Baclofen but Not Diazepam Alleviates Alcohol-Seeking Behavior and Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Stressed Withdrawn Mice.


:This study compares the impact of repeated injections of baclofen (an agonist of GABAB receptors) or diazepam (a benzodiazepine having an agonist action on GABAA receptors) given during the alcohol-withdrawal period on the stress-induced restoration of alcohol-seeking behavior and hypothalamic-pituitary-adrenal (HPA) axis dysfunction after a long (4 weeks) abstinence. Thus, C57BL/6 mice were submitted to a 6-month alcohol consumption [12% volume/volume (v/v)] and were progressively withdrawn to water before testing. Diazepam (Valium®, Roche) and baclofen (Baclofen®, Mylan) were administered intraperitoneally for 15 consecutive days (1 injection/day) during the withdrawal period at decreasing doses ranging from 1.0 mg/kg (Day 15) to 0.25 mg/kg (Day 1) for diazepam and from 1.5 mg/kg (Day 15) to 0.37 mg/kg (Day 1) for baclofen. Alcohol-seeking behavior was evaluated by alcohol-place preference in an odor recognition task. In the stress condition, mice received three electric footshocks 45 min before behavioral testing. Blood was sampled immediately after behavioral testing, and plasma corticosterone concentrations were measured by commercial enzyme immunoassay kits. Results showed that non-stressed withdrawn mice did not exhibit alcohol-place preference or alteration of plasma corticosterone concentrations relative to water controls. After stress, however, withdrawn mice exhibited a significant alcohol-place preference and higher circulating corticosterone concentrations as compared to stressed water controls. Interestingly, repeated administration during the withdrawal phase of baclofen but not diazepam suppressed both the alcohol-place preference and normalized corticosterone levels in stressed withdrawn animals. In conclusion, this study evidences that a pre-treatment with baclofen but not with diazepam during the withdrawal phase normalized, even after a long period of abstinence, the HPA axis response to stress, which contributes to the long-term preventing effects of this compound on alcohol-seeking behavior.


Front Psychiatry


Frontiers in psychiatry


Rabat Y,Henkous N,Corio M,Nogues X,Beracochea D




Has Abstract


2019-04-16 00:00:00








  • Using multivariate machine learning methods and structural MRI to classify childhood onset schizophrenia and healthy controls.

    abstract:INTRODUCTION:Multivariate machine learning methods can be used to classify groups of schizophrenia patients and controls using structural magnetic resonance imaging (MRI). However, machine learning methods to date have not been extended beyond classification and contemporaneously applied in a meaningful way to clinical...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Greenstein D,Malley JD,Weisinger B,Clasen L,Gogtay N

    更新日期:2012-06-01 00:00:00

  • Neuroimaging Correlates of Suicidality in Decision-Making Circuits in Posttraumatic Stress Disorder.

    abstract::In depression, brain and behavioral correlates of decision-making differ between individuals with and without suicidal thoughts and behaviors. Though promising, it remains unknown if these potential biomarkers of suicidality will generalize to other high-risk clinical populations. To preliminarily assess whether brain...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Barredo J,Aiken E,van 't Wout-Frank M,Greenberg BD,Carpenter LL,Philip NS

    更新日期:2019-02-12 00:00:00

  • The Association of Non-obscene Socially Inappropriate Behavior With Attention-Deficit/Hyperactivity Disorder Symptoms, Conduct Problems, and Risky Decision Making in a Large Sample of Adolescents.

    abstract::Non-obscene socially inappropriate behavior (NOSI) is recognized as part of the tic disorder spectrum but has received little attention from researchers to date. A study in 87 patients with Tourette syndrome showed that comorbid attention-deficit/hyperactivity disorder (ADHD) and conduct disorder were also associated ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Brandt V,Kerner Auch Koerner J,Palmer-Cooper E

    更新日期:2019-09-13 00:00:00

  • A Randomized Controlled Trial on the Efficacy of a Psychosocial Behavioral Intervention to Improve the Lifestyle of Patients With Severe Mental Disorders: Study Protocol.

    abstract::Patients with severe mental disorders die on average 20 years prior to the general population. This mortality gap is mainly due to the higher prevalence of physical diseases and the adoption of unhealthy lifestyle behaviors.The LIFESTYLE trial aims to evaluate the efficacy of a new psychosocial group intervention (inc...

    journal_title:Frontiers in psychiatry



    authors: Sampogna G,Fiorillo A,Luciano M,Del Vecchio V,Steardo L Jr,Pocai B,Barone M,Amore M,Pacitti F,Dell'Osso L,Di Lorenzo G,Maj M,LIFESTYLE Working Group.

    更新日期:2018-06-07 00:00:00

  • Increasing Risks of Suicide Attempt and Suicidal Drug Overdose After Head Trauma in Patients With Sleep-Disordered Breathing: A Population-Based Study.

    abstract::Objective: To determine the risks of suicide attempt (SA) and suicidal drug overdose (SDO) after head trauma in patients with sleep-disordered breathing (SDB) by using the National Health Insurance Research Database of Taiwan. Methods: We analyzed the data of patients aged ≥20 years who were diagnosed with SDB between...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Harnod D,Lin CL,Harnod T,Kao CH

    更新日期:2020-12-09 00:00:00

  • The Effect of COVID-19 on Mental Health and Wellbeing in a Representative Sample of Australian Adults.

    abstract::There is minimal knowledge about the impact of large-scale epidemics on community mental health, particularly during the acute phase. This gap in knowledge means we are critically ill-equipped to support communities as they face the unprecedented COVID-19 pandemic. This study aimed to provide data urgently needed to i...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Dawel A,Shou Y,Smithson M,Cherbuin N,Banfield M,Calear AL,Farrer LM,Gray D,Gulliver A,Housen T,McCallum SM,Morse AR,Murray K,Newman E,Rodney Harris RM,Batterham PJ

    更新日期:2020-10-06 00:00:00

  • State-Dependent and Trait-Like Characteristics of Dysfunctional Attitudes in Patients With Major Depressive Disorder.

    abstract:Background:Studies have shown that patients with major depressive disorder (MDD) exhibit elevated dysfunctional attitudes (DAs). However, it remains controversial whether the DAs are state-dependent or trait-like features of MDD. Methods:This study recruited 172 patients and 159 healthy controls (HCs) at baseline. DAs...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Liu B,Sun J,Qin X,Wang M,Lu X,Dong Q,Zhang L,Liu J,Ju Y,Wan P,Guo H,Zhao F,Zhang Y,Li L

    更新日期:2020-07-10 00:00:00

  • How Prevalent is "Food Addiction"?

    abstract::Increasing evidence suggests that binge eating-related disorders could be related to addiction-like eating patterns due to the addictive potential of hyperpalatable foods. Subsequently, important implications have been derived for treatment of those disorders and even political actions. However, studies on the prevale...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Meule A

    更新日期:2011-11-03 00:00:00

  • Working Memory Modulates Glutamate Levels in the Dorsolateral Prefrontal Cortex during 1H fMRS.

    abstract::Glutamate is involved in excitatory neurotransmission and metabolic processes related to brain function. Previous studies using proton functional magnetic resonance spectroscopy (1H fMRS) have demonstrated elevated cortical glutamate levels by 2-4% during visual and motor stimulation, relative to periods of no stimula...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Woodcock EA,Anand C,Khatib D,Diwadkar VA,Stanley JA

    更新日期:2018-03-06 00:00:00

  • Nonsuicidal Self-Injury: Its Associations With Pathological Internet Use and Psychopathology Among Adolescents.

    abstract:Background/Hypotheses:As risk factors for nonsuicidal self-injury (NSSI), most studies highlight the importance of internalising disorders, while only a few researches show the connection between externalising disorders and NSSI. Although some papers have introduced the idea that increasing prevalence rates of NSSI are...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Mészáros G,Győri D,Horváth LO,Szentiványi D,Balázs J

    更新日期:2020-08-14 00:00:00

  • Very-Brief, Web-Based Interventions for Reducing Alcohol Use and Related Problems among College Students: A Review.

    abstract::Very-brief, web-based alcohol interventions have great potential due to their convenience, ease of dissemination, and college students' stated preference for this intervention modality. To address the efficacy of these interventions, we conducted a review of the literature to identify randomized controlled trials (RCT...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Leeman RF,Perez E,Nogueira C,DeMartini KS

    更新日期:2015-09-28 00:00:00

  • Pleasure and addiction.

    abstract::What is the role and value of pleasure in addiction? Foddy and Savulescu (1) have claimed that substance use is just pleasure-oriented behavior. They describe addiction as "strong appetites toward pleasure" and argue that addicts suffer in significant part because of strong social and moral disapproval of lives domina...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Kennett J,Matthews S,Snoek A

    更新日期:2013-09-25 00:00:00

  • Current Challenges in Translational and Clinical fMRI and Future Directions.

    abstract::Translational neuroscience is an important field that brings together clinical praxis with neuroscience methods. In this review article, the focus will be on functional neuroimaging (fMRI) and its applicability in clinical fMRI studies. In the light of the "replication crisis," three aspects will be critically discuss...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Specht K

    更新日期:2020-01-08 00:00:00

  • Neurocognition and Social Cognition Predicting 1-Year Outcomes in First-Episode Psychosis.

    abstract::Cognitive performance at illness onset may predict outcomes in first-episode psychosis (FEP), and the change in cognition may associate with clinical changes. Cognitive testing was administered to 54 FEP participants 2 months after entering treatment and to 39 participants after 1 year. We investigated whether baselin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Lindgren M,Holm M,Kieseppä T,Suvisaari J

    更新日期:2020-12-04 00:00:00

  • The Gut Microbiome in Anorexia Nervosa: Friend or Foe?

    abstract::The human gut microbiome is emerging as a key modulator of homeostasis, with far-reaching implications for various multifactorial diseases, including anorexia nervosa (AN). Despite significant morbidity and mortality, the underlying mechanisms of this eating disorder are poorly understood, but the classical view defin...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Ghenciulescu A,Park RJ,Burnet PWJ

    更新日期:2021-01-12 00:00:00

  • Maternal Nutrition and Offspring Stress Response-Implications for Future Development of Non-Communicable Disease: A Perspective From India.

    abstract::Psychological stress is recognized as a major modifiable risk factor for adult non-communicable disease (NCD) that includes depression, type 2 diabetes mellitus, and cardiovascular disease. Dysregulation of hypothalamic-pituitary-adrenal (HPA) axis activity resulting in either exaggerated or blunted cortisol responses...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Krishnaveni GV,Srinivasan K

    更新日期:2019-10-29 00:00:00

  • The Psychological Pressures of Breast Cancer Patients During the COVID-19 Outbreak in China-A Comparison With Frontline Female Nurses.

    abstract::Objective: During the outbreak of the COVID-19 epidemic in China, breast cancer (BC) patients and healthcare workers faced several challenges, resulting in great psychological stress. We measured the psychological status of BC patients and female nurses and compared the severity within the two groups at the peak time-...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Cui Q,Cai Z,Li J,Liu Z,Sun S,Chen C,Wang G

    更新日期:2020-12-15 00:00:00

  • The Obesity-Impulsivity Axis: Potential Metabolic Interventions in Chronic Psychiatric Patients.

    abstract::Pathological impulsivity is encountered in a broad range of psychiatric conditions and is thought to be a risk factor for aggression directed against oneself or others. Recently, a strong association was found between impulsivity and obesity which may explain the high prevalence of metabolic disorders in individuals w...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Sfera A,Osorio C,Inderias LA,Parker V,Price AI,Cummings M

    更新日期:2017-02-13 00:00:00

  • Astrocytic Regulation of Glutamate Transmission in Schizophrenia.

    abstract::According to the glutamate hypothesis of schizophrenia, the abnormality of glutamate transmission induced by hypofunction of NMDA receptors (NMDARs) is causally associated with the positive and negative symptoms of schizophrenia. However, the underlying mechanisms responsible for the changes in glutamate transmission ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Mei YY,Wu DC,Zhou N

    更新日期:2018-11-06 00:00:00

  • Reliving, Replaying Lived Experiences Through Auditory Verbal Hallucinations: Implications on Theories and Management.

    abstract::Objective: This study aims to understand the impact of negative life experience (NLE) in auditory hallucinations (AHs) and explain the heterogeneity in phenomenology of auditory verbal hallucinations (AVHs). Method: In depth interviews were conducted with 21 individuals (7 males and 14 females) experiencing AHs and ac...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Vallath S,Luhrmann T,Bunders J,Ravikant L,Gopikumar V

    更新日期:2018-10-30 00:00:00

  • Development of the WHO Caregiver Skills Training Program for Developmental Disorders or Delays.

    abstract::Globally, 52.9 million children under the age of 5 experience a developmental disability, such as sensory impairment, intellectual disability, and autism spectrum disorders. Of these 95% live in low-and-middle-income countries. Most of these children lack access to care. In light of the growing evidence that caregiver...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Salomone E,Pacione L,Shire S,Brown FL,Reichow B,Servili C

    更新日期:2019-11-11 00:00:00

  • Pathways from cannabis to psychosis: a review of the evidence.

    abstract::The nature of the relationship between cannabis use (CU) and psychosis is complex and remains unclear. Researchers and clinicians remain divided regarding key issues such as whether or not cannabis is an independent cause of psychosis and schizophrenia. This paper reviews the field in detail, examining questions of ca...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Burns JK

    更新日期:2013-10-14 00:00:00

  • Corrigendum: Preventing and Reducing Coercive Measures-An Evaluation of the Implementation of the Safewards Model in Two Locked Wards in Germany.

    abstract::[This corrects the article DOI: 10.3389/fpsyt.2019.00340.]. ...

    journal_title:Frontiers in psychiatry

    pub_type: 已发布勘误


    authors: Baumgardt J,Jäckel D,Helber-Böhlen H,Stiehm N,Morgenstern K,Voigt A,Schöppe E,Mc Cutcheon AK,Velasquez Lecca EE,Löhr M,Schulz M,Bechdolf A,Weinmann S

    更新日期:2020-03-11 00:00:00

  • Identifying phronotypes in psychiatry.

    abstract::Refinements in the methods of diagnosis for psychiatric disorders are critically needed. These new methods should be based on objectively measured brain characteristics that provide clinically useful information. Studying the brain with respect to psychiatric disorders, however, faces numerous challenges. Utilizing te...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Kozel FA

    更新日期:2010-10-20 00:00:00

  • Altered Global Brain Functional Connectivity in Drug-Naive Patients With Obsessive-Compulsive Disorder.

    abstract::Abnormal functional connectivity (FC) within discrete brain networks is involved in the pathophysiology of obsessive-compulsive disorder (OCD) with inconsistent results. In the present study, we investigated the FC patterns of 40 drug-naive patients with OCD and 38 healthy controls (HCs) through an unbiased voxel-wise...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Cui G,Ou Y,Chen Y,Lv D,Jia C,Zhong Z,Yang R,Wang Y,Meng X,Cui H,Li C,Sun Z,Wang X,Guo W,Li P

    更新日期:2020-03-03 00:00:00

  • A Medicinal Herb Scutellaria lateriflora Inhibits PrP Replication in vitro and Delays the Onset of Prion Disease in Mice.

    abstract::Transmissible spongiform encephalopathies (TSE) are characterized by the misfolding of the host encoded prion protein (PrP(C)) into a pathogenic isoform (PrP(Sc)) which leads to the accumulation of β-sheet-rich fibrils and subsequent loss of neurons and synaptic functions. Although many compounds have been identified ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Eiden M,Leidel F,Strohmeier B,Fast C,Groschup MH

    更新日期:2012-02-17 00:00:00

  • Prolonged Bedtime Smartphone Use is Associated With Altered Resting-State Functional Connectivity of the Insula in Adult Smartphone Users.

    abstract::Prolonged bedtime smartphone use is often associated with poor sleep quality and daytime dysfunction. In addition, the unstructured nature of smartphones may lead to excessive and uncontrolled use, which can be a cardinal feature of problematic smartphone use. This study was designed to investigate functional connecti...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章


    authors: Paik SH,Park CH,Kim JY,Chun JW,Choi JS,Kim DJ

    更新日期:2019-07-23 00:00:00

  • Role of the axonal initial segment in psychiatric disorders: function, dysfunction, and intervention.

    abstract::The progress of developing effective interventions against psychiatric disorders has been limited due to a lack of understanding of the underlying cellular and functional mechanisms. Recent research findings focused on exploring novel causes of psychiatric disorders have highlighted the importance of the axonal initia...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审


    authors: Hsu WC,Nilsson CL,Laezza F

    更新日期:2014-08-21 00:00:00

  • Corrigendum: A Brief Review of Paradigm Shifts in Prevention of Alzheimer's Disease: From Cognitive Reserve to Precision Medicine.

    abstract::[This corrects the article DOI: 10.3389/fpsyt.2019.00786.]. ...

    journal_title:Frontiers in psychiatry

    pub_type: 已发布勘误


    authors: Hahn C,Lee CU

    更新日期:2019-12-17 00:00:00

  • Raising Placebo Efficacy in Antidepressant Trials Across Decades Explained by Small-Study Effects: A Meta-Reanalysis.

    abstract:Background:Recent meta-analyses reported placebo response rate in antidepressant trials to be stable since the 1970s. These meta-analyses however were limited in considering only linear time trends, assessed trial-level covariates based on single-model hypothesis testing only, and did not adjust for small-study effects...

    journal_title:Frontiers in psychiatry



    authors: Holper L

    更新日期:2020-07-28 00:00:00