Abstract:
:This study compares the impact of repeated injections of baclofen (an agonist of GABAB receptors) or diazepam (a benzodiazepine having an agonist action on GABAA receptors) given during the alcohol-withdrawal period on the stress-induced restoration of alcohol-seeking behavior and hypothalamic-pituitary-adrenal (HPA) axis dysfunction after a long (4 weeks) abstinence. Thus, C57BL/6 mice were submitted to a 6-month alcohol consumption [12% volume/volume (v/v)] and were progressively withdrawn to water before testing. Diazepam (Valium®, Roche) and baclofen (Baclofen®, Mylan) were administered intraperitoneally for 15 consecutive days (1 injection/day) during the withdrawal period at decreasing doses ranging from 1.0 mg/kg (Day 15) to 0.25 mg/kg (Day 1) for diazepam and from 1.5 mg/kg (Day 15) to 0.37 mg/kg (Day 1) for baclofen. Alcohol-seeking behavior was evaluated by alcohol-place preference in an odor recognition task. In the stress condition, mice received three electric footshocks 45 min before behavioral testing. Blood was sampled immediately after behavioral testing, and plasma corticosterone concentrations were measured by commercial enzyme immunoassay kits. Results showed that non-stressed withdrawn mice did not exhibit alcohol-place preference or alteration of plasma corticosterone concentrations relative to water controls. After stress, however, withdrawn mice exhibited a significant alcohol-place preference and higher circulating corticosterone concentrations as compared to stressed water controls. Interestingly, repeated administration during the withdrawal phase of baclofen but not diazepam suppressed both the alcohol-place preference and normalized corticosterone levels in stressed withdrawn animals. In conclusion, this study evidences that a pre-treatment with baclofen but not with diazepam during the withdrawal phase normalized, even after a long period of abstinence, the HPA axis response to stress, which contributes to the long-term preventing effects of this compound on alcohol-seeking behavior.
journal_name
Front Psychiatryjournal_title
Frontiers in psychiatryauthors
Rabat Y,Henkous N,Corio M,Nogues X,Beracochea Ddoi
10.3389/fpsyt.2019.00238subject
Has Abstractpub_date
2019-04-16 00:00:00pages
238issn
1664-0640journal_volume
10pub_type
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
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abstract::[This corrects the article DOI: 10.3389/fpsyt.2020.00202.]. ...
journal_title:Frontiers in psychiatry
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doi:10.3389/fpsyt.2020.584711
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doi:10.3389/fpsyt.2019.00051
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pub_type: 杂志文章
doi:10.3389/fpsyt.2020.578682
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2014.00002
更新日期:2014-01-24 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2019.00836
更新日期:2019-11-12 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2020.00338
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journal_title:Frontiers in psychiatry
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doi:10.3389/fpsyt.2020.00753
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pub_type: 杂志文章,评审
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2016.00024
更新日期:2016-02-25 00:00:00
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journal_title:Frontiers in psychiatry
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doi:10.3389/fpsyt.2017.00307
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2019.00348
更新日期:2019-05-27 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2017.00312
更新日期:2018-01-22 00:00:00
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journal_title:Frontiers in psychiatry
pub_type: 杂志文章
doi:10.3389/fpsyt.2014.00126
更新日期:2014-09-10 00:00:00
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pub_type: 杂志文章,评审
doi:10.3389/fpsyt.2018.00189
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