrinsic connectivity of the amygdala in MDD still remain unclear. ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2014.00017

    authors: Ramasubbu R,Konduru N,Cortese F,Bray S,Gaxiola-Valdez I,Goodyear B

    更新日期:2014-02-19 00:00:00

  • Text Analysis of Electronic Medical Records to Predict Seclusion in Psychiatric Wards: Proof of Concept.

    abstract::Aim: With the introduction of "Electronic Medical Record" (EMR) a wealth of digital data has become available. This provides a unique opportunity for exploring precedents for seclusion. This study explored the feasibility of text mining analysis in the EMR to eventually help reduce the use of seclusion in psychiatry. ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00188

    authors: Hazewinkel MC,de Winter RFP,van Est RW,van Hyfte D,Wijnschenk D,Miedema N,Hoencamp E

    更新日期:2019-04-11 00:00:00

  • Posttraumatic Stress Disorder and Related Disorders among Female Yazidi Refugees following Islamic State of Iraq and Syria Attacks-A Case Series and Mini-Review.

    abstract::Following the severe attacks by the so-called "Islamic State of Iraq and Syria" on the Yazidi population, which started in summer 2014, the state government of Baden-Württemberg, Germany, funded a Special-Quota Project to bring 1,000 very ill or left-behind women and children who were being held hostage to 22 cities a...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2017.00282

    authors: Gerdau I,Kizilhan JI,Noll-Hussong M

    更新日期:2017-12-13 00:00:00

  • Serum Markers of Inflammation Mediate the Positive Association Between Neuroticism and Depression.

    abstract::Background: The personality trait neuroticism has been implicated in a poor response to stress, may relate to increased concentrations of cytokines and the development of depression. Inflammatory mechanisms may also be associated with the onset, severity and symptoms of depression. Both are related to poor antidepress...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00609

    authors: Schmidt FM,Sander C,Minkwitz J,Mergl R,Dalton B,Holdt LM,Teupser D,Hegerl U,Himmerich H

    更新日期:2018-11-20 00:00:00

  • Insomnia Is Associated With Frequency of Suicidal Ideation Independent of Depression: A Replication and Extension of Findings From the National Health and Nutrition Examination Survey.

    abstract:Objective:Insomnia is associated with suicidality, although the mechanisms of this association are unclear. This study sought to replicate previous findings showing that insomnia symptoms but not sleep duration are associated with frequency of suicidal ideation in adults. We further investigated whether depression or s...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.561564

    authors: Simmons Z,Erickson LD,Hedges D,Kay DB

    更新日期:2020-09-18 00:00:00

  • The Obesity-Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients.

    abstract::Pathological impulsivity is encountered in a broad range of psychiatric conditions and is thought to be a risk factor for aggression directed against oneself or others. Recently, a strong association was found between impulsivity and obesity which may explain the high prevalence of metabolic disorders in individuals w...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2017.00020

    authors: Sfera A,Osorio C,Inderias LA,Parker V,Price AI,Cummings M

    更新日期:2017-02-13 00:00:00

  • Fluctuations in Affective States and Self-Efficacy to Resist Non-Suicidal Self-Injury as Real-Time Predictors of Non-Suicidal Self-Injurious Thoughts and Behaviors.

    abstract:Introduction:Although research over the past decade has resulted in significantly increased knowledge about distal risk factors for non-suicidal self-injury (NSSI), little is known about short-term (proximal) factors that predict NSSI thoughts and behaviors. Drawing on contemporaneous theories of NSSI, as well as the c...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00214

    authors: Kiekens G,Hasking P,Nock MK,Boyes M,Kirtley O,Bruffaerts R,Myin-Germeys I,Claes L

    更新日期:2020-03-20 00:00:00

  • Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder.

    abstract::The most replicated neuroanatomical finding in autism is the tendency toward brain overgrowth, especially in younger children. Research shows that both gray and white matter are enlarged. Proposed mechanisms underlying brain enlargement include abnormal inflammatory and neurotrophic signals that lead to excessive, abe...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2019.00165

    authors: Sokol DK,Maloney B,Westmark CJ,Lahiri DK

    更新日期:2019-04-10 00:00:00